Iron Polyssacharide Complex

Pharmacologic Category

Iron Preparations

Dosing: Adult

Note: Immediate release oral iron products are preferred for treatment of iron-deficiency anemia; enteric coated and slow/sustained release preparations are not desired due to poor absorption (Hershko 2014; Liu 2012). Dose expressed in terms of elemental iron.

Iron-deficiency anemia: Oral: 50 to 200 mg elemental iron/day (Liu 2012; Schrier 2019). Note: Alternate-day dosing (eg, every other day or Monday, Wednesday, Friday) has been shown to result in greater absorption of iron; some experts recommend this dosing schedule in patients who can maintain adherence (Schrier 2019; Stoffel 2017).

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment: Adult

There are no dosing adjustments provided in the manufacturer’s labeling.

Dosing: Hepatic Impairment: Adult

There are no dosing adjustments provided in the manufacturer’s labeling.

Dosing: Pediatric

Note: Dosages are expressed in terms of elemental iron.

Iron deficiency anemia; prevention: Oral:

Infants ≥4 months (receiving human milk as only nutritional source or >50% as source of nutrition without iron fortified food): 1 mg/kg/day (AAP [Baker 2010]); Note: In healthy, term infants, AAP does not recommend routine additional supplementation of iron be considered until at least 4 to 6 months of age if breastfed (full or partial) (AAP [Baker 2010]; Schanler 2011)

Infants ≥6 months and Children <2 years in areas where anemia prevalence is >40%: 10 to 12.5 mg daily for 3 consecutive months in a year (WHO 2016b)

Children 2 years to <5 years in areas where anemia prevalence is >40%: 30 mg daily for 3 consecutive months in a year (WHO 2016b)

Children ≥5 to 12 years in areas where anemia prevalence is >40%: 30 to 60 mg daily for 3 consecutive months in a year (WHO 2016b)

Adolescent menstruating females (nonpregnant females of reproductive potential) in areas where anemia prevalence is >40%: 30 to 60 mg daily for 3 consecutive months in a year (WHO 2016a)

Iron deficiency anemia, treatment: Infants, Children, and Adolescents: Oral: 3 to 6 mg/kg/day in 3 divided doses; suggested maximum daily dose: 200 mg/day (ASPEN Pediatric Nutrition Support Core Curriculum [Corkins 2015]; Kliegman 2016)

Iron supplementation: Note: Refer to product-specific labeling for approved pediatric ages.

Infants and Children <4 years: Oral liquid: Oral: 15 mg daily

Children ≥12 years and Adolescents: Oral: 50 mg daily

Dosing: Renal Impairment: Pediatric

There are no dosing adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosing adjustments provided in the manufacturer's labeling.

Use: Labeled Indications

Iron-deficiency anemia: Management (prevention and treatment) of iron-deficiency anemia

Administration: Oral

Shake liquid well prior to administration.

Administration: Pediatric

Oral: Administer with water or juice between meals for maximum absorption; may administer with food if GI upset occurs; do not administer with milk or milk products. Shake liquid well prior to administration.

Dietary Considerations

Dietary sources of iron include beans, cereal (enriched), clams, beef, lentils, liver, oysters, shrimp, and turkey. Foods that enhance dietary absorption of iron include broccoli, grapefruit, orange juice, peppers and strawberries. Foods that decrease dietary absorption of iron include coffee, dairy products, soy products, spinach, and tea.

Dietary reference intake (elemental iron) (IOM 2001):

0 to 6 months: Adequate intake: 0.27 mg daily

7 to 12 months: RDA: 11 mg daily

1 to 3 years: RDA: 7 mg daily

4 to 8 years: RDA: 10 mg daily

9 to 13 years: RDA: 8 mg daily

14 to 18 years: RDA:

Males: 11 mg daily

Females: 15 mg daily

Pregnancy: 27 mg daily

Lactation: 10 mg daily

19-50 years: RDA:

Males: 8 mg daily

Females: 18 mg daily

Pregnancy: 27 mg daily

Lactation: 9 mg daily

≥50 years: RDA: 8 mg daily

Storage/Stability

Store between 15°C and 30°C (59°F and 86°F).

