The Gupta Lab

Biophysical and Bioinorganic Chemistry • Spectroscopy

The Gupta lab is interested in studying transition metal mediated processes undertaken by pathogens and the corresponding immune response by the human body during infection using bioinorganic, biophysical and computational methodologies.

Transition metal homeostasis is one of mechanisms through which the human body combats microbial attacks. We are studying both the processes undertaken by pathogens during invasion of a host cell and the responses executed by the host cell during such an attack. Our research utilizes advance spectroscopic methodologies like electron paramagnetic resonance (EPR) and solid state NMR spectroscopies to gain insights into the electronic structure of metal centers. Investigation of these physiological events at the interface of chemistry and biology will provide understanding of fundamental processes in the human body during microbial invasion, with implications for human health and therapeutics.