Embedded Files
Uses and Administration
Hyaluronic acid is widely distributed in body tissues and intracellular fluids, including the aqueous and vitreous humour, and synovial fluid; it is a component of the ground substance or tissue cement surrounding cells.
A viscous solution of sodium hyaluronate is used during surgical procedures on the eye, for example for cataract extraction. Introduction of the solution into the anterior or posterior chamber via a fine cannula or needle allows tissues to be separated during surgery and protects them from trauma. Sodium hyaluronate eye drops 0.1% are also used for the relief of dry eye and as a contact lens lubricant.
Sodium hyaluronate is given by intra-articular injection in the treatment of osteoarthritis of the knee. Doses vary according to the preparation used, but are of the order of 20 to 25 mg once weekly for 5 weeks or up to 30 mg once weekly for 3 or 4 weeks; it is generally recommended that the treatment course for any individual joint should not be repeated within 6 months. Sodium hyaluronate is also used during arthroscopic procedures to flush out irrigating solutions and act as a temporary substitute for synovial fluid.
Hyaluronic acid is applied topically to promote wound healing. Zinc hyaluronate has also been used. A film containing sodium hyaluronate and carmellose is used to prevent surgical adhesion. Sodium hyaluronate has also been used in the management of lesions of the oral mucosa.
Hylans , which are polymers derived from hyaluronic acid, are used similarly for osteoarthritis and wound care.
Sodium hyaluronate instilled intravesically has been used as a temporary replacement of the glycosaminoglycan layer in the bladder for the symptomatic treatment of interstitial cystitis.
Topical formulations of diclofenac in hyaluronic acid ( CT-1101 , AT-2101 ) are used in the treatment of actinic keratoses (but distinguish from an oral formulation of afegostat tartrate (Refer to) under investigation for use in Gaucher disease that also carries the code AT-2101).
Hyaluronic acid has been used as a dermal filler for the correction of moderate to severe facial wrinkles and folds (see Photoageing, Refer to ).
(last reviewed 2010-09-02; last modified 2009-09-05)
Reviews.
(last reviewed 2010-09-02; last modified 2004-03-22)
References
1. Goa KL, Benfield P. Hyaluronic acid: a review of its pharmacology and use as a surgical aid in ophthalmology, and its therapeutic potential in joint disease and wound healing.Drugs. 1994; 47: 536–66. PubMed
2. Adams ME, et al.. A risk-benefit assessment of injections of hyaluronan and its derivatives in the treatment of osteoarthritis of the knee.Drug Safety. 2000; 23: 115–30. PubMed
Actinic keratoses
For references to the use of diclofenac in a hyaluronic acid gel in the treatment of actinic keratoses, see Refer to .
(last reviewed 2010-09-02; last modified 2001-05-14)
Dry eye
The usual management of dry eye ( Refer to ) is with artificial tears. Sodium hyaluronate has also been reported to be of some benefit. Alleviation of symptoms1-3 and an increase in tear film stability1,2 has been shown after topical application of sodium hyaluronate solution (0.1 or 0.2%) compared with saline-based placebo solutions. However, another study4failed to show any advantage over placebo, although it has been suggested4,5 that sodium hyaluronate might play a role in maintaining a healthy corneal epithelium.
