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\nWelcome to Ask the Editor. I'm Emily Brewster, an associate editor at Merriam-Webster.\n\u00a0\n- I've never been to a funner party.\n- It was the funnest party I can remember.\n\u00a0\nAs a one-syllable adjective, fun should by all rights have the comparative and superlative forms funner and funnest, just like new has newer and newest. But, spellcheckers and lots of people think funner and funnest are just plain wrong.\n\u00a0\nThe not-quite-kosher status of funner and funnest has its origin in the adjectival status itself of fun. Just as funnest party sounds strange to many of us, there are a number of people who also object to sentences like, \"The party was really fun.\"\n\u00a0\nThey'd prefer we all use fun only as a noun.\n- We had great fun.\n- The party was such fun.\n\u00a0\nAdjectival use dates back at least as far as the 1840s, but until the mid-20th century, it was pretty rare. Perhaps there was something about postwar America that just felt, oh, more fun to people than a noun could express.\n\u00a0\nFun as a noun does continue to be more common, and there are still some who think uses like so fun, very fun, and fun times should be avoided in any kind of serious discourse, but their numbers are dwindling, and the adjective fun is fully accepted by a number of dictionaries, including ours.\n\u00a0\nDoes this mean funner and funnest are destined for full acceptance, too? Certainly possible. Likely, even.\n\u00a0\nMore fun and most fun are still the usual comparative and superlative forms of fun, but funner and funnest are included in our dictionaries, with a sometimes label, because we have plenty of evidence of them in published, edited text.\n\u00a0\nThey're most natural when paired with other similar adjectives; a bigger and funner event, the funnest and funniest person.\n\u00a0\nI say, don't hesitate to use them if you're inclined to. It'll be funner if you do.\n\u00a0\nFor more from our Ask the Editor series, visit merriam-webster.com.","fb_legacy_url":"\/video\/0059-funner.htm","is_editor_choice":1,"is_archived":0,"is_published":1,"published_at":"2015-01-14 06:24:00","last_published_at":"2015-01-14 06:24:00","created_at":"2015-01-14 18:24:22","updated_at":"2022-05-16 13:53:04","tldr":null,"jw_id":"kSQI4Xus","promo_date":"2023-12-25","promo_type":"Sidekick","promo_index":4,"promo_bucket":"random","promo_category_type":"None","promo_category_index":0}; Dictionary Entries Near funny funniment

Abstract: Pacemaking is a basic physiological process, and the cellular mechanisms involved in this function have always attracted the keen attention of investigators. The "funny" (I(f)) current, originally described in sinoatrial node myocytes as an inward current activated on hyperpolarization to the diastolic range of voltages, has properties suitable for generating repetitive activity and for modulating spontaneous rate. The degree of activation of the funny current determines, at the end of an action potential, the steepness of phase 4 depolarization; hence, the frequency of action potential firing. Because I(f) is controlled by intracellular cAMP and is thus activated and inhibited by beta-adrenergic and muscarinic M2 receptor stimulation, respectively, it represents a basic physiological mechanism mediating autonomic regulation of heart rate. Given the complexity of the cellular processes involved in rhythmic activity, an exact quantification of the extent to which I(f) and other mechanisms contribute to pacemaking is still a debated issue; nonetheless, a wealth of information collected since the current was first described more than 30 years ago clearly agrees to identify I(f) as a major player in both generation of spontaneous activity and rate control. I(f)- dependent pacemaking has recently advanced from a basic, physiologically relevant concept, as originally described, to a practical concept that has several potentially useful clinical applications and can be valuable in therapeutically relevant conditions. Typically, given their exclusive role in pacemaking, f-channels are ideal targets of drugs aiming to pharmacological control of cardiac rate. Molecules able to bind specifically to and block f-channels can thus be used as pharmacological tools for heart rate reduction with little or no adverse cardiovascular side effects. Indeed a selective f-channel inhibitor, ivabradine, is today commercially available as a tool in the treatment of stable chronic angina. Also, several loss-of-function mutations of HCN4 (hyperpolarization-activated, cyclic-nucleotide gated 4), the major constitutive subunit of f-channels in pacemaker cells, are known today to cause rhythm disturbances, such as for example inherited sinus bradycardia. Finally, gene- or cell-based methods for in situ delivery of f-channels to silent or defective cardiac muscle represent novel approaches for the development of biological pacemakers eventually able to replace electronic devices.

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Funny Mad Racing is a casual driving game that promises an adventurous journey featuring bouncy cars on dynamic roads. With 40 levels, various cars, and surprisingly funny features, players are in for a delightful hill-climbing experience. The game offers both single-player and 2-player modes, allowing for solo adventures or friendly competitions. As players progress, they can earn coins to unlock new features, adding layers of excitement to the pixelated world.Release DateDecember 2023

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Through funny and moving archival footage, their stories are told alongside incisive commentary from various popular comics, political commentators, and legendary creators, including Cedric the Entertainer, D.L. Hughley, Godfrey, RuPaul, Margaret Cho, Deon Cole, Sandra Bernhard, Norman Lear, and more. Hear how these Black comedy legends made it to the top and influenced so many by doing it their way. 2351a5e196