Medication Patient Education with HCAHPS Considerations

What is this drug used for?

• It is used to help growth and good health.

• It is used to treat or prevent low iron in the body.

• It may be given to you for other reasons. Talk with the doctor.

Frequently reported side effects of this drug

• Constipation

• Stool discoloration

• Diarrhea

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Black, tarry, or bloody stools

• Severe nausea

• Severe vomiting

• Severe abdominal pain

• Vomiting blood

• Abdominal cramps

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Contraindications

Known hypersensitivity to polysaccharide-iron complex or any component of the formulations; hemochromatosis; hemosiderosis

Documentation of allergenic cross-reactivity for other iron-containing products is limited. However, because of similarities in chemical structure and/or pharmacologic actions, the possibility of cross-sensitivity cannot be ruled out with certainty.

Warnings/Precautions

Concerns related to adverse effects:

• Stool discoloration: Oral iron preparations commonly cause dark or black stools; patients should be informed of the effect.

Concurrent drug therapy issues:

• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information. May interfere with absorption of antibiotics.

Special populations:

• Pediatric: Accidental overdose of iron-containing products is a leading cause of fatal poisoning in children under 6 years of age. Keep this product out of the reach of children. In case of accidental overdose call the poison control center immediately.

Dosage form specific issues:

• Oral iron formulations: Immediate release oral iron products are preferred for treatment of iron deficiency anemia; enteric coated and slow/sustained release preparations are not desired due to poor absorption (Hershko 2014; Liu 2012).

Other warnings/precautions:

• Appropriate use: Investigate type of anemia and potential underlying causes (eg, recurrent blood loss) prior to initiating iron supplementation.

• Excipient: Some formulations may contain tartrazine, which is associated with allergic-type reactions. Although rare, hypersensitivity is more frequently seen in individuals with aspirin allergy.

Warnings: Additional Pediatric Considerations

Consider all iron sources when evaluating the dose of iron, including combination products, infant formulas, and liquid nutritional supplements.

Pregnancy Considerations

Maternal iron requirements increase during pregnancy. Adequate iron concentrations to the fetus can be maintained regardless of maternal iron status, except in severe cases of anemia (IOM 2001). Untreated iron deficiency and iron deficiency anemia (IDA) in a pregnant female may be associated with adverse events, including low birth weight, preterm birth, or increased perinatal mortality (ACOG 95 2008; IOM 2001; Pavord 2012).

In general, treatment of iron deficiency or IDA in pregnancy is the same as in non-pregnant females. The majority of studies note iron therapy improves maternal hematologic parameters; however, information related to clinical outcomes in the mother and neonate is limited (Siu 2015). Oral preparations are generally sufficient; however, parenteral iron therapy may be used in females who cannot tolerate or will not take oral iron, in cases of severe iron deficiency, or when malabsorption is present (ACOG 95 2008; Pavord 2012). Enteric-coated and slow/sustained-release preparations may be less effective (ACOG 95 2008).

Breast-Feeding Considerations

Iron is present in breast milk (IOM 2001). It is not known if maternal use of polysaccharide iron complex significantly changes breast milk concentrations.

Maternal iron requirements are increased in breastfeeding women (IOM 2001). Breast milk levels of iron are maintained in females with mild to moderate iron deficiency anemia (IDA), but concentrations decrease if IDA is severe (El-Farrash 2012; Kumar 2008). All postpartum women at risk of gestational anemia (regardless of breastfeeding status) may be given oral iron with or without folic acid for 6 to 12 weeks postpartum to reduce the risk of anemia (WHO 2016c).

Adverse Reactions

>10%: Gastrointestinal: Constipation, darkening of stools, epigastric pain, gastrointestinal irritation, nausea, stomach cramps, vomiting

1% to 10%:

Gastrointestinal: Dental discoloration, diarrhea, heartburn

Genitourinary: Urine discoloration

<1%, postmarketing, and/or case reports: Local irritation

Allergy and Idiosyncratic Reactions

• Aniline Dye Allergy
• Iron Preparation Allergy

Toxicology

• Iron

Metabolism/Transport Effects

None known.

