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Uses and Administration
Drug Profile
Ubidecarenone is a naturally occurring coenzyme involved in electron transport in the mitochondria. It is claimed to be a free radical scavenger and to have antoxidant and membrane stabilising properties. It has been given orally as an adjunct in cardiovascular disorders ( Refer to ). It has also been tried in other conditions associated with coenzyme deficiency, and is promoted as a dietary supplement. Ubidecarenone has been investigated for the management of cancer, Huntington's chorea ( Refer to ), Friedreich's ataxia, and parkinsonism.
For suggested doses in children with mitochondrial disorders, see Administration in Children, Refer to .
Ubiquinol , the reduced form of ubidecarenone, has also been used.
(last reviewed 2015-11-11; last modified 2015-11-13)
References.
(last reviewed 2015-11-11; last modified 2015-11-12)
References
1. Spigset O. Reduced effect of warfarin caused by ubidecarenone.Lancet. 1994; 344: 1372–3. PubMed
2. Garcia Silva MT, et al.. Improvement of refractory sideroblastic anaemia with ubidecarenone.Lancet. 1994; 343: 1039. PubMed
3. Gattermann N, et al.. No improvement of refractory sideroblastic anaemia with ubidecarenone.Lancet. 1995; 345: 1121–2. PubMed
4. Nagao T, et al.. Treatment of warfarin-induced hair loss with ubidecarenone.Lancet. 1995; 346: 1104–5. PubMed
5. Huntington Study Group. A randomized, placebo-controlled trial of coenzyme Q10 and remacemide in Huntington's disease.Neurology. 2001; 57: 397–404. PubMed
6. Roffe L, et al.. Efficacy of coenzyme Q10 for improved tolerability of cancer treatments: a systematic review.J Clin Oncol. 2004; 22: 4418–24. PubMed
7. Sándor PS, et al.. Efficacy of coenzyme Q10 in migraine prophylaxis: a randomized controlled trial.Neurology. 2005; 64: 713–15. PubMed
8. The NINDS NET-PD Investigators. A randomized clinical trial of coenzyme Q10 and GPI-1485 in early Parkinson disease.Neurology. 2007; 68: 20–8. PubMed
9. Bachmeyer C, et al.. Coenzyme Q is effective on anemia in a patient with sideroblastic anemia and mitochondrial myopathy.Blood. 2010; 116: 3681–2. PubMed
10. Vogel AP, et al.. Treatment for speech disorder in Friedreich ataxia and other hereditary ataxia syndromes. Available in The Cochrane Database of Systematic Reviews; Issue 10. Chichester: John Wiley; 2014 (accessed 01/10/15). PubMed
Administration in children
Inherited primary ubidecarenone deficiency results in mitochondrial disorders that cause a clinically heterogeneous group of renal, neurological, myopathic, and multisystem diseases. Treatment is largely supportive and the disorder usually progresses causing significant morbidity and premature death. Ubidecarenone has shown benefit in the treatment of some patients with inherited primary defects and early diagnosis and supplementation is important to limit symptoms and prevent organ damage.
Although unlicensed in the UK, the BNFC states that ubidecarenone may be given for the treatment of mitochondrial disorders. Suggested oral doses, given once or twice daily with food, according to age, are:
neonates: 5 mg, adjusted according to response, up to 200 mg daily
children 1 month to 17 years: 5 mg, adjusted according to response, up to 300 mg daily
References.
(last reviewed 2015-11-11; last modified 2017-01-05)
References
1. Auré K, et al.. Progression despite replacement of a myopathic form of coenzyme Q10 defect.Neurology. 2004; 63: 727–9. PubMed
2. Salviati L, et al.. Infantile encephalomyopathy and nephropathy with CoQ10 deficiency: a CoQ10-responsive condition.Neurology. 2005; 65: 606–8. PubMed
3. Montini G, et al.. Early coenzyme Q10 supplementation in primary coenzyme Q10 deficiency.N Engl J Med. 2008; 358: 2849–50. PubMed
4. Quinzii CM, Hirano M. Coenzyme Q and mitochondrial disease.Dev Disabil Res Rev. 2010; 16: 183–8. PubMed
Cardiovascular disease
Ubidecarenone deficiency is associated with cardiovascular disease, and supplementation has therefore been promoted as an adjunct in the prevention or treatment of various conditions including hypertension, hyperlipidaemias, and heart failure.1-4It has also been studied in the prevention of cardiac surgery complications.5 However, most studies have been small or unreliable, and evidence for a beneficial effect remains inconclusive.
