Do the engineering and risk analysis before starting construction. This is often stated but rarely followed, though doing so clearly improves project performance. Edward Merrow, the founder of the Independent Project Analysis consultancy and author of a book on megaprojects,3 3.Edward W. Merrow, Industrial Megaprojects: Concepts, Strategies, and Practices for Success, first edition, Hoboken, NJ: John Wiley & Sons, 2011. has shown that the best examples of project-definition work reduce both project timelines and costs by roughly 20 percent.

I am a functional health coach and recommend G & G's mega multi to my clients because I have found them to be the best on the market in the UK for being 1) easily absorbed, being bioavailable. 2) They also have all the ingredients in the right amounts that I would wish in a supplement for my clients to maintain good health. 

I live in France and was recently pleased to receive my order in 2 days despite Covid-19!

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This is a high-value, one-a-day (or less) supplement. It contains solid quantities of C, the B vits including the methylated versions of folate and B12 (which is unusual and very good), properly bioavailable forms of E and D, and a great range of the trace elements like copper, manganese, chromium and boron which are often missing. Also bonuses like bioflavonoids and digestive enzymes.

If you want high supplementation of calcium and magnesium which are bulky you'll need them separately. The Cal-M powder is really good.

The best thing about this multivit really is that it all comes in a single capsule. 

(So many multivits out there look great and then you find you have to take three of them to get anywhere and your supply of 120 is only going to last a few weeks and isn't as cost-effective as it first seemed.)

Two of the best areas for first-time visitors are The Amphitheater and Table Rock. Table Rock is close to the main parking area and has easy routes for cutting your teeth on exquisite quartzite faces. The Amphitheater has a longer approach but is home to some of the most classic moderate multi-pitches in the state. One of my favorite memories is topping out on The Prow (5.4) with my friends in November as we watched the sunset over the gorge, aflame with red and orange autumn foliage in every direction.

If you still decide to take a multivitamin, our tests show that you can get a good one for very little money. Use the Ratings, note the nutrient doses, and buy by price. In addition, follow these guidelines:

Avoid megadoses. In general, look for no more than 100 percent of the Food and Drug Administration's Daily Value of the essential vitamins and minerals (one exception is vitamin D, for which the DV is just 400 IU, less than what many people should take). Avoiding big doses is especially important with vitamin A: Just 200 percent of the DV of the retinol form, sometimes listed on labels as vitamin A acetate or palmitate, can increase the risk of birth defects and liver damage.

Look for products that don't exceed about 3,000 IU of vitamin A (2,300 IU for women), or 60 percent of the DV, ideally with at least a third from beta-carotene, the safer form of the vitamin. (Smokers shouldn't take beta-carotene because it may increase their risk of lung cancer.)

 Ignore special claims and add-ons. Claims for benefits such as weight control or increased energy are generally unsubstantiated. Even if botanical ingredients, food extracts, and other substances like lutein and lycopene did have a benefit, the amounts in a multivitamin are probably too small to have any effect.

Consider a multivitamin geared to your age or gender. Men's and senior formulas usually don't contain iron, which is good because those groups generally don't need extra iron, and it can lead to organ damage in people with hemochromatosis, a genetic disorder that causes excessive iron buildup. Senior formulas may also contain more vitamin D. Women's vitamins may have some extra calcium, though rarely enough to meet the daily requirement without the need for a separate supplement.

Polygenic scores were constructed using cohort-specific, ancestry-stratified summary statistics for CAD and CAD-related traits, resulting in 51 GPS across all traits and ancestries. For each trait (for example, CAD) the best-performing combination of cohort-specific, ancestry-stratified GPSs was determined using stepAIC, and their optimal mixing weights (tag_hash_107) were determined using logistic regression in 116,649 individuals of European ancestry in the UK Biobank training dataset. The selected GPSs were linearly combined using these mixing weights to yield multi-ancestry scores predicting CAD for each trait (layer 1). The best-performing combination of multi-ancestry, trait-specific GPSs was determined using stepAIC, and their optimal mixing weights (tag_hash_108) were determined using logistic regression in 116,649 individuals of European ancestry in the UK Biobank training dataset. The selected GPSs were linearly combined using these mixing weights to yield GPSMult (layer 2). Ancestries: AFR, African; EA, East Asian; EUR, European; HISP, Hispanic; SA, South Asian. Source GWAS traits: CAD27,33,34,38,56, body mass index (BMI)38,57, ischemic stroke38,58,59, diabetes mellitus (DM)59,60,61, peripheral artery disease (PAD)38,56,62, glomerular filtration rate (GFR)38,63, systolic blood pressure (SBP)38,64, diastolic blood pressure (DBP)38,64, LDL cholesterol38,65,66, HDL cholesterol38,65,66, triglycerides (TG)38,65,66.

These multi-ancestry trait-specific GPSs were then linearly combined with the multi-ancestry GPSCADANC (from layer 1) to generate the final GPSMult (layer 2). Just as for layer 1, the discriminative capacities (AIC) of these GPS combinations for predicting CAD were assessed to identify the best combination of trait-level scores for mixing82. A logistic regression model was used to estimate the mixing weights for each individual trait-specific GPS as described above. These GPSs were then linearly combined together into a single GPSMult score (layer 2, Fig. 1). Of 51 GWAS- and ancestry-specific GPS that went through layers 1 and 2 of selection and mixing, 32 contributed to the final GPSMult, incorporating GWAS summary statistics from multiple ancestries and multiple CAD-related traits (Fig. 2). LDpred2 parameters selected for each score, whether the score survived after feature selection, and mixing weights from layers 1 and 2 are listed in Supplementary Table 1. 589ccfa754

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