(last reviewed 2010-09-02; last modified 2008-11-26)
References
1. Mengher LS, et al. Effect of sodium hyaluronate (0.1%) on break-up time (NIBUT) in patients with dry eyes.Br J Ophthalmol. 1986; 70: 442–7. PubMed
2. Sand BB, et al.. Sodium hyaluronate in the treatment of keratoconjunctivitis sicca: a double masked clinical trial.Acta Ophthalmol (Copenh). 1989; 67: 181–3. PubMed
3. Condon PI, et al.. Double blind, randomised, placebo controlled, crossover, multicentre study to determine the efficacy of a 0.1% (w/v) sodium hyaluronate solution (Fermavisc) in the treatment of dry eye syndrome.Br J Ophthalmol. 1999; 83: 1121–4. PubMed
4. Shimmura S, et al.. Sodium hyaluronate eyedrops in the treatment of dry eyes.Br J Ophthalmol. 1995; 79: 1007–11. PubMed
5. Aragona P, et al.. Long term treatment with sodium hyaluronate-containing artificial tears reduces ocular surface damage in patients with dry eye.Br J Ophthalmol. 2002; 86: 181–4. PubMed
Osteoarthritis
In osteoarthritis, the size and concentration of hyaluronic acid molecules naturally present in synovial fluid is reduced. Thus, one approach in the management of osteoarthritis ( Refer to ) of the knee is viscosupplementation of the synovial fluid by the intra-articular injection of hyaluronic acid or its derivatives. Such injections may reduce pain over 1 to 6 months but may be associated with a short-term increase in knee inflammation; there is some suggestion that any benefit is longer lasting than with intra-articular corticosteroids. Some studies suggest that viscosupplementation may be an effective option for patients who are unable to take oral NSAIDs or have regular intra-articular corticosteroids, and who are unsuitable candidates for joint replacement surgery, although there appears to be considerable variability in clinical response between products, as well as in the variables being assessed and length of treatment.
References.
(last reviewed 2010-09-02; last modified 2008-09-09)
References
1. Altman RD, Moskowitz R. Intraarticular sodium hyaluronate (Hyalgan) in the treatment of patients with osteoarthritis of the knee: a randomized clinical trial.ibidJ Rheumatol. 1998; 25: 26: 2203–12. PubMed
2. Anonymous. Hyaluronan or hylans for knee osteoarthritis?Drug Ther Bull. 1999; 37: 71–2. PubMed
3. Huskisson EC, Donnelly S. Hyaluronic acid in the treatment of osteoarthritis of the knee.Rheumatology (Oxford). 1999; 38: 602–7. PubMed
4. Wobig M, et al.. The role of elastoviscosity in the efficacy of viscosupplementation for osteoarthritis of the knee: a comparison of hylan G-F 20 and a lower-molecular-weight hyaluronan.Clin Ther. 1999; 21: 1549–62. PubMed
5. Felson DT, Anderson JJ. Hyaluronate sodium injections for osteoarthritis: hope, hype, and hard truths.Arch Intern Med. 2002; 162: 245–7. PubMed
6. Lo GH, et al.. Intra-articular hyaluronic acid in treatment of knee osteoarthritis: a meta-analysis.JAMA. 2003; 290: 3115–21. PubMed
7. Bellamy N, et al.. Viscosupplementation for the treatment of osteoarthritis of the knee. Available in The Cochrane Database of Systematic Reviews; Issue 2. Chichester: John Wiley; 2006 (accessed 09/05/06). PubMed
Wound healing
Hyaluronic acid has been used to aid wound healing,1,2 the overall management of which is discussed on Refer to .
(last reviewed 2010-09-02; last modified 2004-07-21)
References
1. Soldati D, et al.. Mucosal wound healing after nasal surgery: a controlled clinical trial on the efficacy of hyaluronic acid containing cream.Drugs Exp Clin Res. 1999; 25: 253–61. PubMed
2. Harris PA, et al.. Use of hyaluronic acid and cultured autologous keratinocytes and fibroblasts in extensive burns.Lancet. 1999; 353: 35–6. PubMed
Adverse Reactions
There have been reports of a transient rise in intra-ocular pressure when sodium hyaluronate was given into the eye. When injected into the knee, pain and inflammation may occur at the injection site. There have also been occasional reports of hypersensitivity, including, rarely, anaphylaxis.
(last reviewed 2010-09-02; last modified 2006-07-11)
Effects on the eyes
Crystalline deposits on intra-ocular lenses have been reported in patients after use of a high viscosity sodium hyaluronate preparation during cataract surgery.1
(last reviewed 2010-09-02; last modified 2006-07-11)
References
1. Jensen MK, et al.. Crystallization on intraocular lens surfaces associated with the use of Healon GV.Arch Ophthalmol. 1994; 112: 1037–42. PubMed
Effects on the skin
A cutaneous granulomatous reaction has been reported in a woman 5 weeks after treatment with synthetic hyaluronic acid for cosmetic use as a dermal filler.1 All cutaneous lesions resolved spontaneously within 3 months without scarring.
