Co-Trimoxazole

Pharmacologic Category

Antibiotic, Miscellaneous; Antibiotic, Sulfonamide Derivative

Dosing: Adult

Note: Weight-based dosing recommendations are based on the trimethoprim (TMP) component. Each double-strength tablet contains TMP 160 mg and sulfamethoxazole (SMX) 800 mg. Each single-strength tablet contains TMP 80 mg and SMX 400 mg. The undiluted IV solution contains TMP 16 mg per mL and SMX 80 mg per mL. IV solutions must be diluted in D5W prior to use. Diluted IV solutions have limited stability and can precipitate unpredictably; refer to a detailed IV compatibility reference.

General dosing guidelines:

Oral: 1 to 2 double-strength tablets every 12 to 24 hours. Note: Serum creatinine and potassium concentrations should be monitored in outpatients receiving high-dose therapy (>5 mg/kg/day [TMP component]) (Gentry 2013).

IV: 8 to 20 mg/kg/day (TMP component) divided every 6 to 12 hours.

Bite wound infection, prophylaxis or treatment (animal or human bite) (alternative agent) (off-label use): Oral: One double-strength tablet twice daily; in combination with an appropriate agent for anaerobic coverage. Duration of therapy for prophylaxis is 3 to 5 days (IDSA [Stevens 2014]); duration of therapy for established infection is typically 5 to 14 days and varies based on patient-specific factors, including clinical response factors (Baddour 2019a; Baddour 2019b).

Chronic obstructive pulmonary disease, acute exacerbation: Note: Some experts reserve for patients without risk factors for poor outcomes (eg, <65 years of age without significant comorbidities, FEV1 >50% predicted, infrequent exacerbations) (Sethi 2020).

Oral: One double-strength tablet every 12 hours for 3 to 7 days (GOLD 2020; Sethi 2020; manufacturer's labeling).

Diabetic foot infection, mild (methicillin-resistant Staphylococcus aureus [MRSA]) (off-label use): Oral: Two double-strength tablets twice daily, usually for 1 to 2 weeks (IDSA [Lipsky 2012]; Lipsky 2004). Note: When used as empiric therapy, must be used in combination with other appropriate agents. Some experts also use this agent for selected moderate infections (Lipsky 2012).

Diarrhea, infectious:

Cyclosporiasis (off-label use):

Immunocompromised (AIDS-associated): Limited data available: Oral: One double-strength tablet twice daily for 14 days, followed by secondary prophylaxis with one double-strength tablet 3 times weekly (Pape 1994; Weller 2017).

Immunocompetent: Oral: One double-strength tablet twice daily for 7 to 10 days (CDC 2013; Hoge 1995).

Cystoisosporiasis (isosporiasis) (off-label use):

Immunocompromised (AIDS-associated): Oral, IV: 160 mg (TMP component) twice daily for 7 to 10 days; if symptoms worsen or persist, may increase dose to 160 mg (TMP component) 4 times daily and/or prolong duration to 21 to 28 days. In patients with CD4 <200 cells/mm3, follow treatment with secondary prophylaxis of one double-strength tablet orally 3 times weekly (HHS [OI adult 2017]).

Immunocompetent (usually self-limited; treatment not always indicated): Oral: One double-strength tablet twice daily for 7 to 10 days (CDC 2013).

Shigellosis (widespread resistance [alternative agent if susceptibility is documented]): Oral: One double-strength tablet twice daily for 5 to 7 days (Agha 2017).

Intracranial abscess (brain abscess, intracranial epidural abscess) and spinal epidural abscess (alternative agent for MRSA) (off-label use): IV: 5 mg/kg/dose (TMP component) every 8 to 12 hours (IDSA [Liu 2011]; Sexton 2019a; Sexton 2019b; Southwick 2020). Duration generally ranges from 4 to 8 weeks for brain abscess and spinal epidural abscess and 6 to 8 weeks for intracranial epidural abscess, but some patients require a longer course. The appropriate duration depends on cultured pathogen(s) and patient-specific factors, including clinical response (Sexton 2019a; Sexton 2019b; Southwick 2020).

Melioidosis (Burkholderia pseudomallei) infection (off-label use):

Initial intensive therapy (as a potential add-on to primary therapy [ceftazidime or a carbapenem] in focal disease of the CNS, prostate, bone, joint, skin, or soft tissue) (Currie 2019): Oral, IV:

40 to 60 kg: 240 mg (TMP component) twice daily.

>60 kg: 320 mg (TMP component) twice daily.

Eradication therapy (begin after completion of initial intensive therapy) (Lipsitz 2012): Oral:

40 to 60 kg: 240 mg (TMP component) twice daily.

>60 kg: 320 mg (TMP component) twice daily.

Meningitis, bacterial (alternative agent for MRSA, L. monocytogenes, E. coli, and other Enterobacteriaceae) (off-label use): IV: 5 mg/kg/dose (TMP component) every 6 to 12 hours (IDSA [Tunkel 2004]; IDSA [Tunkel 2017]). Note: Some experts prefer 5 mg/kg/dose (TMP component) every 8 hours (Tunkel 2019).

Nocardiosis (off-label use): Limited data available to guide treatment. Due to concerns for resistance, susceptibility testing should be performed on isolates (CDC 2017).

Cutaneous infections (superficial; no other organ involvement): Oral: 5 to 10 mg/kg/day (TMP component) in 2 divided doses (Spelman 2019).

Pulmonary infection (mild to moderate) (Spelman 2019):

Immunocompetent patients: Oral: 5 to 10 mg/kg/day (TMP component) in 2 divided doses.

Immunocompromised patients: IV: 15 mg/kg/day (TMP component) in 3 to 4 divided doses.

Pulmonary infection (severe), CNS, disseminated, or multi-site infection: IV: 15 mg/kg/day (TMP component) in 3 to 4 divided doses (Spelman 2019). Note: When used as empiric therapy, must be used in combination with 1 to 2 additional agents. Consult an infectious diseases specialist for specific treatment recommendations.

Duration: Prolonged treatment is required (range: 3 months to ≥1 year [combined parenteral/oral therapy]) (Spelman 2019).

Osteomyelitis due to MRSA (alternative agent) (off-label use): Oral, IV: 4 mg/kg/dose (TMP component) every 12 hours with rifampin (IDSA [Liu 2011]).

Peritonitis, spontaneous bacterial (prevention) (off-label use):

High-risk patients (eg, hospitalized patients with Child-Pugh class B or C cirrhosis and active GI bleeding): Oral: One double-strength tablet twice daily (Runyon 2017).

Long-term secondary SBP prophylaxis: Oral: One double-strength tablet once daily (Runyon 2017).

Pneumocystis pneumonia:

Prophylaxis, primary and secondary (off-label dose):

HIV-infected: Oral: One double-strength tablet once daily or one single-strength tablet once daily (preferred regimens) or one double-strength tablet 3 times weekly (alternative regimen). Note: In patients also requiring prophylaxis for toxoplasmosis, one double-strength tablet once daily should be used (HHS [OI adult 2017]).

Duration in HIV-infected patients receiving ART: Continue until undetectable viral load and CD4 count >200 cells/mm3 for >3 months (HHS [OI adult 2017]); some experts discontinue primary prophylaxis in patients with CD4 counts between 100 and 200 cells/mm3 who are receiving ART and have had an undetectable viral load for ≥3 to 6 months (HHS [OI adult 2017]; COHERE 2010).

Immunocompromised host, HIV-uninfected (eg, transplant recipients, cancer-related, hematopoietic stem cell transplant [HSCT]) (off-label dose): Oral: One double-strength tablet once daily or one single-strength tablet once daily (preferred regimens); alternatively, one double-strength tablet 3 times weekly (Fishman 2001; Montoya 2001; Tomblyn 2009).

Duration after solid organ transplant (except lung): ≥6 to 12 months and during periods of increased immunosuppression (eg, treatment for acute rejection) (Fishman 2019; Martin 2013).

Duration after lung transplant: Lifelong therapy should be considered (Martin 2013; Palmer 2017).

Duration for cancer-related (including HSCT) in patients at high risk for PCP infection: Based on expert opinion, continue until risk factor(s) for PCP infection are no longer present (Neumann 2013, Thomas 2017). Consult other specialized databases for more detailed information.

Treatment (off-label dose) (HHS [OI adult 2017]; ATS [Limper 2011]; Thomas 2017): Note: Secondary prophylaxis should be initiated immediately upon completion of therapy.

Moderate to severe infection: IV: 15 to 20 mg/kg/day (TMP component) in 3 or 4 divided doses for 21 days; may switch to oral therapy after clinical improvement. Note: Patients with moderate or severe infection (PaO2 <70 mm Hg at room air or alveolar-arterial oxygen gradient ≥35 mm Hg) should receive adjunctive glucocorticoids.

Mild to moderate infection: Oral: 15 to 20 mg/kg/day (TMP component) in 3 divided doses for 21 days or two double-strength tablets 3 times daily.

Prostatitis (off-label use):

Acute bacterial prostatitis: Oral: One double-strength tablet twice daily for 6 weeks (Lipsky 2010; Meyrier 2019a).

Chronic bacterial prostatitis (alternative agent): Oral: One double-strength tablet twice daily for ≥6 weeks (Lipsky 2010; Meares 1975; Meyrier 2019b).

Prosthetic joint infection (off-label use): Treatment (following pathogen-specific IV therapy in patients undergoing 1-stage exchange or debridement with retention of prosthesis): Oral:

Note: Duration of therapy ranges from a minimum of 3 months to indefinitely, depending on patient specific factors (Berbari 2018).

Staphylococci (methicillin-resistant) and Enterobacteriaceae: One double-strength tablet twice daily. For the first 3 to 6 months of therapy for staphylococcal infections, combine with rifampin (Berbari 2018; IDSA [Osmon 2013]).

Q fever (C. burnetii) (preferred agent for pregnant women ≤32 weeks of gestation; alternative agent for non-pregnant adults) (off-label use): Oral: Acute illness: One double-strength tablet twice daily during pregnancy but not beyond 32 weeks' gestation; administer with folic acid supplementation. Note: Discontinue therapy for the final 8 weeks of pregnancy due to hyperbilirubinemia risk (CDC [Anderson 2013]).

Septic arthritis (without prosthetic material) due to MRSA (alternative agent following initial IV therapy with an appropriate antibiotic) (off-label use): Oral: Two double-strength tablets twice daily or 4 mg/kg/dose (TMP component) twice daily (maximum: 320 mg [TMP component]/dose) for completion of 3- to 4-week total treatment course (IV and oral) (Goldenberg 2017; IDSA [Liu 2011]).

Sexually transmitted infections:

Epididymitis in patients ≥35 years of age and who are at low risk for sexually transmitted infections (ie, likely to be caused by enteric organisms) (alternative agent) (off-label use): Oral: One double-strength tablet twice daily for 10 days (Eyre 2019).

