Lee Lab
Seoul National Univeristy
Seoul National Univeristy
Our laboratory primarily focuses on proteins, as defects in protein function are closely linked to the onset of numerous diseases. By understanding protein structures at a molecular level, we aim to discover novel therapeutic candidates that modulate disease-associated protein functions and to optimize protein-based therapeutics.
Our lab combines structural biology, de novo protein design, biophysics, and cell biology to understand protein function at the molecular level and address longstanding biological questions. Using techniques such as X-ray crystallography and cryo-electron microscopy (cryo-EM), we determine high-resolution three-dimensional protein structures and apply this knowledge to engineer new protein-based therapeutic strategies, including antibody drugs and protein drug delivery systems.
Current research themes:
Development of stimuli-responsive polymorphic protein cages for drug delivery via protein engineering
Discovery of de novo designed nanobodies/minibinders for organ/cell specific delivery
Discovery of novel Aurora kinase A inhibitors that suppress protein–protein interaction mechanisms