Speaker: 中山洋平（東北大）

Date: Sep. 13th 17:00-

Title: Rectification effect in biomolecular motor F1-ATPase

Abstract:

We experimentally investigated a rectification effect in a biomolecular motor, F1-ATPase [1]. The physiological role of F1-ATPase is the synthesis of adenosine triphosphate (ATP), which is used as a source of free energy. Furthermore, F1-ATPase has a function to selectively suppress the hydrolysis of ATP when the driving force is insufficient [2]. This selective suppression leads to the rectification effect to the effective driving force. The obtained performance of the rectification turns out not to be attained with one-dimensional ratchet potential. This fact may indicate that the rectification mechanism of F1-ATPase is optimized to function in a thermal environment. I would like to also talk about stochastic models that describe the previous experiments of F1-ATPase, and explain our model of the rectification.

[1] Y. Nakayama and S. Toyabe, Phys. Rev. Lett. 126, 208101 (2021).

[2] A. V. Syroeshkin, E. A. Vasilyeva, and A. D. Vinogradov, FEBS Letters 366, 29 (1995). D. Bald, et al., Journal of Biological Chemistry 273, 865 (1998). M. A. Galkin and A. D. Vinogradov, FEBS Letters 448, 123 (1999).