Benzoyl Peroxide

Pharmacologic Category

Acne Products; Topical Skin Product; Topical Skin Product, Acne

Dosing: Adult

Acne:

Topical formulations: Apply sparingly once daily; gradually increase to 2 to 3 times/day if needed. If excessive dryness or peeling occurs, reduce dose frequency or concentration. If excessive stinging or burning occurs, remove with mild soap and water; resume use the next day.

Topical cleansers: Wash once or twice daily; control amount of drying or peeling by modifying dose frequency or concentration.

Dosing: Geriatric

Refer to adult dosing.

Dosing: Renal Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Adult

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Pediatric

Acne: Children ≥7 years and Adolescents (Eichenfield 2013): Limited data available in ages <12 years: Topical:

Topical formulations: Apply sparingly once daily; gradually increase to 2 to 3 times daily if needed. If excessive dryness or peeling occurs, reduce dose frequency or concentration. If excessive stinging or burning occurs, remove with mild soap and water; resume use the next day.

Topical cleansers: Wash once or twice daily; control amount of drying or peeling by modifying dose frequency or concentration

Dosing: Renal Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Dosing: Hepatic Impairment: Pediatric

There are no dosage adjustments provided in the manufacturer's labeling.

Use: Labeled Indications

Acne vulgaris, acne rosacea: Treatment of mild to moderate acne vulgaris and acne rosacea

Clinical Practice Guidelines

Acne:

American Academy of Dermatology, "Guidelines of Care for the Management of Acne Vulgaris," May 2016

Administration: Topical

All products: Avoid contact with eyes and other mucous membranes. Some products may stain certain fabrics; avoid contact with clothing or furniture. May bleach hair. If bothersome dryness or peeling occurs, reduce dose frequency or drug concentration. If excessive stinging or burning occurs after any single application, remove with mild soap and water; resume use the next day.

Cleansers: Wet skin areas to be treated prior to administration. Gently massage into skin for 10 to 20 seconds, working into a full lather. Rinse thoroughly and pat dry.

Cloths: Wet face with water. Wet cloth with a little water and work into a full lather. Cleanse face with cloth for 10 to 20 seconds. Rinse thoroughly and pat dry. Throw away cloth; do not flush.

Foam: Prime can prior to initial use (refer to manufacturer's labeling for priming instructions). Shake vigorously and tap bottom of can onto palm or solid surface 3 times prior to each use. Dispense foam into palm of hand or applicator pad and cover entire affected area and rub in until completely absorbed. Some products can remain on skin and others should be rinsed off after a brief period of time (refer to manufacturers labeling). Rinse applicator with water and allow to dry after use; wash hands with soap and water after use.

Other dose forms: After cleansing skin, smooth small amount over affected area. Shake lotion well prior to use.

Administration: Pediatric

Topical: For external use only. Avoid contact with eyes, eyelids, lips, and mucous membranes; rinse with water if accidental contact occurs. Some products may bleach or discolor hair, dyed fabrics, or carpeting; avoid contact with hair, clothing, furniture, or carpeting. Avoid unnecessary sun exposure; apply sunscreen if going outside.

Cleansers: Wet skin areas to be treated prior to administration. Rinse thoroughly and pat dry.

Cloths: Wet face with water. Wet cloth with a little water and work into a full lather. Cleanse face with cloth for 10 to 20 seconds. Rinse thoroughly and pat dry. Throw away cloth; do not flush.

Foam: Prime can prior to initial use; refer to manufacturer’s labeling for priming instructions. Holding can upright, dispense foam into palm of hand or applicator pad and cover entire affected area and rub in until completely absorbed. Some products can remain on skin and others should be rinsed off after a brief period of time (refer to manufacturer's labeling). Rinse applicator with water and allow to dry after use; wash hands with soap and water after use.

Other dose forms: After cleansing skin, smooth small amount over affected area. If bothersome dryness or peeling occurs, reduce dose frequency or drug concentration. If excessive stinging or burning occurs after any single application, remove with mild soap and water; resume use the next day.

