Materia medica (lit.: 'medical material/substance') is a Latin term from the history of pharmacy for the body of collected knowledge about the therapeutic properties of any substance used for healing (i.e., medications). The term derives from the title of a work by the Ancient Greek physician Pedanius Dioscorides in the 1st century AD, De materia medica, 'On medical material' (  , Peri hyls iatriks, in Greek).

The term materia medica was used from the period of the Roman Empire until the 20th century, but has now been generally replaced in medical education contexts by the term pharmacology. The term survives in the title of the British Medical Journal's "Materia Non Medica" column.


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The earliest known writing about medicine was a 110-page Egyptian papyrus. It was supposedly written by the god Thoth in about 16 BC. The Ebers papyrus is an ancient recipe book dated to approximately 1552 BC. It contains a mixture of magic and medicine with invocations to banish disease and a catalogue of useful plants, minerals, magic amulets and spells.[1] The most famous Egyptian physician was Imhotep, who lived in Memphis around 2500 B.C. Imhotep's materia medica consisted of procedures for treating head and torso injuries, tending of wounds, and prevention and curing of infections, as well as advanced principles of hygiene.

In India, the Ayurveda is traditional medicine that emphasizes plant-based treatments, hygiene, and balance in the body's state of being. Indian materia medica included knowledge of plants, where they grow in all season, methods for storage and shelf life of harvested materials. It also included directions for making juice from vegetables, dried powders from herb, cold infusions and extracts.[2]

The earliest Chinese manual of materia medica, the Shennong Bencao Jing (Shennong Emperor's Classic of Materia Medica), was compiled in the 1st century AD during the Han dynasty, attributed to the mythical Shennong. It lists some 365 medicines, of which 252 are herbs. Earlier literature included lists of prescriptions for specific ailments, exemplified by the Recipes for Fifty-Two Ailments found in the Mawangdui tomb, which was sealed in 168 BC. Succeeding generations augmented the Shennong Bencao Jing, as in the Yaoxing Lun (Treatise on the Nature of Medicinal Herbs), a 7th-century Tang dynasty treatise on herbal medicine.

Galen was a philosopher, physician, pharmacist and prolific medical writer. He compiled an extensive record of the medical knowledge of his day and added his own observations. He wrote on the structure of organs, but not their uses; the pulse and its association with respiration; the arteries and the movement of blood; and the uses of theriacs. "In treatises such as On Theriac to Piso, On Theriac to Pamphilius, and On Antidotes, Galen identified theriac as a sixty-four-ingredient compound, able to cure any ill known".[4] His work was rediscovered in the 15th century and became the authority on medicine and healing for the next two centuries. His medicine was based on the regulation of the four humors (blood, phlegm, black bile, and yellow bile) and their properties (wet, dry, hot, and cold).[5]

The Greek physician Pedanius Dioscorides, of Anazarbus in Asia Minor, wrote a five-volume treatise concerning medical matters, entitled    in Greek or De materia medica in Latin. This famous commentary covered about 600 plants along with therapeutically useful animal and mineral products. It documented the effects of drugs made from these substances on patients. De materia medica was the first extensive pharmacopeia, including about a thousand natural product drugs (mostly plant-based), 4,740 medicinal usages for drugs, and 360 medical properties (such as antiseptic, anti-inflammatory, stimulant). The book was heavily translated, and portrayed some of the emblematic actions of physicians and herbalists. One such page is Physician Preparing an Elixir.

The most useful books of botany, pharmacy and medicine used by students and scholars were supplemented commentaries on Dioscorides, including the works of Fuchs, Anguillara, Mattioli, Maranta, Cesalpino, Dodoens, Fabius Columna, Gaspard and Johann Bauhin, and De Villanueva/Servetus. In several of these versions, the annotations and comments exceed the Dioscoridean text and have much new botany. Printers were not merely printing the authentic materia medica, but hiring experts on the medical and botanical field for criticism, commentaries, that would raise the stature of the printers and the work.[3]