Granuloma inguinale (donovanosis) (alternative agent) (off-label use): Oral: One double-strength tablet every 12 hours for at least 3 weeks and until lesions have healed (CDC [Workowski 2015]). Note: If symptoms do not improve within the first few days of therapy, another agent (eg, aminoglycoside) can be added (CDC [Workowski 2015]).

Skin/soft tissue infection, mild to moderate (outpatient treatment) (off-label use): Oral: One to two double-strength tablets twice daily (IDSA [Liu 2011]; IDSA [Stevens 2014]; Miller 2015); treat for 5 to 14 days depending on severity and clinical response (IDSA [Stevens 2014]; Spelman 2019). Note: For empiric therapy of purulent cellulitis, monotherapy with sulfamethoxazole/trimethoprim is appropriate. For empiric therapy of nonpurulent cellulitis, guidelines suggest an additional agent (eg, amoxicillin, cephalexin) for beta-hemolytic streptococci (IDSA [Liu 2011]; IDSA [Stevens 2014]). However, limited data suggest that sulfamethoxazole and trimethoprim is an effective alternative agent for treatment of nonpurulent cellulitis (Bowen 2017; Miller 2015).

Stenotrophomonas maltophilia infections (hospital-acquired pneumonia [HAP], ventilator-associated pneumonia [VAP], bacteremia, or other sites) (off-label use): IV: 15 mg/kg/day (TMP component) in 3 or 4 divided doses (Lewis 2017; Looney 2009).

Toxoplasma gondii encephalitis (AIDS-associated) (off-label use):

Primary prophylaxis: Oral: One double-strength tablet once daily (preferred) or one double-strength tablet 3 times weekly or one single-strength tablet once daily; primary prophylaxis is indicated for T. gondii IgG-positive patients with CD4 count <100 cells/mm3. Continue primary prophylaxis following initiation of ART until CD4 count >200 cells/mm3 for >3 months; some experts discontinue primary prophylaxis in patients with a CD4 count between 100 to 200 cells/mm3 who are receiving ART and have had an undetectable viral load for ≥3 to 6 months (HHS [OI adult 2017]).

Treatment (alternative agent): Oral, IV: 10 mg/kg/day (TMP component) in 2 divided doses for at least 6 weeks; longer duration may be needed if clinical or radiologic disease is extensive or response is incomplete at 6 weeks (HHS [OI adult 2017]).

Secondary prophylaxis (chronic maintenance therapy) (alternative agent): Oral: One double-strength tablet twice daily or, alternatively, one double-strength tablet once daily (lower dose may be associated with increased relapse risk). Continue following initiation of ART until CD4 count >200 cells/mm3 for >6 months (HHS [OI adult 2017]).

Urinary tract infection: Note: Uncomplicated urinary tract infection (UTI) has traditionally been defined as infection in an otherwise healthy nonpregnant female with a normal urinary tract; UTI in other patient populations has been considered complicated. Some experts instead categorize UTI as either acute simple cystitis (mild infection limited to the bladder with no signs/symptoms of upper tract or systemic infection in a nonpregnant adult) or complicated UTI (pyelonephritis or cystitis symptoms with other signs/symptoms of systemic infection) (Hooton 2019a; Hooton 2019b).

Acute uncomplicated or simple cystitis: Note: Avoid use if resistance prevalence is known to exceed 20% or if patient has risk factors for multidrug resistant gram-negative infection (Hooton 2019a; Hooton 2019b): Oral: One double-strength tablet twice daily; treat females for 3 days (Hooton 2019a; IDSA [Gupta 2011]) and males for 7 days (Hooton 2019b).

Cystitis, uncomplicated, prophylaxis for recurrent infection (off-label use): Note: Prophylaxis may be considered in nonpregnant women with bothersome, recurrent uncomplicated cystitis despite nonantimicrobial preventative measures. The optimal duration of treatment has not been established; duration ranges from 3 to 12 months, with periodic assessment and monitoring (AUA/CUA/SUFU [Anger 2019]; Hooton 2019c).

Continuous prophylaxis: Oral: One-half of a single-strength tablet once daily or 3 times weekly (AUA/CUA/SUFU [Anger 2019]; Stamm 1980).

Postcoital prophylaxis: Females with cystitis temporally related to sexual intercourse: Oral: One-half to one single-strength tablet as a single dose immediately before or after sexual intercourse (AUA/CUA/SUFU [Anger 2019]; Stapleton 1990).

Urinary tract infection, complicated (including pyelonephritis) (outpatient targeted therapy [if the isolate is known to be susceptible]): Oral: One double-strength tablet twice daily for 14 days (IDSA [Gupta 2011]); for women who have a rapid response to treatment, some experts treat for 7 to 10 days (Hooton 2019d). Note: Oral therapy should follow appropriate parenteral therapy. For outpatient treatment of mild infection, a single dose of a long-acting parenteral agent is acceptable prior to oral therapy; for outpatients who are more ill or are at risk for more severe illness, consider continuing parenteral therapy until culture and susceptibility results are available (Hooton 2019d; IDSA [Gupta 2011]).

* See Dosage and Administration in AHFS Essentials for additional information.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment: Adult

Manufacturer's labeling: Oral, IV:

CrCl >30 mL/minute: No dosage adjustment necessary.

CrCl 15 to 30 mL/minute: Administer 50% of recommended dose.

CrCl <15 mL/minute: Use is not recommended and is contraindicated per the manufacturer's labeling in severe renal disease if renal function cannot be monitored.

Alternative recommendations:

Golightly 2013:

Oral: Note: The following dosage adjustments are based on a usual maintenance dose of 1 double-strength tablet every 12 hours.

GFR 10 to 50 mL/minute: One double-strength tablet once, followed by 1 single-strength tablet every 12 hours.

GFR <10 mL/minute: Avoid use; if necessary, 1 double-strength tablet once, followed by 1 single-strength tablet every 24 hours.

Hemodialysis: One double-strength tablet once, followed by 1 single-strength tablet every 24 hours (dose after hemodialysis on dialysis days).

IV: Note: The following dosage adjustments are based on a usual maintenance dose of 4 to 5 mg/kg (TMP component) every 6 hours.

GFR 10 to 50 mL/minute: 4 to 5 mg/kg (TMP component) every 12 hours.

GFR <10 mL/minute: Avoid use; if necessary, 2.5 to 5 mg/kg (TMP component) every 24 hours.

Hemodialysis: 2.5 to 5 mg/kg (TMP component) every 24 hours (dose after hemodialysis on dialysis days).

HHS (OI adult 2017) Pneumocystis pneumonia (PCP), treatment: Note: Renal function may be estimated using the Cockcroft-Gault formula for dosage adjustment purposes.

Oral: Note: The following dosage adjustments are based on a usual maintenance dose of 2 double-strength tablets every 8 hours.

CrCl 10 to 30 mL/minute: Two double-strength tablets every 12 hours.

CrCl <10 mL/minute: One double-strength tablet every 12 hours or 2 double-strength tablets every 24 hours.

Hemodialysis: Two double-strength tablets once daily (dose after hemodialysis on dialysis days); consider therapeutic drug monitoring to optimize therapy.

IV: Note: The following dosage adjustments are based on a usual maintenance dose of 5 mg/kg (TMP component) every 8 hours.

CrCl 10 to 30 mL/minute: 5 mg/kg (TMP component) every 12 hours.

CrCl <10 mL/minute: 5 mg/kg (TMP component) every 24 hours.

Hemodialysis: 5 mg/kg (TMP component) once daily (dose after hemodialysis on dialysis days); consider therapeutic drug monitoring to optimize therapy.

CRRT (Heintz 2009; Trotman 2005): Drug clearance is highly dependent on the method of renal replacement, filter type, and flow rate. Appropriate dosing requires close monitoring of pharmacologic response, signs of adverse reactions due to drug accumulation, as well as drug concentrations in relation to target trough (if appropriate). The following are general recommendations only (based on dialysate flow/ultrafiltration rates of 1 to 2 L/hour and minimal residual renal function) and should not supersede clinical judgment:

CVVH/CVVHD/CVVHDF: Oral, IV: 2.5 to 7.5 mg/kg (TMP component) every 12 hours. Note: Dosing regimen dependent on clinical indication. Critically ill patients with P. jirovecii pneumonia receiving CVVHDF may require up to 10 mg/kg (TMP component) every 12 hours (Heintz 2009).

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in manufacturer’s labeling. Use with caution; use is contraindicated in cases of marked hepatic damage.

Dosing: Pediatric

Note: Dosage recommendations are based on the trimethoprim (TMP) component:

General dosing, susceptible infection: Infants ≥2 months, Children, and Adolescents: Oral, IV: 6 to 12 mg TMP/kg/day in divided doses every 12 hours; maximum single dose: 160 mg TMP/dose (Red Book [AAP 2015])

Catheter (peritoneal dialysis); exit-site or tunnel infection: Limited data available: Infants, Children, and Adolescents: Oral: 5 to 10 mg TMP/kg/dose once daily; maximum dose: 80 mg TMP/dose (ISPD [Warady 2012])

Cyclosporiasis: Limited data available: Infants ≥2 months, Children, and Adolescents: Oral: 8 to 10 mg TMP/kg/day in divided doses twice daily for 7 to 10 days; maximum single dose: 160 mg TMP (Red Book [AAP 2015])

Meningitis: Infants ≥2 months, Children, and Adolescents: IV: 10 to 20 mg TMP/kg/day divided every 6 to 12 hours for 7 to 21 days; duration dependent on the pathogen and clinical course (Tunkel 2004)

MRSA, community-acquired mild to moderate skin/soft tissue infection: Infants ≥2 months, Children, and Adolescents: Oral: 8 to 12 mg TMP/kg/day in divided doses every 12 hours (Liu 2011); alternatively, use of 20 mg TMP/kg/day in divided doses every 6 hours has been reported (Long 2012). If using empirically, consider addition of group A streptococcal coverage.

Otitis media, acute: Infants ≥2 months, Children, and Adolescents: Oral: 6 to 10 mg TMP/kg/day in divided doses every 12 hours for 10 days. Note: Due to resistance of S. pneumoniae, should not be used in patients that fail first-line amoxicillin therapy (AAP [Lieberthal 2013]).