Storage/Stability

Store at 15°C to 30°C (59°F to 86°F).

Medication Patient Education with HCAHPS Considerations

What is this drug used for?

• It is used to treat pimples (acne).

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Dry skin

• Skin irritation

• Itching

• Peeling

• Sensation of warmth

Other side effects of this drug: Talk with your doctor right away if you have:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.

Note: This is not a comprehensive list of all side effects. Talk to your doctor if you have questions.

Consumer Information Use and Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a limited summary of general information about the medicine's uses from the patient education leaflet and is not intended to be comprehensive. This limited summary does NOT include all information available about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not intended to provide medical advice, diagnosis or treatment and does not replace information you receive from the healthcare provider. For a more detailed summary of information about the risks and benefits of using this medicine, please speak with your healthcare provider and review the entire patient education leaflet.

Medication Safety Issues

​Sound-alike/look-alike issues:

Contraindications

Hypersensitivity to benzoyl peroxide or any other component of the formulation.

Warnings/Precautions

Concerns related to adverse effects:

• Bleaching effects: May bleach hair, colored fabric, or carpet.

• Hypersensitivity reaction: Rare but serious and potentially life-threatening allergic reactions or severe irritation have been reported with use of topical OTC benzoyl peroxide or salicylic acid containing products; it has not been determined if the reactions are due to the active ingredients (benzoyl peroxide or salicylic acid), the inactive ingredients, or a combination of both. Hypersensitivity reactions may occur within minutes to a day or longer after product use and differ from local skin irritation (redness, burning, dryness, itching, peeling or slight swelling) that may occur at the site of product application. Treatment should be discontinued if hives or itching develop; patients should seek emergency medical attention if reactions such as throat tightness, difficulty breathing, feeling faint, or swelling of the eyes, face, lips, or tongue develop. Before using a topical OTC acne product for the first time, consumers should apply a small amount to 1 or 2 small affected areas for 3 days to make sure hypersensitivity symptoms do not develop. (FDA Drug Safety Communication 2014).

• Skin irritation: Skin irritation (eg, burning, itching, peeling, redness, swelling) may occur; discontinue use if severe irritation develops.

Dosage form specific issues:

• Benzyl alcohol and derivatives: Some dosage forms may contain benzyl alcohol; large amounts of benzyl alcohol (≥99 mg/kg/day) have been associated with a potentially fatal toxicity (“gasping syndrome”) in neonates; the “gasping syndrome” consists of metabolic acidosis, respiratory distress, gasping respirations, CNS dysfunction (including convulsions, intracranial hemorrhage), hypotension and cardiovascular collapse (AAP 1997; CDC 1982); some data suggests that benzoate displaces bilirubin from protein binding sites (Ahlfors 2001); avoid or use dosage forms containing benzyl alcohol with caution in neonates. See manufacturer’s labeling.

Concurrent drug therapy issues:

• Sulfone products: Concomitant use of benzoyl peroxide with sulfone products (eg, dapsone, sulfacetamide) may cause temporary discoloration (yellow/orange) of facial hair and skin. Application of products at separate times during the day or washing off benzoyl peroxide prior to application of other products may avoid skin discoloration (Dubina 2009).

Other warnings/precautions:

• Appropriate use: For external use only; avoid contact with eye, eyelids, lips, mouth, and mucous membranes. Inform patients to use skin protection (eg, sunscreen) and minimize prolonged exposure to sun or tanning beds.

Warnings: Additional Pediatric Considerations

Some dosage forms may contain propylene glycol; in neonates large amounts of propylene glycol delivered orally, intravenously (eg, >3,000 mg/day), or topically have been associated with potentially fatal toxicities which can include metabolic acidosis, seizures, renal failure, and CNS depression; toxicities have also been reported in children and adults including hyperosmolality, lactic acidosis, seizures and respiratory depression; use caution (AAP 1997; Shehab 2009).

