Abstract: This presentation explores the emergence of goal-directed behavior and cognition from the foundational principles of autopoiesis and far-from-equilibrium self-organization. Drawing on the process ontology of Maturana and Varela, and extending it with insights from cybernetics and artificial life, it shows how reaction networks can spontaneously evolve into self-sustaining, resilient systems. These autopoietic organizations exhibit goal-directedness not through pre-set representations, but through their ability to compensate perturbations via acquired condition-action rules. Cognition emerges as the system’s capacity to adaptively regulate its internal dynamics in response to environmental challenges, guided by implicit “knowledge” encoded in its components. The presentation outlines how evolutionary dynamics select for increasingly robust and adaptable systems, leading to layered architectures of control, from dissipative structures to catalyzed networks and genetic regulation. This framework bridges theoretical biology, systems science, and artificial life, offering a minimal yet rigorous account of the origins of agency, cognition, and purpose in living systems.