Publications
PEER REVIEWED RESEARCH (open access noted with*)
1. Forman, H.J. and Feigelson, P.
Kinetic evidence indicating the absence during catalysis of an unbound ferroprotoporphyrin form of tryptophan oxygenase.
Biochemistry 10: 760‑763, 1971. PMID: 5544666
2. Brady, F.O., Forman, H.J. and Feigelson, P.
The role of superoxide and hydroperoxide in the reductive activation of tryptophan‑2,3‑dioxygenase.
J. Biol. Chem. 246: 7119‑7124, 1971.* PMID: 5167018
3. Forman, H.J. and Feigelson, P.
The effects of allosteric interaction on the kinetics, spectra and tertiary structure of Pseudomonad tryptophan oxygenase.
J. Biol. Chem. 247: 256‑259, 1972.* PMID: 5017765
4. Forman, H.J. and Fridovich, I.
Electrolytic univalent reduction of oxygen in aqueous solution demonstrated with superoxide dismutase.
Science 175: 339, 1972.* PMID: 17814545
5. Brady, F.O., Monaco, M.E., Forman, H.J., Schutz, G. and Feigelson, P.
On the role of copper in activation and catalysis by tryptophan‑2,3‑dioxygenase.
J. Biol. Chem. 247: 7915‑7922, 1972.* PMID: 4640930
6. Forman, H.J., Evans, H.J., Hill, R.L. and Fridovich, I.
Histidine at the active site of superoxide dismutase.
Biochemistry 12: 823‑827, 1973.* PMID: 4346922
7. Forman, H.J. and Fridovich, I.
On the stability of bovine superoxide dismutase: the effects of metals.
J. Biol. Chem. 248: 2645‑2649, 1973.* PMID: 4697386
8. Forman, H.J. and Fridovich, I.
Superoxide dismutase: a comparison of rate constants.
Arch. Biochem. Biophys. 158: 396‑400, 1973. PMID: 4354035
9. Forman, H.J., Waddell, R., Hamilton, P.B. and Grisolia, S.
Activation of carbamyl phosphate synthase by N‑acetyl‑L‑aspartate.
Biochem J. 143: 63‑66, 1974. * PMID: 4377221
10. Forman, H.J. and Grisolia, S.
The effects of cyanate, carbamyl phosphate and growth on the glutamine dependent carbamyl phosphate synthetase from rat spleen and brain.
Physiol. Chem. & Physics 6: 213‑233, 1974. PMID: 4500013
11. Forman, H.J. and Kennedy, J.A.
Role of superoxide radical in mitochondrial dehydrogenase reactions.
Biochem. Biophys. Res. Commun. 60: 1044‑1050, 1974. PMID: 4372996
12. Forman, H.J. and Kennedy, J.
Superoxide production and electron transport in mitochondrial oxidation of dihydroorotic acid.
J. Biol. Chem. 250: 4322‑4326, 1975.* PMID: 165196
13. Forman, H.J. and Kennedy, J.
Dihydroorotate dependent superoxide production in rat brain and liver; a function of the primary dehydrogenase.
Arch. Biochem. Biophys. 173: 219‑224, 1976. PMID: 176947
14. Forman, H.J. and Kennedy, J.
Effects of chaotropic agents versus detergents on dihydroorotate dehydrogenase.
J. Biol. Chem. 252: 3379‑3387, 1977.* PMID: 193834
15. Forman, H.J. and Kennedy, J.
Purification and characterization of the superoxide producing primary dihydroorotate dehydrogenase from rat liver mitochondria.
Preparative Biochemistry 7: 345‑355, 1977. PMID: 199900
16. Forman, H.J. and Kennedy, J.
Mammalian dihydroorotate dehydrogenase: Physical and catalytic properties of the primary enzyme.
Arch. Biochem. Biophys. 191: 23‑31, 1978. PMID: 216313
17. Forman, H.J., York, J.L. and Fisher, A.B.
Mechanism for the potentiation of oxygen toxicity by disulfiram.
J. Pharmacol. Exp. Ther. 212: 452‑455, 1980. PMID: 6244385
18. Kravetz, G., Fisher, A.B. and Forman, H.J.
The oxygen‑adapted rat model: tolerance to oxygen at 1.5 and 2 ata.
Aviat. Space Environ. Med. 51: 775‑777, 1980. PMID: 7417143
19. Arad, I.D., Forman, H.J. and Fisher, A.B.
Ascorbate efflux from guinea pig and rat lungs: effect of starvation and O2 exposure.
J. Lab. Clin. Med. 96: 673‑681, 1980. PMID: 6252268
20. Forman, H.J., Nelson, J. and Fisher, A.B.
Rat alveolar macrophages require NADPH for superoxide production in the respiratory burst.
J. Biol. Chem. 255: 9879‑9883, 1980.* PMID: 6253456
21. Forman, H.J. and Fisher, A.B.
Antioxidant enzymes in rat granular pneumocytes: constitutive levels and effect of hyperoxia.
Lab. Invest. 45: 1‑6, 1981. PMID: 6894775
22. Jowa, L.B., Fisher, A.B. and Forman, H.J.
Glucose‑dependent chemiluminescence by resting rat alveolar macrophages.
J. Reticuloendothelial Soc. 30: 99‑105, 1981. PMID: 7277359
23. Forman, H.J., Aldrich, T.K., Posner, M.A. and Fisher, A.B.
Differential paraquat accumulation and redox kinetics in rat lung cells.
J. Pharmacol. Exp. Ther. 221: 428‑433, 1982. PMID: 7077538
24. Forman, H.J., Williams, J.J., Nelson, J., Daniele, R.P. and Fisher, A.B.
Hyperoxia inhibits stimulated superoxide release by rat alveolar macrophages.
J. Appl. Physiol. 53: 685‑689, 1982. PMID: 6290436
25. Aldrich, T.K., Fisher, A.B. and Forman, H.J.
Paraquat inhibits mixed‑function oxidation by rat lung.
J. Appl. Physiol. 54: 1089‑1096, 1983. PMID: 6853285
26. Forman, H.J. and Nelson, J.
Effect of extracellular calcium on superoxide release by rat alveolar macrophages.
J. Appl. Physiol. 54: 1249‑1253, 1983. PMID: 6305896
27. Cameron, A.R., Nelson, J., and Forman, H.J.
Depolarization and increased conductance precede superoxide release by concanavalin A stimulated rat alveolar macrophages.
Proc. Natl. Acad. Sci. USA 80: 3726‑3728, 1983.* PMCID: PMC394123
28. Forman, H.J., Rotman, E.I. and Fisher, A.B.
The roles of selenium and sulfur‑containing amino acids in protection against oxygen toxicity.
Lab. Invest. 49: 148‑153, 1983. PMID: 6876743
29. Glass, M., Sutherland, M.W., Forman, H.J. and Fisher, A.B.
Selenium deficiency potentiates paraquat‑induced lipid peroxidation in isolated perfused rat lung.
J. Appl. Physiol. 59: 619‑622, 1985. PMID: 4030615
30. Sutherland, M.W., Glass, M., Nelson, J., Lyen, Y. and Forman, H.J.
Oxygen toxicity: loss of lung macrophage function without metabolite depletion.
J. Free Radic. Biol. Med. 1: 209‑214, 1985. PMID: 3013977
31. Sutherland, M.W., Nelson, J., Harrison, G. and Forman, H.J.
The effect of t‑butyl hydroperoxide on NADPH, glutathione and the respiratory burst of rat alveolar macrophages.
Arch. Biochem. Biophys. 243: 325‑331, 1985. PMID: 3002274
32. Forman, H.J., Nelson, J. and Harrison, G.
Hyperoxia alters the effect of Ca2+ on rat alveolar macrophage superoxide production.
J. Appl. Physiol. 60: 1300‑1305, 1986. PMID: 3009390
33. Glass, M., Forman, H.J., Rotman, E.I., Clark, J.M., Pietra, G.G. and Fisher, A.B.
Bronchoalveolar polymorphonuclear leukocytes in pulmonary oxygen toxicity.
J. Hyperbaric Med. 1: 107‑121, 1986.
34. Harrison, G. and Forman, H.J.
Progressive loss of the macrophage respiratory burst in oxygen toxicity.
J. Free Radic. Biol. Med. 2: 129‑134, 1986. PMID: 3819334
35. Dorio, R.J., Nelson, J. and Forman, H.J.
A dual role for calcium in the regulation of superoxide generation by stimulated rat alveolar macrophages.
Biochim. Biophys. Acta 928: 137-143, 1987. PMID: 3032276
36. Forman, H.J., Dorio, R.J. and Skelton, D.C.
Hydroperoxide induced damage to alveolar macrophage function and membrane integrity: alterations in intracellular free Ca2+ and membrane potential.
Arch. Biochem. Biophys. 259: 457-465, 1987. PMID: 2827576
37. Dorio, R.J. and Forman, H.J.
Ethanol inhibition of signal transduction in superoxide production by rat alveolar macrophages: A proposed mechanism for ethanol-related pneumonia.
Ann. Clin. Lab. Sci. 18: 190-194, 1988.* PMID: 2839095
38. Dorio, R.J., Hoek, J.B., Rubin, E. and Forman, H.J.
Ethanol modulation of rat alveolar macrophage superoxide production.
Biochem. Pharmacol. 37: 3528-3531, 1988. PMID: 2844192
39. Robison, T.W., Duncan, D.P. and Forman, H.J.
Kinetics of uptake and distribution of arachidonic acid by rat alveolar macrophages.
Prostaglandins 36: 443-461, 1988. PMID: 3238001
40. Loeb, G.A., Skelton, D.C., Coates, T.D. and Forman, H.J.
Role of the selenium-dependent glutathione peroxidase in antioxidant defense in rat alveolar macrophages.
Exp. Lung Res. 14: 921-936, 1988. PMID: 2783166
41. Ryer-Powder, J.E. and Forman, H.J.
Adhering lung macrophages produce superoxide demonstrated with Desferal-Mn(IV).
Free Radic. Biol. Med. 6: 513-518, 1989. PMID: 2545553
42. Loeb, G.A., Skelton, D.C. and Forman, H.J.
Dependence of mixed disulfide formation in alveolar macrophages upon production of oxidized glutathione: effect of selenium deficiency.
Biochem. Pharmacol. 38: 3119-3122, 1989. PMID: 2783166
43. Warburton, D., Buckley, S., Cosico, L. and Forman, H.J.
Sublethal oxidant injury inhibits signal transduction in rat type II pneumocytes.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 257: L217-L220, 1989. PMID: 2552828
44. Forman, H.J. and Kim, E.
Inhibition by linoleic acid hydroperoxide of rat alveolar macrophage superoxide production: effects upon mitochondrial and plasma membrane potentials.
Arch. Biochem. Biophys. 274: 443-452, 1989. PMID: 2552924
45. Robison, T.W., Duncan, D.P. and Forman, H.J.
Chemoattractant and leukotriene B4 production from rat alveolar macrophages exposed to nitrogen dioxide.
Am. J. Respir. Cell Mol. Biol. 3: 21-26, 1990. PMID: 2163652
46. Forman, H.J. and Skelton, D.C.
Protection of alveolar macrophages from hyperoxia by g-glutamyl transpeptidase.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 259: L102-L107, 1990. PMID: 1974390
47. Robison, T.W., Duncan, D.P., Coates, T.D. and Forman, H.J.
Inhibition of production of LTB4 and chemoattractant from rat alveolar macrophages treated with t-butyl hydroperoxide is independent of ATP depletion.
Biochim. Biophys. Acta 1045: 9-16, 1990. PMID: 2164422
48. Robison, T.W., Sevanian, A. and Forman, H.J.
Inhibition of arachidonic acid release by nordihydroguaiaretic acid and its antioxidant action in rat alveolar macrophages and Chinese hamster lung fibroblasts.
Toxicol. Appl. Pharmacol. 105: 113-122, 1990. PMID: 2118282
49. Robison, T.W. and Forman, H.J.
t‑Butylhydroperoxide stimulates alveolar macrophage biosynthesis of cyclooxygenase products.