Pregnancy Risk Factor

C

Pregnancy Considerations

Animal reproduction studies have not been conducted. Topical products are recommended as initial therapy for the treatment of acne in pregnant females; benzoyl peroxide is one of the preferred agents (Chien 2016; Kong 2013; Leechman 2006).

Breast-Feeding Considerations

It is not known if benzoyl peroxide is present in breast milk.

Although the manufacturer recommends that caution be exercised when administering benzoyl peroxide to breastfeeding women, benzoyl peroxide is considered compatible with breastfeeding (WHO 2002). In general, the use of topical agents is preferred over systemic agents for the treatment of facial acne in women who are breastfeeding and benzoyl peroxide is one of the preferred agents. Avoid applying large amounts over prolonged periods of time to decrease the potential for systemic absorption (Butler 2014; Kong 2013; Leechman 2006). Avoid direct infant contact with treated skin.

Adverse Reactions

1% to 10%: Dermatologic: Desquamation (≤5%), erythema (≤5%), contact dermatitis (1% to 3%)

Frequency not defined: Dermatologic: Skin irritation, xeroderma

Allergy and Idiosyncratic Reactions

• Benzoyl Peroxide Allergy

Metabolism/Transport Effects

None known.

Drug Interactions Open Interactions

Dapsone (Topical): Benzoyl Peroxide may enhance the adverse/toxic effect of Dapsone (Topical). Specifically, the use of these agents in combination may cause skin and facial hair to temporarily turn a tan or yellow/orange color. Risk C: Monitor therapy

Isotretinoin (Topical): Benzoyl Peroxide may diminish the therapeutic effect of Isotretinoin (Topical). Management: Avoid combined use of benzoyl peroxide and topical isotretinoin. If concomitant use cannot be avoided, consider separating application times and monitoring for signs and symptoms of clinical failure of isotretinoin. Risk D: Consider therapy modification

Dosage Forms: US

Excipient information presented when available (limited, particularly for generics); consult specific product labeling. [DSC] = Discontinued product

Cream, External:

Clearskin: 10% (30 g)

Foam, External:

BenzEFoam: 5.3% (60 g [DSC], 100 g) [contains cetearyl alcohol, disodium edta, methylparaben, propylene glycol, propylparaben]

BenzEFoamUltra: 9.8% (100 g [DSC]) [contains cetearyl alcohol, disodium edta, methylparaben, propylene glycol, propylparaben]

BenzePrO: 5.2% (60 g) [contains cetostearyl alcohol, disodium edta, methylparaben, propylene glycol, propylparaben, trolamine (triethanolamine)]

BenzePrO: 5.3% (60 g, 100 g) [contains cetearyl alcohol, disodium edta, methylparaben, propylene glycol, propylparaben, trolamine (triethanolamine)]

BenzePrO Short Contact: 9.8% (100 g) [contains cetearyl alcohol, disodium edta, methylparaben, propylene glycol, propylparaben]

BP Foam: 5.3% (60 g [DSC], 100 g [DSC]); 9.8% (100 g [DSC]) [contains methylparaben, propylparaben]

Enzoclear: 9.8% (100 g) [contains cetearyl alcohol, disodium edta, methylparaben, propylene glycol, propylparaben]

Riax: 5.5% (100 g); 9.5% (100 g) [contains methylparaben, propylparaben]

Generic: 5.3% (60 g [DSC], 100 g [DSC]); 9.8% (100 g [DSC], 113 g)

Gel, External:

Acne Medication 2.5: 2.5% (60 g) [contains disodium edta]

Acne Medication 5: 5% (42.5 g, 60 g, 90 g) [contains edetate disodium]

Acne Medication 10: 10% (42.5 g, 60 g) [contains edetate disodium]

Acne-Clear: 10% (42.5 g)

