K.E.M. Radiology
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Department of Radiology
Seth G.S. Medical College and K.E.M. Hospital, Mumbai , India
Interventional Case Record
Contributed by : Saiprasad Shelke
Plug assisted retrograde transvenous obliteration (PARTO) of varices in a patient with cirrhosis of the liver, portal hypertension and gastric varices.
Introduction:
Upper gastrointestinal endoscopy is usually the first-line diagnostic and management tool for bleeding gastric varices (1). When endoscopy fails to control gastric variceal bleeding, a trans jugular intrahepatic portosystemic shunt (TIPS) is recommended to decompress the portal circulation (1, 2). However, TIPS may not be suitable for some patients with poor hepatic reserve, portal vein thrombosis, hepatic encephalopathy, or severe thrombocytopenia (1-3). Balloon-occluded retrograde transvenous obliteration (BRTO) is an endovascular technique that was refined in Japan as a therapeutic adjunct or alternative to TIPS for management of gastric varices (4). The BRTO technique has been described in many reports (4-7) and has shown considerable effectiveness with low rebleeding rates (4-10). Its advantages over TIPS include less invasiveness and greater performance ease in patients with poor hepatic reserve, encephalopathy, or refractory ascites (2,7,8). However, as BRTO requires an occlusion balloon catheter and sclerosing agents to occlude the portosystemic shunt, the indwelling catheter results in long procedural times and complications. Here we describe an alternative to balloon for retrograde shunt occlusion using a Vascular Plug.
Case presentation:
A 48-year old woman known to have hypothyroidism since 10 years, presented with complaints of two episodes of massive hematemesis. It was characterised by coffee ground vomitus, not preceded by retching, mixed with food particles and contained blood clots. Laboratory investigations showed a Hb 5.3 gm %, HBV, HCV and HIV negative. Ultrasound of abdomen showed hepatomegaly with altered echotexture, moderate splenomegaly with peri splenic and peripancreatic collaterals. UGI scopy showed Isolated Gastric Varices-1 (IGV-1) for which glue therapy was done. THe patient had persistent bleeding despite endoscopic management and was then referred to us for further intervention. CECT confirmed the ultrasound findings of liver cirrhosis and portal hypertension and showed a prominent gastrorenal shunt measuring 11 mm in calibre. [Figure 1)].
Fig 1 Preprocedural axial and coronal CT scan images show prominent fundal gastric varices.
Under local anesthesia, the right CFV was punctured and access obtained using 8F sheath. Using 4F SIM1 and Terumo guide wire gastrorenal shunt (GRS) was cannulated and documented (Figure 2).
Figure 2: Selective cannulation of gastrorenal shunt using 4F SIM1 catheter
Terumo guide wire was exchanged for AES stiff wire with help of Progreat microcatheter and Boston V18 wire. The 8F short sheath was exchanged for 10 F COOK 80 cm long sheath. A 2nd AES stiff was passed adjoining the 10F long sheath and 4F cobra catheter was secured within the gastrorenal shunt. An Amplatz Vascular Plug 16 mm was placed in the gastro renal shunt and shunt gram obtained. (Figure 3)
Figure 3: Fluoroscopic image showing Amplatz Vascular Plug 16 mm at the narrowest region of the gastrorenal shunt through the 10 F vascular sheath and cobra catheter placed coaxially adjoining it.
Following this, the vascular plug was deployed halfway at the narrowest region of the gastrorenal shunt .Contrast injection showed stasis of injected contrast in the gastro renal shunt and gastric varices. Once stasis was confirmed gelfoam pledgets of uniform size were injected from the cobra catheter placed next to the long sheath within the GRS. Gelfoam sheets were cut with scissors and gelfoam and contrast agents were mixed into a slurry by sequential mixing through a 3-way stopcock connected to 2 syringes. The gelfoam slurry was injected through the Cobra catheter to achieve filling and stasis within the entire efferent shunt and varices. Post-embolization venography using the Cobra catheter was performed again, to confirm complete occlusion of the efferent shunt and complete stasis within the varices (Figure 3). On confirmed completion, the vascular plug was deployed completely and detached. The renal vein patency was documented (Figure 4).
Figure 4 :Left internal iliac angiogram showing prostatic artery(arrows) arising from the anterior division of the internal iliac artery. (C) Angiogram obtained at right anterior oblique view (30 degrees) showing the entire course of prostatic artery. (D) 3D Angiography of the internal iliac artery showing the common trunk arising from gluteal-pudendal trunk of IIA giving rise to superior vesicular artery(arrowhead) and prostatic artery(arrows).
A CT scan was done one week post procedure showed complete obliteration of gastric varices and gastrorenal shunt. (Figure 5)
Figure 5: CT images one week after PARTO show complete obliteration of the targeted varices.