Welcome to the Kiwon Lee Research Group
Welcome to the Kiwon Lee Research Group
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Our goal
Our goal
Even today, many people continue to suffer and lose their lives to disease. Our goal is to investigate the fundamental mechanisms of diseases caused by genetic and epigenetic defects at the molecular level and, ultimately, to develop therapies based on this foundational knowledge.Â
Currently, our lab focuses on the following key research areas:
Research
Research
1. Establishment of an in vitro differentiation model to investigate genetic defects in hematopoietic diseases, including platelet disorders and malignancies, using human hematopoietic stem cells (HSCs) and induced pluripotent stem cells (iPSCs).
In vitro-differentiated megakaryocytes
Humanized mouse model
2. Investigation of molecular pathways involved in genetic disorders associated with RUNX1 (Runt-related transcription factor 1) deficiency, a key regulator of hematopoiesis.
Single cell RNA-sequencing
3. Mechanistic investigation of hematopoietic diseases, including the development of malignancies driven by abnormal differentiation of hematopoietic stem cells, and the advancement of targeted therapeutic strategies.
Join us
Join us
We are looking for motivated graduate students, postdocs, and undergraduate interns aiming for graduate school to join our team. Our research focuses on the mechanisms of hematopoietic development and related diseases. Utilizing hematopoietic stem cells, induced pluripotent stem cells (iPSCs), diverse mammalian cell lines, and ex-vivo mouse models, we explore molecular pathways and pursue therapeutic strategies through transcriptomic, genetic, and epigenetic approaches.
Please send CV and inquires to Prof. Kiwon Lee. (leekw@hufs.ac.kr)
Department of Bioscience and Biotechnology at HUFS
Department of Bioscience and Biotechnology at HUFS
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