Benziq: 5.25% (50 g) [contains benzyl alcohol, disodium edta, trolamine (triethanolamine)]

Benziq LS: 2.75% (50 g) [contains trolamine (triethanolamine)]

BP Gel: 5% (60 g) [contains benzyl alcohol, edetate disodium, trolamine (triethanolamine)]

BP Gel: 5.5% (60 g [DSC]); 10% (60 g) [contains benzyl alcohol, disodium edta, trolamine (triethanolamine)]

BPO: 4% (42.5 g); 8% (42.5 g) [contains benzyl alcohol, cetyl alcohol]

Clearplex V: 5% (45 g [DSC])

Clearplex X: 10% (45 g [DSC])

OC8: 7% (45 g [DSC]) [contains disodium edta, propylene glycol]

Generic: 2.5% (60 g); 5% (60 g, 90 g); 6.5% (113 g); 8% (113 g); 10% (56 g [DSC], 60 g, 90 g)

Kit, External:

AcneFree Acne Clearing System: Wash 2.5% and lotion 3.7% [contains disodium edta, polysorbate 80, propylene glycol]

AcneFree Severe Clearing Syst: Wash 2.5% and lotion 10% [contains benzalkonium chloride, butylparaben, cetyl alcohol, disodium edta, edetate (edta) sodium (tetrasodium), ethylparaben, isobutylparaben, methylisothiazolinone, methylparaben, propylene glycol, propylparaben, soybeans (glycine max)]

BPO Creamy Wash: Wash 4% (170.1 g) and bar soap 5% (2 x 21 g) [DSC], Wash 8% (170.1 g) and bar soap 5% (2 x 21 g) [DSC] [contains disodium edta, methylparaben]

Inova: Pad 4% (30s) and tocopherol 5% (28s), Pad 8% (30s) and tocopherol 5% (28s) [contains disodium edta, methylparaben]

Liquid, External:

Benzac AC Wash: 5% (226 g)

BenzePrO Creamy Wash: 7% (180 g) [contains cetyl alcohol, edetate disodium, propylene glycol]

Benziq Wash: 5.25% (175 g) [contains benzyl alcohol, cetyl alcohol, disodium edta, propylene glycol]

Benzoyl Peroxide Cleanser: 6% (170.3 g, 340.2 g) [contains cetyl alcohol, edetate disodium, propylene glycol]

Benzoyl Peroxide Wash: 5% (148 g, 237 g, 148 mL, 236 mL) [contains cetyl alcohol, edetate disodium, propylene glycol]

Benzoyl Peroxide Wash: 5% (142 g, 227 g) [contains edetate disodium]

Benzoyl Peroxide Wash: 10% (148 g, 237 g, 148 mL) [contains cetyl alcohol, edetate disodium, propylene glycol]

Benzoyl Peroxide Wash: 10% (142 g, 227 g) [contains edetate disodium]

BP Foaming Wash: 10% (227 g [DSC]) [contains cetearyl alcohol, methylparaben]

BP Wash: 2.5% (227 g); 5% (113 g, 142 g, 227 g) [contains cetearyl alcohol, methylparaben]

BP Wash: 7% (473 mL) [contains benzyl alcohol, cetyl alcohol, propylene glycol, trolamine (triethanolamine)]

BP Wash: 10% (142 g, 227 g) [contains cetearyl alcohol, methylparaben]

BPO-10 Wash: 10% (227 g [DSC]) [contains methylparaben, propylene glycol, propylparaben]

BPO-5 Wash: 5% (227 g [DSC]) [contains methylparaben, propylene glycol, propylparaben]

Desquam-X Wash: 5% (140 g [DSC]); 10% (140 g [DSC]) [contains edetate disodium]

Neutrogena Clear Pore: 3.5% (125 mL) [contains disodium edta, menthol]

PanOxyl: 2.5% (156 g) [soap free; contains cetearyl alcohol]

PanOxyl Creamy Wash: 4% (170 g)

