Dihydrotestosterone (DHT) is a potent and highly energetic androgen implicated for men pattern hair loss. Dihydrotestosterone is produced mostly in the prostate gland, souffrance, adrenal glands and hair follicles. The formation of dihydrotestosterone involved testosterone as a prohormone. Testosterone is metabolized by either of the two types of isoenzymes: 5-alpha reductase type I actually and 5-alpha reductase type II changing it to a more active dihydro- form.

Androgen target cells are the sites of dihydrotestosterone formation which include the androgen dependent and androgen sensitive regions in the body. In the androgen sensitive region, the nuclear membrane and microsomes take part in the conversion process. Although, testosterone is masteron produced mainly in the souffrance, production of dihydrotestosterone occurs any place in the body where testosterone has entered the cells of the androgen dependent tissue. Inside the scalp, the androgen dependent locations include the frontotemporal region, the crown and the vertex. Essentially, these are web sites where hair tumble occurs at the beginning of male pattern hair loss.

Dihydrotestosterone and Man Pattern Hair Loss

Within the androgen dependent regions on the scalp, testosterone is transformed into dihydrotestosterone. Dihydrotestosterone then binds to the androgen receptors in the hair follicles. The vom männlichen geschlechtshormon receptors actually bind both testosterone and dihydrotestosterone. However, the dihydro- form has higher affinity to and dissociates more slowly from the receptors. Thus, higher levels of the body hormone are retained in the receptors. The existence of the androgens in the hair follicles actually helps hair growth. However, in genetically predisposed individuals, high levels of DHT can prevent hair growth, even completely stopping it. Since a result, the influenced area on the remaining hair little by little thins and may turn completely bald. Even if baldness has not yet occurred, the influenced may still look balding because of progressive miniaturization of hair. Normally, this type of hair reduction starts during puberty where the body produces high levels of testosterone.

Dihydrotestosterone can only exert the negative effects on predisposed individuals. Male pattern hair loss is heritable. People who inherit the gene that predisposes the problem become susceptible to the action of DHT. They are likely to experience hair losing during puberty nevertheless they might not really notice it until after thirty where substantial amount of hair was lost. The problem influences more than 50 % of men, but the same condition is also determined in women.

At present, you routine hair loss has no cure. Affected individuals, however, can find treatments that can stop hair reduction effectively. Since the role of DHT has been recognized and widely accepted, the suggested treatment for the condition is the one which addresses the condition with DHT. The DHT levels on the scalp should be maintained at levels where it cannot harm the hair follicles. This can be done by instituting treatments that block the creation of the hormone such as treatments that lessen the enzyme that catalyzes the conversion process. The drugs minoxidil and finasteride are known as DHT blockers because they work mainly by blocking the conversion process. Both drugs are proven effective in stopping male pattern hair loss. They could also choose for natural treatments that blocks DHT and stimulates hair regrowth.