Prostaglandins 40: 13-28, 1990. PMID: 2117767
50. Walther, F.J., Wade, A.B., Warburton, D. and Forman, H.J.
Ontogeny of antioxidant enzymes in the fetal lamb lung.
Exp. Lung Res. 17: 39-45, 1991. PMID: 2013272
51. Walther, F.J., Wade, A.B., Warburton, D. and Forman, H.J.
Augmentation of superoxide dismutase activity in alveolar type II cells.
Am. J. Respir. Cell Mol. Biol. 4: 364-368, 1991. PMID: 1901719
52. Heisterkamp, N., Rajpert-De Meyts, E., Uribe, L., Forman, H.J. and Groffen, J.
Identification of a novel human g-glutamyl cleaving enzyme related to g-glutamyl transpeptidase.
Proc. Natl. Acad. Sci. USA 88: 6303-6307, 1991.* PMCID: PMC52071
53. Chang, M., Shi, M. and Forman, H.J.
Exogenous glutathione protects endothelial cells from menadione toxicity.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 262: L637-643, 1992. PMID: 1350424
54. Rajpert-De Meyts, E., Shi, M., Chang, M., Robison,T.W., Groffen, J., Heisterkamp, N. and Forman, H.J.
Transfection with g-glutamyl transpeptidase enhances recovery from glutathione depletion using extracellular glutathione.
Toxicol. Appl. Pharmacol. 114: 56-62, 1992. PMID: 1350117
55. Livingston, F.R., Lui, E., Loeb, G. and Forman, H.J.
Sublethal oxidant stress induces a reversible increase in intracellular calcium dependent on NAD(P)H oxidation in rat alveolar macrophages.
Arch. Biochem. Biophys. 299: 83-91, 1992. PMID: 1444455
56. Robison, T.W. and Forman, H.J.
Dual effects of nitrogen dioxide upon rat alveolar macrophage arachidonate metabolism.
Exp. Lung Res.19: 21-36, 1993. PMID: 8440201
57. Robison, T.W., Murphy, J.K., Beyer, L.L., Richters, A. and Forman, H.J.
Depression of stimulated arachidonate metabolism and superoxide production in rat alveolar macrophages following in vivo exposure to 0.5 ppm NO2.
J. Toxicol. Environ. Health 38: 273-292, 1993. PMID: 8383773
58. Murphy, J.K. and Forman, H.J.
Effects of sodium and pH upon the respiratory burst and pH regulation of rat alveolar macrophages.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 264: L523-532, 1993.* PMID: 8388649
59. Shi, M., Gozal, E., Choy, H.A. and Forman, H.J.
Extracellular glutathione and g-glutamyl transpeptidase prevent H2O2-induced injury by 2,3-dimethoxy-1,4-naphthoquinone.
Free Radic. Biol. Med. 15: 57-67, 1993. PMID: 8103030
60. Murphy, J.K., Livingston, F.R., Gozal, E., Torres, M. and Forman, H.J.
Stimulation of the rat alveolar macrophage respiratory burst by extracellular adenine nucleotides.
Am. J. Respir. Cell Mol. Biol. 9: 505-510, 1993. PMID: 8217191
61. Shi, M., Iwamoto, T. and Forman, H.J.
g-Glutamylcysteine synthetase and glutathione increase in quinone-induced oxidative stress in bovine pulmonary artery endothelial cells.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 267: L414-L421, 1994. PMID: 7943345
62. Shi, M.M., Kugelman, A., Iwamoto, T., Tian, L. and Forman, H.J.
Quinone-induced oxidative stress elevates glutathione and induces g-glutamylcysteine synthetase activity in rat lung epithelial L2 cells.
J. Biol. Chem. 269: 26512-26517, 1994.* PMID: 7929374
63. Kugelman, A., Choy, H.A., Liu, R.M., Shi, M., Gozal, E. and Forman, H.J.
g-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L-2 epithelial cells.
Am. J. Respir. Cell Mol. Biol. 11: 586-592, 1994.* PMID: 7946387
64. Murphy, J.K., Livingston, F.R., Duncan, D.P., Hoyal, C. and Forman, H.J.
Modulation of the alveolar macrophage respiratory burst by hydroperoxides.
Free Radic. Biol. Med. 18: 37-45, 1995. PMID: 7896169
65. Thomas, M.J., Robison, T.W., Samuel, M. and Forman, H.J.
Detecting and identifying volatile aldehydes as dinitrophenylhydrazones using gas chromatography mass spectrometry.
Free Radic. Biol. Med. 18: 553-557, 1995. PMID: 9101246
66. Robison, T.W., Zhou, H. and Forman, H.J.
Modulation of ADP-stimulated inositol phosphate metabolism in rat alveolar macrophages by oxidative stress.
Arch. Biochem. Biophys. 318: 215-220, 1995. PMID: 7726564
67. Robison, T.W., Samuel, M., Forman, H.J. and Thomas, M.J.
Release of aldehydes from rat alveolar macrophages exposed in vitro to low concentrations of nitrogen dioxide.
Biochim. Biophys. Acta 1256: 334-340, 1995. PMID: 7786896
68. Liu, R.-M., Hu, H., Robison, T.W. and Forman, H.J.
Differential enhancement of g-glutamyl transpeptidase and g-glutamylcysteine synthetase by tert-butylhydroquinone in rat lung epithelial L2 cells.
Am. J. Respir. Cell Mol. Biol. 14: 186-191, 1996. PMID: 8630269
69. Liu, R.-M., Hu, H., Robison, T.W. and Forman, H.J.
Increased g-glutamylcysteine synthetase and g-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity.
Am. J. Respir. Cell Mol. Biol. 14: 192-197, 1996. PMID: 8630270
70. Hoyal, C.R., Gozal, E., Zhou, H., Foldenauer, K. and Forman, H.J.
Modulation of the rat alveolar macrophage respiratory burst by hydroperoxides is calcium dependent.
Arch. Biochem. Biophys. 326: 166-171, 1996. PMID: 8579366
71. Kaul, N. and Forman, H.J.
Activation of NF-κB by the respiratory burst of macrophages.
Free Radic. Biol. Med. 21: 401-405, 1996. PMID: 8855453
72. Hoyal, C.R., Thomas, A.P. and Forman, H.J.
Hydroperoxide-induced increases in intracellular calcium due to annexin VI translocation and inactivation of plasma membrane Ca2+-ATPase.
J. Biol. Chem. 271: 29205-29210, 1996.* PMID: 8910578
73. Qiu, X., Forman, H.J., Schönthal, A.H. and Cadenas, E.
Induction of p21 mediated by reactive oxygen species during the metabolism of aziridinylbenzoquinones by HCT116 cells.
J. Biol. Chem. 271: 31915-31921, 1996. PMID: 8943236
74. Choi, J., Liu, R.-M. and Forman, H.J.
Adaptation to oxidative stress: Quinone-mediated protection of signaling in rat lung epithelial L2 cells.
Biochem. Pharmacol. 53: 987-993, 1997. PMID: 9174112
75. Tian, L., Shi, M.M. and Forman, H.J.
Increased transcription of the regulatory subunit of g-glutamylcysteine synthetase in rat lung epithelial L2 cells exposed to oxidative stress or glutathione depletion.
Arch. Biochem. Biophys. 342: 126-133, 1997. PMID: 9185621
76. Zhou, H., Duncan, R.F., Robison, T.W. and Forman, H.J.
Ca2+-dependent p47phox translocation in hydroperoxide modulation of the alveolar macrophage respiratory burst.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 273: L1042-L1047, 1997.* PMID: 9374733
77. Anderson, C.P., Tsai, J., Park, C.K., Tian, L., Liu, R.M., Forman, H.J. and Reynolds, C.P.
Buthionine sulfoximine alone and in combination with melphalan is highly cytotoxic for human neuroblastoma cells.
Eur. J. Cancer 33: 2016-2019, 1997. PMID: 9516845
78. Suzuki, Y.J., Forman, H.J. and Sevanian, A.
Oxidants as stimulators of signal transduction.
Free Radic. Biol. Med. 22: 269-285, 1997. PMID: 8958153
79. Kaul, N., Choi, J. and Forman, H.J.
Transmembrane redox signaling activates NF-κB in macrophages.
Free Radic. Biol. Med. 24: 202-207, 1998. PMID: 9436632
80. Kaul, N., Gopalakrishna, R., Gundimeda, U., Choi, J. and Forman, H.J.
Role of protein kinase C in basal and hydrogen peroxide-stimulated NF-κB activation in the murine macrophage J774A.1 cell line.
Arch. Biochem. Biophys. 350: 79-86, 1998. PMID: 9466823
81. Liu, R.-M., Shi, M.M., Giulivi, C. and Forman, H.J.
Quinones increase g-glutamyl transpeptidase expression by multiple mechanisms in rat lung epithelial cells.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 274: L330-L336, 1998.* PMID: 9530167
82. Hoyal, C.R., Girón-Calle, J. and Forman, H.J.
The alveolar macrophage as a model of calcium signaling in oxidative stress.
J. Toxicol. Environ. Health B Crit Rev. 1: 117-134, 1998. PMID: 9650533
83. Moellering, D., McAndrew, J., Patel, R.P., Cornwell, T., Lincoln, T., Cao, X., Messina, J.L., Forman, H.J., Jo, H. and Darley-Usmar, V.M.
Nitric oxide dependent induction of glutathione synthesis through increased expression of g-glutamylcysteine synthetase.
Arch. Biochem. Biophys. 358: 74-82, 1998. PMID: 9750167
84. Forman, H.J., Zhou, H., Gozal, E. and Torres, M.
Modulation of the alveolar macrophage superoxide production by protein phosphorylation.
Environ. Health Perspect. 106 S5:1185-1190, 1998. PMCID: PMC1533363*
85. Liu, R.-M., Gao, L., Choi, J. and Forman, H.J.
g-Glutamylcysteine synthetase: mRNA stabilization and independent subunit transcription by 4-hydroxy-2-nonenal.
Am. J. Physiol.: Lung Cel. Molec. Physiol. 275: L861-L869, 1998.* PMID: 9815102
86. Anderson, C.P., Tsai, J.M., Meek, W.E., Liu, R.-M., Tang, Y., Forman, H.J. and Reynolds, C.P.
Depletion of glutathione by buthionine sulfoximine alone is cytotoxic for human neuroblastoma cell lines via apoptosis.
Exp. Cell Res. 246:183-192, 1999. PMID: 9882527
87. Moellering, D., Mc Andrew, J., Patel, R.P., Forman, H.J., Mulcahy, R.T., Jo, H. and Darley-Usmar, V.M.
The induction of GSH synthesis by nanomolar concentrations of NO in endothelial cells: a role for g-glutamylcysteine synthetase and g-glutamyl transpeptidase.
FEBS Lett. 448: 292-296, 1999. PMCID: PMC1222359
88. Gao, L. Kim, K.J., Yankaskas, J.R. and Forman, H.J.
Abnormal glutathione transport in cystic fibrosis airway epithelia.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 277: L113-118, 1999.* PMID: 10409237
89. Torres, M. and Forman, H.J.
Activation of several MAP kinases upon stimulation of rat alveolar macrophages: role of the NADPH oxidase.
Arch. Biochem. Biophys. 366: 231-239, 1999. PMID: 10356288
90. Choi, J., Liu, R.-M., Kundu, R.K., Sangiorgi, F., Wu, W., Maxson, R. and Forman, H.J.
Molecular mechanism of decreased glutathione content in HIV type 1 Tat-transgenic mice.
J. Biol. Chem. 275: 3693-3698, 2000.* PMID: 10652368
91. Choi, J., Opalenik, S.R., Wu, W., Thompson, J.A. and Forman, H.J.
Modulation of GSH synthetic enzymes by acidic fibroblast growth factor.
Arch. Biochem. Biophys. 375: 201-209, 2000. PMID: 10683268
92. Lee, Y.J., Galoforo, S.S., Sim, J.E., Ridnour, L.A., Choi, J., Forman, H.J., Corry, P.M. and Spitz, D.R.
Dominant-negative Jun N-terminal protein kinase (JNK-1) inhibits metabolic oxidative stress during glucose deprivation in a human breast carcinoma cell line.
