This book has been revised to bring it up to date. At the same time, I have rewritten many sections on mechanisms, the added material being an elementary account of the sort of evidence that has led workers to suggest the mechanisms that are acceptable at the present time. This treatment should be more interesting to the reader and will give him a better understanding of this branch of organic chemistry.

I'm currently in a Ph.D program for pharmaceutical sciences. Long story short my background is cell biology and I originally worked in a Cancer lab. My lab relocated and I could not follow. I was placed into a medicinal chemistry lab. This is how things work here, we get little choice. Anyway, I love my PI hes great, and my lab mates also great. However I have no clue what I'm doing. I have a project thats moving along nicely but once again . . . I don't even know why it's moving along.


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I don't understand chemistry, I have a mere 8 credit hours from my undergrad in chemistry, and now I am asked to operate under conditions that would require a significant chemistry foundation. In my eyes all I have been doing is mixing what I am told to mix, run it through a column, perform TLC, NMR, and mass spec, and that's it. I don't know why I'm using one solvent over another. I don't know the mechanism behind any of my reactions, and hours and hours of googling has yet to teach me anything about them. No matter how many questions I ask (and I ask a lot) I don't retain anything or understand half of it because it's all upper level concepts to which I have no base to put them on. How am I suppose to defend any thesis like this? How could I ever start a career? I have no motivation in lab because I don't understand anything,at all. I don't have either the time or the drive to teach myself years of chemistry I never learned. Moving labs is 100% NOT an option here. I don't know what to do, any advice is appreciated.

That means that you will have to adapt to your current environment - i.e. to learn some core chemistry concepts. Without them, it is indeed difficult to find motivation to work on a project you don't understand.

Time: I'd say that catching up on the background is one of your main priorities and is essential for your future as a researcher (given the circumstances). Luckily, you don't have to catch up on "years" of chemistry - start off with the areas that are most essential to your work (not specific questions, however, but rather general topics that are closely related to your experiments).

What if you were to take a step back and look at the various research interests of the PI? Find something that interests you, where you have something to contribute? In other words, find some point of interdisciplinary intersection. And leave the heavy duty chemistry to the people in the lab who trained in chemistry. 0852c4b9a8

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