翁義程

翁義程

Yi-Cheng Weng

E-mail: r03b21009@ntu.edu.tw

Address: Room504, Department of Life Science, National Taiwan University

No. 1, Sec. 4, Roosevolt Road, Taipei, 106 Taiwan

Phone: +886-2-3366-2499 (O)

Research topics

在膀胱癌病患中，Calreticulin(CRT)在尿液中的的量有明顯的增加，可做為篩檢癌症的重要marker之一。在實驗室的先前研究中發現，CRT可經由影響細胞膜上beta-1 integrin的glycosylation來造成癌細胞轉移。在CRT knockdown的細胞株當中，fucosyltransferase-1(FUT-1) 的表現量降低，使integrin fucosylation減少而使細胞貼附能力下降，並減少in vivo model中的癌細胞轉移。

在我的研究當中，希望透過immunoprecipitation(IP)的方式收集細胞上的beta-1 integrin，並分析在CRT knockdown細胞株上integrin的fucosylation pattern是否發生變化，進而找到能影響細胞貼附能力特定的glycosylation site，藉此對於癌細胞轉移的機制有更多的了解。

自我介紹

家居台北，從小對自然生物就有濃厚興趣，

因此來到台大生科系，且很高興能到李心予

老師實驗室裡向老師和學長姐們學習。希望

未來能在科學領域做出一番貢獻!

Education

Bachelor, Life Science, National Taiwan University, Taipei, 2010-2014

2nd year Master, Life Science, National Taiwan University, Taipei,

Leadership experiences

1. Organizer of Activity section in 2013 Intercultural Discovery and Exchange in Asia Project. 2013

2. Student representative of graduate student of Department of Life Science. 2014-2015

3. Leader of student council of Department of Life Science. 2012-2013

Poster presentation

Yi-Cheng Weng, Kuan-Ying Lu, Hsinyu Lee. Knockdown of calreticulin suppresses fucosylation of beta1 integrin and cell adhesion in PC3 prostate cancer cell. 2015 ASCB Meeting in San Diego

Research Papers

Wen-Chin Weng, Kuan-Hung Lin, Pei-Yi Wu, Yi-Chien Lu, Yi-Cheng Weng, Bo-Jeng Wang, Yung-Feng Liao, Wen-Ming Hsu, Wang-Tso Lee, Hsinyu Lee. Calreticulin Regulates VEGF-A in Neuroblastoma Cells. Mol Neurobiol, 2015 Aug;52(1):758-70. doi: 10.1007/s12035-014-8901-8. Epub 2014 Oct 7.