Free Radic. Biol. Med. 28: 575-584, 2000. PMID: 10719239
93. Jha, N. Jurma, O. Lalli, G. Liu, Y., Pettus, E.H., Greenamyre, J.T., Liu, R.-M., Forman, H.J. and Andersen, J.K.
Glutathione depletion in PC12 results in selective inhibition of mitochondrial complex I activity: implications for Parkinson’s disease.
J. Biol. Chem. 275: 26096-26101, 2000.* PMID: 10846169
94. Girón-Calle, J. and Forman, H.J.
Phospholipase D and priming of the respiratory burst by H2O2 in NR8383 alveolar macrophages.
Am. J. Respir. Cell Mol. Biol. 23: 748-754, 2000.* PMID: 11104727
95. Liu, R.-M., Borok, Z. and Forman, H.J.
4-Hydroxy-2-nonenal increases g-glutamylcysteine synthetase gene expression in alveolar epithelial type II cells.
Am. J. Respir. Cell Mol. Biol. 24: 499-505, 2001.* PMID: 11306445
96. Gao, L., Broughman, J.R., Iwamoto, T., Tomich, J.M., Venglarik, C.J. and Forman, H.J.
Synthetic chloride channel restores glutathione secretion in cystic fibrosis airway epithelia.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 281: L24-L30, 2001.* PMID: 11404241
97. Gozal, E., Forman, H.J., and Torres, M.
ADP stimulates the respiratory burst without activation of ERK and AKT.
in rat alveolar macrophages.
Free Radic. Biol. Med. 31: 679-687, 2001. PMID: 11522453
98. Gao, L., Yankaskas, J.R., Fuller, C.M., Sorscher, E.J., Matalon, S. Forman, H.J. and Venglarik, C.J.
Chlorzoxazone or 1-EBIO increases Na+ absorption across cystic fibrosis airway epithelial cells.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 281: L1123-L1129, 2001.* PMID: 11597903
99. Levonen, A.-L., Dickinson, D.A., Mulcahy, R.T., Forman, H.J., and Darley-Usmar, V.M.
Biphasic effects of 15-deoxy-D12,14 -prostaglandin J2 on glutathione induction and apoptosis in human endothelial cells.
Arterioscler. Thromb. Vasc. Biol. 21: 1846-51, 2001.* PMID: 11701476
100. Girón-Calle, J., Srivatsa, K., and Forman, H.J.
Priming of the alveolar macrophage respiratory burst by H2O2 is prevented by the phosphatidylcholine-specific phospholipase C inhibitor, tricyclodecan-9-yl-xanthate (D609).
J. Pharmacol. Exp. Ther. 301: 87-94, 2002.* PMID: 11907161
101. Moellering, D., Go, Y.-M., Levonen, A.-L., Patel, R.P., Dickinson, D.A., Forman, H.J., and Darley-Usmar, V.M.
Induction of glutathione synthesis by oxidized low density lipoprotein and 1-palmitoyl-2-arachidonyl phosphatidylcholine: protection from oxidant-mediated cytotoxicity.
Biochem. J. 362: 51-59, 2002.* PMID: 11829739
102. West, J.A.A., Williams, K.J., Toskala E., Nishio, S., Fleschner, C., Forman, H.J., Buckpitt, A.R., and Plopper, C.G.
Induction of tolerance to naphthalene in Clara cells is dependent on a stable phenotypic adaptation favoring maintenance of the GSH pool.
Am. J. Pathol. 160: `1115-1127, 2002. PMCID: PMC1867174*
103. Iles, K.E., Dickinson, D.A., Watanabe, N., Iwamoto, T. and Forman, H.J.
AP-1 activation through endogenous H2O2 generation by alveolar macrophages.
Free Radic. Biol. Med. 32: 1304-1313, 2002. PMID: 12057768
104. Forman, H.J., Torres, M. and Fukuto, J.
Redox signaling.
Mol. Cell. Biochem. 234: 49-62, 2002. PMID: 12162460
105. Dickinson, D.A. and Forman, H.J.
Cellular glutathione and thiols metabolism.
Biochem. Pharmacol. 64: 1021-1028, 2002. PMID: 12213601
106. Watanabe, N., Dickinson, D.A., Krzywanski, D.M., Iles, K.E., Zhang, H., Venglarik, C.J. and Forman, H.J.
A549 subclones demonstrate heterogeneity in toxicological sensitivity and antioxidant profile.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 283: L726-736, 2002.* PMID: 12225949
107. Dickinson, D.A., Iles, K.E., Watanabe, N., Iwamoto, T., Zhang, H., Krzywanski, D.M. and Forman, H.J.
4-hydroxynonenal induces glutamate cysteine ligase through JNK in HBE1 cells.
Free Radic. Biol. Med. 33: 974-987, 2002. PMID: 12361807
108. Watanabe, N., Iwamoto, T., Dickinson, D.A., Iles, K.E., and Forman, H.J.
Activation of the mitochondrial caspase cascade in the absence of protein synthesis does not require c-Jun N-terminal kinase
Arch. Biochem. Biophys. 405: 231-240, 2002. PMID: 12220537
109. Iles, K.E. and Forman, H.J.
Macrophage signaling and the respiratory burst.
Immunol. Res. 26: 95-105, 2002. PMID: 12403349
110. Forman, H.J. and Torres, M.
Reactive oxygen species and cell signaling: respiratory burst in macrophage signaling.
Am. J. Resp. Crit. Care Med. 166: S4-S8, 2002.* PMID: 12471082
111. Dickinson, D.A. and Forman, H.J.
Glutathione in defense and signaling: lessons from a small thiol.
Ann. N.Y. Acad. Sci. 973: 488-504, 2002. PMID: 12485918
112. Torres, M. and Forman, H.J.
Vanadate inhibition of protein tyrosine phosphatases mimics hydrogen peroxide in the activation of the ERK pathway in alveolar macrophages.
Ann. N.Y. Acad. Sci. 973: 345-348, 2002. PMID: 12485891
113. Dickinson, D.A., Iles, K.E., Zhang, H., Blank, V. and Forman, H.J.
Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression.
Faseb J. (January 2, 2003) 10.1096/fj.02-0566fje (Full text - online).*
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114. Watanabe, N. and Forman, H.J.
Autooxidation of extracellular hydroquinones is a causative event for the cytotoxicity of menadione and DMNQ in A549-S cells.
Arch. Biochem. Biophys. 411: 145-157, 2003. PMCID: PMC2795776*
115. Watanabe, N., Iwamoto, T., Bowen, K.D., Dickinson, D.A., Torres, M. and Forman, H.J.
Bio-effectiveness of Tat-catalase conjugate: A potential tool for the identification of H2O2-dependent cellular signal transduction pathways.
Biochem. Biophys. Res. Commun. 303: 287-293, 2003. PMID: 12646200
116. Dickinson, D.A., Moellering, D.R., Iles, K.E., Patel, R.P., Levonen, A.-L. Wigley, A., Darley-Usmar, V.M. and Forman, H.J.
Cytoprotection against oxidative stress and the regulation of glutathione synthesis.
Biol. Chem. 384: 527-537, 2003. PMID: 12751783
117. West, J.A.A., Van Winkle, L.S., Morin, D., Fleschner, C.A., Forman, H.J., Buckpitt, A.R., and Plopper, C.G.
Repeated inhalation exposures of the bioactivated cytotoxicant naphthalene produce airway specific clara cell tolerance in mice.
Toxicological Sciences 75: 161-168, 2003* PMID: 12805647
118. Thome, U., Lazrak, A., Chen, L., Kirk, M.C., Thomas, M.J., Forman, H.J. and Matalon, S.
Novel SIN-1 reactive intermediates modulate chloride secretion across murine airway cells.
Free Radic. Biol. Med. 35: 662-675, 2003. PMID: 12957658
119. Venglarik, C.J., Girón-Calle, J., Wigley, A.F., Malle, E., Watanabe, N. Forman, H.J.
Hypochlorous acid alters bronchial epithelial cell membrane properties and prevention by extracellular glutathione.
J. Appl. Physiol. 95: 2444-2452, 2003.* PMID: 14514700
120. Liu, R.-M., Liu, Y., Forman, H.J., Olman, M., and Tarpey, M.M.
Glutathione regulates transforming growth factor-b-stimulated collagen production in fibroblasts.
Am. J. Physiol.: Lung Cell. Molec. Physiol. 286: L121-L128, 2004.* PMID: 12959930
121. Krzywanski, D.M., Dickinson, D.A., Iles, K.E., Wigley, A.F., Franklin, C.C., Liu, R.M., Kavanagh, T.J., and Forman, H.J.
Variable regulation of glutamate cysteine ligase subunit proteins affects glutathione biosynthesis in response to oxidative stress.
Arch Biochem Biophys. 423:116-25, 2004. PMID: 14871475
122. Forman, H.J., Fukuto, J.M., and Torres, M.
Redox signaling - thiol chemistry defines which reactive oxygen and nitrogen species can act as second messengers.
Am. J. Physiol: Cell Physiol. 287: C246-C256, 2004. PMID: 15238356
123. Mirecki, A., Fitzmaurice, P., Ang, L. Kalasinsky, K.S., Peretti, F.J., Aiken, S.S., Wickham, D.J., Sherwin, A. Nobrega, J.N. Forman, H.J., and Kish, S.J.
Brain antioxidant systems in human methamphetamine users.
J. Neurochem. 89: 1396-1408, 2004.* PMID: 15189342
124. Dickinson, D.A., Levonen, A.-L., Moellering, D.R., Arnold, E.K., Zhang, H., Darley-Usmar, V.M., Forman, H.J.
Human glutamate cysteine ligase gene regulation through the electrophile response element
Free Radic. Biol. Med. 37: 1152-1159, 2004. PMID: 15451055
125. Zhang, H., Dickinson, D.A., Liu, R.-M., and Forman, H.J.
4-Hydroxynonenal increases g-glutamyl transpeptidase gene expression through mitogen activated protein kinases pathways.
Free Radic. Biol. Med. 38: 463-471, 2005.*
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126. Rahman, I., Biswas, S.K., Jimenez, L.A., Torres, M., Forman, H.J.
Glutathione, stress responses, and redox signaling in lung inflammation.
Antioxid. Redox Signal. 7: 42-58, 2005. PMID: 15650395
127. Ridnour, L.A., Sim, J.E., Choi, J., Dickinson, D.A., Forman, H.J., Ahmad, I.M., Coleman, M.C., Hunt, C.R., Goswami, P.C., and Spitz, D.R.
Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.
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128. lles, K.E., Dickinson, D.A., Wigley, A,F., Welty, N.E., Blank, V. and Forman, H.J.
HNE increases HO-1 through activation of the ERK pathway in pulmonary epithelial cells.
Free Radic. Biol. Med. 39: 355-364, 2005.*
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129. Martín, M.E., Muñoz, F.M., Dickinson, D.A., Forman, H.J., del Río, R.M., Salinas, M. and Fando, J.L.
Protective effect of L-trans-pyrrolidine-2,4-dicarboxilic acid preload against cell death by oxygen/glucose deprivation in differentiated PC12 cells.
J. Neuroscience Res. 82: 93-102, 2005 PMID: 16049970
130. Zhang, H., Liu, H., Iles, K.E., Liu, R.-M., Postlethwait, E.M., Laperche, Y., and Forman, H.J.
4-Hydroxynonenal induces rat g-glutamyl transpeptidase through mitogen-activated protein kinase-mediated electrophile response element/nuclear factor erythroid 2-related factor 2 signaling.
Am. J. Respir. Cell Mol. Biol. 34: 174-181, 2006.*
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131. Zhang, H., Liu, H., Dickinson, D.A., Liu, R.-M., Postlethwait, E.M., Laperche, Y., and Forman, H.J.
g-Glutamyl transpeptidase is induced by 4-hydroxynonenal via EpRE/Nrf2 signaling in rat epithelial type II cells.
Free Radic. Biol. Med. 40: 1281-1292, 2006.*
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132. Chinta, S.J., Kumar, J.M., Zhang, H., Forman, H.J., Andersen, J.K.