(last reviewed 2015-11-11; last modified 2015-11-13)
References
1. Ho MJ, et al.. Blood pressure lowering efficacy of coenzyme Q10 for primary hypertension. Available in The Cochrane Database of Systematic Reviews; Issue 4. Chichester: John Wiley; 2009 (accessed 28/10/15). PubMed
2. Madmani ME, et al.. Coenzyme Q10 for heart failure. Available in The Cochrane Database of Systematic Reviews; Issue 6. Chichester: John Wiley; 2014 (accessed 28/10/15). PubMed
3. Flowers N, et al.. Co-enzyme Q10 supplementation for the primary prevention of cardiovascular disease. Available in The Cochrane Database of Systematic Reviews; Issue 12. Chichester: John Wiley; 2014 (accessed 28/10/15). PubMed
4. Yang YK, et al.. Coenzyme Q10 treatment of cardiovascular disorders of ageing including heart failure, hypertension and endothelial dysfunction.Clin Chim Acta. 2015; 450: 83–89. PubMed
5. de Frutos F, et al.. Prophylactic treatment with coenzyme Q10 in patients undergoing cardiac surgery: could an antioxidant reduce complications? A systematic review and meta-analysis.Interact Cardiovasc Thorac Surg. 2015; 20: 254–9. PubMed
Statin-induced muscle disorders
For a discussion of the use of ubidecarenone in statin-induced muscle disorders, see Effects on Skeletal Muscle, under Simvastatin, Refer to .
(last reviewed 2015-11-11; last modified 2015-11-13)
Preparations: Single-Ingredient
The following preparations list represents a compilation of all available salt forms or related substances for this drug product.
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
ARGENTINA: Azidac Q10;BRAZIL: Coex¤; Vinocard Q10;CANADA: Cardio 10; Co-Q-10¤; CoQuinone; Migraine Prevention Formula; Migraine Relief; Ultra COQ10¤;CHINA: Fu Xin (辅辛); He Fu (合夫); Neuquinon (能气朗);FRANCE: Bio-Quinon Q10 Super¤; Q10;HONG KONG: CoQuinone¤; Eiquinon; Salcotan¤;HUNGARY: Myoqinon; Q-Gel¤;INDIA: Atp; Co.Q.Care; Coq; Coten; Miraqule;INDONESIA: Alerten; Co-En Q; Coten; Enzimten; KQ; Nuzym; Q-Ten; Qubi¤; Ubi-Q; VQ¤;ITALY: Caomet¤; Cardioton¤; Coedieci¤; Decafar¤; Decarene¤; Decorenone; Dymion¤; Iuvacor¤; Miodene¤; Miotyn¤; Mitocor¤; Oropigma Gel; Roburis¤; Tricoxen; Ubicarden¤; Ubicardio¤; Ubicor; Ubidenone¤; Ubidex¤; Ubifactor¤; Ubilab¤; Ubimaior; Ubisan¤; Ubisint¤; Ubiten¤; Ubivis¤; Ubixal¤;JAPAN: Adelir¤; Kaitron¤; Lacobile¤; Neuquinon; Tridemin; Ubequinon¤; Yube-Q¤;MALAYSIA: Alerten; Bio-Quinone; Eurobio Bio-SMEDDS Q10; Hovid Q-10 SupraBio; Neuquinon; Surbex CoQ10;MEXICO: CoQuinone;PHILIPPINES: Addlife; Alerten; EssenVida; Neuquinon; Nu Qten; Qten; Vitalive;POLAND: Envit Q10¤; Vita Care Q10¤;PORTUGAL: Q 10; Ubenzima; Ubicondrial¤;RUSSIAN FEDERATION: Cudevita (Кудевита)¤; Qudesan (Кудесан); Valeocor-Q10 (Валеокор-Q10);SINGAPORE: Alerten; CoQuinone¤; Ubi-Q; Vita Co-Enzyme Q10;THAILAND: Alerten; Bio Q10 VQ50; Bio-Quinone; Decaquinon; VQ¤;UNITED KINGDOM: Bio-Quinone; BioActive Q10; Co-Q-10¤;UNITED STATES: Active Q; Co-Q-10¤; CoQuinone; UBQH;
Preparations: Multi-Ingredient
The following preparations list represents a compilation of all available salt forms or related substances for this drug product.
The symbol ¤ denotes a preparation which is discontinued or no longer actively marketed.