Pneumocystis jirovecii pneumonia (PCP) (HIV-exposed/-positive):

Prophylaxis:

Infants (at least 4 weeks of age) and Children: Oral: 5 to 10 mg TMP/kg/day or 150 mg TMP/m2/day; dose may be given as a single daily dose or in divided doses every 12 hours given 2 to 3 days per week on consecutive days or alternating days; maximum daily dose: TMP 320 mg/day (HHS [OI pediatric 2016])

Adolescents: Oral: 80 to 160 mg TMP daily or alternatively, 160 mg TMP 3 times weekly (HHS [OI adult 2017]):

Treatment:

Infants >2 months and Children: Initial: IV: 15 to 20 mg TMP/kg/day in divided doses every 6 hours for 21 days; as acute pneumonitis subsides in patients with mild to moderate disease and no malabsorption issues nor diarrhea, may transition to oral therapy of same daily dose (15 to 20 mg/kg/day TMP) administered in divided doses 3 or 4 times daily (HHS [OI pediatric 2016])

Adolescents (HHS [OI adult 2017]):

Mild to moderate: Oral: 15 to 20 mg TMP/kg/day in 3 divided doses for 21 days or alternatively, 320 mg TMP 3 times daily for 21 days

Moderate to severe: Initial: IV: 15 to 20 mg TMP/kg/day in 3 to 4 divided doses for 21 days; may switch to oral after clinical improvement

Q-Fever (Coxiella burnetii); mild infection (doxycycline therapeutic failure): Limited data available, dose should be based on severity of illness: Children <8 years: Oral: Usual dose range: 8 to 10 mg TMP/kg/day in divided doses twice daily for 14 days; a wider dose range of 4 to 20 mg TMP/kg/day divided twice daily has been suggested to address varying degrees of severity; however, reported pediatric efficacy experience (eg, case series) are lacking; monitor patients receiving doses at the high and low end of the range closely for efficacy and possible adverse effects (Bradley 2017; CDC 2013)

Shigellosis: Infants ≥2 months, Children, and Adolescents: Note: Due to reported widespread resistance empiric therapy with sulfamethoxazole and trimethoprim is not recommended (CDC-NARMS 2010; WHO 2005)

Oral:

Manufacturer's labeling: 8 mg TMP/kg/day in divided doses every 12 hours for 5 days; maximum single dose: 160 mg TMP

Alternate dosing: IDSA recommendations for infectious diarrhea: 10 mg TMP/kg/day in divided doses every 12 hours for 3 days (for immunocompetent patients) or 7 to 10 days (for immunocompromised patients); maximum single dose: 160 mg TMP (Guerrant 2001)

IV: 8 to 10 mg TMP/kg/day in divided doses every 6, 8, or 12 hours for up to 5 days

Toxoplasmosis (HIV-exposed/infected):

Prophylaxis, primary:

Infants ≥2 months and Children: Oral: 150 mg TMP/m2/day; dose may be administered as a single daily dose (preferred) or in divided doses every 12 hours; alternatively, may also be given 3 times weekly for 3 consecutive or alternating days (HHS [OI pediatric 2016])

Adolescents: Oral: 160 mg TMP daily (preferred) or 160 mg TMP 3 times weekly or 80 mg TMP daily (HHS [OI adult 2017])

Treatment, encephalitis: Adolescents: Oral, IV: 10 mg/kg/day TMP in two divided doses for at least 6 weeks; longer duration may be required in some patients; following treatment all patients should receive chronic maintenance therapy daily (HHS [OI adult 2017])

Secondary prophylaxis (chronic suppressive therapy, alternative regimen): Note: Only use when pyrimethamine is unavailable or not tolerated:

Infants and Children: Oral: 150 mg TMP/m2/day once daily (HHS [OI pediatric 2016])

Adolescents: Maintenance therapy; postencephalitis treatment: Oral: 160 mg TMP once or twice daily: May discontinue when asymptomatic and CD4 count >200 cells/mm3 for >6 months in response to ART. Note: Once-daily dosing may be associated with an increased risk of relapse; if used, a gradual transition (eg, follow acute treatment with 4 to 6 weeks of 160 mg TMP twice daily before lowering to once-daily dosing) may be beneficial (HHS [OI adult 2017])

Urinary tract infection:

Treatment:

Oral:

Infants and Children 2 to 24 months: 6 to 12 mg TMP/kg/day in divided doses every 12 hours for 7 to 14 days (AAP 2011)

Children >24 months and Adolescents: 8 mg TMP/kg/day in divided doses every 12 hours for 3 days; longer duration may be required in some patients; maximum single dose: 160 mg TMP

IV: Infants ≥2 months, Children, and Adolescents: 8 to 10 mg TMP/kg/day in divided doses every 6, 8, or 12 hours for up to 14 days with serious infections

Prophylaxis: Infants ≥2 months, Children, and Adolescents: Oral: 2 mg TMP/kg/dose once daily (Mattoo 2007; Red Book [AAP 2012])

Dosing: Renal Impairment: Pediatric

Manufacturer’s labeling: Infants ≥2 months, Children, and Adolescents: Oral, IV:

CrCl >30 mL/minute: No adjustment required.

CrCl 15 to 30 mL/minute: Administer 50% of recommended dose.

CrCl <15 mL/minute: Use is not recommended.

Alternative recommendations:

Children and Adolescents (Veltri 2004): Note: Renally adjusted dose recommendations are based on doses of 3 to 5 mg/kg/dose every 12 hours. IV, Oral:

CrCl 10 to 50 mL/minute/1.73 m2: 3 to 5 mg TMP/kg/dose every 18 hours

CrCl <10 mL/minute/1.73 m2: 3 to 5 mg TMP/kg/dose every 24 hours

Hemodialysis: 3 to 5 mg TMP/kg/dose every 24 hours; administer 2.5 mg TMP/kg/dose after each dialysis session

CRRT (CAVH/CVVH/CAVHD/CVVHD):

Combined dialysis flow + ultrafiltration rate <1,500 mL/m2/hour: 3 to 5 mg TMP/kg/dose every 18 hours

Combined dialysis flow + ultrafiltration rate ≥ 1,500 mL/m2/hour: 4 to 5 mg TMP/kg/dose every 18 hours

Pneumocystis jirovecii pneumonia (PCP):

Treatment (Veltri 2004):

Children: Note: Renally adjusted dose recommendations are based on doses of 5 mg/kg/dose every 6 hours. IV, Oral:

CrCl 10 to 50 mL/minute/1.73 m2: 5 mg TMP/kg/dose every 8 hours

CrCl <10 mL/minute/1.73 m2: 5 mg TMP/kg/dose every 12 hours

Hemodialysis: 5 mg/kg/dose every 12 hours; administer 2.5 mg TMP/kg/dose after each dialysis session

Continuous renal replacement therapy (CRRT): CAVH/CVVH/CAVHD/CVVHD: 5 mg TMP/kg/dose every 8 hours

Adolescents (HHS [OI adult 2016]): IV, Oral:

CrCl 10 to 30 mL/minute: 5 mg TMP/kg/dose IV every 12 hours or 320 mg TMP orally every 12 hours

CrCl <10 mL/minute: 5 mg TMP/kg/dose IV every 24 hours or 160 mg TMP orally every 12 hours or 320 mg TMP orally every 24 hours

Hemodialysis: 5 mg TMP/kg/dose IV or 320 mg TMP orally; administer dose after dialysis on dialysis days

Prophylaxis (Masur 2002): Adolescents: Oral:

CrCl 15 to 30 mL/minute: 40 mg or 80 mg TMP daily or 80 mg TMP 3 times weekly

CrCl <15 mL/minute: 40 mg or 80 mg TMP daily or 80 mg TMP 3 times weekly. While the guidelines do acknowledge the alternative of giving 80 mg TMP daily, this may be inadvisable in the uremic/ESRD patient.

Hemodialysis: 40 mg or 80 mg TMP after each dialysis session

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling. Use with caution; use is contraindicated in cases of marked hepatic damage.

Calculations

• Body Surface Area (Mosteller Method)
• Creatinine Clearance by Cockcroft-Gault
• Creatinine Clearance by Cockcroft-Gault (SI units)
• Creatinine Clearance by Cockcroft-Gault with IBW
• Creatinine Clearance by Cockcroft-Gault with IBW (SI units)
• Creatinine Clearance by Jelliffe
• Creatinine Clearance by Sanaka
• Glomerular Filtration Rate by Abbreviated MDRD
• Glomerular Filtration Rate by Abbreviated MDRD (SI units)
• Glomerular Filtration Rate by MDRD
• Glomerular Filtration Rate by MDRD (IDMS-Traceable SCr)
• Glomerular Filtration Rate by MDRD (SI units)
• Glomerular Filtration Rate by Schwartz
• Glomerular Filtration Rate Estimate in African Americans by AASK Equation

Use: Labeled Indications

Oral: Treatment of urinary tract infections (UTIs) due to Escherichia coli, Klebsiella and Enterobacter spp, Morganella morganii, Proteus mirabilis, and Proteus vulgaris; acute otitis media; acute exacerbations of chronic obstructive pulmonary disease due to susceptible strains of Haemophilus influenzae or Streptococcus pneumoniae; treatment and prophylaxis of Pneumocystis pneumonia (PCP); traveler's diarrhea due to enterotoxigenic E. coli; treatment of shigellosis caused by Shigella flexneri or Shigella sonnei.

IV: Treatment of PCP; treatment of shigellosis caused by S. flexneri or S. sonnei; treatment of severe or complicated UTIs due to E. coli, Klebsiella and Enterobacter spp, M. morganii, P. mirabilis, and P. vulgaris.

* See Uses in AHFS Essentials for additional information.

Use: Off-Label: Adult

Bite wound infection, prophylaxis or treatment (animal or human bite)Level of Evidence [C, G]

Based on the Infectious Diseases Society of America (IDSA) guidelines for the diagnosis and management of skin and soft tissue infections (SSTI), sulfamethoxazole/trimethoprim, in combination with an appropriate agent for anaerobic coverage, is an effective and recommended alternative for the prophylaxis and treatment of animal bite wounds.

Clinical experience suggests the utility of sulfamethoxazole/trimethoprim as an alternative agent for the prophylaxis and treatment of human bite wounds Ref.

CyclosporiasisLevel of Evidence [B, G]

Data from a randomized, double-blind, placebo-controlled trial in immunocompetent patients Ref and a prospective cohort study in patients with HIV Ref support the use of sulfamethoxazole/trimethoprim in the treatment of cyclosporiasis.

Based on the Centers for Disease Control and Prevention (CDC) recommendations for the treatment for cyclosporiasis, sulfamethoxazole/trimethoprim is the preferred treatment for cyclosporiasis (immunocompetent or HIV-infected patients).

Cystitis, uncomplicated, prophylaxis for recurrent infectionLevel of Evidence [C, G]

Data from a limited number of clinical trials of continuous prophylaxis and postcoital prophylaxis suggest that sulfamethoxazole/trimethoprim may be beneficial in the prophylaxis of recurrent uncomplicated cystitis Ref.

Based on the American Urological Association/Canadian Urological Association/Society of Urodynamics, Female Pelvic Medicine & Urogenital Reconstruction guidelines for recurrent uncomplicated urinary tract infections in women, sulfamethoxazole/trimethoprim is an effective and recommended agent and may be considered for prophylaxis of recurrent uncomplicated cystitis in nonpregnant women Ref.