Up-regulation of g-glutamyl transpeptidase activity following glutathione depletion has a compensatory rather than inhibitory effect on mitochondrial complex I activity: implications for Parkinson's disease.
Free Radic. Biol. Med. 40: 1557-1563, 2006.*
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133. Rinna, A. Torres, M., and Forman, H.J.
Stimulation of the alveolar macrophage respiratory burst by ADP causes selective glutathionylation of protein tyrosine phosphatase 1B.
Free Radic. Biol. Med. 41: 86-91, 2006.*
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134. Liu, H., Zhang, H., Iles, K.E., Rinna, A. Merrill, G., Yodoi, J., Torres, M., and Forman, H.J.
The ADP-stimulated NADPH oxidase activates the ASK-1/MKK4/JNK pathway in alveolar macrophages.
Free Radic. Res. 40: 865-874, 2006.*
http://dx.doi.org/ 10.1080/10715760600758514 PMCID: PMC2713795
135. Choi, J., Forman, H.J., Ou, J., Lai, M.M.C., Seronello, S., Nandipati, A.
Redox modulation of the hepatitis C virus replication complex is calcium dependent.
Free Radic. Biol. Med. 41: 1488–1498, 2006.*
http://dx.doi.org/10.1016/j.freeradbiomed.2006.08.008 PMID: 17023276
136. Cantin, A.M., White, T.B., Cross, C.E., Forman, H.J., Sokol, R.J., and Borowitz, D.
Antioxidants in cystic fibrosis.
Free Radic. Biol. Med. 42: 15-31, 2007.*
http://dx.doi.org/ 10.1016/j.freeradbiomed.2006.09.022 PMCID: PMC2696206
137. Zhang, H., Court, N., and Forman, H.J.
Submicromolar concentrations of 4-hydroxynonenal induce glutamate cysteine ligase expression in HBE1 cells.
Redox Reports 12: 101-106, 2007.*
http://dx.doi.org/ 10.1179/135100007X162266 PMCID: PMC2730489
138. Liu, H., Zhang, H. and Forman, H.J.
Silica induces macrophage cytokines through phosphatidylcholine-specific
phospholipase C with H2O2.
Am. J. Respir. Cell Mol. Biol. 36: 594-599 2007.*
http://dx.doi.org/ 10.1165/rcmb.2006-0297OC PMCID: PMC1899332
139. Cruz, C.M., Rinna, A., Forman, H.J., Ventura, A.L.M., Persechini, P.M. and Ojcius, D.M.
ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages.
J. Biol. Chem. 282: 2871–2879, 2007.*
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140. Forman, H.J.
Use and abuse of exogenous H2O2 in studies of signal transduction.
Free Radic. Biol. Med. 42: 926–932, 2007.*
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141. Zhang, H. and Forman, H.J.
Acrolein induces heme oxygenase-1 through PKCd and PI3K in human bronchial epithelial cells.
Am. J. Respir. Cell Molec. Biol. 38: 483-490, 2008.*
http://dx.doi.org/10.1165/rcmb.2007-0260OC PMID: 18048804
142. Rinna, A. and Forman, H.J.
SHP-1 inhibition by 4-hydroxynonenal activates Jun N-terminal kinase and glutamate cysteine ligase.
Am. J. Respir. Cell Molec. 39: 97-104, 2008.*
http://dx.doi.org/10.1165/rcmb.2007-0371OC PMCID: PMC2438451
143. Ding, Y., Choi, K.J., Kim, J.H., Han, X., Piao, Y., Jeong, J.-H., Choe, W., Kang, I., Ha, J., Forman, H.J., Lee, J., Yoon, K.-S., Kim, S.S.
Endogenous H2O2 regulates GSH redox via Nrf2 downstream of PI 3-kinase during muscle differentiation.
Am. J. Pathol. 172: 1529-1541, 2008.*
http://dx.doi.org/10.2353/ajpath.2008.070429 PMCID: PMC240841
144. Janssen-Heininger, Y.M.W., Mossman, B.T., Heintz, N.H., Forman, H.J., Kalyanaraman, B., Finkel, T., Stamler, J.S., Rhee, S.G., and Van der Vliet, A.
Redox-based regulation of signal transduction: principles, pitfalls, and promises.
Free Radic. Biol. Med. 45: 1-17, 2008.*
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145. Bindoli A., Fukuto J.M., Forman H.J.
Thiol chemistry in peroxidase catalysis and redox signaling.
Antioxid. Redox Signal. 10: 1-16, 2008*
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146. Sunagawa, S., Choi, J., Forman, H.J., and Medina, M.
Hyperthermic stress-induced increase in the expression of glutamate-cysteine ligase and glutathione levels in the symbiotic sea anemone Aiptasia pallida.
Comp. Biochem. Physiol. Part B 151: 133-138 2008*
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147. Forman, H.J., Fukuto, J.M., Miller, T., Zhang, H., Rinna, A., and Levy, S.
The chemistry of cell signaling by reactive oxygen and nitrogen species and 4-hydroxynonenal.
Arch. Biochem. Biophys. 477: 183-195, 2008*
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148. Chen, J.-L., Lin, H.H. Kim, K.J., Lin, A., Forman, H.J. and Ann, D.K.
Novel roles for protein kinase Cδ-dependent signaling pathways in acute hypoxic stress-induced autophagy.
J. Biol. Chem. 283: 34432-34444, 2008*
http://dx.doi.org/10.1074/jbc.M804239200 PMCID: PMC2590682
149. Forman, H.J., Zhang, H. and Rinna, A.
Glutathione: Overview of its protective roles, measurement, and biosynthesis.
Molec. Aspects Med. 30:1-12, 2009*
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150. Franklin, C.C., Backos, D.S., Mohar, I., White, C.C., Forman, H.J. and Kavanagh, T.J.
Structure, function, and post-translational regulation of the catalytic and modifier subunits of glutamate cysteine ligase.
Molec. Aspects Med. 30: 86-98, 2009*
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151. Zhang, H., Shih, A., Rinna, A., and Forman, H.J.
Resveratrol and 4-hydroxynonenal act in concert to increase glutamate cysteine ligase expression and glutathione in human bronchial epithelial cells.
Arch. Biochem. Biophys. 481: 110-115, 2009*
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152. Zhang, H. and Forman, H.J.
Signaling pathways involved in phase II gene induction by α, β-unsaturated aldehydes.
Toxicol. Industrial Health 25: 269-278, 2009*
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153. Mahaffey, C.M., Zhang, H., Rinna, A., Holland, W., Mack, P.C., and Forman, H.J.
Multidrug resistant protein-three gene regulation by the transcription factor Nrf2 in human bronchial epithelial and non-small cell lung carcinoma.
Free Radic. Biol. Med. 46: 1650-1657, 2009*
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154. Soñanez-Organis, J.G., Peregrino-Uriarte, A.B., Gómez-Jiménez, S., López-Zavala, A., Forman, H.J., and Yepiz-Plascencia, G.
Molecular characterization of hypoxia inducible factor-1 (HIF-1) from the white shrimp Litopenaeus vannamei and tissue-specific expression under hypoxia.
Comp. Biochem. Physiol. Part C 150: 395-405, 2009
http://dx.doi.org/ 10.1016/j.cbpc.2009.06.005 PMID: 19540931
155. Levy, S., Jaiswal, A., and Forman, H.J.
The role of c-Jun phosphorylation in EpRE activation of Phase II genes.
Free Radic. Biol. Med 15: 1172-1179, 2009*
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156. Zhang, H. and Forman, H.J.
Redox regulation of g-glutamyl transpeptidase.
Am. J. Respir. Cell Molec. 41: 509-515, 2009*
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157. Zhang, H., Shih, A., Rinna, A. and Forman, H.J.
Exacerbation of tobacco smoke mediated apoptosis by resveratrol: an unexpected consequence of its antioxidant action.
Int. J. Biochem. Cell Biol. 43:1059-1064, 2011* epub in 2010
http://dx.doi.org/10.1016/j.biocel.2009.12.022 PMCID: PMC2891685
158. Forman, H.J., Maiorino, M., Ursini, F.
Signaling functions of reactive oxygen species.
Biochemistry 49: 835-42, 2010*
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159. Levy, S., and Forman, H.J.
c-Myc is a Nrf2-interacting protein that negatively regulates phase II genes through their electrophile responsive elements.
IUBMB Life 62: 237-246, 2010* PMCID: PMC2852429
160. Liu, R.-M., Choi, J., Wu, J.H., Gaston-Pravia, K.A., Lewis, K.M., Brand, J.D., Reyes Mochel, N.S., Krzywanski, D.M., Lambeth, J.D., Hagood, J.S., Forman, H.J., Thannickal V.J., and Postlethwait, E.M.
Oxidative modification of nuclear mitogen activated protein kinase phosphatase 1 is involved in transforming growth factor beta1-induced expression of plasminogen activator inhibitor 1 in fibroblasts.
J. Biol. Chem. 285:16239–16247, 2010*
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161. Forman, H.J.
Reactive oxygen species and a,b-unsaturated aldehydes as second messengers in signal transduction.
Ann. N.Y. Acad. Sci. 1203: 35-44, 2010*
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162. Vázquez-Medina, J.P., Crocker, D.E., Forman, H.J., and Ortiz, R.M.
Prolonged fasting does not increase oxidative damage or inflammation in a naturally adapted mammal, the northern elephant seal.
J. Exper. Biol. 213: 2524-2530, 2010*
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163. Zhang, H., and Forman, H.J.
Reexamination of the electrophile response element sequences and context reveals a lack of consensus in gene function.
Biochimica Biophysica Acta 1799: 496–501, 2010*
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164. Soñanez-Organis, J.G., Peregrino-Uriarte, A.B., Sotelo-Mundo, R.R., Forman, H.J, and Yepiz-Plascencia, G.
Hexokinase from the white shrimp Litopenaeus vannamei: cDNA sequence, structural protein model and regulation via HIF-1 in response to hypoxia.
Comp Biochem Physiol B Biochem Mol Biol. 158: 242-249, 2011 PMID: 21199679
165. Vázquez-Medina, Zenteno-Savín, T., Forman, H.J., J.P., Crocker, D.E., and Ortiz, R.M.
Prolonged fasting increases glutathione biosynthesis in postweaned northern elephant seals.
J. Exper. Biol. 214: 1294-1299, 2011* PMCID: PMC3063111
166. Premasekharan, G., Nguyen, K., Contreras, J., Ramon, V., Leppert, V.J., and Forman, H.J.
Iron-mediated lipid peroxidation and lipid raft disruption in low-dose silica-induced macrophage cytokine production.
Free Radic. Biol. Med. 51: 1184–1194, 2011
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167. Kalyanaraman, B., Darley-Usmar, V. Davies, K.J., Dennery, P.A., Forman, H.J., Grisham, M.B., Mann, G.E., Moore, K. Roberts II, L.J.; and Ischiropoulos, H.
Measuring reactive oxygen and nitrogen species with fluorescence probes: challenges and limitations.
Free Radic. Biol. Med. 52: 1-6, 2012*
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168. Mahaffey, C., Mahaffey, N.C., Holland, W., Zhang, H., Gandara, D.R., Mack, P.C., and Forman, H.J.
Aberrant regulation of the MRP3 gene in non-small cell lung carcinoma.
J. Thoracic Oncol. 7:34-39, 2012* epub 2011
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169. Vázquez-Medina, Zenteno-Savín, T., Tift, M.S., Forman, H.J., J.P., Crocker, D.E., and Ortiz, R.M.
Apnea stimulates the adaptive response to oxidative stress in elephant seal pups.
J. Exper. Biol. 214: 4193-4200, 2011*
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170. Nguyen, K., Premasekharan, G., Yuen, A., Forman, H.J., and Leppert, V.J.
Effect of engineered solid and mesoporous silica particle physical properties on in vitro toxicity.
MRS Proceedings 2011 1357: mrss11-1357-ll03-17
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171. Forman, H.J. and Ursini, F.
What is an antioxidant: reductant, nucleophile, electrophile, scavenger or hormetic? Searching for consensus between chemistry and biology.
