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Background: Iron deficiency may impair aerobic performance. This study aimed to determine whether treatment with intravenous iron (ferric carboxymaltose) would improve symptoms in patients who had heart failure, reduced left ventricular ejection fraction, and iron deficiency, either with or without anemia.
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Methods: We enrolled 459 patients with chronic heart failure of New York Heart Association (NYHA) functional class II or III, a left ventricular ejection fraction of 40% or less (for patients with NYHA class II) or 45% or less (for NYHA class III), iron deficiency (ferritin level
Conclusions: Treatment with intravenous ferric carboxymaltose in patients with chronic heart failure and iron deficiency, with or without anemia, improves symptoms, functional capacity, and quality of life; the side-effect profile is acceptable. (ClinicalTrials.gov number, NCT00520780).
Prognostic value of three iron deficiency definitions in patients with advanced heart failure. / Papadopoulou, Charikleia; Reinhold, Johannes; Grner-Hegge, Nicolai; Kydd, Anna; Bhagra, Sai; Parameshwar, K. Jayan; Lewis, Clive; Martinez, Luis; Pettit, Stephen J.
N2 - Aims: There is uncertainty about the definition of iron deficiency (ID) and the association between ID and prognosis in patients with advanced heart failure. We evaluated three definitions of ID in patients referred for heart transplantation. Methods and results: Consecutive patients assessed for heart transplantation at a single UK centre between January 2010 and May 2022 were included. ID was defined as (1) serum ferritin concentration of
AB - Aims: There is uncertainty about the definition of iron deficiency (ID) and the association between ID and prognosis in patients with advanced heart failure. We evaluated three definitions of ID in patients referred for heart transplantation. Methods and results: Consecutive patients assessed for heart transplantation at a single UK centre between January 2010 and May 2022 were included. ID was defined as (1) serum ferritin concentration of
Name of the Study: HEART-FID/ Baseline characteristics of patients in the randomized study to investigate the efficacy and safety of ferric carboxymaltose as treatment for heart failure with iron deficiency
In patients with heart failure, iron deficiency is common and is associated with worse symptoms and outcomes than those in patients with heart failure without iron deficiency. The IRONOUT HF trial showed that oral iron therapy did not improve exercise capacity in patients who had heart failure with a reduced ejection fraction and iron deficiency. In contrast, other trials (AFFIRM-AHF, IRONMAN trials) showed that intravenous ferric carboxymaltose treatment improved the quality of life and functional capacity in patients who had heart failure with a reduced ejection fraction and iron deficiency. Ferric carboxymaltose therapy reduces symptoms and improves quality of life in patients who have heart failure with a reduced ejection fraction and iron deficiency. Additional evidence about the effects of ferric carboxymaltose on clinical events is needed.
The aim of this study was to evaluate the incidence of heart failure death and hospitalization with ferric carboxymaltose therapy in heart failure patients with reduced ejection fraction and iron deficiency.
Among the 8195 patients screened in the HEART-FID study, 3065 patients (Lvef < % 40 with iron deficiency) were included in this double-blind, randomized trial. Intravenous ferric carboxymaltose or placebo therapy was administered in two doses 7 days apart. Follow-up occurred every 3 months, with ferric carboxymaltose or placebo administered every 6 months on the basis of hemoglobin and iron indexes. The primary outcome was a hierarchical composite of death within 12 months after randomization, hospitalizations for heart failure within 12 months after randomization, or change from baseline to 6 months in the 6-minute walk distance.
Among patients with chronic systolic heart failure and iron deficiency, IV ferric carboxymaltose although there is no statistically significant difference was associated with a marginal improvement in cardiovascular outcomes compared with placebo. IV ferric carboxymaltose appeared to be safe. Further research on the topic appears warranted. 0852c4b9a8
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