Mitochondria – the powerhouses of the cell – are vital communication and regulatory entities for cellular health, and their misregulation is associated directly with aging, and consequential diseases including cancer and neurodegeneration. Futuristic medical interventions demand discovering ways to restore healthy cellular function, particularly in brain neurons. At Krea University, the Mitochondrial Networks and Disease (MiND) laboratory will achieve this through the following focused research areas:
Mitochondrial membrane proteins, mito-dysregulation in brain aging and neurodegeneration.
Membrane protein interactome, molecular failures in cancer.
Pioneering peptidomimetics design and engineering as targeted long-term bio-therapeutics.
AI- and experimental membrane protein thermodynamics, interdisciplinary synthetic biology.
Membrane proteins as interventions for novel antibacterials for ESKAPEE pathogens (tangential project).
Prof. Dr. R. Mahalakshmi
PhD, FNA, FASc, FNASc
Professor and Wellcome-DBT Fellow
Latest Announcements:
Sharing the acceptance of our chapter on "Structural Organization and Mechanistic Models of the β-Barrel Assembly Machinery" in Comprehensive Biophysics, 2nd Ed, Elsevier Inc.! Congratulations Akanksha and Aadya!
Sharing my excitement about our recently accepted research article on "Bilayer mechano-chemical properties are determinants of membrane protein interface energetics"in Biochemistry! Congratulations Swadha!