郭清德

郭清德

Research topics

利用微機電系統技術來設計、構裝及建立一套可模擬體內腫瘤微環境之生物反應晶片，其能達到高通量快速篩選及最佳化毒殺癌細胞方法並朝向個人化精準醫療發展。

自我介紹

喜愛籃球運動，平常興趣為電影及音樂欣賞 ！

Education

09/2008 ~06/2013 Ph.D. in Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan

Ph.D. thesis: “Modeling of Tumor Microenvironment via Microfluidics: Probing the Traits of Epithelial-Mesenchymal Transition and Cancer Stem Cell”

Research advisor: Prof. Andrew M. Wo

09/2003~06/2005 M.S. in Power Mechanical Engineering, National Tsing Hua University, Hsinchu, Taiwan

Master thesis: “Design and Fabrication of AC Electrokinetic Micropump for Bio-Microfluidic Flow Control”

Research advisor: Prof. Cheng-Hisen Liu

09/1999~07/2003 B.S. in Mechanical and Electro-Mechanical Engineering, National Sun Yat-sen University, Kaohsiung, Taiwan

Coursework was focused on control systems.

Working experiences

01/2017~present Postdoctoral Fellow, Department of Electrical Engineering & Department of Life Science, National Taiwan University, Taipei, Taiwan

12/2015~12/2016 Postdoctoral Fellow, Division of Molecular Radiation Biology, Department of Radiation Oncology,

UT Southwestern Medical Center, Dallas, Texas, U.S.A.

04/2015~12/2015 Postdoctoral Fellow, Department of Life Science & Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan

02/2014~02/2015 Postdoctoral Fellow, Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei, Taiwan

08/2013~01/2014 Postdoctoral Fellow, Institute of Applied Mechanics, National Taiwan University, Taipei, Taiwan

11/2006~09/2008 Research Assistant, Research Center for Applied Sciences, Academia Sinica, Taipei, Taiwan

03/2004~07/2005 Research Assistant, Electronics & Optoelectronics Research Laboratories, Industrial Technology Research Institute, Hsinchu, Taiwan

Joural publications

1. National Taiwan University-Kyoto University-Tsukuba University 12th Mini-symposium 2013. (Also involved in the arranging team)

2. Federation of American Societies for Experimental Biology 2014.

3. American Society for Cell biology conference 2014.

4. Tsukuba Global Science Week 2015.

Research Publications

1. Ching-Te Kuo, Jong-Yueh Wang, Yu-Fen Lin, Andrew M. Wo, Benjamin P. C. Chen, and Hsinyu Lee, “Three-dimensional spheroid culture targeting versatile tissue bioassays using a PDMS-based hanging drop array,” Scientific Reports (Nature Publishing Group), 7, 4363, 2017.

2. Ching-Te Kuo, Jong-Yueh Wang, Andrew M. Wo, Benjamin P. C. Chen, and Hsinyu Lee, “ParaStamp and Its Applications to Cell Patterning, Drug Synergy Screening, and Rewritable Devices for Droplet Storage,“ Advanced Biosystems, 1, 1700048, 2017. (be selected as the front cover and highlighted by Advanced Science News; http://www.advancedsciencenews.com/parastamp-rewritable-microarrays-cell-patterning-drug-screening/)

3. Ching-Te Kuo, Cheng-Yu Chi, Pei-Yi Wu, Fang-Tzu Chuang, Yueh-Chien Lin, Hao-Kai Liu, Guan-Syuan Huang, Tzu-Ching Tsai, Andrew M. Wo, Hsinyu Lee, and Si-Chen Lee, “Observation of "wired” cell communication over 10-µm and 20-µm poly(dimethylsiloxane) barriers in tetracycline inducible expression systems,” Journal of Applied Physics, 119, 024702, 2016.

4. Jung-Chi Liao, T. Tony Yang, Rueyhung Roc Weng, Ching-Te Kuo, and Chih-Wei Chang, “TTBK2: A Tau Protein Kinase Beyond Tau Phosphorylation,” BioMed Research International, 575170, 2015.

5. Ching-Te Kuo, Hao-Kai Liu, Guan-Syuan Huang, Chi-Hao Chang, Chen-Lin Chen, Ken-Chao Chen, Ruby Yun-Ju Huang, Ching-Hung Lin, Hsinyu Lee, Chiun-Sheng Huang, and Andrew M. Wo, “A Spatiotemporally defined in vitro microenvironment for controllable signal delivery and drug screening,” Analyst, 139, 4846-4854, 2014.

6. Ching-Te Kuo, Fang-Tzu Chuang, Pei-Yi Wu, Yueh-Chien Lin, Hao-Kai Liu, Guan-Syuan Huang, Tzu-Ching Tsai, Cheng-Yu Chi, Andrew M. Wo, Hsinyu Lee, and Si-Chen Lee, “Experimental Demonstration of Bindingless Signal Delivery in Human Cells via Microfluidics,” Journal of Applied Physics, 116, 044702, 2014.

7. Ching-Te Kuo, Chi-Ling Chiang, Chi-Hao Chang, Hao-Kai Liu, Guan-Syuan Huang, Ruby Yun-Ju Huang, Hsinyu Lee, Chiun-Sheng Huang, and Andrew M. Wo, “Modeling of Cancer Metastasis and Drug Resistance via Biomimetic Nano-Cilia and Microfluidics,” Biomaterials, 35(5), 1562-1571, 2014.

