When Light meets Cells
Lip Ket Chin
Assistant Professor
Department of Electrical Engineering
City University of Hong Kong
lkchin at cityu dot edu dot hk
Lip Ket Chin is an Assistant Professor in the Department of Electrical Engineering at City University of Hong Kong. Before he joined CityU, he was a Senior Research Fellow at Nanyang Technological University, Singapore; as well as a Research Fellow at Harvard Medical School and Center for System Biology, Massachusetts General Hospital (USA). He received the B.Eng & Ph.D from Nanyang Technological University, Singapore.
His research interests include: nanophotonics, nanoplasmonics, optofluidics, biosensors and biomedical instrumentation, translational research, etc.
Education
PhD School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore
Thesis: Single cell refractive index measurement via Lab-on-a-chip system
BEng School of Electrical & Electronic Engineering, Nanyang Technological University, Singapore
Experience
2022 - Present Assistant Professor, City University of Hong Kong, Hong Kong SAR
2018 - 2022 Research Fellow, Harvard Medical School
& Center for System Biology, Massachusetts General Hospital, USA
2014 - 2022 Senior Research Fellow, School of Electrical & Electronic Engineering
Nanyang Technological University, Singapore
2013 - 2014 Research Scientist, Water Optics Technology, Singapore
2011 - 2013 Research Fellow, School of Electrical & Electronic Engineering
Nanyang Technological University, Singapore
News and Updates
New Article in ACS Nano on Dual-Enhanced Plasmonic Biosensing for Point-of-Care Sepsis Detection
Call for Papers
Nanophotonic systems leverage light field manipulation and strong modal confinement at the nanoscale level to implement sensitive biosensing schemes. The interplay between affinity layers and the surface passivation strategies are essential to transform these conceptual devices into powerful technologies for sensitive and selective biosensors of target analytes (cancer biomarkers, cytokines, ions, proteins, exosomes, antibodies, mRNA, etc.) from a biological fluid, which is of great relevance to clinical diagnosis. Most importantly, nanophotonic biosensors achieved detection limits that surpass other non-optical methods.
The scope of this Special Issue is to amass research in nanophotonic biosensors, with an emphasis on works that demonstrate the potential translational aspect to challenging realistic environments and those that demonstrate high-level integration with supporting technologies. In this regard, we welcome submissions that involve the following topics:
Use of nanophotonic systems (plasmonics, photonic crystals, structured optical fibers, waveguide, etc.) for the detection of analytes in biological fluids (tear, saliva, urine, plasma, whole blood, etc.);
Robust fabrication methods of nanophotonic systems indicative of a strong translational potential for deployment;
System-level integration of nanophotonic devices with portable readout optical systems for point of care applications;
Biosensing with nanophotonic systems that incorporate benchmark studies with gold standards (ELISA, PCR, HPLC, etc.);
Integrated nanophotonics–microfluidics integration for combined on-chip sample preparation and sensing.
Dr. Abraham Vázquez-Guardado
Dr. Lip Ket Chin
Guest Editors
Call for Papers
Photonic biosensors showing superior sensitivity are ideal for the detection of both biomolecules (e.g. proteins, nucleic acid, extracellular vesicles, exosomes) and bioparticles (e.g. viruses, bacteria, cells, protozoa) with flexible detection mechanisms, including label-free methods (absorbance, colorimetry, refractive index change), fluorescence, chemifluorescence, chemiluminescence, etc. Recent advancements of photonic biosensors especially with the synergy of microfluidic, deep learning, metamaterial technologies have demonstrated ultra-high sensitivity, accuracy and rapid detection time. It has enabled groundbreaking researches especially in detecting and analyzing sample heterogeneity (down to single bioparticle or biomolecule) for rare biomarker discoveries and antimicrobial resistance studies.
The goal of this Research Topic is to bring together a collection of papers that used optical and photonic technologies to innovate biosensors for point-of-care disease diagnosis, microbial detection in food and water monitoring, antimicrobial resistance studies, etc. This topic covers research ranging from fundamental discoveries to technology advancement and translational applications.
We welcome the submission of manuscripts including, but not limited to, the following topics:
• Photonic, plasmonic and metamaterial-based biosensors
• Photonic biomedical devices for point-of-care disease diagnosis
• Photonic biosensors for food and water monitoring
• Novel optical biosensors for antimicrobial resistance research
Keywords: Biosensors, photonics, biomedical applications, environmental monitoring, antimicrobial resistance
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.
Dr. Lip Ket Chin
Dr. Eduardo Fernandez
Dr. Fei Deng
Editors