SARS eFiling is a free, online process for the submission of returns and declarations and other related services. This free service allows taxpayers, tax practitioners and businesses to register free of charge and submit returns and declarations, make payments and perform a number of other interactions with SARS in a secure online environment.

There are multiple ways in which SARS-CoV-2 viruses are classified. Each classification type can be appropriate, depending on the context in which SARS-CoV-2 is being communicated. SARS-CoV-2 is often discussed in the context of lineages (and sublineages). The most commonly used classification system for lineages is Pango. Nextclade may also be used in this context. In a larger context, lineages or groups of related lineages may be classified using Greek letters (such as Omicron) by the World Health Organization (WHO). These classification methods enable scientists to communicate similarities and differences between SARS-CoV-2 viruses.


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Our objective here is to introduce a naming system that facilitates discussion of large scale diversity patterns of SARS-CoV-2 and label clades that persist for at least several months and have significant geographic spread. This objective is distinct from and complementary to Rambaut et al. 2020 (1), who proposed a dynamic system for labeling transient lineages that have local epidemiological significance. Their proposal results in a large number of short lived labels that maintain some information on the hierarchical structure and facilitate discussion of local short term dynamics, but are not intended to provide large scale structure.

Definition of major clades

We propose to name a new major clade when it reaches a frequency of 20% globally. When calculating these frequencies, care has to be taken to achieve approximately even sampling of sequences in time and space since sequencing effort varies strongly between countries. A clade name consists of the year it emerged and the next available letter in the alphabet. A new clade should be at least 2 mutations away from its parent major clade.

Ying Liu, Albert A Gayle, Annelies Wilder-Smith, Joacim Rocklv, The reproductive number of COVID-19 is higher compared to SARS coronavirus, Journal of Travel Medicine, Volume 27, Issue 2, March 2020, taaa021,

All active SARs are required to complete LSAM Training prior to gaining access to the LSAM. The LSAM Training link is located on the VIP main page. To register for LSAM training, SARs must submit a copy of their SAR approval letter to CoreLogic at: VA_Helpdesk.DARS@CoreLogic.com. If you do not have a copy, contact SAR Support for assistance.

In letters to several banks where Hunter Biden and Biden family members have accounts, Ranking Member Comer requests all financial records, documents, and communications related to suspicious activity reports generated for Hunter Biden, his business partners, and other members of the Biden family.

Minister De Jonge and minister Schouten send a letter about the situation regarding SARS-CoV-2 infections on mink farms, the advisory opinion of the Outbreak Management Team for Zoonoses (OMT-Z) and future policy on mink farms.

On 15 March 2023, WHO announced that, going forward, the Greek letters will only be assigned to VOCs, while VOIs will be referred to using established scientific nomenclature systems such as those used by Nextstrain and Pango (e.g. XBB.1.5/23A for the latest VOI). WHO and TAGVE will undertake regular risk assessments for both VOIs and VOCs.

Efficacy was calculated in around 28,000 people from 18 to 94 years of age who had no sign of previous infection. The trial showed a 94.1% reduction in the number of symptomatic COVID-19 cases in the people who received the vaccine (11 out of 14,134 vaccinated people got COVID-19 with symptoms) compared with people who received dummy injections (185 out of 14,073 people who received dummy injections got COVID-19 with symptoms). This means that the vaccine demonstrated a 94.1% efficacy in the trial. The trial also showed 90.9% efficacy in participants at risk of severe COVID-19, including those with chronic lung disease, heart disease, obesity, liver disease, diabetes or HIV infection.

Allergic reactions (hypersensitivity) have been seen in people receiving the vaccine. A very small number of cases of anaphylaxis (severe allergic reaction) have occurred. Therefore, as for all vaccines, Spikevax, including the adapted vaccines, should be given under close medical supervision, with the appropriate medical treatment available in case of allergic reactions. People who have a severe allergic reaction when they are given a dose of Spikevax or its adapted vaccines should not receive subsequent doses.

A very small number of cases of erythema multiforme (red patches on the skin with a dark red centre and paler red rings) have occurred. Allergic reactions have also occurred in people receiving the vaccine, including a very small number of cases of severe allergic reactions (anaphylaxis).

