I think aside from a probable geographical preference over each case, when you want to imply "I have no issue with it", the difference between the two is so subtle that one can consider them quite interchangeable. This similar question acknowledges my take.

I will say that there is a difference, if used in spoken language, depending on where the emphasis is placed. If the speaker puts any emphasis on themself ("it's okay with me") then they are seeking to draw attention to the fact that their opinion may differ from that of other people. But even then, there's not necessarily any difference between the two ("I'm okay with it..." says the same thing).


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For me, answering the question "Do you like this color?" with "I'm OK with it", very clearly means "I would prefer you to choose a different color, but if you really like it that much, or you have different considerations for choosing this color, then I will not veto your decision of the color".

On the other hand, answering the question "Do you like this color?" with "It's OK with me", very clearly means "I don't care much about what color you choose, unless, understandably, it's absolutely hideous, and this is not one of those"

The words "it" and "that" are often used interchangeably in the English language, and, for whatever reason, the collective subconscious deems an object labeled by speech with "it" as more likely to potentially be animate than objects labeled with "that".

For example... "That's OK with me." and "I'm OK with that." are analogous. In English, we do not refer to things that are likely to make their own choices (or begin making their own choices) with "that". It feels very distant, if that makes sense.

Diving deeper: For the sentence "It's OK with me." to be completely analogous to "I'm OK with it.", in terms of meaning, the "it" in the sentence has to be non-living, or considered unable to make it's own choices. Otherwise, the first sentence "It's OK with me." can be viewed as "it", "that", or "they/he/she" are OK with me in the sense that you are not making the decision to be OK. The sentence "I'm OK with it." makes it very hard to confuse if you are being OK or if "it" is being OK.

I agree with those who say that the two expressions are essentially synonymous. I think the main difference is actually just this: "I'm OK with it" is newer. See, for instance, Google ngrams. (I wouldn't trust the sharp recent dropoff in "It's OK with me" - Google ngrams gets unreliable after about 2008.) But I don't know if that says anything about which expression you should use.

So in this context, after already having said, "I have no problem with this color" and then introducing a contrast with with "Yea, actually...", you have to say something that contrasts with the first statement. "I'm OK with it" would be a mistake since it doesn't contrast. "It's OK with me" works because although there's only a subtle contrast between the two, it's significant enough to count.

I went to a baby shower this weekend. Never did I think it would inspire me to write a blog, but as I sat there celebrating this new little person that would soon join our extended family, it reminded me of my journey.

When Joey was diagnosed at 15 months, my world came crashing down. My precious little baby would now have life-long struggles and my future for him was shattered. Will he walk? Will he talk? Will he be able to read? Will he have friends? Will he be happy? Will he be okay? Will I be okay?

PRISMS, Parents and Researchers Interested In Smith-Magenis Syndrome, is dedicated to providing information and support to families of persons with Smith-Magenis Syndrome (SMS), sponsoring research and fostering partnerships with professionals to increase awareness and understanding of SMS.

My name is Randi Tanenbaum from Manalapan, NJ. I am one of the Regional Representatives for New York and New Jersey. Our daughter Marnie, was born in 2016 and was diagnosed with SMS at 4 years of age. There are so many reasons why I feel compelled to represent PRISMS- when my family and I received our diagnosis the ONLY resource we had was PRISMS. The content from the site and the people we have spoken to has been invaluable. Without PRISMS we would be lost. This is a community of people who truly care about their families and I want to do the same locally.

My name is Jean Marie. I live in Louisville, KY. I am a single mother of an amazing SMSer, Nico. Nico was born in 2007 and diagnosed with SMS in 2008. I immediately joined PRISMS, Inc. to connect and for the support of other families that understand life with SMS. I work part time in administration for a residential provider for disabled adults and part time in a pediatric oncology inpatient unit as Registered Nurse. Annually, my family and I host a PRISMS fundraiser with the dream that PRISMS, Inc. will be able to offer even more support to SMS families in the future!

My name is Barbara Watson, and my husband and I have three children. We live in Latrobe, which is in southwestern PA. Our youngest, James (22 years old in 2024), was misdiagnosed throughout his childhood as having ADHD and autism. At 19 he was finally sent for genetic testing and we learned he had the mutation form of SMS. What a difference it would have made for James and our family if we had had a community of people like Prisms to offer advice and encouragement! I have learned a lot about accessing supports in our area, and about education: what worked and what did not for James. I am happy to share this experience or just chat about life with this challenging diagnosis.

