In each Lollishot level, the player controls their weapon positioned at the top of a tower and must stop candy creatures climbing up from below. To attack, press and hold the weapon at the top of the tower and drag to aim the shot; when released, the bullet will fly along the chosen trajectory and may ricochet upon hitting the sides of the tower. Before the battle, the player can choose one of two main weapons: a candy bomb gun or a candy laser. During combat, support skills can be activated to gain an advantage, such as creating a small explosion upon impact, applying a sticky caramel coating to slow down enemies for a short time, or summoning a candy laser beam to deal area-of-effect damage. Sugar pellets will occasionally appear along the tower; when bullets hit them, the player collects resources. The goal of each level is to eliminate all enemies before they reach the top of the tower. The game ends in failure if five creatures pass. The game has three challenge levels, unlocked sequentially after the player completes the previous level, and the difficulty increases as more and stronger enemies appear. After each level, the player receives unique candy factory rewards, which can be used to purchase additional support items or upgrade weapons for subsequent battles.