Cystoisosporiasis (Isosporiasis)Level of Evidence [G]

Based on the US Department of Health and Human Services (HHS) guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents, sulfamethoxazole/trimethoprim is an effective and recommended agent for treatment or chronic suppressive therapy (secondary prophylaxis) of Isospora belli infection in adolescent and adult HIV-infected patients.

Based on the CDC recommendations for the treatment for cystoisosporiasis, sulfamethoxazole/trimethoprim is the preferred treatment for Cystoisospora belli (Isospora belli) in immunocompetent (when treatment is indicated) or immunosuppressed patients (expert consultation is recommended).

Diabetic foot infectionLevel of Evidence [G]

According to the IDSA clinical practice guideline for the diagnosis and treatment of diabetic foot infections, sulfamethoxazole/trimethoprim is a reasonable treatment option for mild diabetic foot infections.

EpididymitisLevel of Evidence [C]

Clinical experience suggests that sulfamethoxazole/trimethoprim is an alternative agent for the treatment of epididymitis Ref.

Granuloma inguinale (Donovanosis)Level of Evidence [G]

Based on the CDC sexually transmitted diseases treatment guidelines, sulfamethoxazole/trimethoprim is an effective and recommended alternative agent in the treatment of granuloma inguinale.

Head lice (Pediculosis capitis)Level of Evidence [C, G]

Most sulfamethoxazole and trimethoprim trials for the treatment of head lice studied the drug in addition to standard treatment. There is little evidence to support treatment with sulfamethoxazole/trimethoprim as a single agent for head lice infestation, but it may have some benefit when used as part of combination therapy. Current guidelines do not recommend the use of sulfamethoxazole/trimethoprim for head lice infestation if other options are available. Access Full Off-Label Monograph

Intracranial abscess (brain abscess, intracranial epidural abscess) and spinal epidural abscess (methicillin-resistant Staphylococcus aureus)Level of Evidence [C, G]

IDSA guidelines cite limited data evaluating the effectiveness of sulfamethoxazole/trimethoprim in the treatment of brain abscess and spinal epidural abscess caused by methicillin-resistant Staphylococcus aureus (MRSA). However, the guidelines support the initial use and evaluation of vancomycin treatment; if vancomycin is contraindicated or resistance is expected, use of linezolid or sulfamethoxazole/trimethoprim should be considered as alternative therapy. Sulfamethoxazole/trimethoprim can be given as a single agent or in combination with rifampin Ref.

Clinical experience also suggests the utility of sulfamethoxazole/trimethoprim as an alternative agent for MRSA intracranial epidural abscess Ref.

Melioidosis (Burkholderia pseudomallei) infectionLevel of Evidence [G]

An HHS Workshop on treatment of and postexposure prophylaxis for Burkholderia pseudomallei and B. mallei infection suggests the use of sulfamethoxazole/trimethoprim as a potential addition to initial intensive therapy (with ceftazidime or a carbapenem) in focal disease of the CNS, prostate, bone, or other deep-seated infection, and as eradication therapy (initiated after completion of initial intensive therapy) Ref.

Meningitis, bacterialLevel of Evidence [G]

Based on the IDSA guidelines for the management of bacterial meningitis and health care-associated ventriculitis and meningitis, sulfamethoxazole/trimethoprim is an effective and recommended alternative agent for the treatment of meningitis due to MRSA, Listeria monocytogenes, E. coli, and other susceptible Enterobacteriaceae.

NocardiosisLevel of Evidence [C]

Data from a limited number of patients studied suggest that sulfamethoxazole/trimethoprim may be beneficial for the treatment of nocardiosis (as monotherapy or combination therapy, depending on severity of infection) Ref.

Clinical experience also suggests the utility of sulfamethoxazole/trimethoprim in the treatment of nocardiosis Ref.

OsteomyelitisLevel of Evidence [G]

According to IDSA guidelines, sulfamethoxazole/trimethoprim, in combination with rifampin, is a reasonable treatment option for MRSA osteomyelitis Ref.

Peritonitis, spontaneous bacterial (prevention)Level of Evidence [B, G]

Data from controlled trials support use of sulfamethoxazole/trimethoprim as primary long-term prophylaxis in cirrhotic patients with low protein ascites with or without renal or liver impairment, or as secondary long-term prophylaxis in patients who have experienced a prior SBP episode.

According to AASLD and EASL guidelines, long-term prophylaxis with daily sulfamethoxazole/trimethoprim should be considered as secondary prophylaxis in patients who have experienced a prior SBP episode, and as primary prophylaxis in cirrhotic patients with low protein ascites. Increasing bacterial resistance rates to antibiotics used in the treatment and prevention of SBP have been documented; therefore, local epidemiological patterns should be considered, and use of antibiotic prophylaxis should be restricted to patients at high risk of SBP. Access Full Off-Label Monograph

ProstatitisLevel of Evidence [C]

Data from open-label, non-comparative studies suggest the utility of sulfamethoxazole/trimethoprim in the treatment of chronic bacterial prostatitis Ref. In addition, clinical experience suggests the utility of sulfamethoxazole/trimethoprim in the treatment of acute and chronic bacterial prostatitis Ref.

Prosthetic joint infectionLevel of Evidence [C, G]

Data from a limited number of patients in a prospective, consecutive, therapeutic case series with no control group suggest that sulfamethoxazole/trimethoprim may be beneficial for the treatment of prosthetic joint infection Ref. Additional data may be necessary to further define the role of sulfamethoxazole/trimethoprim in the treatment of this condition.

Based on the IDSA clinical practice guideline for the diagnosis and management of prosthetic joint infection, sulfamethoxazole/trimethoprim is an effective and recommended agent for treatment and chronic oral antimicrobial suppression of prosthetic joint infection due to staphylococci (methicillin-resistant) or Enterobacteriaceae, after completion of pathogen-specific parenteral therapy in patients undergoing 1-stage exchange or debridement with retention of prosthesis.

Q fever (Coxiella burnetii)Level of Evidence [G]

Based on the CDC diagnosis and management of Q fever guidelines, sulfamethoxazole/trimethoprim given for the treatment of Q fever (Coxiella burnetii) is effective and recommended in the management of this condition in pregnant women up to 32 weeks' gestation (alternative agent in nonpregnant adults).

Septic arthritis (methicillin-resistant Staphylococcus aureus)Level of Evidence [G]

Based on the IDSA guidelines for the treatment of MRSA infections in adults and children, sulfamethoxazole/trimethoprim is an effective and recommended treatment option for septic arthritis without prosthetic material caused by MRSA following initial therapy with an appropriate IV antibiotic.

Skin and soft tissue infectionsLevel of Evidence [C, G]

Data from a limited number of patients studied suggest that sulfamethoxazole/trimethoprim may be beneficial for the treatment of uncomplicated skin infections caused by streptococci Ref.

Clinical experience also suggests the utility of sulfamethoxazole/trimethoprim as an alternative agent in the treatment of mild skin and soft tissue infections (including impetigo and erysipelas) caused by streptococci Ref.

Based on the IDSA guidelines for the diagnosis and management of SSTIs and the treatment of MRSA infections in adults and children, sulfamethoxazole/trimethoprim is an effective and recommended treatment option for mild to moderate SSTIs caused by MRSA.

Stenotrophomonas maltophilia infectionsLevel of Evidence [C]

Data from a limited number of patients studied suggest that sulfamethoxazole/trimethoprim may be beneficial for the treatment of Stenotrophomonas maltophilia infections Ref.

Clinical experience also suggests the utility of sulfamethoxazole/trimethoprim in the treatment of Stenotrophomonas maltophilia Ref.

Toxoplasma gondii encephalitis (prophylaxis/treatment/chronic maintenance) in HIV-infected patientsLevel of Evidence [G]

Based on the US Department of Health and Human Services (HHS) guidelines for prevention and treatment of opportunistic infections in HIV-infected adults and adolescents, sulfamethoxazole/trimethoprim is an effective and recommended agent for primary prophylaxis of Toxoplasma gondii encephalitis and is an effective and recommended alternative agent for the treatment of or as chronic maintenance therapy of T. gondii encephalitis in HIV-infected patients.

Level of Evidence Definitions

Level of Evidence Scale

Clinical Practice Guidelines

Acne:

American Academy of Dermatology, "Guidelines of care for the management of acne vulgaris," May 2016

Ascites:

AASLD Practice Guidelines: “Management of Adult Patients with Ascites Due to Cirrhosis: Update 2012,” 2012

Chronic Obstructive Pulmonary Disease

GOLD, "Global Strategy for Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease," 2020

Diabetic Foot Infection:

IDSA, “The Diagnosis and Treatment of Diabetic Foot Infections,” 2012

Drug-Induced Liver Injury:

American College of Gastroenterology (ACG), “2014 ACG Guideline for Idiosyncratic Drug-induced Liver Injury,” July 2014

Meningitis and Ventriculitis, Healthcare-associated:

IDSA, "Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis," February 2017

Methicillin-Resistant Staphylococcus aureus (MRSA) Infections:

Infectious Diseases Society of America, “Practice Guidelines for the Treatment of Methicillin-Resistant Staphylococcus Aureus,” February 2011

Opportunistic Infections:

HHS, Guidelines for the Prevention and Treatment of Opportunistic Infections Among HIV-Exposed and HIV-Infected Children, December 2016

HHS, Guidelines for the Prevention and Treatment of Opportunistic Infections in HIV-Infected Adults and Adolescents, 2017

Osteomyelitis, Native Vertebral:

IDSA, "Clinical Practice Guidelines for the Diagnosis and Treatment of Native Vertebral Osteomyelitis in Adults," 2015

Peritoneal Dialysis Infections:

ISPD Guidelines, Adults: Peritoneal Dialysis-Related Infections, April 2010

Prosthetic Joint Infection:

IDSA, “Diagnosis and Management of Prosthetic Joint Infection: Clinical Practice Guideline,” January 2013

Q Fever:

CDC, “Diagnosis and Management of Q Fever”, March 2013

Sexually Transmitted Disease:

CDC, “Sexually Transmitted Diseases Treatment Guidelines,” June 2015.

Public Health Agency of Canada, “Canadian Guidelines on Sexually Transmitted Infections," January 2010

Shigella Dysentery Type 1:

World Health Organization (WHO), "Guidelines for the Control of Shigellosis, Including Epidemics Due to Shigella dysenteriae Type 1," 2005

Skin and Soft-tissue Infection:

IDSA, “Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections,” June 2014.

Urinary Tract Infections:

IDSA, “International Clinical Practice Guidelines for the Treatment of Acute Uncomplicated Cystitis and Pyelonephritis in Women,” March 2011

Urinary Tract Infections, Catheter-Related:

IDSA, “Diagnosis, Prevention, and Treatment of Catheter- Associated Urinary Tract Infection in Adults,” February 2010

Administration: IV

Infuse diluted solution IV over 60-90 minutes; not for IM injection.

