Dr. Hironmoy Sarkar
Assistant Professor (Stage II)
Department of Microbiology
Raiganj University
West bengal -733134
Email: h.sarkar@raiganjuniversity.ac.in
M.Sc. - Bangalore University
Ph.D. - Delhi University
ORCID: 0000-0001-9713-0300
Research Interest:
Development of drug combination to counter antibiotic Resistance:
High occurrences of antibiotic resistance in bacteria are becoming an emerging problem worldwide. We are running out of antimicrobial drugs to counter the rapid rate of antibiotic resistance. There is an urgent need to develop new drugs or combinations of existing drugs that can effectively inhibit the growth and occurrence of antibiotic resistance. To solve this problem, we are investigating the effectiveness of FDA-approved drugs as antimicrobials in combination with antibiotics.
Cell-fate decision from mitosis to meiosis:
Cells undergo transformation within to achieve a specific stable phenotype through cell-fate decisions. The fundamental aspect of this is to convert momentary changes in gene expression by external signals. An important and very much coordinate cell-fate decision is the generation of haploid gametes from diploid progenitor cells by the process of gametogenesis. A fundamental aspect of gametogenesis is the specialized cell division, meiosis. This is unique to sexually reproducing organisms. The meiotic cell cycle generates the gametes that are crucial for the survival and evolution of species. The key feature of meiosis is the expression of genes that transform the mitotic cell division into the specialized meiotic divisional programme. The understanding of intrinsic and extrinsic factors responsible for changes of cell-fate decision from mitosis to meiosis is crucial to understand of the important biological process, meiosis.
Publications:
[In Pubmed]
Chakraborty J, Mondal R, Sultana J, Banerjee S, Mandal AK, Sarkar H*. Repurposing of dibucaine and niflumic acid as antimicrobial agentsin combination with antibiotics against Staphylococcus aureus. The Journal of Antibiotics (2024), DOI: 10.1038/s41429-024-00759-7, IF:3.3 (* corresponding author)
Deepyaman Das, Anis Ahmad Chaudhary, Mohamed A. M. Ali, Abdullah S. Alawam, Hironmoy Sarkar*, Soumita Podder*. Insights into the identification and evolutionary conservation of key genes in the transcriptional circuits of meiosis initiation and commitment in budding yeast. FEBS Openbio. 2023; 13(12):2290-2305. https://doi.org/10.1002/2211-5463.13728 IF: 2.6
Chakraborty J, Chaudhary AA, Khan SU, Rudayni HA, Rahaman SM, Sarkar H*. CRISPR/Cas-Based Biosensor As a New Age Detection Method for Pathogenic Bacteria. ACS Omega. 2022;7(44):39562-39573. doi: 10.1021/acsomega.2c04513. PMID: 36385843. IF: 4.1
Joydeep Chakraborty, Atanu Maity & Hironmoy Sarkar*. A systematic drug repurposing approach to identify promising inhibitors from FDA-approved drugs against Nsp4 protein of SARS-CoV-2. Journal of Biomolecular Structure and Dynamics (2021), 41;2:550-559 . https://doi.org/10.1080/07391102.2021.2009033. IF:3.4
Bhattacharya I, Sharma SS,Sarkar H, Gupta A, Pradhan BS, Majumdar SS.FSH mediated cAMP signalling upregulates the expression of Gα subunits in pubertal rat Sertoli cells. Biochem Biophys Res Commun. (2021),5;569:100-105. doi: 10.1016/j.bbrc.2021.06.094 . IF:2.98
Das S, Sarkar H*, Podder S*. In-silico identification of key regulators instigating the pre-meiotic phase during respiration in Saccharomyces cerevisiae. FEMS Yeast Research. 2021.18;21(2).foab006. Doi: 10.1093/femsyr/foab006. IF: 3.193 *Corresponding authors
Indrashis Bhattacharya, Sayon Basu, Bhola Shankar Pradhan, Hironmoy Sarkar, Perumal Nagarajan, Subeer S Majumdar . Testosterone augments FSH signaling by upregulating the expression and activity of FSH-Receptor in Pubertal Primate Sertoli cells. Mol Cell Endocrinol (2019). 482:70-80. DOI: 10.1016/j.mce.2018.12.012. PMID: 30579957, IF: 3.6
Indrashis Bhattacharya, Hironmoy sarkar, Subeer S Majumdar. The Effect of Pulsatile Hormonal Stimulation on Gene Expression in Cultured Rat Sertoli Cells. Journal of Endocrinology and Reproduction (2018), Vol 22(1), 44-54, DOI: 10.18311/jer/2018/23491.
Indrashis Bhattacharya, Mukesh Gautam, Hironmoy Sarkar,Mansi Shukla,and Subeer S Majumdar. Advantages of pulsatile hormone treatment for assessing hormone induced gene expression by cultured rat Sertoli cells.Cell and Tissue Research (2017). 368(2):389-396; DOI: 10.1007/s00441-016-2410-1; PMID: 27139181; IF: 3
Abul Usmani, Nirmalya Ganguli, Subodh Jain, Nilanjana Ganguli, Rajesh Sarkar, Mayank Choubey, Mansi Shukla, Hironmoy Sarkar, and Subeer Majumdar. Robust generation of transgenic mice by simple hypotonic solution mediated delivery of transgene in testicular germ cells. Mol Ther Methods Clin Dev (2016). 3: 16076; DOI: 10.1038/mtm.2016.76; PMID: 27933305; IF: 4.5
Hironmoy Sarkar, Satyapal Arya, Umesh Rai, and Subeer S. Majumdar. A study of differential expression of testicular genes in various reproductive phases of Hemidactylusflaviviridis (wall lizard) to derive their association with onset of spermatogenesis and its relevance to mammals. PlosOne (2016).11(3): e0151150. DOI:10.1371/journal.pone.0151150; PMID: 26963275, IF: 2.74
Indrashis Bhattacharya, Sayon Basu, Kanchan Sarda, Mukkesh Gautam, Perumal Nagarajan, Bhola Shankar Pradhan, Hironmoy Sarkar, Yendrembam Sangeeta Devi, and Subeer S. Majumdar. Low Levels of Gαs and Ric8b in Testicular Sertoli Cells May Underlie Restricted FSH Action During Infancy in Primates. Endocrinology (2015). 156(3):1143-55. DOI: 10.1210/en.2014-1746; PMID:25549048;IF: 3.96
Abul Usmani, Nirmalya Ganguli,Hironmoy Sarkar, SuveeraDhup, Suryaprakash R. Batta, Manoj Vimal, NilanjanaGanguli, SayonBasu, P. Nagarajan, and Subeer S. Majumdar.A non-surgical approach for male germ cell mediated gene transmission through transgenesis.Scientific Reports (2013). 3: 3430. DOI: 10.1038/srep03430; PMID: 24305437; IF: 3.99
Patent:
Application no: 202331036080
Published on The Patent Office Journal No. 22/2023; Dated 02/06/2023; Page no: 40830
Present PhD Students:
Joydeep Chakraborty - joydeep.chakraborty.211@gmail.com (ORCID: 0000-0002-6699-4074)
Deepyaman Das - deepyaman.das@gmail.com (ORCID: 0000-0002-0514-1916)
Extramural funding:
Open Positions:
Open position for PhD Student: Interested student , preferably MSc in microbiology, can contact by email.