We organize a three days conference on the occasion of the 60th birthday of John Bechhoefer whose aim is to explore the scientific fertilization between information theory, control theory and non-equilibrium (bio)physics. The conference will be very interdisciplinary and will regroup at Université Côte d'Azur during the time of the conference applied physicists, theoretical physicists, chemists and mathematicians. The invited speakers will cover the full spectrum going from pure mathematics to physics and biophysics and will give talks accessible to nonspecialists, in particular to PhD students.