(last reviewed 2010-09-02; last modified 2008-07-16)
References
1. Ghislanzoni M, et al.. Cutaneous granulomatous reaction to injectable hyaluronic acid gel.Br J Dermatol. 2006; 154: 755–8. PubMed
Inflammatory reaction
Severe peritoneal inflammation has been reported1 after use of a sodium hyaluronate-based bioresorbable membrane to prevent postoperative adhesion formation.
(last reviewed 2010-09-02; last modified 2006-07-11)
References
1. Klingler PJ, et al.. Seprafilm®-induced peritoneal inflammation: a previously unknown complication: report of a case.Dis Colon Rectum. 1999; 42: 1639–43. PubMed
Precautions
Porphyria
The Drug Database for Acute Porphyria, compiled by the Norwegian Porphyria Centre (NAPOS) and the Porphyria Centre Sweden, classifies hyaluronic acid given by injection for the treatment of musculoskeletal disorders as not porphyrinogenic; it may be used as a drug of first choice and no precautions are needed.1
(last reviewed 2010-09-02; last modified 2011-10-13)
References
1. The Drug Database for Acute Porphyria. Available at: Link (accessed 06/10/11)
Preparations: Single-Ingredient
The following preparations list represents a compilation of all available salt forms or related substances for this drug product.
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
ARGENTINA: Acuaiss¤; Aquify; Artelac Rebalance; Artflex; Biosol; Cientific Synovial; Cruzal Uro; Cruzal; Cystistat; Dropstar; Gengigel; Hialudorf; Hyabak¤; Hyalart; Hyalofill; Hyalomb; Hyalone; Hyasol; Iuronicoderm; Lacripharma¤; Maxiostenil; Miniostenil; Osmolagrimas¤; Perlavita; Provisc¤; Synvisc; Viscoderm¤;AUSTRALIA: AMO Vitrax¤; Fermathron¤; Healon; Hylo-Forte; Hylo-Fresh; Luxyal; Ophthalin¤; Provisc; Synvisc; Vismed¤;AUSTRIA: Amvisc¤; Artzal; Bionect¤; Connettivina¤; Etamucin¤; Fermathron; Healonid¤; Hyalgan; Provisc¤;BELGIUM: Fermathron¤; Gengigel¤; Healon¤; Hyalgan; Provisc¤;BRAZIL: Biolon¤; Densitium¤; Euflexxa; Fermathron; Healon¤; Hyaludermin; Hyaly; Lubrinat; Macrolane; Polireumin; Renehavis; Restylane; Sportvis; Suplasyn¤; Suprahyal; Synvisc;CANADA: Amvisc¤; Biolon¤; Cystistat; Durolane; Eyestil¤; Healon¤; Hyalgan; Hyalofill¤; Hydraplenish; Hylashield¤; Monovisc; NeoVisc; Orthovisc; Suplasyn; Synvisc; Visine Advance Extended Relief¤;CHILE: Biolon¤; Eucerin Emulsion¤; Healon¤; Hyabak; Hyalgan; Hyalsense; Hylaform¤; Lagricel Ofteno; Neolucid Ultra HR; Oftafilm; Suprahyal; Synvisc¤; Toptear;CHINA: ARTZ (阿尔治); Hialid (爱丽); Hyal (哈艾路); Hycosan (玻璃酸钠); Iviz (爱维); Runjie (润洁); Shipeike (施沛克); Sofast (施沛特);CZECH REPUBLIC: Curasan¤; Healon¤; Hyalgan;DENMARK: Artz¤; Hyalart; Hyalgan;FINLAND: Artzal¤; Healon¤; Hyalgan;FRANCE: Adant; Aftamed; Amvisc¤; Arthrum