J. Wine Res. 22: 139–141, 2011
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172. Zhang, H., Liu, H., Borok, Z., Davies, K.J., Ursini, F., and Forman, H.J.
Cigarette smoke extract-stimulated epithelial-mesenchymal transition through Src activation.
Free. Radic. Biol. Med. 52: 1437-1442, 2012*
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173. Pickering, A.M, Linder, R.A., Zhang, H., Forman, H.J., Davies, K.J.A.
Nrf2 dependent induction of proteasome and Pa28αβ regulator is required for adaptation to oxidative stress.
J. Biol. Chem. 287: 10021-10031, 2012*
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174. Zhang, H., Liu, H., Davies, K.J.A., Sioutas, C., Morgan, T., Finch, C.E., and Forman, H.J.
Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments.
Free. Radic. Biol. Med. 52: 2038-2046, 2012.*
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175. Sticozzi, C., Belmonte, G., Pecorelli, A., Arezzini, B., Gardi, C., Maioli, E., Clelia, M., Marzia, T., Forman, H.J., and Valacchi, G.
Cigarette smoke affects keratinocytes Srb1 expression and localization via H2O2 production and HNE protein adducts formation.
PLoS ONE 7(3): e33592. 2012*
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176. Zhang, H., and Forman, H.J.
Glutathione synthesis and its role in redox signaling.
Semin Cell Dev Biol. 2012 September; 23(7): 722–728.*
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177. Chepelev, N.L., Zhang, H., Liu, H., McBride, S., Seal, A.J., Morgan, T.E., Finch, C.E., Willmore, W.J., Davies, K.J.A., and Forman, H.J.
Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction.
http://dx.doi.org/10.1016/j.redox.2013.01.005 PMCID: PMC3757680
178. Forman, H.J., Davies, K.J., and Ursini, F.
How do nutritional antioxidants really work: nucleophilic tone and para-hormesis versus free radical scavenging in vivo.
Free Radic. Biol. Med. 66: 24-35, 2014*
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179. Forman, H.J., Ursini, F., and Maiorino, M.
An overview of mechanisms of redox signaling.
J. Mol. Cell. Cardiol. 73: 2–9, 2014*
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180. Sticozzi, C., Belmonte, G., Cervellati, F., Muresan, X.M., Pessina, F., Lim, Y., Forman, H.J., and Valacchi, G.
Resveratrol protects SR-B1 levels in keratinocytes exposed to cigarette smoke.
Free Radic. Biol. Med. 69: 50-57, 2014*
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181. Qiu, F., Chen, Y.R,, Liu, X., Chu, C.Y., Shen, L.J., Xu, J., Gaur, S., Forman, H.J., Zhang, H., Zheng, S., Yen, Y., Huang, J., Kung, H.J., and Ann, DK.
Arginine starvation impairs mitochondrial respiratory function in ASS1-deficient breast cancer cells.
Sci Signal. 2014 Apr 1;7(319):ra31*
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182. Cervellati, F., Muresan, X., Sticozzi, C., Gambari, R., Montagner, G., Forman, H.J., Torricelli, C. Maioli, E., and Valacchi, G.
Comparative effects between electronic and cigarette smoke in human keratinocytes.
Toxicol. In Vitro 28: 999-1005, 2014*
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183. Forman, H.J. and Ursini, F.
Para-hormesis: An innovative mechanism for the health protection brought by antioxidants in wine.
Nutrition and Aging 2: 117–124, 2014*
http://dx.doi.org/10.3233/NUA-130033
184. Schwarzländer, M., Wagner, S., Ermakova, Y.G., Belousov, V.V., Radi, R., Beckman, J.S., Buettner, G.R., Demaurex, N., Duchen, M.R., Forman, H.J., Fricker, M.D., Gems, D., Halestrap, A.P., Halliwell, B., Jakob, U., Johnston, I.G., Jones, N.S., Logan, D.C., Morgan, B., Müller, F.L., Nicholls, D.G., Remington, S.J., Schumacker, P.T., Winterbourn, C.C., Sweetlove, L.J., Meyer, A.J., Dick, T.P., and Murphy, M.P.
The ‘mitoflash’ probe cpYFP does not respond to superoxide.
Nature 514, E12–E14 (23 October 2014)*
doi:10.1038/nature13858 PMID: 25341790
185. Forman, H.J., Augusto, O., Brigelius-Flohe, R., Dennery, P.A., Kalyanaraman,, B., Ischiropoulos, H., Mann, G.E., Radi, R., Roberts II, L.J., Vina, J., and Davies, K.J.A.
Even free radicals should follow some rules: A guide to free radical research terminology and methodology.
Free Radic. Biol. Med. 78: 233–235, 2015*
doi:10.1016/j.freeradbiomed.2014.10.504 PMID: 25462642
186. Pecorelli, A., Natrella, F., Belmonte, G., Miracco, C., Cervellati, F., Ciccoli, L., Mariottini, A., Rocchi, R., Vatti, G., Bua, A., Canitano, R., Hayek, J., Forman, H.J., and Valacchi, G.
NADPH oxidase activation and 4-hydroxy-2-nonenal/aquaporin-4 adducts as possible new players in oxidative neuronal damage presents in drug-resistant epilepsy.
BBA - Molecular Basis of Disease 1852: 507-519, 2015*
doi:10.1016/j.bbadis.2014.11.016 PMID: 25460197
187. Bosello-Travain, V., Forman, H.J., Roveri, A., Toppo, S., Ursini, F., Venerando, R., Warnecke, C., Zaccarin, M., and Maiorino, M.
Glutathione peroxidase 8 is transcriptionally regulated by HIFa and modulates growth factor signaling in HeLa cells.
Free Radic. Biol. Med. 81: 58–68, 2015
http://dx.doi.org/10.1016/j.freeradbiomed.2014.12.020 PMID: 25557012
188. Zhang, H., Davies, K.J.A., and Forman, H.J.
TGFb1 rapidly activates Src through a non-canonical redox signaling mechanism.
Arch. Biochem. Biophys. 568: 1-7, 2015*
doi: 10.1016/j.abb.2015.01.001. PMCID: PMC4339486
189. Pecorelli, A., Belmonte, G., Meloni, I. Cervellati, F., Gardi, C,, Sticozzi, C., De Felice, C., Signorini, C., Cortelazzo, C., Leoncini, S., Ciccoli, L., Renieri, A., Forman, H.J., Hayek, J., and Valacchi, G.
Alteration of serum lipid profile, SRB1 loss and impaired Nrf2 activation in CDKL5 disorder.
Free Radic. Biol. Med 86: 156-165, 2015
doi: 10.1016/j.freeradbiomed.2015.05.010 PMID: 26006105
190. Zhang, H., Davies, K.J.A., and Forman, H.J.
Oxidative stress response and Nrf2 signaling in aging.
Free Radic. Biol. Med. 88, Part B: 314–336, 2015*
doi:10.1016/j.freeradbiomed.2015.05.036 PMCID: PMC4628850
191. Cervellati, C., Sticozzi; C., Romani, A., Belmonte, G., De Rasmo, D., Signorile, A., Cervellati, F., Milanese, C., Mastroberardino, P.G., Pecorelli, A., Savelli, V., Forman, H.J., Hayek, J., and Valacchi, G.
Impaired enzymatic defensive activity, mitochondrial and proteasome dysfunction are involved in RTT cells oxidative damage.
Biochim Biophys Acta. 1852: 2066-2074, 2015*
doi: 10.1016/j.bbadis.2015.07.014. PMID: 26189585
192. Zhang, H., and Forman, H.J.
4-Hydroxynonenal activates Src through a non-canonical pathway that involves EGFR/PTP1B.
Free Radic. Biol. Med. 89:701-707, 2015*
doi: 10.1016/j.freeradbiomed.2015.08.025. PMCID: PMC4684732
193. Ursini, F., Maiorino, M., and Forman, H.J.
Redox Homeostasis: The Golden Mean of Healthy Living
doi:10.1016/j.redox.2016.01.010 PMCID: PMC4732014
194. Appenzeller-Herzog. C., Bánhegyi, G., Bogeski, I., Davies, K.J., Delaunay-Moisan, A., Forman, H.J., Görlach, A., Kietzmann, T., Laurindo, F., Margittai, E., Meyer, A.J., Riemer, J., Rützler, M., Simmen, T., Sitia, R., Toledano, M.B., and Touw, I.P.
Transit of H2O2 across the endoplasmic reticulum membrane is not sluggish.
Free Radic Biol Med. 94:157-160, 2016
doi: 10.1016/j.freeradbiomed.2016.02.030. PMID: 26928585
195. Forman, H.J.
Glutathione - From antioxidant to post-translational modifier.
Arch. Biochem. Biophys. 595: 64–67, 2016*
doi:10.1016/j.abb.2015.11.019 PMCID: PMC4838773
196. Forman, H.J., Bernardo, A., and Davies, K.J.A.
What is the concentration of hydrogen peroxide in blood and plasma?
Arch Biochem Biophys. 9: 48-53, 2016
doi: 10.1016/j.abb.2016.05.005. PMID: 27173735
197. Cheng, H., Saffari, A., Sioutas, C., Forman, H.J., Morgan, T.E., and Finch, C.E.
Nanoscale particulate matter from urban traffic rapidly induces oxidative stress and inflammation in olfactory epithelium with concomitant effects on brain.
Environ Health Perspect. 124:1537–1546, 2016*
doi: 10.1289/EHP134 PMCID: PMC5047762
198. Forman, H.J.
Redox signaling: an evolution from free radicals to aging.
Free Radic Biol Med. 97:398-407, 2016*
doi: 10.1016/j.freeradbiomed.2016.07.003 PMCID: PMC4996735
199. Forman, H.J., Davies, M.J., Krämer, A.C., Miotto, G., Zaccarin, M., Zhang, H., and Ursini, F.
Protein cysteine oxidation in redox signaling: Caveats on sulfenic acid detection and
quantification.
Arch Biochem Biophys. 617: 26–37 (2017)*
doi: 10.1016/j.abb.2016.09.013. PMCID: PMC5318241
200. Zhang, H., and Forman, H.J.
Signaling by 4-hydroxy-2-nonenal: Exposure protocols, target selectivity and degradation.
Arch Biochem Biophys. 617: 145–154 (2017)*
doi: 10.1016/j.abb.2016.11.003. PMCID: PMC5318232
201. Zhang, H., and Forman, H.J.
4-hydroxynonenal-mediated signaling and aging.
Free Radic Biol Med. 111: 219-225 (2017)*
doi:10.1016/j.freeradbiomed.2016.11.03 PMCID: PMC5438786
202. Zhang, H., Zhou, L., Yuen, J., Birkner, N., Leppert, V., O'Day, P.A., and Forman, H.J.
Delayed Nrf2-regulated antioxidant gene induction in response to silica nanoparticles.
Free Radic Biol Med. 108: 311-319, 2017*
doi: 10.1016/j.freeradbiomed.2017.04.002 PMCID: PMC5480609
203. Zhou, L., Forman, H.J., Ge, Y., and Lunec, J.
Multi-walled carbon nanotubes: a cytotoxicity study in relation to functionalization, dose and dispersion.
Toxicol. in Vitro 42: 292–298, 2017*
doi: 10.1016/j.tiv.2017.04.027 PMCID: PMC5577988
204. Premshekharan, G., Zhang, H., Nguyen, K., Forman, H.J., and Leppert, V.J.
Low dose inflammatory potential of silica particles in human-derived THP-1 macrophage cell culture studies – mechanism and effects of particle size and iron.
Chem. Biol. Interact. 272: 160–171, 2017*
doi: 10.1016/j.cbi.2017.05.004 PMCID: PMC5619987
205. Skvortsova, L., Perfelyeva, A., Khussainova, E., Mansharipova, A., Forman, H.J., and Djansugurova, L.
Association of GCLM -588C/T and GCLC -129T/C promoters polymorphisms of genes coding the subunits of glutamate cysteine ligase with ischemic heart disease development in Kazakhstan population.
Disease Markers 2017, Article ID 4209257, 2017*
doi:10.1155/2017/4209257 PMCID: PMC5516751
206. Zhang, H., Liu, H., Yuen, J., and Forman, H.J.
Temporal changes in glutathione biosynthesis during the lipopolysaccharide-induced inflammatory response of THP-1 macrophages.