Administration: Injectable Detail

pH: 10

Administration: Oral

Administer without regard to meals. Administer with at least 8 ounces of water.

Administration: Pediatric

Oral: Administer without regard to meals. Shake suspension well before use.

Parenteral: IV infusion: Do not administer IM. Must be diluted in D5W prior to administration. Inspect solution for evidence of cloudiness or precipitation prior to administration; infuse diluted solution IV over 60 to 90 minutes.

Dietary Considerations

Should be taken with 8 oz of water. May be taken without regard to meals.

Storage/Stability

Injection: Store at room temperature; do not refrigerate. Less soluble in more alkaline pH. Solution must be diluted prior to administration. Following dilution, store at room temperature; do not refrigerate. Manufacturer recommended dilutions and stability of parenteral admixture at room temperature (25°C):

5 mL/125 mL D5W; stable for 6 hours.

5 mL/100 mL D5W; stable for 4 hours.

5 mL/75 mL D5W; stable for 2 hours.

Studies have also confirmed limited stability in NS; detailed references should be consulted.

Suspension, tablet: Store at controlled room temperature of 15°C to 25°C (59°F to 77°F). Protect from light.

Preparation for Administration: Adult

IV: Must dilute well in D5W prior to administration (ie, 1:15 to 1:25, which equates to 5 mL of drug solution diluted in 75-125 mL base solution)

Preparation for Administration: Pediatric

IV: Dilute in D5W only.

Usual preparation: Dilute to 1:25 dilution (5 mL drug to 125 mL D5W)

Fluid restriction: Dilute to 1:15 dilution (5 mL drug to 75 mL D5W)

Compatibility

See Trissel’s IV Compatibility Database

Open Trissel's IV Compatibility

Medication Patient Education with HCAHPS Considerations

What is this drug used for?

• It is used to treat or prevent bacterial infections.

Frequently reported side effects of this drug

• Nausea

• Vomiting

• Diarrhea

• Lack of appetite

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Severe sulfonamide reaction like rash; red, swollen, blistered, or peeling skin; red or irritated eyes; mouth, throat, nose, or eye sores; fever, chills, or sore throat.

• Cough that is new or worse

• Loss of strength and energy

• Any bruising or bleeding

• Liver problems like dark urine, fatigue, lack of appetite, nausea or abdominal pain, light-colored stools, vomiting, or yellow skin.

• High potassium like abnormal heartbeat, confusion, dizziness, passing out, weakness, shortness of breath, or numbness or tingling feeling.

• Aseptic meningitis like headache, fever, chills, severe nausea or vomiting, stiff neck, rash, sensitivity to lights, fatigue, or confusion.

• Low blood sugar like dizziness, headache, fatigue, feeling weak, shaking, fast heartbeat, confusion, increased hunger, or sweating.

• Kidney problems like unable to pass urine, blood in the urine, change in amount of urine passed, or weight gain.

• Low sodium like headache, difficulty focusing, trouble with memory, confusion, weakness, seizures, or change in balance.

• Mood changes

• Sensing things that seem real but are not

• Muscle pain

• Joint pain

• Purple patches on skin or mouth

• Shortness of breath

• Severe injection site pain

• Burning

• Edema

• Irritation

• Clostridioides (formerly Clostridium) difficile-associated diarrhea like abdominal pain or cramps, severe diarrhea or watery stools, or bloody stools

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Medication Safety Issues

Sound-alike/look-alike issues:

Geriatric Patients: High-Risk Medication:

Contraindications

Hypersensitivity to any sulfa drug, trimethoprim, or any component of the formulation; history of drug induced-immune thrombocytopenia with use of sulfonamides or trimethoprim; megaloblastic anemia due to folate deficiency; infants <2 months (manufacturer's labeling), infants <4 weeks (CDC 2009); marked hepatic damage or severe renal disease (if patient not monitored); concomitant administration with dofetilide

Note: Although the FDA approved product labeling states this medication is contraindicated with other sulfonamide-containing drug classes, the scientific basis of this statement has been challenged. See “Warnings/Precautions” for more detail.

Canadian labeling: Additional contraindications (not in US labeling): Blood dyscrasias; pregnancy; breastfeeding.

Warnings/Precautions

Concerns related to adverse effects:

• Blood dyscrasias: Fatalities associated with severe reactions including agranulocytosis, aplastic anemia, and other blood dyscrasias have occurred; discontinue use at first sign of rash or signs of serious adverse reactions.

• Dermatologic reactions: Fatalities associated with severe reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis have occurred; discontinue use at first sign of rash.

• Hepatic necrosis: Fatalities associated with hepatic necrosis have occurred; discontinue use at first sign of rash or signs of serious adverse reactions.

• Hyperkalemia: May cause hyperkalemia; potential risk factors for trimethoprim-induced hyperkalemia include high dosage (20 mg/kg/day of trimethoprim), renal impairment, older age, hypoaldosteronism, and concomitant use of medications causing or exacerbating hyperkalemia (Perazella 2000).

• Hypoglycemia: May cause hypoglycemia, particularly in malnourished, or patients with renal or hepatic impairment.

• Hyponatremia: Severe and symptomatic hyponatremia may occur, particularly in patients treated for Pneumocystis jirovecii pneumonia (PCP).

• Sulfonamide (“sulfa”) allergy: Traditionally, concerns for cross-reactivity have extended to all compounds containing the sulfonamide structure (SO2NH2). An expanded understanding of allergic mechanisms indicates cross-reactivity between antibiotic sulfonamides and nonantibiotic sulfonamides may not occur, or at the very least this potential is extremely low (Brackett 2004; Johnson 2005; Slatore 2004; Tornero 2004). In particular, mechanisms of cross-reaction due to antibody production (anaphylaxis) are unlikely to occur with nonantibiotic sulfonamides and antibiotic sulfonamides. A nonantibiotic sulfonamide compound which contains the arylamine structure and therefore may cross-react with antibiotic sulfonamides is sulfasalazine (Zawodniak 2010). T-cell-mediated (type IV) reactions (eg, maculopapular rash) are less understood and it is not possible to completely exclude this potential based on current insights. In cases where prior reactions were severe (Stevens-Johnson syndrome/TEN), some clinicians choose to avoid exposure to these classes.

• Superinfection: Prolonged use may result in fungal or bacterial superinfection, including C. difficile-associated diarrhea (CDAD) and pseudomembranous colitis; CDAD has been observed >2 months postantibiotic treatment.

• Thrombocytopenia: Immune mediated thrombocytopenia may occur. Severe cases which may be life-threatening or fatal have been reported. Thrombocytopenia usually resolves within 1 week following discontinuation of therapy.

Disease-related concerns:

• Asthma/allergies: Use with caution in patients with allergies or asthma.

• Hepatic impairment: Use with caution in patients with hepatic impairment.

• Renal impairment: Use with caution in patients with renal impairment; dosage adjustment recommended. Maintain adequate hydration to prevent crystalluria.

• Thyroid dysfunction: Use with caution in patients with thyroid dysfunction.

Concurrent drug therapy issues:

• Drug-drug interactions: Potentially significant interactions may exist, requiring dose or frequency adjustment, additional monitoring, and/or selection of alternative therapy. Consult drug interactions database for more detailed information.

• Leucovorin: Avoid concomitant use when treating Pneumocystis jirovecii pneumonia (PCP) in HIV patients; may increase risk of treatment failure and death.

Special populations:

• AIDS patients: Incidence of adverse effects appears to be increased in patients with AIDS.

• Elderly: Use with caution in elderly patients; greater risk for more severe adverse reactions, including hyperkalemia associated with trimethoprim use. Elderly patients are at an increased risk for severe and potentially life-threatening hyperkalemia when trimethoprim is used concomitantly with medications known to cause or exacerbate hyperkalemia, such as spironolactone, ACE inhibitors, or ARBs (Antoniou 2010; Antoniou 2011; Antoniou, 2015).

• G6PD deficiency: Use with caution in patients with G6PD deficiency; hemolysis may occur (dose-related).

• Patients with potential for folate deficiency: Use with caution in patients with potential folate deficiency (malnourished, chronic anticonvulsant therapy, or elderly).

• Porphyria: Use with caution in patients with porphyria.

• Pregnant women: Use during pregnancy may be associated with embryo-fetal toxicity.

• Slow acetylators: May be more prone to adverse reactions.

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension, and cardiovascular collapse (AAP ["Inactive" 1997]; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.

• Propylene glycol: Some dosage forms may contain propylene glycol; large amounts are potentially toxic and have been associated hyperosmolality, lactic acidosis, seizures, and respiratory depression; use caution (AAP ["Inactive" 1997]; Zar 2007).

• Sulfite sensitivity: Injection may contain sodium metabisulfite, a sulfite that may cause allergic-type reactions, including anaphylactic symptoms and life-threatening or less severe asthmatic episodes in certain susceptible persons. The overall prevalence of sulfite sensitivity in the general population is unknown and probably low. Sulfite sensitivity is seen more frequently in asthmatic than in nonasthmatic persons.

Other warnings/precautions:

• Appropriate use: When used for uncomplicated urinary tract infections, this combination should not be used if a single agent is effective. Additionally, sulfonamides should not be used to treat group A beta-hemolytic streptococcal infections.

* See Cautions in AHFS Essentials for additional information.

Geriatric Considerations

Elderly patients appear at greater risk for more severe adverse reactions.

Trimethoprim decreases potassium excretion through competitive inhibition of epithelial sodium channels in the kidney (similar to the action of amiloride), and may cause hyperkalemia in certain susceptible patients, including the elderly (Ben Salem 2014; Perazella 2000). Elderly patients receiving trimethoprim (alone or in combination with sulfamethoxazole) concomitantly with other agents known to cause or exacerbate hyperkalemia (spironolactone, ACE inhibitors, or ARBs) are at an increased risk for severe and potentially life-threatening hyperkalemia (Antoniou 2010; Antoniou 2011; Antoniou 2015).

Warnings: Additional Pediatric Considerations

Sulfa antibiotics have been shown to displace bilirubin from protein binding sites which may potentially lead to hyperbilirubinemia and kernicterus in neonates and young infants; do not use in neonates; avoid use in infants <2 months unless other options are not available (eg, Pneumocystis).

Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures and respiratory depression; use caution (AAP, 1997; Shehab, 2009).

Pregnancy Risk Factor

D

Pregnancy Considerations

Sulfamethoxazole and trimethoprim cross the placenta.