Drug Interactions Open Interactions

Alpha-Lipoic Acid: Iron Preparations may decrease the absorption of Alpha-Lipoic Acid. Alpha-Lipoic Acid may decrease the absorption of Iron Preparations. Risk D: Consider therapy modification

Antacids: May decrease the absorption of Iron Preparations. Management: Separate dosing of oral iron preparations and antacids as much as possible to avoid decreased efficacy of iron preparation. If coadministered with antacids, monitor for decreased therapeutic effects of iron preparations. Risk D: Consider therapy modification

Baloxavir Marboxil: Polyvalent Cation Containing Products may decrease the serum concentration of Baloxavir Marboxil. Risk X: Avoid combination

Bictegravir: Iron Preparations may decrease the serum concentration of Bictegravir. Management: Bictegravir, emtricitabine, and tenofovir alafenamide can be administered with iron preparations under fed conditions, but coadministration with or 2 hours after an iron preparation is not recommended under fasting conditions. Risk D: Consider therapy modification

Bisphosphonate Derivatives: Polyvalent Cation Containing Products may decrease the serum concentration of Bisphosphonate Derivatives. Management: Avoid administration of oral medications containing polyvalent cations within: 2 hours before or after tiludronate/clodronate/etidronate; 60 minutes after oral ibandronate; or 30 minutes after alendronate/risedronate. Exceptions: Pamidronate; Zoledronic Acid. Risk D: Consider therapy modification

Cefdinir: Iron Preparations may decrease the serum concentration of Cefdinir. Red-appearing, non-bloody stools may also develop due to the formation of an insoluble iron-cefdinir complex. Management: Avoid concurrent cefdinir and oral iron when possible. Separating doses by several hours may minimize interaction. Iron-containing infant formulas do not appear to interact with cefdinir. Risk D: Consider therapy modification

Deferiprone: Polyvalent Cation Containing Products may decrease the serum concentration of Deferiprone. Management: Separate administration of deferiprone and oral medications or supplements that contain polyvalent cations by at least 4 hours. Risk D: Consider therapy modification

Dimercaprol: May enhance the nephrotoxic effect of Iron Preparations. Risk X: Avoid combination

Dolutegravir: Iron Preparations may decrease the serum concentration of Dolutegravir. Management: Administer dolutegravir at least 2 hours before or 6 hours after oral iron. Administer dolutegravir/rilpivirine at least 4 hours before or 6 hours after oral iron. Alternatively, dolutegravir and oral iron can be taken together with food. Risk D: Consider therapy modification

Eltrombopag: Polyvalent Cation Containing Products may decrease the serum concentration of Eltrombopag. Management: Administer eltrombopag at least 2 hours before or 4 hours after oral administration of any polyvalent cation containing product. Risk D: Consider therapy modification

Elvitegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Elvitegravir. Management: Administer elvitegravir 2 hours before or 6 hours after the administration of polyvalent cation containing products. Risk D: Consider therapy modification

Entacapone: Iron Preparations may decrease the serum concentration of Entacapone. Management: Consider separating doses of the agents by 2 or more hours to minimize the effects of this interaction. Monitor for decreased therapeutic effects of levodopa during concomitant therapy, particularly if doses cannot be separated. Risk D: Consider therapy modification

Ferric Hydroxide Polymaltose Complex: May decrease the serum concentration of Iron Preparations. Specifically, the absorption of oral iron salts may be reduced. Management: Do not administer intravenous (IV) ferric hydroxide polymaltose complex with other oral iron preparations. Therapy with oral iron preparations should begin 1 week after the last dose of IV ferric hydroxide polymaltose complex. Risk D: Consider therapy modification

Histamine H2 Receptor Antagonists: May decrease the absorption of Iron Preparations. Risk C: Monitor therapy

