David Sinclair Supplement List 2023

Dr. David Sinclair is a popular longevity expert and a Harvard professor; he is most known for his book Lifespan: Why We Age and Why We Don’t Have to. Much of David Sinclair's Supplement Stack is shared in this book. However, there are more recent updates that he has only shared on Twitter, podcasts and Reddit. It's important to note that David does not promote or endorse any supplement brands.

Note that this supplement list and protocol were updated in September 2023 to reflect David's changes.

Even though he does not promote brands, as many people respect Dr. Sinclair, they want to know his complete supplement list, so I have extensively researched and can share with you David Sinclair supplements for 2023:

Mornings

NMN 1,000 mg (1 gram) 500mg (half a gram) daily
14/09/2023 Note: See the video below where he mentions at the India Today forum that he now takes 500mg daily.

With Yogurt, the following supplements:

Resveratrol 1,000 mg
Fisetin 500 mg daily
Quercetin 500mg daily
Spermidine 1,000 mg

Evenings

Metformin 800mg but not on evenings before resistance training; note it is a prescription drug. See below.

Other Supplements, Vitamins, and Drugs That he Takes

Vitamin D3

Vitamin K2

Omega-3 fish oil

Alpha Lipoic Acid

Coenzyme Q10

Aspirin 81mg

Statin

Nicotinamide Mononucleotide (NMN) 1,000 mg 500mg per day in the morning

Nicotinamide Mononucleotide (NMN) is an important molecule that has been studied for its potential to extend lifespan and improve overall health. It is a precursor to NAD+, an essential metabolic molecule many proteins need to function correctly.

NMN is gaining popularity among those looking to extend their lifespan and improve their health. Still, it is essential to consider the appropriate dosage of NMN for the best results. While 1,000 mg is a high dose of NMN, studies done in humans with NMN use 250 mg per day and lower amounts of 250-500 mg have also been shown to be sufficient to benefit from NMN’s health-- and longevity-promoting effects.

Dr. David Sinclair, a prominent researcher in aging and longevity, is one of many experts who recommends taking NMN. He takes NMN and not NR; he believes NR does not extend lifespan. For those looking to take NMN as part of a longevity regimen, Dr. Sinclair takes 1,000 mg per day. Interestingly, I found he does not take TMG (trimethylglycine), a supplement that many longevity researchers, biohackers and experts take to prevent the depletion of his methyl groups.

Below is the video from early 2023, where Dr. Sinclair mentions that he now takes half a gram a day.

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Trans-Resveratrol 1,000 mg per day in the Morning.

Dr David Sinclair takes 1,000 mg of trans-resveratrol in the morning mixed with yoghurt to increase its bioavailability.

Polyphenol is a type of antioxidant naturally found in small amounts in foods like grapes, blueberries, raspberries, mulberries, and peanuts. However, to get the full effects it's best taken as a concentrated supplement.

When taken as a supplement, it is thought to act as a “caloric restriction mimetic, " activating beneficial cellular pathways. Studies have pointed to benefits such as reduced inflammation and oxidative stress in healthy people and improved memory metabolic and cardiovascular markers in people with obesity, hypertension, type 2 diabetes, fatty liver disease, and cardiovascular disease.

Some studies have shown, and experts believe that pterostilbene is a better SIRT 1 activator than trans resveratrol because it is more bioavailable. However, since it can be challenging to find a supplement that contains both pterostilbene and trans-resveratrol, many experts recommend taking trans-resveratrol in the morning and pterostilbene in the evening for the best results.

Fisetin 500 mg in the morning with Yoghurt

David Sinclair takes 500 mg of Fisetin every morning with Yoghurt. He has been taking it for over two years. Fisetin is a flavonoid found in plants and fruits, and the fatty food source helps increase its bioavailability.

Studies conducted by Yu-Fen Lin and the team have suggested that Fisetin can reduce chronic stress in mice. It is believed that Fisetin helps remove senescent cells from our bodies and has a range of beneficial effects, including anti-inflammatory, anti-oxidant, anti-tumorigenic, anti-invasive, anti-angiogenic, anti-diabetic, neuroprotective, and cardioprotective effects.

Sinclair believes Fisetin is an important part of his anti-aging regimen, and its potential benefits are worth exploring. It is important to note if you plan to take Fisetin, discuss it with your doctor. For Dr Sinclair, both quercetin and fisetin go hand in hand as potent flavonoids.

Spermidine 1,000 mg per Day

Spermidine is a compound that has recently become interesting due to its potential health benefits. Studies have found a difference in mortality risk between the top and bottom third of spermidine intakes, similar to that associated with a 5.7-year younger age. Additionally, studies in 2019 and 2018 have found a noticeable benefit in older adults with cognitive impairment. David takes 1,000 mg of wheat germ extract daily, equivalent to 1 mg of pure spermidine trihydrochloride.

Spermidine supplements are available in wheat germ extract and a pure form (spermidine trihydrochloride). While supplementation is an option, spermidine can also be found in large quantities through day-to-day food sources. Some of the best sources of spermidine include mushrooms, legumes, whole grains, and certain types of fish.

Although spermidine research is in its infancy, the potential health benefits are encouraging. For those looking to increase their spermidine intake, taking a supplement or incorporating spermidine-rich foods into their diet are two options.

Metformin 800 mg in Evening

Metformin has been around since 1922, used to treat diabetes and is believed to offer longevity benefits due to its activation of the AMPK cellular pathway. This prescription drug must be acquired through a doctor's prescription and is typically taken daily by diabetics and those using it for healthspan extension. David Sinclair takes 800mg of Metformin at night, except on nights when he exercises the next day. He also skips taking resveratrol on days he exercises. This is believed to benefit his overall health and longevity by inhibiting mitochondrial function. Metformin has been studied extensively in the past few decades. It has been found to offer many potential health benefits, such as reducing inflammation, lowering blood glucose levels, and improving insulin sensitivity.

Other items that we have researched and are on the David Sinclair Supplement List

While I have mentioned above the leading supplements that Dr Sinclair takes to increase his health and lifespan, there are several other supplements and drugs he takes, some to assist further his main longevity supplement stack and others that are required for good general health and wellbeing,

Omega-3 fish oil in the evening
Alpha Lipoic Acid, a SIRT activator he mentions he takes the S form of ALA
Aspirin 81mg
Coenzyme Q10 is used for increased mitochondrial energy production but also helps people taking statins
Statin used to keep cholesterol and takes due to a history of cardiovascular disease in his family
Vitamin D3 Approximately 2,000IU per day
Vitamin K2 dose not known and is used to keep calcium out of the arteries

What Brands of Supplements Does David Sinclair Use?

It's not known what brands of supplements David Sinclair uses. He stated in his book "Lifespan: Why We Age―and Why We Don't Have To" and on podcasts like "The Joe Rogan Experience" that he doesn't endorse any brands. However, in his book, he also stated that the resveratrol he takes is leftovers from his lab. In regards to NMN, he does have a financial stake in MetroBiotech which is developing a more bioavailable form of NMN called MIB-626, therefore it's very likely he is using this brand/form of NMN. Note this brand/form of NMN is still in development and is not avaiaiable to the public.

Other Things David Does to Remain Healthy and Increase Lifespan

Intermittent Fasting Dave practices a 16/8 fasting regime, usually only having one meal a day, and his entire regime has been shown to decrease inflammation and
maintains a healthy diet without sugar deserts and is low in carbohydrates; in addition, he keeps red meat consumption to a minimum, With regards to sugars and deserts, he occasionally sneaks a taste.