Speaker: Kristian Blom (Max Planck)

Date and style: Oct.20th 16:30- 

Zoom:

https://kyoto-u-edu.zoom.us/j/7324458143?pwd=OawQQkX7pJ7yAbjA6RrWuT6dJd9F7I.1&omn=83824634426

ミーティング ID: 732 445 8143

パスコード: 1234

Title: Milestoning estimators of dissipation in systems observed at a coarse resolution

Abstract:

Many non-equilibrium, active processes are observed at a coarse-grained level, where different microscopic configurations become projected onto the same observable state. As a simple example consider the dynamics of a molecular machine whose motion is blurred due to the finite resolution of a microscope. Such “lumped” observables generally display memory, and in many cases the irreversible character of the underlying microscopic dynamics becomes blurred, e.g., when the projection hides dissipative cycles. As a result, the observations appear less irreversible, and it is very challenging to conclusively infer the degree of broken time-reversal symmetry. In this talk I will show that, contrary to intuition, by ignoring parts of the already coarse-grained state space via a procedure called milestoning, we may improve entropy-production estimates [1]. Through various example we show that milestoning systematically renders observations ”closer to underlying microscopic dynamics”, and thereby improves thermodynamic inference from lumped data assuming a given range of memory. 

[1] K. Blom, K. Song, E. Vouga, A. Godec, & D.E. Makarov, Milestoning estimators of dissipation in systems observed at a coarse resolution, Proc. Natl. Acad. Sci. U.S.A. 121 (17) e2318333121, https://doi.org/10.1073/pnas.2318333121 (2024).