H; Biovisc¤; Coxarthrum; Durolane; Effidia¤; Euflexxa; Go-On; Healon¤; Healonid¤; Hyabak¤; Hyal-Drop¤; Hyalgan; Hyaline; Hyalofemme¤; Hyalofill¤; Hyalugel; Hyaluzinc; Hylo-COMOD¤; Hylovis; Hyluprotect¤; Ialuset; Idune¤; Ostenil; Oxens; Provisc¤; Sinovial; Structovial; Succeev¤; Suplasyn¤; Synocrom; Synvisc; Vismed¤; Vitrax¤;GERMANY: Artelac Splash¤; Arthrease¤; Artroject¤; Biolan; Biolon¤; Comfort Shield; Comfort Tears; Crespine; Curavisc; Cystistat¤; Dispasan¤; Endogel¤; Fermathron¤; Gelbag¤; Genteal HA¤; Go-On; Healon¤; Hy-GAG¤; Hya-Ject¤; Hya-Ophtal¤; Hyabak; Hyal-System¤; Hyalart; HyalOne; Hyalubrix; Hyaluron¤; Hylaform¤; Hylan; Hylo-COMOD; Hylo-Gel; Hylo-Lasop¤; Hylo-Vision; Hymovis; Hysan; Jossalind¤; Laservis¤; Monovisc; Orthovisc; Ostenil; Oxyal¤; Provisc; Recosyn; Sinovial; SportVis; Suplasyn¤; Synvisc; TwinVisc; Uni-Injekt¤; Unike; Viscoseal; Visiol¤; Vislube; Vismed; Visthesia; Xidan EDO¤; Z-Hyalcoat; Z-Hyalin;GREECE: Arthryal; Biolon¤; Gonilert; Healon¤; Hyalart; Hyalovet Plus; Hyaluroprol; Provisc¤; Viscure; Yardel;HONG KONG: Artelac Advanced; Belotero Balance [check mims]; Connettivina; Go-On; Healon¤; Hialid; Hicle; Hyalgan; HyalOne; Hyaluron; Hyruan; Ial¤; Jonexa; Ophthalin¤; Ostenil; Provisc¤; Renehavis; Suplasyn; Synocrom; Synvisc; Vismed;HUNGARY: Conheal; Curiosin; Healon¤; Hyalgan; Ial¤; Ophthalin¤; Provisc¤;INDIA: Fain; Halonix; Healon; Hymoist; Hyopt; Hyvisc; LG Hyal; LG Hyruan; Synvisc; Visial;INDONESIA: Adant; Bionect; Cytistat; DualVis; Durolane; Hialid; Hyalgan; Hyaloph; Lydium; Matafres; Navitae; Osflex; Ostenil; Revanesse; Sanorine; Sinovial; SportVis; Suplasyn; Synvisc; Umarone;IRELAND: Healonid¤; Hyalgan; Ophthalin¤; Provisc¤; Suplasyn¤;ISRAEL: Adant¤; Amvisc¤; Arthrease¤; Biolon; Curavisc¤; Eyecon; Healon¤; Hylo-COMOD¤; Hysan¤; Ophthalin¤; Orthovisc¤; Suplasyn¤; Synvisc¤;ITALY: Artelac Advanced; Artz; Biolon¤; Bionect¤; Cicatridina; Connettivina; Dropstar; Durolane; Fillast; Go-On; Healon¤; Hy-Drop; Hyabak; Hyalart; Hyalgan; Hyalistil; Hyalofill-F; Hyalubrix; Hylo-COMOD; Hyluprotect; Ial; Ialect¤; Ialoclean; Ialum; Ialurex; Irilens; Jaloskin; Ocustil¤; Oftaial; Ophtalin¤; Opisial¤; Otoial¤; Oxyal; Provisc; Rugantil¤; Skin-B¤; Skin-R¤; Synocrom; Synvisc; Vismed;JAPAN: Hyalein; Suvenyl; Synvisc;MALAYSIA: Adant; Aftamed; Aragan Plus; Curiosin; Eye HA Plus; Gengigel; Go-On; Healon¤; Hialid; Hyal; Hyalgan; Hyalubrix; Hylo-COMOD; Hyruan¤; Joint HA Plus; Jointmax; Juvederm; Laservis¤; Provisc¤; Sinovial¤; Suplasyn; Synvisc; Viscoseal; Visiol; Vislube¤; Vismed;MEXICO: Biolon¤; Biovisc; Dropstar; Euflexxa; Eyestil; Hyasol¤; Hyruan Plus; Lagricel; Suprahyal; Synvisc; Zonaker;MONACO: Oxyal¤;NETHERLANDS: Healon¤;NORWAY: Amvisc¤; Healon¤; Provisc¤;NEW ZEALAND: AMO