PanOxyl Foaming Wash: 10% (156 g)

PanOxyl Wash: 10% (156 g [DSC]) [contains alcohol, usp, methylparaben]

PanOxyl-4 Creamy Wash: 4% (170 g [DSC]) [contains cetearyl alcohol, methylparaben]

PR Benzoyl Peroxide Wash: 7% (180 g, 473 mL) [contains cetyl alcohol, edetate disodium, propylene glycol]

Liquid Extended Release, External:

Advanced Acne Wash: 4.4% (104 mL)

Lotion, External:

Acne Medication 5: 5% (29.5 mL) [odorless; contains disodium edta]

Acne Medication 10: 10% (29.5 mL) [odorless; contains edetate disodium]

Benzoyl Peroxide Cleanser: 3% (340.2 g [DSC]); 9% (340.2 g [DSC]) [contains cetyl alcohol, edetate disodium, propylene glycol]

Zaclir Cleansing: 8% (297 g)

Miscellaneous, External:

BenzePrO Foaming Cloths: 6% (60 ea) [contains cetyl alcohol]

BPO Foaming Cloths: 6% (60 ea) [contains methylparaben]

Dosage Forms: Canada

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Gel, External:

Benzac W Wash10 Nettoyant: 10% (20 mL, 225 mL)

Anatomic Therapeutic Chemical (ATC) Classification

• D10AE01

Generic Available (US)

May be product dependent

Pricing: US

Cream (Clearskin External)

10% (per gram): $0.13

Foam (BenzEFoam External)

5.3% (per gram): $0.35

Foam (BenzePrO External)

5.2% (per gram): $16.69

5.3% (per gram): $13.08

Foam (BenzePrO Short Contact External)

9.8% (per gram): $13.08

Foam (Benzoyl Peroxide External)

9.8% (per gram): $9.83

Foam (Enzoclear External)

9.8% (per gram): $16.95

Foam (Riax External)

5.5% (per gram): $6.52

9.5% (per gram): $6.52

Gel (Benzoyl Peroxide External)

2.5% (per gram): $0.33

5% (per gram): $0.34

6.5% (per gram): $18.00

8% (per gram): $19.95

10% (per gram): $0.35

Kit (AcneFree Acne Clearing System External)

2.5 & 3.7% (per mL): $0.05

Kit (AcneFree Severe Clearing Syst External)

2.5 & 10% (per each): $23.40

Kit (Inova External)

4 & 5% (per each): $5.48

8 & 5% (per each): $5.48

Liquid (Benzac AC Wash External)

5% (per gram): $0.74

Liquid (BenzePrO Creamy Wash External)

7% (per gram): $4.60

Liquid (PanOxyl Creamy Wash External)

4% (per gram): $0.05

Liquid (PanOxyl External)

2.5% (per gram): $0.05

Liquid (PanOxyl Foaming Wash External)

10% (per gram): $0.05

Liquid (PR Benzoyl Peroxide Wash External)

7% (per mL): $0.30

7% (per gram): $4.60

Misc (BenzePrO Foaming Cloths External)

6% (per each): $11.14

Disclaimer: A representative AWP (Average Wholesale Price) price or price range is provided as reference price only. A range is provided when more than one manufacturer's AWP price is available and uses the low and high price reported by the manufacturers to determine the range. The pricing data should be used for benchmarking purposes only, and as such should not be used alone to set or adjudicate any prices for reimbursement or purchasing functions or considered to be an exact price for a single product and/or manufacturer. Medi-Span expressly disclaims all warranties of any kind or nature, whether express or implied, and assumes no liability with respect to accuracy of price or price range data published in its solutions. In no event shall Medi-Span be liable for special, indirect, incidental, or consequential damages arising from use of price or price range data. Pricing data is updated monthly.

