The International Symposium on Intelligent IoT and Edge Computing Applications (ISIoTEC 2025) invites researchers, practitioners, and industry experts to submit original and innovative work on the latest advancements in the Internet of Things (IoT) and Edge Computing. ISIoTEC 2025 will be held on April 22-24, 2025, bringing together leading experts to discuss the development, implementation, and potential of IoT and edge technologies in transforming industries, enhancing digital infrastructures, and creating smart environments. This symposium will serve as a platform to exchange insights, address challenges, and explore applications of these technologies in various domains. ISIoTEC 2025 will be held in conjunction with The 16th International Conference on Ambient Systems, Networks, and Technologies (ANT 2025), Patras, Greece, April 22-24, 2025.