Vitrax¤; Healon¤; Hyalgan¤; Hylaform¤; Juvederm¤; Ophthalin¤; Provisc; Restylane¤; Synvisc¤;PHILIPPINES: Aragan Plus; Curiosin; Euflexxa; Go-On; Hameron; Hialid; Hyorth; Juvederm; Lacure; Provisc; Synove; Synvisc; Viscus;POLAND: Biolan; Cicatridina; Dezaftan¤; Hialeye; Hyabak; Hyal-Drop; Hyalgan; Hylo-COMOD; Hylo-Gel; Mucovagin; Nebu-Dose Hialuronic; Orthovisc¤; Starazolin Hydrobalance; Suplasyn¤; Synvisc; SynviscOne;PORTUGAL: Artz¤; Gengigel¤; Hyalart; Hyalofill¤; Hylo-COMOD¤;RUSSIAN FEDERATION: Curiosin (Куриозин); Eyestill (Айстил); Healon (Хеалон)¤; Hyalgan (Гиалган); Hylo-COMOD (Хило-КОМОД)¤; Hylomax-COMOD (Хиломакс-КОМОД)¤; Synoart (Синоарт);SOUTH AFRICA: Amvisc; Biolon¤; Biolone; Healon; Microvisc; Provisc; Suplasyn; Synvisc¤; Vitrax;SINGAPORE: AMO Vitrax; Curiosin; Cystistat¤; Go-On; Healon¤; Hialid; Hyalgan; Hyalubrix; Hylaform¤; Hylo-COMOD; Juvederm; Monovisc; Ophthalin¤; Orthovisc; Provisc¤; Restylane¤; Revanesse; Sanorine¤; Suplasyn; Synvisc; Vislube¤; Vismed;SPAIN: Hyabak¤; Hyalart¤; Hyalgan; Iiyalgon¤; Pandermin Cicatrizante¤;SWEDEN: AMO Vitrax¤; Amvisc¤; Artzal; Healon¤; Hyalgan; Synvisc¤;SWITZERLAND: AMO Vitrax¤; Biolon¤; Fermavisc¤; Healon¤; Hyal-Drop¤; Hyalur¤; HycoSan5¤; Hylo-COMOD¤; Hylo-Gel¤; Hysan¤; Ial¤; Ialugen; Laservis¤; Ostenil¤; Rhinogen; Sinovial¤; Suplasyn¤; Synvisc¤; Viscoseal¤; Visiol¤; Vislube¤; Vismed¤;THAILAND: Adant; AMO Vitrax¤; Atri III; Atri; Connettivina¤; Curiosin; Go-On; Healon¤; Hialid; Hyalgan; Hyruan; Ial; Juvederm Ultra XC; Juvederm Volbella With Lidocaine; Juvederm Voluma with Lidocaine; Ophthalin¤; Provisc; Restylane; Suplasyn; Synvisc; Vislube;TURKEY: Adant; Amvisc¤; Biolon¤; Eyestil; Healon¤; Hyalgan; Ial¤; Ophtalin Plus¤; Orthovisc; Ostenil; Provisc¤; Synvisc;UNITED KINGDOM: Amvisc; Arthrease; BioLon; Clinitas; Cystistat; Euflexxa; Fermathron¤; Gengigel; Healonid¤; Hyabak; Hyalgan; Hyalofill; Hycosan; Hylo-Forte; Hylo-Tear; Lubristil; Lumecare Extra Gentle; Microvisc; Ocusan; Ophthalin; Optrex Contact Lens Friendly Eye Drops¤; Orthovisc; Ostenil; Oxyal; Provisc; Supartz¤; Suplasyn; Synocrom; Synvisc; Viscoseal; Visiol; Vismed; Z-Hyalcoat;UKRAINE: Curiosin (Куриозин); Deviscar (Девискар); Hyalgan (Гиалган); Hyaral (Гиарал); Kuriosin (Куриозин); Optinol (Оптинол); Synhyal (Сингиал);UNITED STATES: AMO Vitrax¤; Amvisc; Bionect; Coease; Euflexxa; Healon; Hyalgan; HyGel; Hylaform¤; Hylase; Hylira; Hymovis; Juvederm Voluma XC; Juvederm; Monovisc; Orthovisc; Perlane; ProVisc; Restylane; Shellgel; Supartz; Synvisc;VENEZUELA: Healon¤; Hyalgan; Lagricel Ofteno; Oftafilm; Provisc; Suprahyal; Synvisc; Toptear;
Preparations: Multi-Ingredient
The following preparations list represents a compilation of all available salt forms or related substances for this drug product.