An increased risk of congenital malformations (neural tube defects, cardiovascular malformations, urinary tract defects, oral clefts, club foot) following maternal use of sulfamethoxazole and trimethoprim during pregnancy has been observed in some studies. Folic acid supplementation may decrease this risk (Crider 2009; Czeizel 2001; Hernandez-Diaz 2000; Hernandez-Diaz 2001; Matok 2009). Due to theoretical concerns that sulfonamides pass the placenta and may cause kernicterus in the newborn, neonatal health care providers should be informed if maternal sulfonamide therapy is used near the time of delivery (HHS [OI adult]).

The pharmacokinetics of sulfamethoxazole and trimethoprim are similar to nonpregnant values in early pregnancy (Ylikorkala 1973). Sulfamethoxazole and trimethoprim are recommended for the prophylaxis or treatment of Pneumocystis jirovecii pneumonia (PCP), prophylaxis of Toxoplasmic gondii encephalitis (TE), and for the acute and chronic treatment of Q fever in pregnancy (CDC 2013; HHS [OI adult]). Sulfonamides may also be used to treat other infections in pregnant women when clinically appropriate; use during the first trimester should be limited to situations where no alternative therapies are available (ACOG 717 2017).

Breast-Feeding Considerations

Sulfamethoxazole and trimethoprim are present in breast milk.

The manufacturer states that the exposure of sulfamethoxazole and trimethoprim to the breastfeeding infant would be 2% to 5% of the recommended daily dose for infants >2 months of age (maternal dose, milk concentration, and infant dose not specified). The relative infant dose (RID) of trimethoprim is 3% when compared to an infant therapeutic trimethoprim dose of 10 mg/kg/day. In general, breastfeeding is considered acceptable when the RID is <10% (Anderson 2016; Ito 2000).

The RID of trimethoprim was calculated using a mean milk concentration of 2 mcg/mL, providing an estimated daily infant dose via breast milk of <0.3 mg/kg/day. Using an average sulfamethoxazole milk concentration of 5.34 mcg/mL, the estimated daily infant sulfamethoxazole dose via breast milk would be <0.8 mg/kg/day. These milk concentrations were obtained following a maternal dose of trimethoprim 80 mg-sulfamethoxazole 400 mg as either 2 tablets (n=40) or 3 tablets (n=10) twice daily for a minimum of 5 days to women within 5 days of delivery (Miller 1974).

The therapeutic use of sulfamethoxazole and trimethoprim is contraindicated in infants <2 months of age due to the possibility of bilirubin displacement resulting in kernicterus and hemolytic anemia caused by immature erythrocyte enzyme systems; theoretically, the risk of kernicterus and hemolytic anemia is present in breastfed infants exposed to sulfamethoxazole and trimethoprim via breast milk (Mitrano 2009). The manufacturer recommends that caution be used if administered to nursing women, especially if breastfeeding infants that are ill, jaundiced, premature, or stressed due to the potential risk of bilirubin displacement and kernicterus. Avoid use of sulfamethoxazole in women who are breastfeeding an infant with G6PD deficiency (WHO 2002) or hyperbilirubinemia (Della-Giustina 2003). The WHO considers sulfamethoxazole and trimethoprim compatible with breastfeeding in older, healthy, full-term infants with monitoring of the infant for jaundice and hemolysis (WHO 2002). In general, antibiotics that are present in breast milk may cause nondose-related modification of bowel flora. Monitor infants for GI disturbances (WHO 2002).

Lexicomp Pregnancy & Lactation, In-Depth

• Sulfamethoxazole and Trimethoprim

Briggs' Drugs in Pregnancy & Lactation

• Sulfonamides
• Trimethoprim

Adverse Reactions

Frequency not defined:

Cardiovascular: Allergic myocarditis, periarteritis nodosa (rare)

Central nervous system: Apathy, aseptic meningitis, ataxia, chills, depression, fatigue, hallucination, headache, insomnia, nervousness, peripheral neuritis, seizure, vertigo

Dermatologic: Erythema multiforme (rare), exfoliative dermatitis (rare), pruritus, skin photosensitivity, skin rash, Stevens-Johnson syndrome (rare), toxic epidermal necrolysis (rare), urticaria

Endocrine & metabolic: Hyperkalemia (generally at high dosages), hypoglycemia (rare), hyponatremia

Gastrointestinal: Abdominal pain, anorexia, diarrhea, glottis edema, kernicterus (in neonates), nausea, pancreatitis, pseudomembranous colitis, stomatitis, vomiting

Genitourinary: Crystalluria, diuresis (rare), nephrotoxicity (in association with cyclosporine), toxic nephrosis (with anuria and oliguria)

Hematologic & oncologic: Agranulocytosis, anaphylactoid purpura (IgA vasculitis; rare), aplastic anemia, eosinophilia, hemolysis (with G6PD deficiency), hemolytic anemia, hypoprothrombinemia, leukopenia, megaloblastic anemia, methemoglobinemia, neutropenia, thrombocytopenia

Hepatic: Cholestatic jaundice, hepatotoxicity (including hepatitis, cholestasis, and hepatic necrosis), hyperbilirubinemia, increased transaminases

Hypersensitivity: Anaphylaxis, angioedema, hypersensitivity reaction, serum sickness

Neuromuscular & skeletal: Arthralgia, myalgia, rhabdomyolysis (mainly in AIDS patients), systemic lupus erythematosus (rare), weakness

Ophthalmic: Conjunctival injection, injected sclera, uveitis

Otic: Tinnitus

Renal: Increased blood urea nitrogen, increased serum creatinine, interstitial nephritis, renal failure

Respiratory: Cough, dyspnea, pulmonary infiltrates

Miscellaneous: Fever

<1%, postmarketing, and/or case reports: Acute respiratory distress syndrome (Miller 2019), dysgeusia (Syed 2016), immune thrombocytopenia (formerly known as idiopathic thrombocytopenic purpura), metabolic acidosis, prolonged Q-T interval on ECG, thrombotic thrombocytopenic purpura

* See Cautions in AHFS Essentials for additional information.

Allergy and Idiosyncratic Reactions

• Sulfonamide Antibiotic Allergy

Metabolism/Transport Effects

Refer to individual components.

Drug Interactions Open Interactions

Ajmaline: Sulfonamides may enhance the adverse/toxic effect of Ajmaline. Specifically, the risk for cholestasis may be increased. Risk C: Monitor therapy

Alpelisib: May decrease the serum concentration of CYP2C9 Substrates (High risk with Inducers). Risk C: Monitor therapy

Amantadine: Trimethoprim may enhance the adverse/toxic effect of Amantadine. Specifically, the risk of myoclonus and/or delirium may be increased. Amantadine may increase the serum concentration of Trimethoprim. Trimethoprim may increase the serum concentration of Amantadine. Risk C: Monitor therapy

Aminolevulinic Acid (Systemic): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Systemic). Risk X: Avoid combination

Aminolevulinic Acid (Topical): Photosensitizing Agents may enhance the photosensitizing effect of Aminolevulinic Acid (Topical). Risk C: Monitor therapy

Amodiaquine: Trimethoprim may enhance the neutropenic effect of Amodiaquine. Trimethoprim may increase the serum concentration of Amodiaquine. Risk X: Avoid combination

Androgens: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Exceptions: Danazol. Risk C: Monitor therapy

Angiotensin II Receptor Blockers: Trimethoprim may enhance the hyperkalemic effect of Angiotensin II Receptor Blockers. Risk C: Monitor therapy

Angiotensin-Converting Enzyme Inhibitors: Trimethoprim may enhance the hyperkalemic effect of Angiotensin-Converting Enzyme Inhibitors. Risk C: Monitor therapy

Antidiabetic Agents: May enhance the hypoglycemic effect of Hypoglycemia-Associated Agents. Risk C: Monitor therapy

AzaTHIOprine: Sulfamethoxazole may enhance the myelosuppressive effect of AzaTHIOprine. Risk C: Monitor therapy

AzaTHIOprine: Trimethoprim may enhance the myelosuppressive effect of AzaTHIOprine. Risk C: Monitor therapy

BCG (Intravesical): Antibiotics may diminish the therapeutic effect of BCG (Intravesical). Risk X: Avoid combination

BCG Vaccine (Immunization): Antibiotics may diminish the therapeutic effect of BCG Vaccine (Immunization). Risk C: Monitor therapy

Chloroprocaine: May diminish the therapeutic effect of Sulfonamide Antibiotics. Management: Avoid concurrent use of chloroprocaine and systemic sulfonamide-based antimicrobials whenever possible. Risk D: Consider therapy modification

Cholera Vaccine: Antibiotics may diminish the therapeutic effect of Cholera Vaccine. Management: Avoid cholera vaccine in patients receiving systemic antibiotics, and within 14 days following the use of oral or parenteral antibiotics. Risk X: Avoid combination

CycloSPORINE (Systemic): Sulfonamide Antibiotics may enhance the nephrotoxic effect of CycloSPORINE (Systemic). Sulfonamide Antibiotics may decrease the serum concentration of CycloSPORINE (Systemic). Risk C: Monitor therapy

CYP2C9 Inhibitors (Moderate): May decrease the metabolism of CYP2C9 Substrates (High risk with Inhibitors). Risk C: Monitor therapy

Dabrafenib: May decrease the serum concentration of CYP2C9 Substrates (High risk with Inducers). Management: Seek alternatives to the CYP2C9 substrate when possible. If concomitant therapy cannot be avoided, monitor clinical effects of the substrate closely (particularly therapeutic effects). Risk D: Consider therapy modification

Dapsone (Systemic): Trimethoprim may increase the serum concentration of Dapsone (Systemic). Dapsone (Systemic) may increase the serum concentration of Trimethoprim. Risk C: Monitor therapy

Dapsone (Topical): Trimethoprim may enhance the adverse/toxic effect of Dapsone (Topical). More specifically, trimethoprim may increase the risk for hemolysis Risk C: Monitor therapy

Dexketoprofen: May enhance the adverse/toxic effect of Sulfonamides. Risk C: Monitor therapy

Digoxin: Trimethoprim may increase the serum concentration of Digoxin. Risk C: Monitor therapy

Dofetilide: Trimethoprim may increase the serum concentration of Dofetilide. Risk X: Avoid combination

Enzalutamide: May decrease the serum concentration of CYP2C9 Substrates (High risk with Inducers). Management: Concurrent use of enzalutamide with CYP2C9 substrates that have a narrow therapeutic index should be avoided. Use of enzalutamide and any other CYP2C9 substrate should be performed with caution and close monitoring. Risk D: Consider therapy modification

Eplerenone: Trimethoprim may enhance the hyperkalemic effect of Eplerenone. Risk C: Monitor therapy

Fexinidazole [INT]: May increase the serum concentration of Products Containing Propylene Glycol. Risk X: Avoid combination

Fosphenytoin: May decrease the serum concentration of Trimethoprim. Trimethoprim may increase the serum concentration of Fosphenytoin. Management: Consider alternatives to this combination when possible, to avoid potential decreased trimethoprim efficacy and increased phenytoin concentrations/effects. Monitor patients receiving this combination closely for both of these possible effects. Risk D: Consider therapy modification

