After having reviewed the Prima's Collectors' Edition guide for Assassin's Creed II, this guide was kind of disappointing by comparison. For one thing, the quality of the paper used for the book to be pretty soft and flimsy, like those in mass produced magazines, definitely not of a collectors' edition.

5.PrognosisClinical prognostic scores such as the FLIPI are used to identify patients with aggressive disease and the shortest remission times [4]. The index uses age >60 years, elevated serum LDH, haemoglobin < 120 g/L, >4 nodal sites and advanced stage (III or IV) to predict overall survival. It has been validated prospectively in the rituximab (R) era while the FLIPI-2 is a prognostic score developed during the rituximab era and includes additional parameters of 2-microglobulin, bone marrow involvement and nodal mass >6cm [5]. These indices however cannot be used to guide treatment and do not incorporate any biological data influencing the evolution of follicular lymphoma. An integrated clinico-genetic risk model, the m7-FLIPI, which includes high risk FLIPI score, poor ECOG performance status, and non-silent mutations in 7 genes known to be dysregulated in FL canidentify high- and low-risk groups of patients more robustly than FLIPI alone but is unable to predict early relapse [6]. To date, the strongest prognostic factor is duration of response following first-line immuno-chemotherapy with progression within two years of treatment associated with 50% 5-year OS, compared to 90% in patients who progress later [7].


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So that the preparation of future priests in this regard may be less inadequate and may better meet their needs in the work that awaits them, the Congregation for Catholic Education, having consulted widely with experts in the matter, and especially with the Pontifical Commission for Social Communications, is pleased to offer to seminaries the present "Guide" in the hope that it will help in some way in carrying out their responsibilities. Whatever possible future developments and local diversity of situation there may be, all institutes of priestly formation must today urgently face a common core of fundamental questions concerning the personal conduct of receivers, the pastoral use of the mass media, and specialized formation for particular works. On the basis of the experience of recent years we here give some general guidelines for all three levels of formation, leaving to Their Excellencies the Bishops and to Reverend Educators their application to concrete circumstances and local necessities.

5. The present situation. The guidelines given in the Ratio Fundamentalis were therefore to be borne in mind by the competent episcopal conferences while preparing the Ratio for their respective countries, so that they might be put into effect in a specific way in each seminary's regulations and study programmes.

7.The object. The proper and direct object of the initiation and specific education with which the Guide is concerned is in the first place those media of communication of our day often referred to as the mass media, 13 or as diffusion techniques, or mass communication, or audiovisuals. They are also called by various other, more or less inadequate, names, but the Decree Inter mirifica, later followed by the new Code of Canon Law, 14 has more properly called them "instruments of social communication": "the press, the cinema, the radio, the television and the other instruments with similar characteristics" (no. 1). They are in fact distinguished by their high-level technical emphasis, by their specially outstanding suitability for achieving communication, which is the primary factor in the phenomenon of socialization 15 which is such a feature of today.

As an antidote to time-wasting, sometimes even alienating indulgence in superficial media programmes, the students should be guided to the love and practice of reading, study, silence and meditation. They should be encouraged, and be provided with the necessary conditions for community dialogue and prayer. This will serve to remedy the isolation and self-absorbtion caused by the unidirectional communication of the mass media, and will revive the authentic and absolute value proper to the Christian profession and the priestly ministry, particularly those of obedience and evangelic poverty,31 which the materialist and consumerist vision of human existence offered by the instruments of social communication very often rejects or ignores.

b) to train them to be masters and guides of others (receivers in general, educators, all those who work in the mass media) through instruction, catechesis, preaching, etc., and as consultants, confessors, spiritual directors;

"Like Jesus, like the Apostles, priests are totally at the service of God and men: this is their destiny. Hence the duty of their formation, a duty that devolves upon them more and more as time goes by. Spiritual formation [...]; pastoral formation, seeking and examining, in the light of the documents of the Second Vatican Council, how to serve more effectively the world in which they are called to live and work in the name of Christ. Doctrinal formation: rooted in faith and adapted to the times, a formation which will help them better to understand the world through study that is not only phenomenological but also nourished with the life-blood of Revelation and Tradition, that will enable them to think clearly and thus be the leaven in the mass and bring to the world the light of Christ."

1. A profound educational action, in the family, in the school, in the parish, through the catechism, to instruct and guide the young to a balanced and disciplined use of the mass media, helping them to form a critical judgement, illumined by faith, on what they see, hear and read (cf. Inter mirifica, nos 10, 16; Communio et progressio, nos 67-70, 107);

innocent of any combination or conspiracy, and in no way participating in or encouraging the unlawful acts of others. This was the great contention between the parties at the trial. In this posture of the case, it was essential to a fair and impartial trial and to the due protection of the rights of the plaintiff, that a precise and accurate instruction should be given to the jury, prescribing the rule of law by which a party who is present at the commission of a trespass, but not actively participating therein, may be held liable as a trespasser for aiding and abetting the unlawful act. In this particular the rulings at the trial were not sufficiently explicit. By omitting to give the instruction asked for by the plaintiff in his fourth prayer, and substituting in its stead another ruling, we think the court left the case to the jury without a clear, intelligible, and exact statement of the rule of law adapted to the facts in proof and necessary to guide them in making a proper application of the testimony. The effect of the instruction given to the jury was to lead them to believe that the defendants could not be held liable as principals for aiding and assisting in the unlawful acts by countenancing and approving the measures which were taken, or by making no opposition or manifesting no disapprobation of them, unless they stood in such relation as would naturally enable them to exercise some authority, control or influence over the actors; as where the actors are wives or children, especially daughters, and the persons present are husbands or fathers of such actors. This was clearly erroneous; not only because it annexed a limitation or qualification to the rule by which aiders and abettors are held to be principals, which does not exist, but also because it omitted to meet that part of the evidence which tended to show that both the defendants were present, giving aid and assistance to the actors in the unlawful enterprise, towards whom they stood in no such relation as is contemplated in the instructions. We do not however, mean to say that we give our sanction to the fourth instruction asked for by the plaintiff as containing a just and correct statement of the law. The first clause is too broad and sweeping in its definition of what legally constitutes an aiding

Russell admittedly testified that a screw with a pointed tip could qualify as a drill because when a screw turns into anything, it is going to open a passage for itself or it is going to create a hole. (Docket Entry # 33, Russell deposition). Carlozzi unequivocally established, however, that, "The spiral tip of the Acufex screw is not designed for, and does not, drill into or cut into bone." (Docket *400 Entry # 27, Ex. D,  9). Rather, the Acufex screw requires a separate drill bit to drill the holes into the bone mass. (Docket Entry # 27, Ex. D,  5). The Acufex screw itself does not perform substantially the same function of drilling a passage through bone in substantially the same way as the claimed invention. Nor does the Acufex screw perform substantially the same function of cutting into bone in substantially the same way as the claimed invention. The fact that Acufex' brochure describes the screw as having a pointed tip does not establish that this pointed tip performs substantially the same function in substantially the same way, as interpreted by one skilled in the art, as the drill in claim 4 of the '421 patent. (Docket Entry # 27, Ex. D,  8). Moreover, Russell's testimony relied on by plaintiffs and summarized supra was propounded during the course of litigation and therefore has little if any effect on what the words in claim 4 mean. See Lear Siegler, Inc. v. Aeroquip Corporation, 733 F.2d at 889 ("litigation-induced pronouncements of inventor ... have no effect on what the words of that document in fact do convey"). Summary judgment as to claim 4 is therefore appropriate inasmuch as the Acufex screw does not infringe literally or equivalently the drill feature of claim 4 of the '421 patent. 2351a5e196

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