Levodopa: Iron Preparations may decrease the serum concentration of Levodopa. Only applies to oral iron preparations. Management: Consider separating doses of the agents by 2 or more hours to minimize the effects of this interaction. Monitor for decreased therapeutic effects of levodopa during concomitant therapy, particularly if doses cannot be separated. Risk D: Consider therapy modification

Levothyroxine: Iron Preparations may decrease the serum concentration of Levothyroxine. Management: Separate oral administration of iron preparations and levothyroxine by at least 4 hours. Separation of doses is not required with parenterally administered iron preparations or levothyroxine. Risk D: Consider therapy modification

Methyldopa: Iron Preparations may decrease the serum concentration of Methyldopa. Management: Consider separating doses of methyldopa and orally administered iron preparation by 2 or more hours. Monitor for decreased efficacy of methyldopa if an oral iron preparation is initiated/dose increase, or increased efficacy if discontinued/dose decreased. Risk D: Consider therapy modification

PenicillAMINE: Polyvalent Cation Containing Products may decrease the serum concentration of PenicillAMINE. Management: Separate the administration of penicillamine and oral polyvalent cation containing products by at least 1 hour. Risk D: Consider therapy modification

Phosphate Supplements: Iron Preparations may decrease the absorption of Phosphate Supplements. Management: Administer oral phosphate supplements as far apart from the administration of an oral iron preparation as possible to minimize the significance of this interaction. Exceptions: Sodium Glycerophosphate Pentahydrate. Risk D: Consider therapy modification

Proton Pump Inhibitors: May decrease the absorption of Iron Preparations. Risk C: Monitor therapy

Quinolones: Iron Preparations may decrease the serum concentration of Quinolones. Management: Give oral quinolones at least several hours before (4 h for moxi- and sparfloxacin, 2 h for others) or after (8 h for moxi-, 6 h for cipro/dela-, 4 h for lome-, 3 h for gemi-, and 2 h for levo-, nor-, oflox-, pefloxacin, or nalidixic acid) oral iron. Exceptions: LevoFLOXacin (Oral Inhalation). Risk D: Consider therapy modification

Raltegravir: Polyvalent Cation Containing Products may decrease the serum concentration of Raltegravir. Management: Administer raltegravir 2 hours before or 6 hours after administration of the polyvalent cations. Dose separation may not adequately minimize the significance of this interaction. Risk D: Consider therapy modification

Tetracyclines: May decrease the absorption of Iron Preparations. Iron Preparations may decrease the serum concentration of Tetracyclines. Management: Avoid this combination if possible. Administer oral iron preparations at least 2 hours before, or 4 hours after, the dose of the oral tetracycline derivative. Monitor for decreased therapeutic effect of oral tetracycline derivatives. Exceptions: Eravacycline. Risk D: Consider therapy modification

Trientine: Polyvalent Cation Containing Products may decrease the serum concentration of Trientine. Management: Avoid concomitant administration of trientine and oral products that contain polyvalent cations. If oral iron supplements are required, separate the administration by 2 hours. If other oral polyvalent cations are needed, separate administration by 1 hour. Risk D: Consider therapy modification

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Capsule, Oral:

EZFE 200: 200 mg [non-toxic; contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #10 (quinoline yellow)]

Ferrex 150: 150 mg [contains fd&c blue #1 aluminum lake, fd&c red #40 aluminum lake, fd&c yellow #5 aluminum lake]

Ferric x-150: 150 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, tartrazine (fd&c yellow #5)]

IFerex 150: 150 mg [DSC] [contains brilliant blue fcf (fd&c blue #1), fd&c red #40, fd&c yellow #10 (quinoline yellow)]

Myferon 150: 150 mg

NovaFerrum 50: 50 mg

Nu-Iron: 150 mg [contains brilliant blue fcf (fd&c blue #1), fd&c red #40]

PIC 200: 200 mg [DSC]

Poly-Iron 150: 150 mg

Generic: 150 mg

Liquid, Oral:

NovaFerrum 125: Polysaccharide-iron complex 125 mg and cholecalciferol 100 units per 5 mL (180 mL) [alcohol free, dye free, gluten free, lactose free, sodium free, sugar free; contains sodium benzoate; raspberry-grape flavor]

NovaFerrum Pediatric Drops: 15 mg/mL (120 mL) [alcohol free, dye free, gluten free, lactose free, sodium free, sugar free; contains sodium benzoate; raspberry-grape flavor]

Generic Available (US)

May be product dependent

Pricing: US

Capsules (EZFE 200 Oral)

434.8 (200 Fe) mg (per each): $0.36

Capsules (NovaFerrum 50 Oral)

50 mg (per each): $0.18

Capsules (Nu-Iron Oral)

150 mg (per each): $0.51

Capsules (Poly-Iron 150 Oral)

150 mg (per each): $0.28

Capsules (Polysaccharide Iron Complex Oral)

150 mg (per each): $0.28

Liquid (NovaFerrum 125 Oral)

125-100 mg-unit/5 ml (per mL): $0.14

Liquid (NovaFerrum Pediatric Drops Oral)

15 mg/mL (per mL): $0.19

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Pharmacodynamics/Kinetics

Onset of action: Hematologic response: Red blood cells form within 3 to 10 days; similar onset as parenteral iron salts; Maximum effect: Peak reticulocytosis occurs in 5 to 10 days, and hemoglobin values increase within 2 to 4 weeks

Absorption: Oral: Iron is absorbed in the duodenum and upper jejunum; in persons with normal iron stores 10% of an oral dose is absorbed; this is increased to 20% to 30% in persons with inadequate iron stores; food and achlorhydria will decrease absorption

Protein binding: To transferrin

Excretion: Urine, sweat, sloughing of intestinal mucosa, and by menses

Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Effects on Dental Treatment

No significant effects or complications reported

Effects on Bleeding

No information available to require special precautions

Index Terms

Iron Polysaccharide Complex; Iron-Polysaccharide Complex; Niferex

References

American College of Obstetricians and Gynecologists, “ACOG Practice Bulletin No. 95: Anemia in Pregnancy,” Obstet Gynecol, 2008, 112(1):201-7.[PubMed 18591330]

Baker RD, Greer FR, Committee on Nutrition American Academy of Pediatrics. Diagnosis and prevention of iron deficiency and iron-deficiency anemia in infants and young children (0-3 years of age). Pediatrics. 2010;126(5):1040-1050.[PubMed 20923825]

Corkins MR, Balint J, Bobo E, et al, eds. The A.S.P.E.N Pediatric Nutrition Support Core Curriculum. 2nd ed. Silver Spring: MD: American Society of Parenteral and Enteral Nutrition, 2015.

El-Farrash RA, Ismail EA, Nada AS. Cord blood iron profile and breast milk micronutrients in maternal iron deficiency anemia. Pediatr Blood Cancer. 2012;58(2):233-238. doi: 10.1002/pbc.23184.[PubMed 21548016]

EZFE 200 (polysaccharide-iron complex) [prescribing information]. Chattanooga, TN: R.A. McNeil Co; November 2010.

Ferrex 150 (polysaccharide-iron complex) [prescribing information]. Boca Raton, FL: Breckenridge Pharmaceutical Inc; November 2016.

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Institute of Medicine (IOM). Nutrition During Lactation. Washington, D.C. The National Academies Press, 1991. Available at http://www.nap.edu

IOM (Institute of Medicine), Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc, Washington, DC: National Academy Press, 2001.

Kliegman RM, Stanton BMD, St. Geme J, Schor NF, eds. Nelson' s Textbook of Pediatrics. 20th ed. Philadelphia, PA: Saunders Elsevier; 2016.

Kumar A, Rai AK, Basu S, et al. Cord blood and breast milk iron status in maternal anemia. Pediatrics. 2008;121(3):e673-e677. doi: 10.1542/peds.2007-1986.[PubMed 18310187]

Liu K and Kaffes AJ. Iron deficiency anaemia: a review of diagnosis, investigation and management. Eur J Gastroenterol Hepatol. 2012;24(2):109-116. doi: 10.1097/MEG.0b013e32834f3140.[PubMed 22157204]

Myferon 150 (polysaccharide-iron complex) [prescribing information]. Richmond, IN: M.E. Pharmaceuticals Inc; February 2014.