Herbs (Hypoglycemic Properties): May enhance the hypoglycemic effect of Hypoglycemia-Associated Agents. Risk C: Monitor therapy

Hypoglycemia-Associated Agents: May enhance the hypoglycemic effect of other Hypoglycemia-Associated Agents. Risk C: Monitor therapy

Lactobacillus and Estriol: Antibiotics may diminish the therapeutic effect of Lactobacillus and Estriol. Risk C: Monitor therapy

LamiVUDine: Trimethoprim may increase the serum concentration of LamiVUDine. Risk C: Monitor therapy

Leucovorin Calcium-Levoleucovorin: May diminish the therapeutic effect of Trimethoprim. Management: Avoid concurrent use of leucovorin or levoleucovorin with trimethoprim (plus sulfamethoxazole) for Pneumocystis jirovecii pneumonia. If trimethoprim is used for another indication, monitor closely for reduced efficacy. Risk X: Avoid combination

Local Anesthetics: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Local Anesthetics. Specifically, the risk for methemoglobinemia may be increased. Risk C: Monitor therapy

Lumacaftor and Ivacaftor: May decrease the serum concentration of CYP2C9 Substrates (High Risk with Inhibitors or Inducers). Lumacaftor and Ivacaftor may increase the serum concentration of CYP2C9 Substrates (High Risk with Inhibitors or Inducers). Risk C: Monitor therapy

Maitake: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Risk C: Monitor therapy

Mecamylamine: Sulfonamides may enhance the adverse/toxic effect of Mecamylamine. Risk X: Avoid combination

Memantine: Trimethoprim may enhance the adverse/toxic effect of Memantine. Specifically, the risk of myoclonus and/or delirium may be increased. Trimethoprim may increase the serum concentration of Memantine. Memantine may increase the serum concentration of Trimethoprim. Risk C: Monitor therapy

Mercaptopurine: Sulfamethoxazole may enhance the myelosuppressive effect of Mercaptopurine. Risk C: Monitor therapy

Mercaptopurine: Trimethoprim may enhance the myelosuppressive effect of Mercaptopurine. Risk C: Monitor therapy

MetFORMIN: Trimethoprim may increase the serum concentration of MetFORMIN. Risk C: Monitor therapy

Methenamine: May enhance the adverse/toxic effect of Sulfonamide Antibiotics. Specifically, the combination may result in the formation of an insoluble precipitate in the urine. Risk X: Avoid combination

Methotrexate: Trimethoprim may enhance the adverse/toxic effect of Methotrexate. Management: Consider avoiding concomitant use of methotrexate and either sulfamethoxazole or trimethoprim. If used concomitantly, monitor for the development of signs and symptoms of methotrexate toxicity (e.g., bone marrow suppression). Risk D: Consider therapy modification

MetroNIDAZOLE (Systemic): May enhance the adverse/toxic effect of Products Containing Propylene Glycol. A disulfiram-like reaction may occur. Risk X: Avoid combination

MiFEPRIStone: May increase the serum concentration of CYP2C9 Substrates (High risk with Inhibitors). Management: Use CYP2C9 substrates at the lowest recommended dose, and monitor closely for adverse effects, during and in the 2 weeks following mifepristone treatment. Risk D: Consider therapy modification

Monoamine Oxidase Inhibitors: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Risk C: Monitor therapy

Nitric Oxide: May enhance the adverse/toxic effect of Methemoglobinemia Associated Agents. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Risk C: Monitor therapy

Pegvisomant: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Risk C: Monitor therapy

Phenytoin: Trimethoprim may increase the serum concentration of Phenytoin. Phenytoin may decrease the serum concentration of Trimethoprim. Management: Consider alternatives to this combination when possible, to avoid potential decreased trimethoprim efficacy and increased phenytoin concentrations/effects. Monitor patients receiving this combination closely for both of these possible effects. Risk D: Consider therapy modification

Phenytoin: Sulfamethoxazole may increase the serum concentration of Phenytoin. Risk D: Consider therapy modification

Porfimer: Photosensitizing Agents may enhance the photosensitizing effect of Porfimer. Risk C: Monitor therapy

Potassium P-Aminobenzoate: May diminish the therapeutic effect of Sulfonamide Antibiotics. Risk X: Avoid combination

PRALAtrexate: Trimethoprim may increase the serum concentration of PRALAtrexate. More specifically, trimethoprim may decrease excretion of pralatrexate. Management: Closely monitor for increased pralatrexate serum level and/or possible toxicity with concomitant use of trimethoprim. Monitor for decreased pralatrexate levels with discontinuation of trimethoprim. Risk C: Monitor therapy

PRALAtrexate: Sulfamethoxazole may increase the serum concentration of PRALAtrexate. More specifically, sulfamethoxazole may decrease excretion of pralatrexate. Management: Closely monitor for increased pralatrexate serum level and/or possible toxicity with concomitant use of sulfamethoxazole. Monitor for decreased pralatrexate levels with discontinuation of sulfamethoxazole. Risk C: Monitor therapy

Prilocaine: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Prilocaine. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Management: Monitor patients for signs of methemoglobinemia (e.g., hypoxia, cyanosis) when prilocaine is used in combination with other agents associated with development of methemoglobinemia. Avoid lidocaine/prilocaine in infants receiving such agents. Risk C: Monitor therapy

Procainamide: Trimethoprim may increase serum concentrations of the active metabolite(s) of Procainamide. Trimethoprim may increase the serum concentration of Procainamide. Risk D: Consider therapy modification

Procaine: May diminish the therapeutic effect of Sulfonamide Antibiotics. Risk X: Avoid combination

Prothionamide: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Risk C: Monitor therapy

Pyrimethamine: May enhance the adverse/toxic effect of Trimethoprim. Risk C: Monitor therapy

Quinolones: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Quinolones may diminish the therapeutic effect of Agents with Blood Glucose Lowering Effects. Specifically, if an agent is being used to treat diabetes, loss of blood sugar control may occur with quinolone use. Risk C: Monitor therapy

Repaglinide: CYP2C8 Inhibitors (Weak) may increase the serum concentration of Repaglinide. Risk C: Monitor therapy

RifAMPin: May decrease the serum concentration of Trimethoprim. Risk C: Monitor therapy

RifAMPin: May decrease the serum concentration of Sulfamethoxazole. Risk C: Monitor therapy

Rifapentine: May decrease the serum concentration of CYP2C9 Substrates (High risk with Inducers). Risk C: Monitor therapy

Salicylates: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Risk C: Monitor therapy

Sapropterin: Trimethoprim may decrease the serum concentration of Sapropterin. Specifically, trimethoprim may decrease tissue concentrations of tetrahydrobiopterin. Risk C: Monitor therapy

Selective Serotonin Reuptake Inhibitors: May enhance the hypoglycemic effect of Agents with Blood Glucose Lowering Effects. Risk C: Monitor therapy

Sodium Nitrite: Methemoglobinemia Associated Agents may enhance the adverse/toxic effect of Sodium Nitrite. Combinations of these agents may increase the likelihood of significant methemoglobinemia. Risk C: Monitor therapy

Sodium Picosulfate: Antibiotics may diminish the therapeutic effect of Sodium Picosulfate. Management: Consider using an alternative product for bowel cleansing prior to a colonoscopy in patients who have recently used or are concurrently using an antibiotic. Risk D: Consider therapy modification

Spironolactone: Trimethoprim may enhance the hyperkalemic effect of Spironolactone. Risk C: Monitor therapy

Sulfonylureas: Sulfonamide Antibiotics may enhance the hypoglycemic effect of Sulfonylureas. Risk C: Monitor therapy

Typhoid Vaccine: Antibiotics may diminish the therapeutic effect of Typhoid Vaccine. Only the live attenuated Ty21a strain is affected. Management: Vaccination with live attenuated typhoid vaccine (Ty21a) should be avoided in patients being treated with systemic antibacterial agents. Use of this vaccine should be postponed until at least 3 days after cessation of antibacterial agents. Risk D: Consider therapy modification

Varenicline: Trimethoprim may increase the serum concentration of Varenicline. Management: Monitor for increased varenicline adverse effects with concomitant use of trimethoprim, particularly in patients with severe renal impairment. International product labeling recommendations vary. Consult appropriate labeling. Risk C: Monitor therapy

Verteporfin: Photosensitizing Agents may enhance the photosensitizing effect of Verteporfin. Risk C: Monitor therapy

Vitamin K Antagonists (eg, warfarin): Sulfonamide Antibiotics may enhance the anticoagulant effect of Vitamin K Antagonists. Risk D: Consider therapy modification

Test Interactions

Increased creatinine (Jaffé alkaline picrate reaction); increased serum methotrexate by dihydrofolate reductase method

Gene Testing May Be Considered

• G6PD - Sulfamethoxazole

Genes of Interest

• Cytochrome P450 2C9
• Cytochrome P450 3A4
• HLA-B Major Histocompatability Complex
• N-Acetyltransferase 2
• NAT2 - Sulfamethoxazole

Monitoring Parameters

CBC, serum potassium, creatinine, BUN

Advanced Practitioners Physical Assessment/Monitoring

Perform and assess culture and sensitivity results prior to initiating therapy. Obtain CBC with differential periodically during therapy. Obtain liver function tests and renal function tests prior to starting therapy. Screen for history of renal or liver impairment. Obtain serum potassium, creatinine, and BUN at onset of therapy and periodically throughout long-term therapy. Screen for history of asthma, allergies, and thyroid dysfunction. Establish risk vs benefit in elderly patients and those with AIDS, glucose 6-phosphate dehydrogenase (G6PD) deficiency, folate deficiency, or porphyria. Test for Clostridioides (formerly Clostridium) difficile-associated diarrhea if patient develops diarrhea. Discontinue use at the first sign of a rash.

Nursing Physical Assessment/Monitoring

Check ordered labs and report any abnormalities. Monitor for severe or bloody diarrhea and send a specimen to the lab to test for Clostridioides (formerly Clostridium) difficile-associated diarrhea. Monitor for and educate patient to report signs or symptoms of liver impairment (dark urine, jaundice, nausea, vomiting, lack of appetite) or any rash or other skin changes. Monitor for and educate patient to report signs of low blood sugar (dizziness, headache, fatigue, feeling weak, shaking, tachycardia, confusion, increased hunger, or sweating). Instruct patient to take medication with at least 8 ounces of water.

