The Imran Series is an Urdu spy novel series created by famous Pakistani writer Ibn-e-Safi. Ali Imran is the pivotal character, a comical secret agent who controls the Secret Service as X-2 but appears to work as a normal member of the Secret Service. Except for a handful of people, no one knows his status as the chief of the Service.
Original author Ibn-e-Safi used the Secret Service as a central focus of the Imran Series. Later authors, continuing the series, added new members of the Secret Service. Real-world locations are not used in the series, instead fictional countries and place names are used.
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Early in the series Imran is portrayed as a hired agent of the Secret Service. Later he becomes a regular member of the agency. The other agents are not aware that he is their chief officer. As Imran, they laugh and sneer at him, but as X-2 they dread him.
Sulaiman is Imran's cook and housekeeper. Imran and Sulaiman often have comic interactions about the food Sulaiman is going to prepare. Sulaiman was originally employed by Imran's father. He dislikes Imran's bodyguard Joseph, who is always drunk. Later in the series, he marries a girl named Gulrukh.
Tsung He's next appearance is in Joank Ki Wapsee, in a story line that continues in Zehreeli Tasweer and Baebaakon Ki Talaash. Tsung He is working for an international criminal organization, Zeroland. Tsung He is the major villain in many other novels such as Seh Rangee Maut, Muta-Harrik Dhaariyaan, Joank Aur Naagan, Halaakat Khaez, Zebra Maen, and Jangal Ki Sheheriyat.
Ibne Safi had written the first two novels of the Humbug story-line, Dilchasp Hadisaa and Bay-Awaaz Sayyarah, when he fell sick for three years. The third and final novel of this narrative arc, Daerh Matwaalay, was written after his recovery.[15]
Ibn-e-Safi has written many novels involving Theresia, the Bumble-bee of Bohemia, or T3B. She is a very smart woman who represents the criminal organization Zeroland. She can disguise herself by changing her expression. She is very impressed with Imran's personality and is attracted to him.[3]
Ad Lava,[18] Allama Dehshatnak,[4][5][19] Alphonse[2][3][7] and Deadly Frog (a.k.a. King Chang)[20] are other significant characters in the Imran series. All of these except Allama Dehshatnak were killed by Imran. Adlie de Savana, or Louisa, was a French intelligence agent and James Harley, a foreign agent of X-2, were initially allies of Imran but turned against him and were killed by him.[21]
The character of Tiger was created by Mazhar Kaleem and continued in Zaheer Ahmed's novels. Tiger is a student of Imran's in Judo, martial arts and disguise. He is called "the second Imran" because his field work is outstanding. His real name is Abdul Ali and he is a Muslim.
Juana was introduced into the series by Mazhar Kaleem. He is an American Negro and a member of the criminal organization "Master Killers", which assassinates prominent personalities. Master Killers was hired to kill Imran in Imran Ki Maut. Juana came to Pakasia as part of a team of four assassins. Master Killers failed to kill Imran, and after an intense battle Juana accepted Imran as his master. Juana is an excellent martial arts fighter, 7.5 feet (2.3 metres) tall. He has a cruel nature and a strong body like a wrestler. Like Joseph, Juana sometimes acts as a personal body guard of the Prince of Dhump.
In Mazhar Kaleem's contributions four characters (Captain Khawar, Lieutenant Siddique, Lieutenant Chauhan and Sergeant Nomani) are called the "Four Stars" to the series. Siddique is the chief of the Four Stars. Chauhan is incomparable at field work. Nomani is the most intelligent agent in the Secret Service.
Find the best Urdu novels to read online, including romantic novels, action-adventure novels, Islamic historic novels, and more. We have a wide selection of novels to choose from, so you're sure to find something you'll love.
Novel series of disulfide and sulfone hybrid analogs (1-20) were synthesized and characterized through EI-MS and (1)H NMR and evaluated for -glucuronidase inhibitory potential. All synthesized analogs except 13 and 15 showed excellent -glucuronidase inhibitory potential with IC50 value ranging in between 2.20-88.16M as compared to standard d-saccharic acid 1,4 lactone (48.41.25M). Analogs 19, 16, 4, 1, 17, 6, 10, 3, 18, 2, 11, 14 and 5 showed many fold potent activity against -glucuronidase inhibitor. Structure activity relationship showed that substitution of electron withdrawing groups at ortho as well as para position on phenyl ring increase potency. Electron withdrawing groups at meta position on phenyl ring showed slightly low potency as compared to ortho and para position. The binding interactions were confirmed through molecular docking studies.
