Initial Rx

1. Glimepiride needs to be stopped and substituted by insulin. (1)

2. Basal bolus regimen with a total dose of 0.3/Kg/day units of insulin (lower end of starting dose) can be started. (2)

Better to avoid correctional insulin on the first day.

1. Moghissi ES, Korytkowski MT, DiNardo M, et al.; American Association of Clinical Endocrinologists;American Diabetes Association. American Association of Clinical Endocrinologists and American Diabetes Association consensus statement on inpatient glycemic control. Diabetes Care 2009;32:1119–1131
2. Insulin Order Sets & In-Hospital Management of Diabetes (Canadian Guidelines on in-hospital management of Diabetes)