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Pharmacologic Category
Antiseptic, Topical; Antiseptic, Vaginal; Topical Skin Product
Dosing: Adult
Antiseptic: Topical: Apply to affected area as needed.
Surgical scrub: Topical: Apply solution to wet skin or hands, scrub for ~5 minutes, rinse; refer to product labeling for specific procedure-related instructions.
Vaginal irritation: Douche: Insert 0.3% solution vaginally once daily for 5-7 days
Dosing: Geriatric
Refer to adult dosing.
Use: Labeled Indications
External antiseptic with broad microbicidal spectrum for the prevention or treatment of topical infections associated with surgery, burns, minor cuts/scrapes; relief of minor vaginal irritation
Medication Patient Education with HCAHPS Considerations
What is this drug used for?
• It is used to treat or prevent bacterial infections.
• It is used to treat vaginal irritation, itching, and soreness.
• It may be given to you for other reasons. Talk with the doctor.
Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:
• Site irritation
• Erythema
• Vaginal pain or swelling
• Chills
• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.
Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.
Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.
Medication Safety Issues
Sound-alike/look-alike issues:
Contraindications
Hypersensitivity to iodine or any component of the formulation
Warnings/Precautions
Concerns related to adverse effects:
• Toxicity: May occur following application of large or prolonged quantities.
Disease-related concerns:
• Burns: Use with caution in patients with burns.
• Renal impairment: Use with caution in patients with renal impairment.
• Thyroid dysfunction: Use with caution in patients with thyroid disorders.
Special populations:
• Pediatric: Use with caution in children.
Other warnings/precautions:
• Appropriate use: When used as a topical antiseptic, improper use may lead to product contamination. Although infrequent, product contamination has been associated with reports of localized and systemic infections. To reduce the risk of infection, ensure antiseptic products are used according to the labeled instructions; avoid diluting products after opening; and apply single-use containers only one time to one patient and discard any unused solution (FDA Drug Safety Communication, 2013).
• Self-medication (OTC use): Do not apply to deep puncture wounds or serious burns; discontinue in case of redness, swelling, irritation or pain; do not use for longer than 1 week.
Pregnancy Considerations
Vaginal products should not be used during pregnancy. Povidine-iodine is absorbed systemically as iodine following topical administration to the vaginal mucosa (Velasco 2009; Vorherr 1980). Following vaginal administration as a douche, iodine concentrations are increased in the maternal urine, amniotic fluid, cord blood and fetal thyroid (Bachrach 1984; Mahillon 1989). Transient hypothyroidism in the newborn has been reported following topical use prior to delivery (Danziger 1987). Refer to Iodine for additional information.
Breast-Feeding Considerations
Iodine can be detected in breast milk following topical application of povidone-iodine (Koga 1995).
Briggs' Drugs in Pregnancy & Lactation
Adverse Reactions
Frequency not defined. Also refer to Iodine monograph.
Local: Edema, irritation, pruritus, rash
Metabolism/Transport Effects
None known.
Drug Interactions Open Interactions
BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Risk X: Avoid combination
BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Risk C: Monitor therapy
Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification
Taurolidine: May enhance the adverse/toxic effect of Povidone-Iodine (Topical). Specifically, concomitant use of taurolidine and povidone-iodine may increase the risk of metabolic acidosis. Risk X: Avoid combination
Dosage Forms: US
Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product
Gel, External:
Aplicare Povidone-Iodine: 10% (118 mL) [latex free]
Miscellaneous, External:
Generic: 10% (2 ea, 4 ea)
Ointment, External:
Generic: 10% (1 g, 28.35 g, 28.4 g [DSC])
Pad, External:
Generic: 10% (1 ea, 100 ea, 200 ea)
Solution, External:
Aplicare Povidone-Iodine: 10% (59 mL, 118 mL, 237 mL, 473 mL, 946 mL, 3800 mL) [latex free]
Aplicare Povidone-Iodine Scrub: 7.5% (59 mL, 118 mL, 237 mL [DSC], 473 mL, 946 mL, 3800 mL) [latex free]
Betadine: 5% (88.7 mL); 10% (15 mL, 118 mL, 237 mL, 473 mL, 946 mL, 3780 mL)
Betadine Skin Cleanser: 7.5% (118 mL [DSC])
Betadine Surgical Scrub: 7.5% (118 mL, 473 mL, 946 mL, 3780 mL)
NuPrep 5% Povidone-Iodine: 5% (5 mL [DSC])
PVP Prep: 10% (473 mL) [latex free]
PVP Scrub: 7.5% (118 mL) [latex free]
Scrub Care Povidone-iodine: 10% (118 mL)
Generic: 10% (30 mL, 236 mL, 237 mL, 473 mL)
Solution, Vaginal:
Summers Eve Disp Medicated: 0.3% (133 mL)
Swab, External:
Betadine Swab Aid: 10% (100 ea [DSC])
Betadine Swabsticks: 10% (1 ea, 3 ea)
Clorox Nasal Antiseptic: 10% (4 ea)
ExCel AP: 7.50% (3 ea) [latex free]
Nasal Antiseptic: 10% (2 ea [DSC])
Generic: 7.5% (50 ea); 10% (1 ea, 2 ea, 3 ea, 50 ea, 75 ea)
Anatomic Therapeutic Chemical (ATC) Classification
- D08AG02
- D09AA09
- D11AC06
Generic Available (US)
May be product dependent
Pricing: US
Gel (Aplicare Povidone-Iodine External)
10% (per mL): $0.02
Ointment (Povidone-Iodine External)
10% (per gram): $0.15
Pads (Povidone-Iodine External)
10% (per each): $0.58
Solution (Aplicare Povidone-Iodine External)
10% (per mL): $0.01
Solution (Aplicare Povidone-Iodine Scrub External)
7.5% (per mL): $0.01
Solution (Betadine External)
5% (per mL): $0.08
10% (per mL): $0.01
Solution (Betadine Surgical Scrub External)
7.5% (per mL): $0.01
Solution (Povidone-Iodine External)
10% (per mL): $0.02
Solution (Scrub Care Povidone-iodine External)
10% (per mL): $0.02
Solution (Summers Eve Disp Medicated Vaginal)
0.3% (per mL): $0.01
Swab (Betadine Swabsticks External)
10% (per each): $0.23
Swab (Clorox Nasal Antiseptic External)
10% (per each): $3.08
Swab (ExCel AP External)
7.5-72% (per each): $12.80
Swab (Povidone-Iodine External)
7.5% (per each): $0.28
10% (per each): $0.16 - $0.30
Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.