Free Radic Biol Med. 13: 304-310, 2017*
doi: 10.1016/j.freeradbiomed.2017.10.010 PMCID: PMC5699958
207. Davies, J.M.S., Cillard, J., Friguet, B., Cadenas, E., Cadet, J., Cayce, R., Fishmann, A., Liao, D., Bulteau, A.-L. Derbré, F. Rébillard, A., Burstein, S., Hirsch , E., Kloner, R.A., Jakowec, M., Petzinger, G., Sauce, D., Sennlaub, F., Limon, I., Ursini, F., Maiorino, M., Economides, C., Pike, C., Cohen, P., Negre Salvayre, A., Halliday, M.R., Lundquist, A.J., Jakowec, M.A., Mechta – Grigoriou, F., Mericskay, M., Mariani, J., Li, Z., Huang, D.,
Grant, E., Forman, H.J., Finch, C.E., Sun, P.Y., Pomatto, L.C.D., Agbulut, O., Warburton, D., Neri, C., Rouis, M., Cillard, P., Capeau, J., Rosenbaum, J., and Davies, K.J.A.
The oxygen paradox, the French paradox, and age related diseases
doi: 10.1007/s11357-017-0002-y PMCID: PMC5745211
208. Zhou, L., Zhang, H., Davies, K.J.A., and Forman, H.J.
Aging-related decline in the induction of Nrf2-regulated antioxidant genes in human bronchial epithelial cells.
Redox Biol. 14: 35–40, 2018*
doi: 10.1016/j.redox.2017.08.014 PMCID: PMC5576992
209. Forman, H.J. and Finch, C.E.
A critical review of assays for hazardous components of air pollution.
Free Radic Biol Med. 117:202-217, 2018
doi: 10.1016/j.freeradbiomed.2018.01.030 PMCID: PMC5845809
210. Hegedűs, C., Kovács, K., Polgár, Z., Regdon, Z., Szabó, É., Robaszkiewicz, A., Forman, H.J., Martner, A., and Virág, L.
Redox control of cancer cell destruction.
doi.org/10.1016/j.redox.2018.01.015 PMCID:PMC5842284
211. Pomatto, L.C.D., Cline, M., Woodward, N., Pakbin, P., Sioutas, C., Morgan, T.E. Finch, C.E., Forman, H.J. and Davies, K.J.A.
Aging attenuates redox adaptive homeostasis and proteostasis in female mice exposed to traffic-derived nanoparticles ('vehicular smog').
Free Radic Biol Med. 121:86-97, 2018
doi: 10.1016/j.freeradbiomed.2018.04.574 PMCID: PMC5987225
212. van der Vliet, A., Dick, T.P., Aust, S.D., Koppenol, W.H., Ursini, F., Kettle, A.J., Beckman, J.S., O'Donnell ,V., Darley-Usmar, V., Lancaster, J., Jr., Hogg, N., Davies, K.J.A., Forman, H.J., and Janssen-Heininger, Y.M.W.
Rust never sleeps: The continuing story of the Iron Bolt.
Free Radic Biol Med.124: 353-357, 2018.
doi: 10.1016/j.freeradbiomed.2018.06.017. PMID: 29913216
213. Thorwald, M. Godoy-Lugo, J.A., Rodriguez, R., Graham, J., Havel, P. Forman, H.J., and Ortiz, R.M.
Nrf2-related gene expression is impaired during a glucose challenge in type II diabetic rat hearts.
Free Radic Biol Med. 130: 306–317, 2019
doi: 10.1016/j.freeradbiomed.2018.10.405 PMID: 30316779
214. Zhou, S., Dodia, C., Feinstein, S.I., Harper, S., Forman, H.J., Speicher, D.W., Fisher, A.B.
Oxidation of peroxiredoxin 6 in the presence of GSH increases its phospholipase A2 activity at cytoplasmic pH.
doi:10.3390/antiox8010004 PMCID: PMC6357108
215. Pattammattel, A., Leppert, V.J., Forman, H.J. and O’Day, P.A.
Surface characterization and chemical speciation of adsorbed iron(III) on oxidized carbon nanoparticles.
Environ. Sci. Processes Impacts 3:548-563, 2019 *
doi: 10.1039/C8EM00545A PMCID: PMC6426675
216. Davies, K.J.A., and Forman, H.J.
Does Bach1 & c-Myc dependent redox dysregulation of Nrf2 & adaptive homeostasis decrease cancer risk in ageing?
Free Radic Biol Med 134: 708-714, 2019 *
doi: 10.1016/j.freeradbiomed.2019.01.028 PMCID: PMC6588462
217. Pomatto, L.C.D., Sun, P.Y., Yu, K., Gullapalli, S., Bwiza, C.P., Sisliyan, C., Wong, S.,
Zhang, H., Forman, H.J., and Davies, K.J.A.
Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.
Redox Biol. 24:101194, 2019 *
doi: 10.1016/j.redox.2019.101194 PMCID: PMC6479762
218. Detterich, J.A., Liu, H., Suriany, S., Kato, R.M., Chalacheva, P., Tedla, B., Shah, P.M., Khoo, M.C., Wood, J.C., Coates, T.D., Milne, G.L., Oh, J.Y., Patel, R.P., and Forman, H.J.
Erythrocyte and plasma oxidative stress appears to be compensated in patients with sickle cell disease during a period of relative health, despite the presence of known oxidative agents.
Free Radic Biol Med 141:408-415, 2019 *
doi:10.1016/j.freeradbiomed.2019.07.004 PMID: 31279092
219. Zhang, H., Zhou, L., Davies, K.J.A., and Forman, H.J.
Silencing Bach1 alters aging-related changes in the expression of Nrf2-regulated genes in primary human bronchial epithelial cells.
Arch. Biochem. Biophys. 672:108074, 2019
doi: 10.1016/j.abb.2019.108074. PMID: 31422075
220. Kopacz, A., Kloska, D. Proniewski, B., Cysewski, D., Personnic, N., Piechota-Polanczyk, A., Kaczara, P., Zakrzewska, A., Forman, H.J., Dulak, J., Jozkowicz, A., Grochot-Przeczek, A.
Keap1 controls protein S-nitrosation and apoptosis-senescence switch in endothelial cells.
https://doi.org/10.1016/j.redox.2019.101304 PMCID: PMC6731384
221. Zhang, H., Haghani, A., Mousavi, A.H., Cacciottolo, M., D'Agostino, C., Safi, N., Sowlat, M.H., Sioutas, C., Morgan, T.E., Finch, C.E., and Forman, H.J.
Cell-based assays that predict in vivo neurotoxicity of urban ambient nano-sized particulate matter.
Free Radic Biol Med. 145:33-41, 2019 *
doi: 10.1016/j.freeradbiomed.2019.09.016. PMCID: PMC7207020
222. Cacciottolo, M., Morgan, T.E., Saffari, A.A,, Shirmohammadi, F., Forman, H.J., Sioutas, C., and Finch, C.E.
Traffic-related air pollutants (TRAP-PM) promote neuronal amyloidogenesis through oxidative damage to lipid rafts.
Free Radic Biol Med. 147: 442-251, 2020 *
doi:10.1016/j.freeradbiomed.2019.12.023. PMCID: PMC7075030
223. Haghani, A., Johnson, R., Safi, N., Zhang, H., Thorwald, M., Mousavi, A., Woodward, N.C., Shirmohammadi, F., Coussa, V., Wise, Jr., J.P., Forman, H.J., Sioutas, C., Allayee, H., Morgan, T.E., and Finch, C.E.
Toxicity of urban air pollution particulate matter in developing and adult mouse brain: Comparison of total and filter-eluted nanoparticles.
Environ. Intl. 136:105510, 2020 *
doi.org/10.1016/j.envint.2020.105510. PMCID: PMC7063839
224. Kopacz, A., Kloska, D., Forman, H.J., Jozkowicz, A., and Grochot-Przeczek, A.
Beyond repression of Nrf2: An update on Keap1.
Free Radic Biol Med. 157: 63-74, 2020 *
https://doi.org/10.1016/j.freeradbiomed.2020.03.023 PMID: 32234331
225. Haghani, A, Morgan, T.E., Forman, H.J., and Finch, C.E.
Air pollution neurotoxicity in the adult brain: emerging concepts from experimental findings.
J. Alzheimer’s Dis. 76: 773-797, 2020
doi: 10.3233/JAD-200377 PMID: 32538853
226. Haghani, A, Cacciottolo, M., Doty, K.R., D’Agostino, C., Thorwald, M., Safi, N., Levine, M.E., Town, T.C., Forman, H.J., Zhang, H., Morgan, T.E., and Finch, C.E.
Mouse brain transcriptome responses to inhaled nanoparticulate matter differed by sex and APOE in Nrf2-NF-kB interactions.
doi: 10.7554/eLife.54822 PMCID: PMC7314548
227. Zhang, H., Zhang, S., Lyn, N., Florentino, A., Li, A., Davies, K.J.A., and Forman, H.J.
Down regulation of glutathione and glutamate cysteine ligase in the inflammatory response of macrophages.
Free Radic Biol Med. 158: 53-59, 2020 *
doi: /10.1016/j.freeradbiomed.2020.06.017 PMCID: PMC7484362
228. Shah, P., Suriany, S., Kato, R., Bush, A.M., Chalacheva, P., Veluswamy, S., Denton, C.C., Russell, K., Khaleel, M., Forman, H.J., Khoo, M.C.K., Sposto, R., Coates, T.D., Wood, J.C., and Detterich, J.
Tricuspid regurgitant jet velocity and myocardial tissue doppler parameters predict mortality in a cohort of patients with sickle cell disease spanning from pediatric to adult age groups – revisiting this controversial concept after sixteen years of additional evidence.
Am. J. Hematol. 96: 31-39, 2020*
doi: 10.1002/ajh.26003 PMID: 32944977
229. Pattammattel, A., Leppert, V.J., Aronstein, P., Robinson, M., Mousavi, A., Sioutas, C., Forman, H.J., and O’Day, P.A.
Iron speciation in particulate matter (PM2.5) from urban Los Angeles using spectro-microscopy methods.
Atmospheric Environment 245: 117988 2021*
doi: 10.1016/j.atmosenv.2020.117988 PMCID: PMC7673293
230. Zhang, H., Morgan, T.E., and Forman, H.J.
Age-related alteration in HNE elimination enzymes.
Arch. Biochem. Biophys. 699: 108749, 2021
doi: 10.1016/j.abb.2020.108749 PMID: 33417945
231. Zhang, H., D’Agostino, C., Cacciottolo, M., Mack, W., Forman, H.J., Sioutas, C., Morgan, T.E., and Finch, C.E.
Urban air pollution particles from Los Angeles: recent variations in neurotoxicity.
J. Alzheimer’s Dis. 82:307–316, 2021
doi: 10.3233/JAD-201577 PMID: 33967042
232. Suriany, S., Xu, I., Liu, H., Ulker, P., Fernandez, E., Sposto, R., Borzage, M., Wenby, R., Meiselman, H.J., Forman, H.J., Coates, T.D., and Detterich, J.A.
Individual red blood cell nitric oxide production in sickle cell anemia: nitric oxide production is increased and sickle shaped cells have unique morphologic change compared to discoid cells.
Free Radic Biol Med. 171:143-155, 2021
doi: 10.1016/j.freeradbiomed.2021.05.007 PMID: 33974976
233. Forman, H.J. and Zhang, H.
Targeting oxidative stress in disease: Promise and limitations of antioxidant therapy.
Nat Rev Drug Discov. 20: 689–709, 2022*
doi: 10.1038/s41573-021-00233-1 PMID: 34194012
234. Henschenmacher, B., Bitsch, A., de las Heras Gala, T., Forman, H.J., Fragoulis, A., Ghezzi, P., Kellner, R., Koch, W., Kuhne, J., Sachno, D., Schmid, G, Tsaioun, K., Verbeek, J., and Wright, R.
