Dr. Lodhi Lab (Philadelphia, PA)

Apply by Contacting Here: Niraj.Lodhi@jefferson.edu

Summary: Early-life exposure to Lead (Pb) is a well-established driver of persistent cognitive deficits, specifically impairing learning and memory. Our preliminary study shows microbiome diversity of enriched environment play a major role to mitigate neurotoxic effects of Pb and we hypothesize that the gut-microbiome-brain axis and epitranscriptomic modifications m6A RNA methylation as critical intermediaries in this process. Our work examines extent to which how Pb-induced microbiome disrupts regulation to undermine cognitive functions, how enriched environment microbiome reverse the impairment  and evaluates Fecal Microbiota Transplantation (FMT) as a therapeutic strategy to rescue these deficits in Rat model.

Time: Hours and availability can be discussed with Dr. Lodhi Lab; term commitment is 3+ months

Paid/Unpaid: Unpaid; Research for Credit (3-credit/semester)

Qualifications:

• Students interested in studying for a Master's or related programs.

Location: 

Dept. of Pathology and Genomic Medicine

Thomas Jefferson University

1020 Locust Street

Philadelphia, PA 19107