Mechanism of Action

Releases free-radical oxygen which oxidizes bacterial proteins in the sebaceous follicles decreasing the number of anaerobic bacteria and decreasing irritating-type free fatty acids

Pharmacodynamics/Kinetics

Absorption: ~5% via skin; gel more penetrating than cream

Metabolism: Converted to benzoic acid in skin

Local Anesthetic/Vasoconstrictor Precautions

No information available to require special precautions

Effects on Dental Treatment

No significant effects or complications reported

Effects on Bleeding

No information available to require special precautions

References

Acne Medication (2.5% benzoyl peroxide) gel [prescribing information]. Livonia, MI: Rugby Laboratories; November 2019.

Acne Treatment Cleansing Bar (benzoyl peroxide) [prescribing information]. Annapolis, MD: Ermis Labs, LLC.

Advanced Acne Wash (benzoyl peroxide) [prescribing information]. Vernon Hills, IL: Elorac Inc; October 2015.

Ahlfors CE. Benzyl alcohol, kernicterus, and unbound bilirubin. J Pediatr. 2001;139(2):317-319.[PubMed 11487763]

Akhavan A and Bershad S, "Topical Acne Drugs: Review of Clinical Properties, Systemic Exposure, and Safety," Am J Clin Dermatol, 2003, 4(7):473-92.[PubMed 12814337]

BenzEFoam (benzoyl peroxide) [prescribing information]. Bridgewater, NJ: Ortho Dermatologics; received May 2020.

BenzEFoam Ultra (benzoyl peroxide) [prescribing information]. Malvern, PA: Encore Dermatology; July 2015.

BenzePrO Creamy Wash (benzoyl peroxide) [prescribing information]. Scottsdale, AZ: ProGen Inc.; received February 2017.

BenzePrO Short Contact Foam (benzoyl peroxide) [prescribing information]. Scottsdale, AZ: PruGen Pharmaceuticals; August 2019.

Benzoyl peroxide 6.5% gel [prescribing information]. Las Vegas, NV: Mesora Pharmc LLC; November 2017.

Benzoyl Peroxide Wash (benzoyl peroxide USP) [prescribing information]. Livonia, MI: Rugby Laboratories; December 2019.

BP Wash (benzoyl peroxide 7%) [prescribing information]. Dallas, TX: Cintex Services, LLC; March 2012.

BPO Gel (benzoyl peroxide) [prescribing information]. Alpharetta, GA: Acella Pharmaceuticals, LLC; July 2018.

Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014;70(3):417.[PubMed 24528912]

Centers for Disease Control (CDC). Neonatal deaths associated with use of benzyl alcohol—United States. MMWR Morb Mortal Wkly Rep. 1982;31(22):290-291. http://www.cdc.gov/mmwr/preview/mmwrhtml/00001109.htm[PubMed 6810084]

Chien AL, Qi J, Rainer B, Sachs DL, Helfrich YR. Treatment of acne in pregnancy. J Am Board Fam Med. 2016;29(2):254-262.[PubMed 26957383]

Clearasil Daily Clear (benzoyl peroxide) [prescribing information]. Parsippany, NJ: Reckitt Benckiser LLC.

Dubina MI, Fleischer AB Jr. Interaction of topical sulfacetamide and topical dapsone with benzoyl peroxide. Arch Dermatol. 2009;145(9):1027-1029. doi:10.1001/archdermatol.2009.186.[PubMed 19770443]

Eichenfield LF, Krakowski AC, Piggott C, et al. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013;131(Suppl 3):S163-186.[PubMed 23637225]

FDA Drug Safety Communication. http://www.fda.gov/downloads/Drugs/DrugSafety/UCM402663.pdf.

"Inactive" ingredients in pharmaceutical products: update (subject review). American Academy of Pediatrics (AAP) Committee on Drugs. Pediatrics. 1997;99(2):268-278.[PubMed 9024461]

Kong YL, Tey HL. Treatment of acne vulgaris during pregnancy and lactation. Drugs. 2013;73(8):779-787.[PubMed 23657872]

Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006;24(2):167-197.[PubMed 16677965]

PR Benzoyl Peroxide Wash (benzoyl peroxide) [prescribing information]. Scottsdale, AZ: PruGen, Inc.