The effect of radiofrequency electromagnetic fields (RF-EMF) on biomarkers of oxidative stress in vivo and in vitro: A protocol for a systematic review.
Environ. Int.158 (2022) 106932*
doi: 10.1016/j.envint.2021.106932 PMID: 34662800
235. O’Day, P.A., Pattammattel, A., Aronstein, P., Leppert, V.J., and Forman, H.J.
Iron speciation in respirable particulate matter and implications for human health.
doi:10.1021/acs.est.1c06962 PMID: 35235749
236. Thorwald, M.A., Godoy-Lugo, J.A., Rodriguez, R., Stanhope, K.L., Graham, J.L., Havel, P. Forman, H.J., and Ortiz, R.M.
Cardiac NF-κB acetylation increases while Nr2-related gene expression and mitochondrial activity are impaired during the progression of diabetes in UCD-T2DM rats.
Antioxidants 2022, 11(5), 927*
doi: 10.3390/antiox11050927 PMID: 35624791
237. Murphy, M.P., Bayir, H., Belousov, V., Chang, C.J., Davies, K.J.A., Davies, M.J., Dick, T.P., Finkel, T., Forman, H.J., Janssen-Heininger, Y., Gems, D., Kagan, V.E., Kalyanaraman, B., Larsson, N.-G., Milne, G.L., Nyström, T., Poulsen, H.E., Radi, R., Van Remmen, H., Schumacker, P.T., Thornalley, P.J., Toyokuni, S., Winterbourn, C.C., Yin, H. and Halliwell, B.
Guidelines for measuring reactive oxygen species and oxidative damage in cells and in vivo.
Nature Metabolism 4: 651-662, 2022 *
238. Pattammattel, A., Tappero, R., Gavrilov,D., Zhang, H., Aronstein, P., Forman, H.J., O’Day, P.A., Yan, H. and Chu, Y.S.
Multimodal X-ray nano-spectromicroscopy analysis of chemically heterogeneous systems.
Metallomics: integrated biometal science 14: 10, 2022 *
BOOKS
1. Forman, H.J. and Cadenas, E., editors
Oxidative Stress and Signal Transduction
Chapman Hall, New York, 475 pp., 1997
2. Forman, H.J., Fukuto, J., and Torres, M., editors
Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
Kluwer Academic Publishers, Dordrecht, 436 pp., 2003
3. Spickett, C.M. and Forman, H.J., editors
Lipid Oxidation in Health and Disease
CRC Press, Boca Raton, 419 pp., 2015
BOOKS
1. Forman, H.J. and Cadenas, E., editors
Oxidative Stress and Signal Transduction
Chapman Hall, New York, 475 pp., 1997
2. Forman, H.J., Fukuto, J., and Torres, M., editors
Signal Transduction by Reactive Oxygen and Nitrogen Species: Pathways and Chemical Principles
Kluwer Academic Publishers, Dordrecht, 436 pp., 2003
3. Spickett, C.M. and Forman, H.J., editors
Lipid Oxidation in Health and Disease
CRC Press, Boca Raton, 419 pp., 2015
CHAPTERS, NON-PEER REVIEWED JOURNALS, CONFERENCE PROCEEDINGS
1. Fisher, A.B., Bassett, D.J.P. and Forman, H.J.
Oxygen toxicity of the lung: Biochemical aspects.
In: Pulmonary Edema: A.P. Fishman and S. Geiger, editors, Am. Physiol. Soc., 1978, pp 207-216.
2. Forman, H.J.
The role of ubisemiquinone in superoxide production by dihydroorotate dehydrogenase.
In: The Significance of Superoxide and Superoxide Dismutase. Vol. I, J.V. Bannister and H.A.O. Hill, editors, Elsevier, 1980, pp 76‑83.
3. Forman, H.J. and Fisher, A.B.
Antioxidant defenses.
In: Oxygen and Living Processes: D.L. Gilbert, editor, Springer-Verlag, 1981, pp 237-249.
4. Forman, H.J. and Boveris, A.
Superoxide radical and hydrogen peroxide in mitochondria.
In: Free Radicals in Biology: Vol. V, W.A. Pryor, editor, Academic Press, 1982, pp 65-90.
5. Forman, H.J., Cameron, A.R. and Nelson, J.
Alteration of membrane properties in the activation of alveolar macrophage superoxide release.
In: Oxy Radicals and Their Scavenging Systems. Vol. II. Cellular. R. Greenwald and G. Cohen, editors, Elsevier, 1983, pp 74‑80.
6. Forman, H.J. and Fisher, A.B.
Role of glutathione peroxidase in tolerance and adaptation to hyperoxia.
In: Oxygen Radicals in Chemistry and Biology. W. Bors, M. Saran, and D. Tait, editors Walter de Gruyter, 1984, pp. 699‑ 705.
\
7. Fisher, A.B. and Forman, H.J.
Natural defense mechanisms against oxygen and its derivatives.
In: Workshop on oxygen: In‑depth study of pathophysiology. Oak Ridge National Laboratories, 1984, pp. 433‑457.
8. Fisher, A.B., Forman, H.J. and Glass, M.
Mechanisms of Pulmonary Oxygen Toxicity.
Lung 162: 255‑259, 1984.
9. Fisher, A.B. and Forman, H.J.
Oxygen utilization and toxicity.
In: Handbook of Physiology, Section 3: The Respiratory System, Vol. I, Circulation and Nonrespiratory Functions: A.P. Fishman and A.B. Fisher, editors, Am. Physiol. Soc., 1985, pp 231-254.
10. Forman, H.J. and Fisher, A.B.
Antioxidant enzymes in the lung.
In: Handbook of Methods in Oxy Radical Research: R.A. Greenwald, editor, CRC Press, 1985, pp 359-364.
11. Forman, H.J.
The effects of oxidant stress on pulmonary metabolic functions.
In: Mechanisms of Lung Injury. T.P. Stein and G. Weinbaum, editors, George F. Stickley Co., 1985, pp. 141-153.
12. Forman, H.J. and Thomas, M.J.
Oxidant production and bactericidal activity of phagocytes.
In: Annual Reviews in Physiology: 1986, pp 669-680.
13. Forman, H.J., Nelson, J. and Harrison, G.
Hyperoxia causes loss of the extracellular calcium dependence of the rat alveolar macrophage respiratory burst.
In: Superoxide and Superoxide Dismutase in Chemistry, Biology and Medicine. G. Rotilio, editor, Elsevier, 1986, pp. 413‑41.
14. Dorio, R.J., Hoek, J.B., Forman, H.J. and Rubin, E.
The effect of ethanol on superoxide production in alveolar macrophages.
Ann. N.Y. Acad. Sci. 492: 324-326, 1986.
15. Coburn, R.F. and Forman, H.J.
Carbon monoxide toxicity.
In: Handbook of Physiology, Section 3: The Respiratory System, Volume 4, Gas Exchange: L.E. Farhi and S.M. Tenney, editors, Am. Physiol. Soc., 1987, pp 439-456.
Published online: 1 JAN 2011, doi: 10.1002/cphy.cp030421
16. Forman, H.J., Skelton, D., Loeb, G.A. and Dorio, R.J.
Membrane permeability and oxidant injury.
(Oxygen Radicals in Biology and Medicine. M.G. Simic, K.A. Taylor, J.F. Ward and C. von Sonntag, editors, Pergamon).
Basic Life Sciences 49: 523-530, 1988.
17. Forman, H.J.
Oxidant radical production and lung injury.
In: Oxygen Radicals: Systemic Events and Disease Processes: D.K. Das and W.B. Essman, editors, Karger, 1990, pp. 71-96.
18. Forman, H.J. and Torres, M.
Leukocytes, macrophages & active molecular species.
In: Basic Science in Toxicology. Proceedings of 5th International Congress of Toxicology: Taylor and Francis, London, 1990, pp. 250-259.
19. Forman, H.J. and Thomas, M.J.
Oxygen metabolism in the lungs.
In: Comprehensive Treatise on Pulmonary Toxicology, Vol 1. Comparative Biology of the Normal Lung: R.A. Parent, editor, CRC Press, 1992, pp. 485-510.
20. Forman, H.J. and Robison, T.W.
Arachidonic acid metabolites and phagocytic cells as mediators of tissue injury.
(In Vitro Toxicology - Mechanisms and New Technology), Mary Ann Libert, New York.
Alternative Methods in Toxicology 8: 3-17, 1991.
21. Forman, H.J. and Torres, M.
Inflammation: an overview.
In: Oxidative Damage & Repair. Chemical, Biological, and Medical Aspects. (Proceedings of the 5th Biennial General Meeting of the International Society for Free Radical Research), Pergamon Press, New York, 1992, pp. 636-641.
22. Forman, H.J., Robison, T.W., Skelton, D.C. and Duncan, D.P.
Perturbation of arachidonate metabolism and membrane function by oxidants.
In: The Molecular Basis of Oxidative Damage by Leukocytes, A. Jesaitis and E.A. Dratz, editors, CRC Press, Boca Raton, 1992, pp.101-111.
23. Forman, H.J.
Role of the g-glutamyl cycle in antioxidant defense.
In: Biological Free Radical Oxidations and Antioxidants, F. Ursini and E. Cadenas, editors, Cleup, University Publisher, Padua, Italy, 1992, pp. 111-114.
24. Forman, H.J.
Membrane potential changes in hydroperoxide-induced cell injury.
In: Active Oxygens, Lipid Peroxides and Antioxidants, K. Yagi, editor, Japan Scientific Societies Press, Tokyo, and CRC Press, Boca Raton, 1993, pp. 149-160.
25. Forman, H.J., Shi, M., Kugelman, A. and Choy, H.A.
Role of g-glutamyl cycle enzymes in antioxidant defense.
Bulletin de la Societe Luxembourgeoise de Biolologie Clinique (Special issue) 69-75, 1993.
26. Forman, H.J., Shi, M., Iwamoto, T., Liu, R.-M. and Robison, T.W.
Measurement of g-glutamyl transpeptidase and g-glutamylcysteine synthetase activities in cells.
Methods Enzymol. 252: 66-71, 1995. PMID: 7476375
27. Forman, H.J., Shi, M., Kugelman, A., Iwamoto, T. and Choy, H.A.
g-Glutamyl cycle enzymes and antioxidant defense.
In: The Oxygen Paradox, K.J.A. Davies and F. Ursini, editors, CLEUP, University Publisher, Padua, Italy, 1995, pp. 223-234.
28. Forman, H.J., Liu, R. and Shi, M.M.
Glutathione synthesis in oxidative stress.
In: Biothiols in Health and Disease, L. Packer and E. Cadenas, editors, Marcel Dekker, Inc., New York, 1995, pp. 189-212.
29. Forman, H.J., Liu, R.-M. and Tian, L.
Glutathione cycling in oxidative stress.
In: Lung Biology in Health and Diseases, C. Lenfant, editor, (Oxygen, Gene Expression and Cellular Function, D. Massaro and L. Clerch, editors), Marcel Decker, Inc., New York, 1997, pp. 99-121.
30. Forman, H.J. and Azzi, A.
On the virtual existence of superoxide anions in mitochondria: thoughts regarding its role in pathophysiology.
31. Thomas, M.J., Robison, T.W. and Forman, H.J.
Assessment of tissue injury from reactive oxygen metabolites.
In: Lung Biology in Health and Diseases, C. Lenfant, editor, (Chronic Lung Disease in Early Infancy, R.D. Bland and J. Coalson, editors) Marcel Decker, Inc., New York 1999, pp. 779-792.
32. Forman, H.J. and Azzi, A.
Production of reactive oxygen species in mitochondria and age-associated pathophysiology: a reality check.
In: Understanding the Process of Aging, E. Cadenas and L. Packer, editors, Marcel Dekker, Inc., New York, 1999, pp. 73-93.
33. Girón-Calle, J. and Forman, H.J.
Cell Ca2+ in signal transduction: modulation in oxidative stress.
In: Antioxidant and Redox Regulation of Genes, C.K. Sen, H. Sies, and P.A. Baeuerle, editors, Academic Press, San Diego, 1999, pp. 105-127.
34 Torres, M. and Forman, H.J.
Redox signaling in macrophages.