NovaFerrum 125 (polysaccharide-iron complex) [prescribing information]. Corpus Christi, TX: Gensavis Pharmaceuticals Inc; October 2013.

NovaFerrum 50 (polysaccharide-iron complex) [prescribing information]. Corpus Christi, TX: Gensavis Pharmaceuticals Inc; October 2013.

NovaFerrum pediatric drops (polysaccharide-iron complex) [prescribing information]. Corpus Christi, TX: Gensavis Pharmaceuticals, LLC; June 2006.

Nu-Iron (polysaccharide-iron complex) [prescribing information]. Solon, OH: DSE Healthcare Solutions LLC; January 2020.

Pavord S, Myers B, Robinson S, Allard S, Strong J, Oppenheimer C; British Committee for Standards in Haematology. UK guidelines on the management of iron deficiency in pregnancy [published correction appears in Br J Haematol. 2012;158(4):559]. Br J Haematol. 2012;156(5):588-600.[PubMed 22512001]

Poly-Iron (polysaccharide-iron complex) [prescribing information]. Madison MS: Cypress Pharmaceutical, Inc; March 2011.

Rao R, Georgieff MK. Iron therapy for preterm infants. Clin Perinatol. 2009;36(1):27-42.[PubMed 19161863]

“Recommendations to Prevent and Control Iron Deficiency in the United States. Centers for Disease Control and Prevention,” MMWR Recomm Rep, 1998, 47(RR-3):1-29.[PubMed 9563847]

Schanler RJ; Executive Committee, Feldman-Winter L, et al. Concerns with early universal iron supplementation of breastfeeding infants. Pediatrics. 2011;127(4):e1097.[PubMed 21460097]

Schrier SL, Auerbach M. Treatment of iron deficiency anemia in adults. Post TW, ed. UpToDate. Waltham, MA: UpToDate Inc. http://www.uptodate.com. Accessed March 25, 2019.

Siu AL; U.S. Preventive Services Task Force. Screening for iron deficiency anemia and iron supplementation in pregnant women to improve maternal health and birth outcomes: U.S. Preventive Services Task Force Recommendation Statement. Ann Intern Med. 2015;163(7):529-36. doi: 10.7326/M15-1707.[PubMed 26344176]

Stoffel NU, Cercamondi CI, Brittenham G, et al. Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials. Lancet Haematol. 2017;4(11):e524-e533. doi: 10.1016/S2352-3026(17)30182-5.[PubMed 29032957]

Stoltzfus RJ, Dreyfuss ML, eds. Guidelines for the use of iron supplements to prevent and treat iron deficiency anemia. Washington, DC; International Life Sciences Institute Press; 1998. https://www.who.int/nutrition/publications/micronutrients/guidelines_for_Iron_supplementation.pdf?ua=1. Accessed March 20, 2019.

United Nations Children's Fund, United Nations University, World Health Organization. Iron deficiency anaemia assessment, prevention, and control. A guide for programme managers, 2001.

World Health Organization (WHO), “Iron Deficiency Anaemia: Assessment, Prevention, and Control. A Guide for Programme Managers,” 2001.

World Health Organization (WHO): Guideline: Daily Iron Supplementation in Adult Women and Adolescent Girls. Geneva, Switzerland: World Health Organization; 2016a. https://www.ncbi.nlm.nih.gov/books/NBK361888/.[PubMed 27195351]

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World Health Organization (WHO): Guideline: Iron supplementation in postpartum women. Geneva: World Health Organization; 2016c. http://www.who.int/nutrition/publications/micronutrients/guidelines/daily_iron_supp_postpartum_women/en/.[PubMed 27583315]

Brand Names: International

Ferricure (LB, LK)

Last Updated 3/28/20