A number of diagnostic tests for SARS-CoV-2 infection (e.g., NAATs, antigen tests) have received Food and Drug Administration (FDA) Emergency Use Authorizations (EUAs) for use in laboratories and points of care (e.g., physician offices, pharmacies, long-term care facilities, school clinics) and for self-administered testing.3 An influenza and SARS-CoV-2 multiplex NAAT that can simultaneously detect and differentiate between influenza A, influenza B, and SARS-CoV-2 also received an EUA from the FDA.4 The FDA also granted authorization to market the first over-the-counter, at-home, molecular NAAT (i.e., Cue COVID-19) and antigen test (i.e., Flowflex COVID-19) for use in people with symptomatic COVID-19.

Reinfection has been reported in people after an initial diagnosis of SARS-CoV-2 infection. Because reinfection can be difficult to distinguish from persistent shedding (i.e., positive NAAT results persisting for weeks or months), the CDC recommends using an antigen test instead of a NAAT in patients who have symptoms compatible with SARS-CoV-2 infection who are within 90 days of recovering from a previous SARS-CoV-2 infection. Because intermittent detection of viral RNA can occur, a negative result on an initial NAAT followed by a positive result on a subsequent test does not necessarily mean a person has been reinfected.11 When the results for an initial and subsequent test are positive, comparative viral sequence data from both tests are needed to distinguish between the persistent presence of viral fragments and reinfection. In the absence of viral sequence data, the cycle threshold (Ct) value from a positive NAAT result may provide information about whether a newly detected infection is related to the persistence of viral fragments or to reinfection. The Ct value is the number of PCR cycles at which the nucleic acid target in the sample becomes detectable. In general, the Ct value is inversely related to the SARS-CoV-2 viral load. Because the clinical utility of Ct values is unclear, an expert should be consulted if these values are used to guide clinical decisions.

Banks use a number of methods to identify potentially suspicious activity, including but not limited to activity identified by employees during day-to-day operations, law enforcement inquiries, or requests, such as those typically seen in section 314(a) and section 314(b) requests, advisories issued by regulatory or law enforcement agencies, transaction and surveillance monitoring system output, or any combination of these.

The BSAR includes a number of additional data elements pertaining to the type of suspicious activity and the financial services involved. Certain fields in the BSAR are marked as "critical" for technical filing purposes. This means the BSA E-Filing System will not accept filings in which these fields are left blank. For these items, the bank must either provide the requested information or check the "unknown" box that is provided with each critical field. Banks should provide the most complete filing information available consistent with existing regulatory expectations, regardless of whether or not the individual fields are deemed critical for technical filing purposes. 68Refer to Filing FinCEN's new Currency Transaction Report and Suspicious Activity Report, FIN-2012-G002, March 29, 2012.

A number of retirees have reported receiving a letter from PBI (Pension Benefit Information, LLC), indicating that personal information about the retiree was on a server that had been exploited by an unauthorized third party.

N1 - Funding Information:The original article this letter relates to was supported in part by a gift to the Keck School of Medicine of the University of Southern California by the W.M. Keck Foundation.

The Impact Factor measures the average number of citations received in a particular year by papers published in the journal during the two preceding years.


 Clarivate Analytics, Journal Citation Reports 2022

Please include the following items when submitting your revised manuscript: A rebuttal letter that responds to each point raised by the academic editor and reviewer(s). You should upload this letter as a separate file labeled 'Response to Reviewers'. A marked-up copy of your manuscript that highlights changes made to the original version. You should upload this as a separate file labeled 'Revised Manuscript with Track Changes'. An unmarked version of your revised paper without tracked changes. You should upload this as a separate file labeled 'Manuscript'. If you would like to make changes to your financial disclosure, please include your updated statement in your cover letter. Guidelines for resubmitting your figure files are available below the reviewer comments at the end of this letter.

If applicable, we recommend that you deposit your laboratory protocols in protocols.io to enhance the reproducibility of your results. Protocols.io assigns your protocol its own identifier (DOI) so that it can be cited independently in the future. For instructions see: -guidelines#loc-laboratory-protocols. Additionally, PLOS ONE offers an option for publishing peer-reviewed Lab Protocol articles, which describe protocols hosted on protocols.io. Read more information on sharing protocols at _medium=editorial-email&utm_source=authorletters&utm_campaign=protocols. e24fc04721

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