In: Nitric Oxide, Biology and Pathobiology, L.J. Ignarro, editor, Academic Press, San Diego, 2000, pp. 329-342.
35. Kaul, N. and Forman, H.J.
Reactive oxygen species in physiology and toxicology: from lipid peroxidation to transcriptional activation.
In: Toxicology of the Human Environment: The Critical Role of Free Radicals, C.J. Rhodes, editor, Taylor and Francis, New York 2000, pp. 310-335.
36. Dickinson, D.A., Liu, R.-M., Iles, K.E., and Forman, H.J.
Signaling for the synthesis of glutathione.
In: Free Radicals in Chemistry, Biology and Medicine, T. Yoshikawa, S. Toyokuni, Y Yamamoto and Y. Naito, editors, OICA International, London, 2000, pp. 139-154.
37. Forman, H.J., Gao, L., Broughman, J.R., Iwamoto, T., Venglarik, C.J., and Tomich, J.M.
Glutathione transport and impaired antioxidant function in cystic fibrosis.
Pediatric Pulmonology 30 (S20): 161-162, 2000.
38. Liu, R.-M., Choi, J. and Forman, H.J.
Oxidant induced regulation of glutathione synthesis.
In: Current Protocols in Toxicology, D.J. Reed, editor, John Wiley & Sons, New York, 2001, Unit 6.7 (1-21). PMID: 23045059
39. Torres, M. and Forman, H.J.
Redox signaling in macrophages.
Mol. Aspects Med. 22: 189-216, 2001.
40. Forman, H.J. and Torres, M.
Signaling by the respiratory burst in macrophages.
IUBMB Life 51: 365-371, 2001. PMID: 11758804
41. Forman, H.J. and Dickinson, D.A.
Oxidative signaling and glutathione synthesis.
In: Thiol Metabolism and Redox Regulation of Cellular Functions, A. Pompella, G. Bánhegyi, and M. Wellman-Rousseau, editors, NATO Science Series IOS Press, 2002, pp. 1-13.
Republished as Biofactors17: 1-12, 2003.
42. Torres, M. and Forman, H.J.
Redox signaling and the MAP kinase pathways.
In: Thiol Metabolism and Redox Regulation of Cellular Functions, A. Pompella, G. Bánhegyi, and M. Wellman-Rousseau, editors, NATO Science Series IOS Press, 2002, pp. 306-316.
Republished as Biofactors17: 287-296, 2003.
43. Dickinson, D., Iles, K and Forman, H.
Signaling pathways in glutathione biosynthesis.
In: Proceedings of the 11th Biennial Meeting of the Society for Free Radical Research International, C. Pasquier, editor, Bologna, Monduzzi Editore, 2003, pages 245-249.
44. Forman H.J., Dickinson D.A. and Iles, K.E.
HNE - Signaling pathways leading to its elimination.
Mol. Aspects Med. 24:189-194, 2003.
45. Dickinson DA, Iles KE, Wigley AF, Forman HJ.
Analysis of transcription factor remodeling in phase II gene expression with curcumin.
Methods Enzymol. 378: 302-18, 2004.
46. Watanabe N, Dickinson DA, Liu RM, Forman HJ.
Quinones and glutathione metabolism.
Methods Enzymol. 378: 319-40, 2004.
47. Zhang H, Forman HJ, and Choi J.
g-Glutamyl transpeptidase in glutathione biosynthesis.
Methods Enzymol. 401: 468-83, 2005
48. Torres, M. and Forman, H.J.
Signal Transduction.
In: Encyclopedia of Respiratory Medicine, Volume 4, G.J. Laurent and S.D. Shapiro, editors, Elsevier, ISBN (Set): 0-12-438360-2, 2006, pp.1-9.
49. Newsam, S., Novini, K., Rich, B., Rinna, A., and Forman, H.J.
Measuring respiratory burst in alveolar macrophages
Proceedings of Workshop on Multiscale Biological Imaging, Data Mining & Informatics
Santa Barbara, September 2006.
50. Forman, H.J.
Hydrogen Peroxide: the Good, the Bad, and the Ugly
In: Oxidants in Biology: a question of balance, G. Valacchi and P.A. Davis editors, Springer, ISBN 978-I-4020-8398-3, 2008, pp 1-18.
51. Gow, A.J. and Forman, H.J.
Oxygen metabolism in the lungs.
In: Comparative Biology of the Normal Lung. Second Edition: R.A. Parent, editor, Elsevier, 2015, pp. 355-374.
52. Spickett, C.M. and Forman, H.J., editors
An introduction to redox balance and lipid oxidation.
In: Lipid Oxidation in Health and Disease, Spickett, C.M. and Forman, H.J., editors, CRC Press, Boca Raton, 2015, pp. 1-22.
53. Forman, H.J., Maiorino, M. and Ursini, F.
Interactions between Nrf2 activation and glutathione in the maintenance of redox homeostasis.
In: Hydrogen Peroxide Metabolism in Health and Disease, Vissers, M.C.M., Hampton, M. and Kettle, A.J., editors, CRC Press, Boca Raton, 2017, pp. 409-521.
54. Zhang, H., Lyn, N., Haghani, A. and Forman, H.J
Detection of HNE modification of proteins in aging mouse tissues: a western blot-based approach.
In: Methods in molecular biology 2144:.237-244, 2020. Curran. S. editor
ISBN: 978-1-0716-0591-2 , 978-1-0716-0592-9; DOI: 10.1007/978-1-0716-0592-9_21
INTERNET PUBLICATIONS, PRESENTATIONS AND WEBINARS
1. Dickinson D.A., Lu S.C. and H.J. Forman
Thiols: Glutathione – Synthesis
The Virtual Free Radical School (uploaded July, 2002)
http://www.healthcare.uiowa.edu/research/sfrbm/virtual.html
2. Dickinson D.A., Forman H.J. and S.C. Lu
Thiols: Glutathione – Regulation
The Virtual Free Radical School (uploaded April, 2003, updated March, 2006) http://www.healthcare.uiowa.edu/research/sfrbm/virtual.html
3. H.J. Forman
Glutathione: antioxidant defense and regulation of its synthesis, in Davies, K. (ed.), Free Radicals and the Oxygen Paradox: Oxidative Stress in Biology, Aging and Disease, The Biomedical & Life Sciences Collection, Henry Stewart Talks Ltd, London, 2007 (online at http://www.hstalks.com/?t=BL0281672-Forman)
4. From PBS Great Valley television show in 2010:
Air Quality Successes and Challenges in the Central Valley
Online at http://video.valleypbs.org/video/1436169471/
5. Forman, H.J.
Glutathione: Protective Roles and Regulation of its Synthesis
Society for Free Radical Biology and Medicine Virtual Free Radical School Webinars
http://www.sfrbm.org/webinar/Glutathione-Protective-Roles/index.html
6. Forman, H.J., Leppert, V., O’Day, P.
The Role of Iron in Magnifying Particle Toxicity
Risk-Based Strategies for Managing Air Quality
University of California, Davis, June 27, 2013
https://www.dropbox.com/sh/cgpha8mb42ucckn/lx6SDNaIlF
BOOK REVIEWS
1. "Thioredoxin and Glutaredoxin Systems: Structure and Function" by A. Holmgren, C.-I. Branden, H. Jornvall, and B.-M. Sjoberg.
J. Free Radic. Biol. Med. 2: 83, 1986.
2. "Biological Oxidants: Generation and Injurious Consequences" by C.G. Cochrane and M.A. Gimbrone, Jr.
Am. J. Physiol. 266: L590, 1994.
3. "Mitochondria and Free Radicals in Neurodegenerative Diseases" by M.F. Beal.
Free Radic. Biol. Med. 24: 876-877, 1998.
4. "Free Radicals and Antioxidant Protocols" by Donald Armstrong.
The Quarterly Review of Biology 74: 341-342, 1999.
LETTERS TO EDITORS
1. Forman, H.J. and Haugaard, N.
Superoxide toxicity.
Trends in Biochemical Sciences 7: 279, 1982.
2. Kaul, N. and Forman, H.J.
Response to Neopterin derivatives to activate NF-κB.
Free Radic. Biol. Med. 23: 179, 1997.
3. Fisher, A.B., and Forman, H.J.
Antioxidants in the Intensive Care Unit
Am. J. Respir. Crit. Care Med. 189:1007-1008 (2014)*
doi:10.1164/rccm.201401-0156LE
EDITORIAL
1. Forman, H.J.
Another reason for taking aspirin.
Am. J. Physiol. 280: L1-2, 2001. PMID: 11133488
2. Forman, H.J. and Ruden, D.
Introduction to serial reviews on EpRE and its signaling pathway.
Free Radic. Biol. Med. 36: 1197-1198, 2004.
3. Forman, H.J. and Dickinson, D.A.
Introduction to serial reviews on 4-hydroxy-2-nonenal as a signaling molecule.
Free Radic. Biol. Med. 37: 594-596, 2004.
4. Forman, H.J.
Signaling by toxicants: introduction.
Free Radic. Biol. Med. 37: 915, 2004.
5. Forman, H.J.
Introduction to serial reviews on peroxiredoxins.
Free Radic. Biol. Med. 38: 1411-1412, 2005.
6. Natarajan, V. and Forman, H.J.
Introduction to serial reviews on redox regulation of phospholipases and sphingomyelinase in cell signaling.
Free Radic. Biol. Med. 40: 363, 2006.
7. Forman, H.J.
Signal transduction and reactive species.
Free Radic. Biol. Med. http://dx.doi.org/ 10.1016/j.freeradbiomed.2009.09.002
8. Forman, H.J.
Critical Methods in Free Radical Biology and Medicine.
Free Radic. Biol. Med. http://dx.doi.org/10.1016/j.freeradbiomed.2009.09.013
9. Davies, K.J. and Forman, H.JDavies, K.J.A. and Forman, H.J.
RasGrf1 and Aging.
10. Forman, H.J.
Methods of lipid oxidation product identification and quantification.
Free Radic. Biol. Med. 59: 1, 2013
11. Andersen, J.K., Davies, K.J.A., and Forman, H.J.
Reactive oxygen and nitrogen species in neurodegeneration.
Free Radic. Biol. Med. 62: 1-3, 2013
12. Siow, R.C.M., and Forman, H.J.
Redox regulation of microRNAs in health and disease
Free Radical Biology and Medicine 64: 1–3, 2013
13. Forman, H.J.,
Antioxidants: GRABbing new headlines
Free Radic. Biol. Med. 1-2, 2014
doi: 10.1016/j.freeradbiomed.2013.10.808
14. Mann, G.E., and Forman, H.J.
Introduction to Special Issue on 'Nrf2 Regulated Redox Signaling and Metabolism in Physiology and Medicine.
Free Radic Biol Med. 88 Part B:91–92, 2015
doi: 10.1016/j.freeradbiomed.2015.08.002.
15. Forman, H.J. and Davies, K.J.A.
Commentary on “Bach1 differentially regulates distinct Nrf2-dependent genes in human venous and coronary artery endothelial cells adapted to physiological oxygen levels” by Chapple, et al.
Free Radic Biol Med. 92:163–164, 2016
doi:10.1016/j.freeradbiomed.2016.01.013
16. Forman, H.J., and Toyokuni, S.
Tribute issue: Helmut Sies and oxidative stress: Venit, vidit, vicit.
Arch. Biochem. Biophys. 595: 2, 2016
doi:10.1016/j.abb.2015.11.020
17. Forman, H.J. and Koppenol, W.H.
Introduction for the Special Issue on the Chemistry of Redox Signaling
Arch. Biochem. Biophys., 617: 1-2 2017
18. Forman, H.J.
On “Biological Effects of the Superoxide Radical” by Irwin Fridovich Arch Biochem Biophys 247(1) (1986) 1-11.
Free Radic. Biol. Med. (in press)
doi: 10.1016/j.abb.2022.109117 PMID: 35007510
MEETING REPORTS
1. Forman, H.J. Wispe, J.R. and Elsayed, N.
First International Conference on Oxidative Stress and Aging, 22-26 March 1994
Society for Free Radical Research Newsletter 4: 1994.
Over 250 abstracts