Human Circulatory System and Ailments

• Human circulatory system is one of the largest logistics systems

• Indicator for many ailments and diseases

• A number of illnesses may be mapped to the degradation in the circulatory network.

  •  Deep vein thrombosis, Brain Stroke, Coronary Artery Disease 

• Degradation in network structures can be mapped to :

  • Variation of coupling across the nodes in time  

  • Addition or removal of nodes/edges

• Derivation of indicators for structural degradation may not be easy owing to their:

  • large and complex structure (may not be accurate at finer levels)

  • Limited availability of state measurements (physical and technical limitations)

Motivated by this, our project aims to study network dynamics in general, trying to asnwer:

• How do the topological deviations affect the network dynamics

• How does the information about topogical change gets transmitted in the network

• What are the time constants associated with the information propogation

• What are the indicators of this change which can be calcuated from sparse measurements