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
ARGENTINA: A-Derma Epitheliale AH; Alosol; Blink Contacts; Cellskinlab Hydragel B5¤; Cremisona¤; Cruzal L; Culuflex H¤; Dexacort-C; Dropstar P; Efyderma Estriat; Estri-Atlas; For-Age; Fusimed; Hyalcrom NF; Hyalcrom; Hyalogran; Hyalomatrix; Hyanac¤; Hydratone; Ingebrax¤; Iuronico Biotic; Lacrimax¤; Maxilac¤; Maxus; Muvar; Natura Confort¤; Neoprost¤; Nio Marine Plus; Ocusun¤; Perlivit HA; Revi-Atlas; TDH Dorf; Vera Plus; Viscoat¤; Vita-C Derms's; Yusin Tears II¤;AUSTRALIA: Atopiclair¤; Blink Contacts; Blink Intensive Tears Plus; Duovisc¤; Optive Fusion; Viscoat¤;AUSTRIA: Healonid Yellow¤; Viscoat¤;BELGIUM: Physiologica Nasal¤; Viscoat¤;BRAZIL: Seprafilm¤;CANADA: Cingal; Healon Yellow¤; Nutrilite Joint Health;CHILE: Epithelial AH¤; Estri-Atlas; Gelclair; Hyaluron¤; Hydragel B5 CKL; Hydraphase Ojos; Hydrating B5 Gel¤; Nasogel; Redermic UV; Redermic; Revi-Atlas; Ureadin Rx RD;CHINA: CP Bright (正大维他); Frecoseryl (润尔乐); Fredex (科恒); Run Jie (润洁);CZECH REPUBLIC: Curiosin¤; Ialugen Plus;FRANCE: Activox; Bactigyn; Cicaplast; Cicatridine; Cicatridine; Esoxx One; Fleximax¤; Hyalogran¤; Hyarhinol¤; Ialuset Plus; Ilast Care; Ilast Hydraclean; Ilast O'Clean; Ilast Post-Op; Monasens; Mucogyne; Mycoress; Saugella Antiseptique; Saugella Dermoliquide; Saugella douceur Poligyn; Tonimer¤; Urgo Cicatrices¤; Veganix¤; Viscoat¤;GERMANY: Aliamare¤; Bepanthen Augentropfen; Crespine +; DisCoVisc; DuoVisc; Gelclair; GeloRevoice; Go-On matrix; Herba-Vision augenbad plus; Herba-Vision Augenbad¤; Herba-Vision Augentrost; Herba-Vision Blaubeere; Hya-Ject Plus¤; Hya-Ject Tendon¤; Hylo Dual; Hylo-Care; Hylo-Fresh; Hylo-Parin; Hylo-Protect¤; Hylo-Vision HD Plus; Hysan Pflegespray; Ialunara¤; Ilast Care; Ilast Hydraclean; ODM; OmniTears; Optive Fusion; Systane Hydration; Thealoz Duo; Trium¤; Viscoat; Visiodoron Malva;GREECE: Hy-Sil; Viscoat¤;HONG KONG: Atopiclair; Belotero Balance with Lidocaine [check mims]; Duovisc¤; Ialumar; Viscoat¤;HUNGARY: Ialugen Plus; Viscoat¤;INDONESIA: Aloclair Plus; Aloclair; Atopiclair; Guardix-Sol; Ialuset Plus; Jointace Active; Ostenil Plus; Redexis; Vitadrop¤;ISRAEL: