Welcome to the Lei Wei laboratory
Exploring Cancer Genomics at Roswell Park Comprehensive Cancer Center
As a computational biologist, my researches focus on understanding the mechanisms of cancer initiation, progression, and prognosis through developing and utilizing computational methods. My recent research areas include:
· Identify driver mutation, etiology, mechanism, and heterogeneity in human & mouse cancer genomes.
· Ultra-sensitive detection of cancerous and precancerous lesions using somatic mutations.
· Develop innovative and integrative open-source computational software for analyzing genomics data.
· Accurate interpretation of complex genomic variants by haplotype-aware annotations.