Fenticonazole

Uses and Administration

Fenticonazole is an imidazole antifungal used locally as the nitrate in the treatment of vulvovaginal candidiasis ( Refer to ). A 200-mg pessary is inserted into the vagina at bedtime for 3 nights or a 600-mg pessary is inserted once only at bedtime. It is also available as a 2% vaginal cream; 5 g is inserted into the vagina twice daily for 3 days. Fenticonazole nitrate is also applied topically as a 2% cream or solution for the treatment of fungal skin infections.

(last reviewed 2010-08-26; last modified 2014-01-13)

Reviews.

(last reviewed 2010-08-26; last modified 2010-04-30)

References

1. Veraldi S, Milani R. Topical fenticonazole in dermatology and gynaecology: current role in therapy.Drugs. 2008; 68: 2183–94. PubMed

Adverse Effects, Treatment and Precautions

Adverse Effects and Precautions

Burning and itching have been reported after the application of fenticonazole nitrate.

Intravaginal preparations of fenticonazole may damage latex contraceptives and additional contraceptive measures are therefore necessary during local application.

For a discussion of the caution needed when using azole antifungals during pregnancy, see under Pregnancy in Precautions of Fluconazole, Refer to .

(last reviewed 2010-08-26; last modified 2008-07-30)

Mechanism of Action

Antimicrobial Action

Fenticonazole is an imidazole antifungal active against a range of organisms including dermatophyte pathogens,Malassezia furfur, andCandida albicans.

(last reviewed 2010-08-26; last modified 2005-04-25)