Sulfadoxine+ Pyrimethamine

Pharmacologic Category

Antimalarial Agent

Reported Use

Short-term prophylaxis and treatment of uncomplicated Plasmodium falciparum malaria including areas where chloroquine resistance has been reported.

Dosage Range

Adults: Oral:

Malaria (uncomplicated) treatment: Sulfadoxine 1,500 mg/pyrimethamine 75 mg (3 tablets) as a single dose.

Malaria prophylaxis:

Semi-immune patients: Sulfadoxine 500 mg/pyrimethamine 25 mg per tablet: 2 or 3 tablets once every 4 weeks

Non-immune patients: Sulfadoxine 500 mg/pyrimethamine 25 mg per tablet: 2 tablets once every 2 weeks or 1 tablet once weekly