Aphtagone¤; Aptha-X¤; Atopiclair¤; Gelclair¤; Salinagel¤; Xclair¤;ITALY: Altergen; Biolastic T5; Cartijoint¤; Connettivina Plus; DisCoVisc¤; Dropyal; Healon Yellow¤; Hyalogran; Hyalosilver; Hylo-Care; Idroskin C; Lesiorepar; Migel; Naset; Osmogel; Respifree; Resvelife; Sirmiogel; Trofo 5; Ulceclar; Vaginol; Viscoat; Xanternet;MALAYSIA: Aloclair; Aqua Care; Atopiclair; Duovisc¤; Hyiodine; Ialumar; Prelactic; Seprafilm; Viscoat¤; Vitadrop¤; Vitara Hyaluron;MEXICO: Cetopic; Cicaplast; Emolin Neo; Grimal; Humylub Ofteno¤; Hyalcrom NF¤; Hyalox; Juventage Skin; Optimila-H; Redemic; Tonimer Balsamic;MONACO: Vitrecor;NETHERLANDS: Hylan;NEW ZEALAND: DisCoVisc¤; Duovisc¤; Viscoat;PHILIPPINES: Artelac Rebalance; Medicurtain; Viscoat;POLAND: Artelac Rebalance; HydroVag; Hylo-Care; Hylo-Parin; Hylo-Protect; Nosolan¤; Proktis-M Plus; Proktis-M; Systane Hydration¤; Thealoz Duo;PORTUGAL: Synchrorose Intensivo¤; Synchrovit¤;RUSSIAN FEDERATION: Artra MSM Forte (Артра МСМ Форте); Hyaferone (Гиаферон); Hylozar-COMOD (Хилозар-КОМОД)¤;SOUTH AFRICA: Duovisc¤; Viscoat;SINGAPORE: Aloclair; Atopiclair; BCC; BioJoint II; Botanical (Nano) Stem Cells Essence; Botanical Whitening Sunblock; Ceradan Hydra; Duovisc; Golden C Recovery Serum; Hydron Pure Radiance Brightening Solution; Hydron Self-Adjusting Retinol Serum; Periogold Intenze; Redexis; RejuvaSkin Anti-Aging Serum; Scar Esthetique; Seprafilm; Viscoat¤; Zeta Artro-Cur;SPAIN: Nefrolit¤;SWEDEN: Healon Yellow¤; Provisc¤; Viscoat¤;SWITZERLAND: Alphastria¤; Hylo-Care¤; Ialugen Plus; Lacrycon; Nasmer 3plus¤; Nasmer free¤; Viscoat¤;THAILAND: Atopiclair; DisCoVisc; Duovisc; Ialumar; Premier-Sof Ac-Klear Anti-Acne Serum; Viscoat;TURKEY: Duovisc¤; Viscoat¤;UNITED KINGDOM: Artelac Rebalance; Atopiclair; Blink Intensive Tears; Canesintima; Gelclair; Hylo-Care; Rohto Dry Eye Relief; Seprafilm; Thealoz Duo; Viscoat¤; VisuXL; Xclair; Zuidex;UKRAINE: Curiosin (Куриозин); Kuriosin (Куриозин);UNITED STATES: Atopiclair; Deflux; DisCoVisc; Gelclair; Healon Yellow¤; Miaderm Radiation Relief; Ocean Nasal Moisturizer; RadiaPlex Rx; Seprafilm; Solesta; Viscoat; Zacare Kit;VENEZUELA: Cepin; Epitheliale AH; Viscoat¤;
Last Updated 1/21/20
Google Sites
Report abuse