Shehab N, Lewis CL, Streetman DD, Donn SM. Exposure to the pharmaceutical excipients benzyl alcohol and propylene glycol among critically ill neonates. Pediatr Crit Care Med. 2009;10(2):256-259.[PubMed 19188870]

World Health Organization (WHO). Breastfeeding and maternal medication, recommendations for drugs in the eleventh WHO model list of essential drugs. 2002. Available at http://www.who.int/maternal_child_adolescent/documents/55732/en/

Brand Names: International

Acnase (BR); Acne Derm (IL); Acnecide (IE); Acnetick-10 (CO); Acnexyl (TH); Acnezoyl (BH, QA, SA); Acnie (TW); Aknederm-BP (TH); Aknefug (EE); Aknefug-Oxid (HU); Aknefug-oxid (PL); Akneroxid (AE, BE, CH, CZ, DE, EG, HU, KW, LU, MY, NL, PL, QA, SG, SK); Akneroxide (AT); Ambix (PL); Antopar (HR, PL); Asepxiagel (CR, DO, GT, HN, NI, PA, SV); Basiron (CZ, DK, FI); Basiron AC (NO, SE); Benoxid (IT); Benoxyl (AE, BB, BF, BH, BJ, BM, BS, BZ, CI, CR, CY, DO, ET, GB, GH, GM, GN, GT, GY, HN, IQ, IR, JM, JO, KE, LR, LY, MA, ML, MR, MU, MW, NE, NG, NI, OM, PA, PR, SA, SC, SD, SL, SN, SR, SV, SY, TN, TT, TZ, UG, VE, YE, ZA, ZM, ZW); Benoxyl AQ AL (MX); Benoxyphil (JO); Benzac (AU, BD, BR, CL, IL, IT, JO, LU, PT); Benzac AC (AE, AU, BH, CO, CR, DO, EC, EG, GT, HK, HN, KR, KW, MX, MY, NI, NZ, PA, PE, PH, QA, SA, SG, SV, TH, TW, VE, VN); Benzac Spots Treatment (PH); Benzac W (BB, BM, BS, BZ, GR, GY, JM, MX, PR, SR, TT); Benzacene (AT); Benzacne (PL); Benzapur (PL); Benzed (KR); Benzihex (AR, CN); Benzihex AC (PY, UY); Benzoile Perossido (IT); Benzolac (ID); Benzomix (IT); Benzox (LK); Benzoylperoxide-Galderma (LU); Benzperox (BG); Bepio Gel (JP); Bexid (SE); Bining (CN); Brevoxyl (AU, CH, DE, FI, FR, KR, LK, MT, NZ, PK, PL, RO, SE, SG, TR, TW); Caress (BD); Clearasil Ultra (IT, PL); Cutacnyl (LB); Dercome (HR); Eclaran (AR, FR, LU, SK, VN); Ecuaderm (VE); Effacne (FR, LU); Enzoxid (LK, TH); Lubexyl (HU, PL); Medigel (PL); Oxazone (KR); Oxigel (BD); Oxy (HU, PE, PL, SE); Oxy Preps. (AU); Pangel (BE); Panoxyl (AE, AT, BB, BH, BM, BR, BS, BZ, CY, DE, FR, GB, GY, IQ, IR, IT, JM, JO, LK, LU, LY, NZ, OM, PH, SR, SY, TH, TT, TW, YE, ZA); PanOxyl (AU, SG); Panoxyl AQ (PY); Pernox Gel (IN); Peroxiben (ES, PT); Persol Gel (IN); Pretty (TW); Reloxyl (IT); Scherogel (AT, IT, LU); Solugel (CL, CO); Stioxyl (SE); Tinagel (LU); Vixiderm (AR)

Last Updated 10/9/20