Course description: Aims to develop deep quantitative understanding of basic forces of evolution, molecular evolution, genetic variations and their dynamics in populations, genetics of complex phenotypes, and genome-wide association studies. Application of these foundational concepts to cutting edge studies in epigenetics, gene regulation and chromatin; cancer genomics, and microbiomes.  Modules consist of lectures, journal club discussions of high impact publications, and guest lectures that provide clinical correlates. Homework assignments and final projects aim to develop hands-on experience and understanding of genomic data from evolutionary principles. 

No prerequisites -- please email us if you are unsure if this course is for you.

See syllabus and calendar page for more information

Reasons why you might want to take this course:

• You want to get a firm understanding of the evolutionary principles underlying modern genomics

• You want to develop the quantitative intuition to enable you to develop new genomic analyses

• You want to learn about both basic and clinical applications of genomics, gene expression analysis, and other sequencing-based technologies

• You want to carefully read important and cutting-edge papers across diverse topics in genomics, including, cancer genomics, association studies, the microbiome, single-cell genomics, and chromatin organization

Suggest textbooks: John H. Gillespie's Population Genetics: A Concise Guide and Graham Coop's PopGen Notes