Mechanism of Action
Povidone-iodine is known to be a powerful broad spectrum germicidal agent effective against a wide range of bacteria, viruses, fungi, protozoa, and spores.
Pharmacodynamics/Kinetics
Absorption: Absorbed systemically as iodine; amount depends upon concentration, route of administration, characteristics of skin
Local Anesthetic/Vasoconstrictor Precautions
No information available to require special precautions
Effects on Dental Treatment
No significant effects or complications reported
Effects on Bleeding
No information available to require special precautions
Index Terms
Polyvinylpyrrolidone with Iodine; PVP-I
References
Bachrach LK, Burrow GN, Gare DJ. Maternal-fetal absorption of povidone-iodine. J Pediatr. 1984;104(1):158-159.[PubMed 6690663 ]
Danziger Y, Pertzelan A, Mimouni M. Transient congenital hypothyroidism after topical iodine in pregnancy and lactation. Arch Dis Child. 1987;62(3):295-296.[PubMed 3566323 ]
Dela Cruz F, Brown DH, Leikin JB, et al, “Iodine Absorption After Topical Administration,” West J Med, 1987, 146(1):43-5.[PubMed 3825108]
Food and Drug Administration. FDA Drug Safety Communication: FDA requests label changes and single-use packaging for some over-the-counter topical antiseptic products to decrease risk of infection. http://www.fda.gov/Drugs/DrugSafety/ucm374711.htm. Updated November 20, 2013. Accessed October 1, 2014.
Koga Y, Sano H, Kikukawa Y, Ishigouoka T, Kawamura M. Effect on neonatal thyroid function of povidone-iodine used on mothers during perinatal period. J Obstet Gynaecol (Tokyo 1995). 1995;21(6):581-585.[PubMed 8640469 ]
Mahillon I, Peers W, Bourdoux P, Ermans AM, Delange F. Effect of vaginal douching with povidone-iodine during early pregnancy on the iodine supply to mother and fetus. Biol Neonate. 1989;56(4):210-217. [PubMed 2804185 ]
Summers Eve (povidone-iodine) [prescribing information]. Lynchburg, VA: C.B. Fleet Company, Inc; August 2013.
Velasco I, Naranjo S, López-Pedrera C, Garriga MJ, García-Fuentes E, Soriguer F. Use of povidone-iodine during the first trimester of pregnancy: a correct practice? BJOG. 2009;116(3):452-455. [PubMed 19187379 ]
Vorherr H, Vorherr UF, Mehta P, Ulrich JA, Messer RH. Vaginal absorption of povidone-iodine. JAMA. 1980;244(23):2628-2629.[PubMed 7431610 ]
Brand Names: International
Abodine (PK); Acydona (ES); Alfadine (PH); Alphadine (QA); Arodin (BD); Bacterodine (DO); Bactroderm (CO); Besetine (KR); Betadine (AU, BG, BH, CH, CZ, EG, ES, FI, FR, GB, GR, HK, HN, HR, IN, IS, IT, KW, LB, LK, LT, LV, MT, MY, NL, NO, PH, PK, PL, PT, RO, SG, SI, SK, TH, UA, VE, VN, ZA, ZW); Betadona (AT); Betaisodona (AT, CY, DE); Betasept (BH); Better-Iodine (TW); Biocil (NZ); Braunol (BE, BG, CH, DE); Braunosan (CH); Braunovidon (AT, EE); Claradone (BH, QA); Curadona (ES); Difexon (CL); E.D.P. (AU); Favol (PY); Igiol (GR); Inadine (IE); Intradine (VE); Iodicare (IL); Iodo-Vit (IL); Iodofon (UY); Iodosept (EG, QA); Iop (PY); Isodine (CO, PE); Li Ze (CN); Marcodine (BR); Pharmadine (TH); Piodine (AE); Piodine VD (QA); Podine (ZA); Polydine (IL); Povibac (AR); Povicide (ZW); Povid (BD); Poviderm (MY); Povidine (IN); Povidyne (EC); Povy-D (PH); Saniquad PVT (ET); Savlon Dry (IE); Septadine (ID); Septidyne (LB); Septika LAR (ID); Throane (TW); Unidone (LK); Varicide (ZW); Videne (IE); Wokadine (LK)
Last Updated 3/25/20
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