Rupal Gupta

Molecular Biophysics/Biochemistry

Rupal Gupta is an Associate Professor in the Chemistry department and a member of the Chemistry, Biochemistry and Physics PhD programs at the CUNY Graduate Center. Dr. Gupta is interested in studying human antimicrobial proteins using biophysical and spectroscopic methodologies. Memebers of the Gupta lab are investigating both the processes undertaken by pathogens during invasion of a host (human) cell and the responses executed by the host cell during such an attack. The laboratory employs advance magnetic resonance (EPR and solid-state NMR) spectroscopies and computational methodologies to examine events at the interface of chemistry and biology. These studies will provide atomic-level understanding of fundamental processes in the human body during infection.

Main Affiliation Email Office

Biochemistry Rupal.Gupta@csi.cuny.edu Building 6S Room 214
Physical Chemistry
Inorganic Chemistry

Areas of Expertise/Research

Fundamental Physical Chemical and Biochemical Research
Enzymology
Rational of metal-related bio-catalysis
NMR, EPR and Mössbauer Spectroscopy

Lab Research Interest

Biophysical and Bioinorganic Chemistry • Spectroscopy

The Gupta lab is interested in studying transition metal mediated processes undertaken by pathogens and the corresponding immune response by the human body during infection using bioinorganic, biophysical and computational methodologies.

Transition metal homeostasis is one of mechanisms through which the human body combats microbial attacks. We are studying both the processes undertaken by pathogens during invasion of a host cell and the responses executed by the host cell during such an attack. Our research utilizes advance spectroscopic methodologies like electron paramagnetic resonance (EPR) and solid state NMR spectroscopies to gain insights into the electronic structure of metal centers. Investigation of these physiological events at the interface of chemistry and biology will provide understanding of fundamental processes in the human body during microbial invasion, with implications for human health and therapeutics.

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