Upon getting the diagnosis we found ourselves being guided on all sides towards PRISMS. Immediately I knew we had found our home; our people. I knew that from this point forward we were not alone and never had been.

Now, a year later, I am excited to be joining this group as one of the Regional Representatives for the state of Alaska. Our journey has been a tough one, but we have learned so much! I hope to bring this same knowledge to the table and offer compassion, insight, love and guidance to those families experiencing the same or similar things. Afterall, We are all on this journey together.

I am excited to be a Regional Representative for NC and help other families navigate this new road. It can seem overwhelming at times but the love that individuals with SMS show, far outweighs the challenging behaviors. I have often thought if we, as adults, would show affection like those with SMS do, the world would be a much better place. I look forward to serving my area and I hope you will reach out.

Connect with RoxanaCLOSEPatty Loyer

AZ, NEMy name is Patty Loyer. I moved to AZ from NC in 1996. Our family of four lives in Gilbert, Arizona. After our son, Joey, was born in 2000, he was diagnosed with SMS at 10 months old. PRISMS has helped us connect with other families, especially before the age of social media. It has also created a place for educators, respite/rehab and medical professionals to look to for guidance and care for this SMS road we are all on.

He has worked as an Internal Auditor for over 8 years and has auditing experience with banks, small non-profits, schools, and other financial services firms. He has been with Deloitte for 7 years, starting with their Internal Controls Group before transitioning to Internal Audit. In his position, he conducts various finance and operational audits for the firm.

My name is Ana Witherspoon, and I live in Spokane Valley, Washington. I have a younger brother who is diagnosed with SMS. He was born in 2004 and was diagnosed when he was 4 years old. I want to represent PRISMS because I want to get more involved with the SMS community and do my best to be a resource.

Allison began her work with PRISMS in 2017 when she joined the Conference Planning Committee and became a member of the Board of Directors in 2019. During her time with PRISMS, she has served on the Conference Planning Committee, the Education Committee and as a Regional Representative for the state of Georgia. Allison also designed and produced PRISMS first webinar program, with the goal of sharing critical information about Smith-Magenis Syndrome, in an easily accessible format.

Allison is a Web Developer for Michael Mackenzie Communications. She holds a Bachelor of Arts in Mass Communication from Louisiana State University and a Masters of Science in Computer Information Systems from Georgia State University.

Allison lives in Roswell, GA, with her husband Alex. In her free time, she enjoys spending time with her husband and three children, playing tennis and water sports. Her youngest daughter, Natalie, was diagnosed with SMS shortly after birth.

Michelle has a B.S. in Journalism and Mass Communications from Iowa State University. She has spent three decades working in public relations, marketing, sales promotion, and event planning in diverse industries including financial services, publishing, and entertainment. Before joining PRISMS, Michelle co-created and operated a successful event rental business for nine years.

Michelle is a native of Minnesota and recently moved to Raleigh, NC, where she lives with her family. Her hobbies include traveling, golfing, watching live music, walking her dog, and spending time with her family and friends.

Dr. Christopher Vlangos is the Senior Director of Clinical Genetics at Tempus AI. His work focuses on clinical assay development, lab management, and building novel technology products in human genetics. Dr. Vlangos received his undergraduate and graduate degrees from Michigan State University where he performed his studies in the lab of Dr. Sarah Elsea. His work in the Elsea lab focused on refining the Smith-Magenis syndrome critical deletion interval, building a physical genetic map of the SMS region, and positional cloning of genes within the SMS region.

Dr. Vlangos went on to pursue postdoctoral research projects at the University of Michigan in genetic causes of kidney disease and caudal birth defects. Prior to joining Tempus, he served at the University of Michigan Medical School as junior faculty in the Department of Pediatrics, and Assistant Professor in Pathology and Assistant Director of the Molecular Diagnostics Laboratory at Virginia Commonwealth University. Dr. Vlangos is board certified in Clinical Molecular Genetics by the American Board of Medical Genetics and Genomics. 152ee80cbc

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