Laguna explored[27] many Mediterranean areas and obtained results concerning many new herbs; he also added these prescriptions and commentaries to the recipes and teachings of Pedanius' Dioscorides. He also includes some animal and mineral products but only those related to simple medicines, that is, animal and mineral products that are medicine or are parts of a medical compound.[28] This was not an illustrated work. In 1555 he re-edited this work with woodcuts.[27]It was reprinted twenty-two times by the end of the 18th century; Laguna wrote very well, with explanations and practical commentaries.[28] He refers to anecdotes, adds commentaries on the plants, provides their synonyms in different languages, and explains their uses in the 16th century. These qualities and the number of woodcuts made this work very popular and appreciated in medicine far beyond the 16th century. He had problems with Mattioli for using some of his commentaries without mentioning him.[28]

The ancient phrase survives in modified form in the British Medical Journal's long-established "Materia Non Medica" column, the title indicating non-medical material that doctors wished to report from their travels and other experiences. For example, in June 1977, the journal contained "Materia Non Medica" reports on an exhibition at the Whitechapel Art Gallery by a London physician, the making of matches by hand in an Indian village by a missionary general practitioner, and a cruise to Jamaica by a University of the West Indies lecturer in medicine.[37]

Chinese materia medica (CMM) is becoming increasingly important in modern health care, with the potential for new or improved clinical protocols and reduction in treatment costs. Conventional approaches to drug discovery are based on knowledge of biological systems and screen phenotypes in the context of a whole organism. It will be valuable to identify the CMM that would induce certain biological responses (such as angiogenesis). The authors have developed a database that they plan to commercialize that contains traditional knowledge of Chinese medicine and pharmacology along with their own experimental data from controlled scientific observations by using the zebrafish as a model of CMM-induced pathology. The database is visualized and functions via the World Wide Web by subscription or license. The authors have also written software for personal digital assistant (PDA) devices that supports multiple users performing screening experiments worldwide. This provides a platform for the study of CMM, and data mining of this resource will help evaluate CMM in the context of experimental observations of biological aberrations.

Ethnopharmacological relevance:  Medicinal diets have a history of more than 2000 years. Locally referred to as yaoshan (Chinese: ), a medicinal diet is understood in China as a dietary product that combines herbs and food with the purpose of preventing and treating diseases or improving health under the guidance of traditional Chinese medicine theory. Medicinal diets are used in Chinese people's daily life and in specialized restaurants. Hundreds of Chinese materia medica (CMM) are used in medicinal diets; however, a comprehensive evaluation of medicinal diets is lacking.

Your teachers at the Herbal Academy have created this Herbal Materia Medica Course to guide you through the process of studying, researching, and observing plants in order to create an herbal materia medica. Designed for herbalists in the making, seasoned herbalists, and those of you not yet sure if this is the right path for you, this program will walk you through the process of studying one herb at a time, teaching you how to create (or add to) your materia medica.

In the introduction, you will learn the benefits of studying one herb at a time and choose the herb (or herbs) to include in your materia medica as you work through the course. You will begin researching the first categories for your materia medica pages.

In this lesson, we will explore several safety considerations in more depth and examine the resources that can help you research these important topics so you can add this information to your materia medica.

In the Preface, Dioscorides indicates that, instead of presenting his materia medica ("the materials of medicine") in alphabetical order (which, he complains, "splits off genera and properties from what most resembles them"), "I shall endeavor to use a different arrangement and describe the classes according to the properties of the individual drugs." The scheme was to organize by category or class and then by the physiological effect of the drug on the body. This classification of drugs with similar pharmaceutical properties was too subtle to be readily comprehended, however, and was made even more obscure when, ironically, later copyists alphabetized the material, completely rearranging its original schema. De Materia Medica was the basis for pharmaceutical and herbal writing until the end of the sixteenth century, transmitted in large part by the increasingly voluminous commentaries of the Italian physician Pier Andrea Mattioli.

As a surgeon to the Roman legions of Emperor Claudius in the first century, the author Dioscorides had plenty of opportunity to travel and catalogue substances used in treating illnesses and wounds. His text De materia medica looks at the medical uses of more than 1,000 plant and animal products, wines and minerals. He rejected alphabetical ordering and chose to classify the material as animal, vegetable and mineral. This picture of Dioscorides comes from the facsimile edition of the superbly illustrated medieval text Medicina Antiqua  (Harvey Miller, 48, $75). As Peter Murray Jones points out in his introduction to this edition, Dioscorides was credited in medieval times as the innovator of illustrated materia medica. ff782bc1db

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