Dosage Forms Considerations

The 5:1 ratio (SMX:TMP) remains constant in all dosage forms.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Intravenous:

Generic: Sulfamethoxazole 80 mg and trimethoprim 16 mg per mL (5 mL, 10 mL, 30 mL)

Suspension, Oral:

Sulfatrim Pediatric: Sulfamethoxazole 200 mg and trimethoprim 40 mg per 5 mL (473 mL) [contains alcohol, usp, fd&c red #40, fd&c yellow #6 (sunset yellow), methylparaben, polysorbate 80, propylene glycol, propylparaben, saccharin sodium]

Sulfatrim Pediatric: Sulfamethoxazole 200 mg and trimethoprim 40 mg per 5 mL (473 mL [DSC]) [contains alcohol, usp, fd&c red #40, fd&c yellow #6 (sunset yellow), methylparaben, polysorbate 80, propylene glycol, propylparaben, saccharin sodium; cherry flavor]

Generic: Sulfamethoxazole 200 mg and trimethoprim 40 mg per 5 mL (20 mL, 473 mL)

Tablet, Oral:

Bactrim: Sulfamethoxazole 400 mg and trimethoprim 80 mg [scored; contains sodium benzoate]

Bactrim DS: Sulfamethoxazole 800 mg and trimethoprim 160 mg [scored; contains sodium benzoate]

Generic: Sulfamethoxazole 400 mg and trimethoprim 80 mg, Sulfamethoxazole 800 mg and trimethoprim 160 mg

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Solution, Intravenous:

Septra: Sulfamethoxazole 80 mg and trimethoprim 16 mg per mL (5 mL) [contains alcohol, usp, propylene glycol, sodium metabisulfite]

Suspension, Oral:

Generic: Sulfamethoxazole 200 mg and trimethoprim 40 mg per 5 mL (100 mL, 400 mL, 800 mL)

Tablet, Oral:

Protrin DF: Sulfamethoxazole 800 mg and trimethoprim 160 mg [DSC]

Sulfatrim Pediatric: Sulfamethoxazole 100 mg and trimethoprim 20 mg

Generic: Sulfamethoxazole 400 mg and trimethoprim 80 mg, Sulfamethoxazole 800 mg and trimethoprim 160 mg

Anatomic Therapeutic Chemical (ATC) Classification

• J01EE01

Generic Available (US)

Yes

Pricing: US

Solution (Sulfamethoxazole-Trimethoprim Intravenous)

400-80 mg/5 mL (per mL): $1.51 - $1.52

Suspension (Sulfamethoxazole-Trimethoprim Oral)

200-40 mg/5 mL (per mL): $0.25 - $0.46

Suspension (Sulfatrim Pediatric Oral)

200-40 mg/5 mL (per mL): $0.24

Tablets (Bactrim DS Oral)

800-160 mg (per each): $3.12

Tablets (Bactrim Oral)

400-80 mg (per each): $1.73

Tablets (Sulfamethoxazole-Trimethoprim Oral)

400-80 mg (per each): $0.66 - $0.78

800-160 mg (per each): $0.37 - $1.40

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Mechanism of Action

Sulfamethoxazole interferes with bacterial folic acid synthesis and growth via inhibition of dihydrofolic acid formation from para-aminobenzoic acid; trimethoprim inhibits dihydrofolic acid reduction to tetrahydrofolate resulting in sequential inhibition of enzymes of the folic acid pathway

Pharmacodynamics/Kinetics

Absorption: Oral: Rapid; almost completely (90% to 100%)

Distribution: Both SMX and TMP distribute to middle ear fluid, sputum, vaginal fluid; TMP also distributes into bronchial secretions

Vd: TMP:

Newborns: ~2.7 L/kg (range: 1.3 to 4.1 hours) (Springer 1982)

Infants: 1.5 L/kg (Hoppu 1989)

Children 1 to 10 years: 0.86 to 1 L/kg (Hoppu 1987)

Adults: ~1.3 L/kg (Hoppu 1987)

Protein binding: SMX: ~70%, TMP: ~44%

Metabolism: Hepatic, both to multiple metabolites; SMX to hydroxy (via CYP2C9) and acetyl derivatives, and also conjugated with glucuronide; TMP to oxide and hydroxy derivatives; the free forms of both SMX and TMP are therapeutically active

Half-life elimination:

TMP: Prolonged in renal failure

Newborns: ~19 hours; range: 11 to 27 hours (Springer 1982)

Infants 2 months to 1 year: ~4.6 hours; range: 3 to 6 hours (Hoppu 1989)

Children 1 to 10 years: 3.7 to 5.5 hours (Hoppu 1987)

Children and Adolescents >10 years: 8.19 hours

Adults: 6 to 11 hours

SMX: 9 to 12 hours, prolonged in renal failure

Time to peak, serum: Oral: 1 to 4 hours

Excretion: Both are excreted in urine as metabolites and unchanged drug

Pharmacodynamics/Kinetics: Additional Considerations

Renal function impairment: Patients with severely impaired renal function exhibit an increase in the half-lives of both components, requiring dosage adjustments.

Geriatric: Total body clearance of trimethoprim was 19% lower in elderly patients.

Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Effects on Dental Treatment

Key adverse event(s) related to dental treatment: Stomatitis.

Effects on Bleeding

No information available to require special precautions

Related Information

• Beers Criteria 2019: Potentially Inappropriate Medication Use in Older Adults ≥65 Years of Age
• Desensitization Protocols
• Relative Infant Dose

Index Terms

Cotrimoxazole; Co-Trimoxazole; Septra; SMX-TMP; SMZ-TMP; Sulfamethoxazole-Trimethoprim; Sulfamethoxazole/Trimethoprim; Sulfatrim; TMP-SMX; TMP-SMZ; Trimethoprim and Sulfamethoxazole; Trimethoprim-Sulfamethoxazole

FDA Approval Date

July 30, 1973

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Brand Names: International

Abacin (IT); Acuco (ZA); Alcorim-F (IN); Anitrim (MX); Avlotrin (BD); Bacdan (TW); Bacin (MY, SG, TH); Bactelan (MX); Bacteric (MX); Bacterol (CL); Bacterol Forte (CL); Bacticel (AR); Bactiver (MX); Bactoprim (TH); Bactramin (JP); Bactrim (AE, AR, AT, AU, BB, BH, BR, CH, CY, CZ, DE, DK, EC, EE, FR, IN, IQ, IR, IT, JO, KW, LB, LV, LY, MT, MX, NO, OM, PK, PL, PT, SA, SE, SK, SY, TH, TR, UA, VN, YE); Bactrim DS (AU, BB); Bactrim F (CO); Bactrim Forte (AT, BE, BH, FI, FR, LB, LU, PH, PT, SE); Bactrimel (GR, VE); Bactropin (MX); Biseptol (BG, LV); Brogamax (MX); Chemotrim (EG, QA); Co-Try (BD); Colizole (IN); Colizole DS (IN); Comazole (MY); Comex (EG); Cotriinol (ZW); Cotrim (BF, BJ, CI, ET, GH, GM, GN, KE, KR, LR, MA, ML, MR, MU, MW, MY, NE, NG, SC, SD, SL, SN, TN, TZ, UG, ZM); Cotrim DS (MY); Cotrimel (HK); Cotrix (AE, CY, IQ, IR, JO, KW, LY, OM, SA, SY, YE); Cotrizol (TW); Cotrizole (ZW); Deprim (MT); Dhatrim (MY); Dibaprim (MX); Diseptyl (IL); Duocide (TW); Duratrimet (DE); Ectaprim (MX); Epitrim (AE, CY, IQ, IR, JO, KW, LY, OM, RO, SA, SY, YE); Escoprim (CH); Espectrin (BR); Eusaprim (AT, FI, IS, IT, NO, SE); Eusaprim Forte (BE); Farcotrim (QA); Fectrim (GB); Gantaprim (IT); Gantrim (IT); Ikaprim (ID); Infectrim (PE); Introcin (CL); Isotrim (IT); Kepinol (DE); Lagatrim (AE, BF, BJ, CI, CY, ET, GH, GM, GN, IQ, IR, JO, KE, KW, LR, LY, MA, ML, MR, MU, MW, NE, NG, OM, SA, SC, SD, SL, SN, SY, TN, TZ, UG, YE, ZM); Lagatrim Forte (BF, BJ, BM, BS, BZ, CI, ET, GH, GM, GN, GY, JM, KE, LR, MA, ML, MR, MU, MW, NE, NG, NL, PR, SC, SD, SL, SN, SR, TN, TT, TZ, UG, ZM); Lidaprim (AE, SA); Lidaprim Forte (AE, AT, SA); Mano-Trim (TH); Mano-Trim Forte (TH); Medixin (IT); Metoxiprim (MX); Metrim (TH); Mezenol (ZW); Mezenol DS (ZW); Microtrim (DE); Morbifurb (CN); Mortin (VN, ZW); Nopil (AE, CY, IQ, IR, JO, KW, LY, OM, QA, SA, SY, YE); Novabact (ZW); Octex (MX); Omsat (BF, BJ, CI, DE, ET, GH, GM, GN, KE, LR, MA, ML, MR, MU, MW, NE, NG, SC, SD, SL, SN, TN, TZ, UG, ZM); Oriprim (RU); Oriprim DS (KE, TZ, UG); Oxaprim (IT); Politrim (BD); Primzole (SG); Purbal (ZA); Resprim (AU); Resprim Forte (AU); Sanprima (ID); Sanprima Forte (ID); Septran (IN, PK, PY); Septran Forte (CR, DO, GT, HN, NI, PA, SV); Septrin (AE, AU, BF, BH, BJ, CI, CY, ES, ET, GB, GH, GM, GN, ID, IE, IQ, IR, JO, KE, KR, KW, LR, LY, MA, ML, MR, MT, MU, MW, MX, NE, NG, OM, PE, PH, SA, SC, SD, SG, SL, SN, SY, TN, TZ, UG, VN, YE, ZM, ZW); Septrin D.S. (EG); Septrin DS (BH, HK); Septrin Forte (AU); Servitrim (MX); Sevatrim (KR); Sigaprim (DE); Sinersul (HR); Soltrim (MX); Suftrex (EC); Sulfacet (DE); Sulfoid Trimetho (MX); Sulfotrimin (DE); Sulotrim (HR); Suntrim (TH); Suntrim Forte (TH); Suprim (PE); Suprin (IT); Tagremin (RO); Timexole (MX); TMS (DE); Trim (IT, ZA); Trimaxazole (SG); Trimetoger (MX); Trimexan (CR, DO, GT, HN, NI, PA, SV); Trimexazol (MX); Trimexazole (TH); Trimezol (BG); Trimol (BH, QA); Trimol D.S. (QA); Trimoprim (HK); Trimox (TW); Trimoxis (PH); Triomax (JO); Trisolvat (CO); Trisul (BD, NZ); Trizole (PH); Tryseptol (UA); Umoxazole (ZW); Xepaprim (ID); Xepaprim Forte (ID); Zoltrim (EC); Zultrop (ID); Zultrop Forte (ID)

Last Updated 3/21/20