Carboxymethylcellulose

Pharmacologic Category

Ophthalmic Agent, Miscellaneous

Dosing: Adult

Dry eyes: Ophthalmic: Instill 1-2 drops into eye(s) 3-4 times/day

Dosing: Geriatric

Refer to adult dosing.

Use: Labeled Indications

Artificial tear substitute

Medication Patient Education with HCAHPS Considerations

What is this drug used for?

• It is used to treat dry eyes.

• It is used to treat eye irritation.

Other side effects of this drug: Talk with your doctor right away if you have any of these signs of:

• Vision changes

• Eye pain

• Severe eye irritation

• Signs of a significant reaction like wheezing; chest tightness; fever; itching; bad cough; blue skin color; seizures; or swelling of face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Medication Safety Issues

Sound-alike/look-alike issues:

Metabolism/Transport Effects

None known.

Drug Interactions Open Interactions

There are no known significant interactions.

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Gel, Ophthalmic, as sodium:

GenTeal: 0.25% (15 mL [DSC], 25 mL [DSC])

Refresh Liquigel: 1% (15 mL)

Refresh Optive: 1 % (10 mL)

Theratears: 1% (28 ea) [contains calcium chloride anhydrous, magnesium chloride, potassium chloride, sodium bicarbonate, sodium chloride, sodium phosphate]

Gel, Ophthalmic, as sodium [preservative free]:

Biolle Gel Tears: 1% (1 ea)

Refresh Celluvisc: 1% (30 ea)

TheraTears Nighttime: 1% (30 ea)

Liquid, Ophthalmic, as sodium:

Sterile Lubricant: 0.7% (15 mL)

Solution, Ophthalmic, as sodium:

Artificial Tears: 1% (15 mL)

Lubricating Plus Eye Drops: 0.5% (30 ea, 50 ea)

Refresh Liquigel: 1% (30 mL)

Refresh Optive: 0.5% (15 mL)

Refresh Optive Advanced: 0.5% (10 mL)

Refresh Plus: 0.5% (30 ea, 50 ea, 70 ea)

Refresh Relieva: 0.5% (10 mL)

Refresh Repair: 0.5% (10 mL [DSC])

Refresh Tears: 0.5% (15 mL, 30 mL)

Theratears: 0.25% (15 mL, 30 mL) [contains calcium chloride dihydrate, magnesium chloride, potassium chloride, sodium bicarbonate, sodium chloride, sodium phosphate, monobasic monohydrate]

Ultra Fresh: 0.5% (15 mL, 30 mL)

Solution, Ophthalmic, as sodium [preservative free]:

Biolle Tears: 0.5% (32 ea)

Refresh Optive Advanced PF: 0.5% (1 ea)

Refresh Optive Mega-3: 0.5% (1 ea)

Refresh Optive PF: 0.5% (1 ea)

Refresh Plus: 0.5% (30 ea, 50 ea)

Theratears PF: 0.25% (30 ea, 32 ea)

Generic Available (US)

May be product dependent

Pricing: US

Gel (Biolle Gel Tears Ophthalmic)

1% (per each): $0.30

Gel (Refresh Celluvisc Ophthalmic)

1% (per each): $0.39

Gel (Refresh Liquigel Ophthalmic)

1% (per mL): $0.63

Gel (Refresh Optive Ophthalmic)

1-0.9% (per mL): $1.20

Gel (TheraTears Nighttime Ophthalmic)

1% (per each): $0.33

Gel (Theratears Ophthalmic)

1% (per each): $0.35

Liquid (Sterile Lubricant Ophthalmic)

0.7% (per mL): $0.41

Solution (Biolle Tears Ophthalmic)

0.5% (per each): $0.30

Solution (Refresh Optive Advanced Ophthalmic)

0.5-1-0.5% (per mL): $0.88

Solution (Refresh Optive Advanced PF Ophthalmic)

0.5-1-0.5% (per each): $0.44

Solution (Refresh Optive Mega-3 Ophthalmic)

0.5-1-0.5% (per each): $0.51

Solution (Refresh Optive Ophthalmic)

0.5-0.9% (per mL): $0.55

Solution (Refresh Optive PF Ophthalmic)

0.5-0.9% (per each): $0.34

Solution (Refresh Plus Ophthalmic)

0.5% (per each): $0.31

Solution (Refresh Relieva Ophthalmic)

0.5-0.9% (per mL): $1.26

Solution (Refresh Tears Ophthalmic)

0.5% (per mL): $0.46

Solution (Theratears Ophthalmic)

0.25% (per mL): $0.56

Solution (Theratears PF Ophthalmic)

0.25% (per each): $0.33

Solution (Ultra Fresh Ophthalmic)

0.5% (per mL): $0.56

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Effects on Dental Treatment

No significant effects or complications reported

Effects on Bleeding

No information available to require special precautions

Index Terms

Carbose D; Carboxymethyl/Glycerin/Poly80; Carboxymethylcellulos/Glycerin; Carboxymethylcellulose Sodium

Brand Names: International

Alembic Veldrop (LK); Carmize (GB); Cellufresh (AU, ES, NZ, PH, TH); Cellufresh MD (PH, TH); Celluvisc (AE, AT, AU, CH, DE, DK, FI, FR, GB, GR, IE, IN, IT, JO, KW, NL, NZ, PH, PT, SA, SE, TH, TW, VN, ZA); Celluvisc MD (TH); Clarastill (PH); CMC (PY); Fresh Tears (BR); Fresh Tears Liquigel (BR); Lacritears (EG); Liangshi (CN); Lubgel (BD); Optive (MY); Qingning (CN); Qingxin (CN); Refresh (LK); Refresh Celluvisc (CO, MY, PE, TW); Refresh Liquigel (AR, CL, CO, EC, EG, GT, HK, MX, PA, PE, SV, TW, VE); Refresh Plus (AU, EG, KR, MY, NZ, TW, VN); Refresh Plus/Celluvisc (HK); Refresh Tear (BD); Refresh Tears (AE, AR, CO, EC, EG, HK, KR, KW, MX, MY, PE, SA, SG, TW, VE, VN); RefreshTears (CL)

Last Updated 3/12/20