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The fruit is edible and rich in vitamin A and has some vitamin C; it is used in a variety of ways as a food and as a meat tenderizer. Chymopapain has been employed, with remarkable success, as an intervertebral disk injection in the lumbar spine (chemonucleolysis). For this purpose, it is recommended that the drug should be administered under local anesthesia rather than under general anesthesia.369 The leaves have been shown to possess antiplasmodial activity against both chloroquine-sensitive and chloroquine-resistant P. falciparum.370

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Aqueous extract of Carica papaya (CP) leaves exhibited antitumor activity and immunomodulatory effects.371 In human peripheral blood mononuclear cells (PBMCs), the production of IL-2 and IL-4 was reduced following the addition of CP extract, whereas that of IL-12p40, IL-12p70, interferon gamma (IFN-), and TNF- was enhanced without growth inhibition. In addition, cytotoxicity of activated PBMCs against K562 was enhanced by the addition of CP extract. Moreover, microarray analyses showed that the expression of 23 immunomodulatory genes, classified by gene ontology analysis, was enhanced by the addition of CP extract. In this regard, CCL2, CCL7, CCL8, and SERPIN B2 were representative of these upregulated genes and thus may serve as index markers of the immunomodulatory effects of CP extract. It is interesting to note that the identified active components of CP extract, which inhibited tumor cell growth and stimulated antitumor effects, have a molecular weight of less than 1000. It has been suggested that the CP leaf extract may potentially provide the means for the treatment and prevention of selected human diseases, such as cancer and various allergic disorders, and may also serve as a immunoadjuvant for vaccine therapy.372 006ab0faaa