ARGENTINA: Azidac Plus; Cardiobiotral; Desgras Piel Naranja¤; Dinavital Q10¤; Fertilix Plus; Marathon Antioxidante; Marathon; QX-100; QX-10;AUSTRALIA: CardiWell Omega Q10; Homme-F; Proactive Multi for 50+; Radiance; Rejufort;BELGIUM: Ostrin Q10¤;BRAZIL: Vinoq;CANADA: Circulation Plus; Clearq; Cosvera; Daily Essentials; Fomitin; Fomix; Lipilux; Mega AO¤; Mig-Relief; Migraine Relief; Migraine Relief; Neutral C + Coenzyme Q10 plus Vitamins & Minerals¤; Protect¤; Q-Absorb; Scortrol; Support Formula¤;CHILE: Eucerin Q10; Infor Q10; Logical¤; Marathon; Trivitana Q10; Ubiten¤; Ultrac Q10¤; Ureadin Facial Antiarrugas;FRANCE: Arterin Plus; Bion Energie Plus; Microbiane Q10¤;GREECE: Supradyn Energy Q10¤;HONG KONG: Cardiozen; Cardiwell Omega Q10; Dubichinone; Tishcon Q-Gel;HUNGARY: Q10;INDIA: Bio-10; Cardi-NRG; Cardio-Pro; Co-Q-Dent¤; Coq Forte; Ecozyme; Enhance; Hairstim-HGF; Hepa; Hi-Q Plus; Hi-Q; Hyrase; I-10; I-Vit Plus; Imunolife¤; Jivak; Jstat; Liveril; Maxoza;INDONESIA: Baliin Q10; Bioquinone; Canergy; Car-Q100; Carniq; Carniten; Carnon; Cartogen; Citen; Co-Q-10; Co-vitala; Combes; Cor-Q; Corsel; Dezire; Enercore; Galten; Glow Enhanz; Kano; L-Core; Lesiten; Life 10; Liproqy; Liveril; Lycoq; Metsel; Mitolife; Natto-10; Q10 Plus; Q10-DS; Qtencom; Qutan-10; RG-Q; Syncore; Ubiforce; Wellman;ITALY: Agedin Plus¤; Anasten Plus; Berart; Coqun; Dermovit¤; Diaberet; Ener-E¤; Linfolipase; Ocustress; Phototrop; Q-Age¤; Salovit; Salva Sole¤; Selemix; Visu Q10; VisuQ10; Vitalmix Complex; Vitalmix Fos;MALAYSIA: Co-Q Plus; Hovid Q-10 SupraBio + L-Carnitine; Hovid Q10 Plus¤; Proviton Plus CoQ10; Seven Seas Nutri-Trio; Surbex Protect; Vitara Hyaluron;MEXICO: Avitil; Gelcavit Q-10; Q-Plus; Usana AO Pro;PHILIPPINES: Enerboost; Havitall; Immuvit; Myoga Q10; Novuskin Lift; Nutrotal; Omega 3 Q10; Polynerv-E with Lecithin; SafeStat; SilyCo Plus;POLAND: Normatabs;SINGAPORE: Aquadeks; Armolipid; Cardio-Essentials¤; CardiOz; Co3E + CoQ10; Enerbolis; Espanone; Essentials¤; Migrate Q10; MQ7+; Profertil; RejuvaSkin Anti-Aging Serum; Scar Esthetique; Surbex Protect;SPAIN: Farnidasa¤;THAILAND: Bio-Trim; Blackmores Radiance Marine Q10;UNITED KINGDOM: A-O-Q10 MaxiPower Formula¤; Efamol Plus Coenzyme Q10¤; Neurozan; NutriScience; Red Kooga Co-Q-10 and Ginseng; VisuXL;UKRAINE: Langena (Лангена); Perfectil Plus (Перфектил Плюс); Vitrum Beauty Q10 (Витрум Бьюти Q10)¤;UNITED STATES: AquADEKS; Cardio Tone; Corvite Free; Diabetiks; Healthy Heart Complex; Mebolic; PreQue 10; ProtectNatal; Triveen-Ten; Xyzbac;VENEZUELA: Uvagen;
Preparations: Pharmacopoeial
The following preparations list represents a compilation of all available salt forms or related substances for this drug product.
USP 42: Ubidecarenone Capsules; Ubidecarenone Tablets; Ubiquinol Capsules;
Last Updated 1/21/20
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