I'm a postdoc working in the Center for Neuroengineering and Therapeutics at the University of Pennsylvania. In 2016, I earned my PhD from Penn as a member of Dr. Brian Litt's Translational Neuroengineering Lab. Prior to that, I attended Lafayette College where I majored in Electrical and Computer Engineering.
For more info, visit my LinkedIn page.
My current research is aimed at improving neuromodulation devices that use electrical stimulation to treat those with intractable epilepsy. Using an acute animal preparation, we attempt to address two main questions:
- What structures should devices target? We chemically induced focal seizures in the cortex and tracked their spread on the surface of the brain and throughout the laminae using high density recording electrodes. This model sheds light on how epileptiform activity evolves spatiotemporally in the cortes and potential areas to stimulate and impede the recruitment of healthy tissue into the seizure focus.
- How can stimulation reach intended targets? We tested microstimulation in the cortex at varying laminar depths to determine the extent of its effect on the local neuron population. The results will inform the size and spacing of stimulating electrodes necessary to reach targeted brain areas in future devices.
My other research focuses on developing hardware to enable the use of novel neural recording technologies, including: high-density, multiplexed micro-ECoG arrays, transparent graphene electrodes, bioresorbable electrode arrays, and ECoG grids with inherently flexible and biocompatible organic electronics.
Spatiotemporal evolution of induced epileptiform activity from surface and laminar field recordings in cat visual cortex. H Bink, et al. In progress from thesis.
Capabilities and limitations of cortical microstimulation and dependence on local architecture. H Bink, et al. In progress from thesis.
Published (Google Scholar)
Bioresorbable silicon electronics for transient spatiotemporal mapping of electrical activity from the cerebral cortex. KJ Yu, D Kuzum, SW Hwang, ..., H Bink, ..., J Viventi, B Litt, JA Rogers. Nature materials. 2016. 15 (7), 782-791.
An implantable, rechargeable neuromodulation research tool using a distributed interface and algorithm architecture. D Bourget, H Bink, S Stanslaski, D Linde, C Arnett, T Adamski, T Denison. 2015. 7th International IEEE/EMBS Conference on Neural Engineering (NER), 61-65.
Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging. D Kuzum, H Takano, E Shim, JC Reed, H Juul, AG Richardson, J De Vries, H Bink, MA Dichter, TH Lucas, DA Coulter, E Cubukcu, B Litt. 2014. Nature communications 5.
Recording and stimulation of the cortical surface for modulation of evoked auditory potentials. V Woods, M Caras, Z Zheng, J Wang, H Bink, S Bossi, M Triumpis, M Insanally, R Froemke, D Sanes, J Viventi. 2014. Neuromodulation 17 (5), e112.
Data acquisition system for high resolution, multiplexed electrode arrays. H Bink, JB Wagenaar, J Viventi. 2013. 6th International IEEE/EMBS Conference on Neural Engineering (NER), 1001-1004.
Flexible organic electronics for use in neural sensing. H Bink, Y Lai, SR Saudari, B Helfer, J Viventi, J Van der Spiegel, B Litt, C Kagan. 2011. Engineering in Medicine and Biology Society, EMBC, 2011 Annual International Conference of the IEEE, 5400-5403.
Cortical dynamics underlying seizure mapping and control. H Bink. PhD Thesis, University of Pennsylvania, 2016.