Prior Academic Affiliation: B.S. Fudan University
Thesis mentor's name: Stephen Forman, MD
Thesis title: Overcoming the challenges of CAR T cell therapy targeting glioblastoma
Fellowships, honors and awards: F99 CA234923 Pre-doc to Post-doc Transition Fellowship, National Cancer Institute (09/2018-08/2024); H.N. & Frances Berger Foundation Fellowship, City of Hope (2015); Scholar-in-training award, American Association for Cancer Research Conference on Immune Cell Therapies for Cancer, 2019; Outstanding poster award, American Society of Gene and Cell Therapy Annual Conference, 2016
Publication:
Pan, Y.J., Chen, Y.Y., Wang, D.R., Wei, C., Guo, J., Lu, D.R., Chu, C.C., and Wang, C.C. 2012. Redox/pH dual stimuli-responsive biodegradable nanohydrogels with varying responses to dithiothreitol and glutathione for controlled drug release. Biomaterials 33:6570-6579.
Chen, Y., Meng, D., Wang, H., Sun, R., Wang, D., Wang, S., Fan, J., Zhao, Y., Wang, J., Yang, S., et al. 2015. VAMP8 facilitates cellular proliferation and temozolomide resistance in human glioma cells. Neuro Oncol 17:407-418.
Xiao, L., Lan, X., Shi, X., Zhao, K., Wang, D., Wang, X., Li, F., Huang, H., and Liu, J. 2017. Cytoplasmic RAP1 mediates cisplatin resistance of non-small cell lung cancer. Cell Death Dis 8:e2803.
Wang, D., Aguilar, B., Starr, R., Alizadeh, D., Brito, A., Sarkissian, A., Ostberg, J.R., Forman, S.J., and Brown, C.E. 2018. Glioblastoma-targeted CD4+ CAR T cells mediate superior antitumor activity. JCI Insight 3.
Wang, D.*, Starr, R., Alizadeh, D., Yang, X., Forman, S.J., and Brown, C.E.* 2019. In Vitro Tumor Cell Rechallenge For Predictive Evaluation of Chimeric Antigen Receptor T Cell Antitumor Function. J Vis Exp (*co-corresponding authors)
Alizadeh, D., Wong, R.A., Yang, X., Wang, D.R., Pecoraro, J.R., Kuo, C.F., Aguilar, B., Qi, Y., Ann, D.K., Starr, R., et al. 2019. IL15 Enhances CAR-T Cell Antitumor Activity by Reducing mTORC1 Activity and Preserving Their Stem Cell Memory Phenotype. Cancer Immunology Research 7:759-772.
Wang, D., Starr, R., Chang, W.C., et al, Chlorotoxin Redirects Chimeric Antigen Receptor T Cells for Specific and Effective Targeting of Glioblastoma. In revision
Akhavan, D., Alizadeh, D., Wang, D., Weist, M.R., Shepphird, J.K., and Brown, C.E. 2019. CAR T cells for brain tumors: Lessons learned and road ahead. Immunol Rev 290:60-84.
Portnow, J.*, Wang, D.*, Tran, V., Chiu, V., et al, Systemic anti-PD-1 immunotherapy results in PD-1 blockade on T cells in the cerebrospinal fluid. In preparation (co-first authors)