8. Ching-Te Kuo, Chi-Ling Chiang, Ruby Yun-Ju Huang, Hsinyu Lee, and Andrew M. Wo, “Configurable 2D and 3D Spheroid Tissue Cultures on Bioengineered Surfaces with Acquisition of Epithelial-Mesenchymal Transition Characteristics,” NPG Asia Materials (Nature Publishing Group), 4, e27, 2012. (be selected on topics of Focus on Biomaterials, bio-inspired materials and biosensors in NPG Asia Materials website)

(http://www.nature.com/am/focus/biomaterials/index.html)

9. Lo-Chang Hsiung, Chi-Ling Chiang, Chen-Ho Wang, Yu-Hsu Huang, Ching-Te Kuo, Ji-Yen Cheng, Ching-Huang Lin, Victoria Wu, Hsien-Ten Chou, De-Shien Jong, Hsinyu Lee, and Andrew M. Wo, “Dielectrophoresis-based cellular microarray for anticancer drug screening in perfusion microenvironments,” Lab on a Chip, 11, 2333-2342, 2011.

10. Ching-Te Kuo and Cheng-Hsien Liu, “A Bubble-Free AC Electrokinetic Micropump Using the Asymmetric Capacitance-Modulated Microelectrode Array for Microfluidic Flow Control,” IEEE/ASME Journal of Microelectromechanical Systems, 18, 38-51, 2009.

11. Ji-Yen Cheng, Meng-Hua Yen, Ching-Te Kuo, and Tai-Horng Young, “A Transparent Cell-Culture Microchamber with a Variably Controlled Concentration Gradient Generator and Flow Rectifier,” Biomicrofluidics, 2, 024105, 2008. (selected for the July, 1, 2008 issue of Virtual Journal of Biological Physics Research)

12. Ching-Te Kuo and Cheng-Hesien Liu, “A Novel Microfluidic Driver via AC Electrokinetics,” Lab on a Chip, 8, 725-733, 2008.

Conference Publications

1. Ching-Te Kuo, Jong-Yueh Wang, Andrew M. Wo, Benjamin P. C. Chen, and Hsinyu Lee, “A novel round bottom µ-well array chip with biomimetic nano-cilia promotes 3D tumor cultures and metastatic bioassays,“ Proceedings of 19th International Conference on Solid-State Sensors, Actuators and Microsystems, Kaohsiung, Taiwan, June 18-22, 2017. (Transducers 2017) (Oral Presentation)

2. Ching-Te Kuo, Chi-Ling Chiang, Chen-Tse Wu, Guan-Syuan Huang, Ruby Yun-Ju Huang, Hsinyu Lee, and Andrew M. Wo, “Microscale Culture and Enrichment of Cancer Stem Cells for Drug Development,” Proceedings of 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Okinawa, Japan, October 28 - November 1, 2012. (MicroTAS 2012)

3. Ching-Te Kuo, Chi-Ling Chiang. Ruby Yun-Ju Huang, Hsinyu Lee, and Andrew M. Wo, “Probing The Traits of Epithelial-Mesenchymal Transition in a Microfluidic Device,” Proceedings of 15th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Seattle, USA, October 2-6, 2011. (MicroTAS 2011)

4. Lo-Chang Hsiung, Chen-Ho Wang, Chi-Ling Chiang, Ching-Te Kuo, Yu-Hsu Huang, Hsinyu Lee, and Andrew M. Wo, “A Cellular Microarray Perfusion System for Chem-drug Screenings,” Proceedings of 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Groningen, The Netherlands, October 3-7, 2010. (MicroTAS 2010)

5. Lo-Chang Hsiung, Chun-Hui Yang, Ching-Te Kuo, Yueh Wang, and Andrew M. Wo, “An Intergrated Microfluidic Multiplexing Platform for Bubble-free Solution Exchanges,” Proceedings of 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences, ICC Jeju, Jeju, Korea, November 1-5, 2009. (MicroTAS 2009)

6. Ji-Yen Cheng, Meng-Hua Yen, Ching-Te Kuo, and Tai-Horng Young, “Long-Term Cell Imaging in a Microchamber with Variablly Controlled Concentration Gradient Gereration,” Focus on Microscopy, Osaka-Awaji, Japan, April 13-16, 2008. (FOM 2008)

7. Ching-Te Kuo and Cheng-Hsien Liu, “A Novel Multifunctional Processor for Bio-Particles,” Proceedings of 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, Paris, France, October 7-11, 2007. (MicroTAS 2007)

8. Ji-Yen Cheng, Meng-Hua Yen, Ching-Te Kuo, and Tai-Horng Young, "Transparent Cell Culture Device with Integrated Heater and Gradient Generator," Proceedings of 8th International Symposium on Laser Precision Microfabrication, Vienna, Austria, April 24-28, 2007. (LPM 2007)

9. Ching-Te Kuo, Chih-Min Yao, Ching-Chen Tu, and Cheng-Hsien Liu, "Design and Simulation of Rotary Electrostatic Comb-Driven Optical Switch," The 8th Nano Engineering and Micro System Technology Workshop, Taiwan, 2004. (Oral Presentation)