吳沛翊

吳沛翊

Address: Room504, Department of Life Science, National Taiwan University

No. 1, Sec. 4, Roosevolt Road, Taipei, 106 Taiwan

Phone: +886-2-3366-2499 (O)

Research topics

Aryl hydrocarbon receptor (AHR)被認為是戴奧辛的接受器，大量表現於肝臟細胞，與解毒作用有關。然而，本實驗室與台大醫學院合作之計畫發現AHR的表現與neuroblastoma病患癒後的表現有關，我的研究主要是利用human neuroblastoma cell line 探討AHR於其中所扮演的角色。

自我介紹

台中人, 興趣網球以及養魚, 也喜愛各式戶外活動

Education

Ph.D. Candidate Zoology, National Taiwan University, Taipei, Taiwan

MS Department of Cell Biology and Anatomy, College of Medicine, National Chung Kung University, Tainan, Taiwan, June 1994

BS Biology, National Chung Kung University, Tainan, Taiwan, June 1992

Employment

02/11-07/11 Adjunct Instructor, Department of Natural Science, Taipei Municipal University of Education.

Award received

06/10 NTU Teaching Assistant Award

06/10 Poster Award of Translational Science- Animal Biotechnology Symposium

06/13 Poster Award of Science Fair of College of Life science, NTU

Research Papers

1. Wu PY, Lin YC, Lan SY, Huang YL, Lee H. Aromatic hydrocarbon receptor inhibits lysophosphatidic acid-induced vascular endothelial growth factor-A expression in PC-3 prostate cancer cells. Biochem Biophys Res Commun. 2013 Aug 2;437(3):440-5.

2. Hsu WM, Huang CC, Wu PY, Lee H, Huang MC, Tai MH, Chuang JH. Toll-like receptor 3 expression inhibits cell invasion and migration and predicts a favorable prognosis in neuroblastoma. Cancer Lett. 2013 Aug 19;336(2):338-46.

3. Wang BJ, Wu PY, Lu YC, Chang CH, Lin YC, Tsai TC, Hsu MC, Lee H. Establishment of a cell-free bioassay for detecting dioxin-like compounds. Toxicol Mech Methods. 2013 Jul;23(6):464-70.

4. Huang TC, Chang HY, Chen CY, Wu PY, Lee H, Liao YF, Hsu WM, Huang HC, Juan HF. Silencing of miR-124 induces neuroblastoma SK-N-SH cell differentiation, cell cycle arrest and apoptosis through promoting AHR and repressing MYCN. FEBS Lett. 2011 Nov 16;585(22):3582-6.

5. Lu MY, Liu YL, Chang HH, Jou ST, Yang YL, Lin KH, Lin DT, Lee YL, Lee H, Wu PY, Luo TY, Shen LH, Huang SF, Liao YF, Hsu WM, Tzen KY; National Taiwan University Neuroblastoma Study Group. Characterization of neuroblastic tumors using 18F-FDOPA PET. J Nucl Med. 2013 Jan;54(1):42-9.

Abstracts

1. Wu PY, Hsu WM, Lee H Aromatic Hydrocarbon Receptor Down-regulates MYCN Expression and Promotes Neural Differentiation of Neuroblastoma. FASEB, 23:740.15, 2009

2. Liu YL, Wu PY, Tzen KY, Jou ST, Lu MY, Yang YL, Chang HH, Lin DT, Lin KH, Hsu, WM, Lee, H Neuroblastic Tumors Demonstrating Stronger 18F-FDOPA Avidity on Positron Emission Tomography Had Higher Level of Aromatic Amino Acid Decarboxylase (DDC) Gene Expression. SIOP, 2011

3. Hsu WM, Wu PY, Lee H Aromatic Hydrocarbon Receptor Down-regulates MYCN Expression and Promotes Neural Differentiation of Neuroblastoma. ANR, POC11, 2010

4. Wu PY, Hsu WM, Lee H Aromatic Hydrocarbon Receptor Down-regulates MYCN Expression and Promotes Neural Differentiation of Neuroblastoma. AEARU, P168, 2009

5. Wu PY, Hsu WM, Lee H Aromatic Hydrocarbon Receptor Down-regulates MYCN Expression and Predicts Favorable Clinical Outcome of Neuroblastoma. ASCB, 63:713,2011