Ibne Safi was the pen name of Asrar Ahmad, a bestselling and prolific Urdu fiction writer, novelist and poet from Pakistan. He is best know for his 125-book Jasoosi Duniya series and the 120-book Imran series. He died on 26 July 1980.
The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an accumulation of intracellular sorbitol, depletion of cytoplasmic NADPH and oxidative stress and causing a variety of different conditions including retinopathy, nephropathy, neuropathy and cardiovascular disorders. While previous efforts have sought to develop inhibitors of this enzyme in order to combat diabetic complications, non-selective inhibition of both ALR2 and the homologous enzyme aldehyde reductase (ALR1) has led to poor toxicity profiles, with no drugs targeting ALR2 currently approved for therapeutic use in the Western world. In the current study, we have synthesized a series of N-substituted thiosemicarbazones with added phenolic moieties, of which compound 3m displayed strong and selective ALR2 inhibitory activity in vitro (IC50 1.18 M) as well as promising antioxidant activity (75.95% free radical scavenging activity). The target binding modes of 3m were studied via molecular docking studies and stable interactions with ALR2 were inferred through molecular dynamics simulations. We thus report the N-substituted thiosemicarbazones as promising drug candidates for selective inhibition of ALR2 and possible treatment of diabetic complications.
N2 - The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an accumulation of intracellular sorbitol, depletion of cytoplasmic NADPH and oxidative stress and causing a variety of different conditions including retinopathy, nephropathy, neuropathy and cardiovascular disorders. While previous efforts have sought to develop inhibitors of this enzyme in order to combat diabetic complications, non-selective inhibition of both ALR2 and the homologous enzyme aldehyde reductase (ALR1) has led to poor toxicity profiles, with no drugs targeting ALR2 currently approved for therapeutic use in the Western world. In the current study, we have synthesized a series of N-substituted thiosemicarbazones with added phenolic moieties, of which compound 3m displayed strong and selective ALR2 inhibitory activity in vitro (IC50 1.18 M) as well as promising antioxidant activity (75.95% free radical scavenging activity). The target binding modes of 3m were studied via molecular docking studies and stable interactions with ALR2 were inferred through molecular dynamics simulations. We thus report the N-substituted thiosemicarbazones as promising drug candidates for selective inhibition of ALR2 and possible treatment of diabetic complications.
AB - The role of aldose reductase (ALR2) in causing diabetic complications is well-studied, with overactivity of ALR2 in the hyperglycemic state leading to an accumulation of intracellular sorbitol, depletion of cytoplasmic NADPH and oxidative stress and causing a variety of different conditions including retinopathy, nephropathy, neuropathy and cardiovascular disorders. While previous efforts have sought to develop inhibitors of this enzyme in order to combat diabetic complications, non-selective inhibition of both ALR2 and the homologous enzyme aldehyde reductase (ALR1) has led to poor toxicity profiles, with no drugs targeting ALR2 currently approved for therapeutic use in the Western world. In the current study, we have synthesized a series of N-substituted thiosemicarbazones with added phenolic moieties, of which compound 3m displayed strong and selective ALR2 inhibitory activity in vitro (IC50 1.18 M) as well as promising antioxidant activity (75.95% free radical scavenging activity). The target binding modes of 3m were studied via molecular docking studies and stable interactions with ALR2 were inferred through molecular dynamics simulations. We thus report the N-substituted thiosemicarbazones as promising drug candidates for selective inhibition of ALR2 and possible treatment of diabetic complications.
A series of novel copolymers were successfully synthesized by ring-opening polymerization (ROP) of 3(S)-methyl-morpholine-2,5-dione (MMD) and 5-methyl-5-benzyloxycarbonyl-1,3-dioxan-2-one (MBC) using stannous octoate as catalyst. The copolymers were characterized by means of 1H-NMR and FT-IR spectroscopy. Gel permeation chromatography (GPC) test shows that the average-number relative molecular mass and average-weight relative molecular mass slightly increase with the increase of MBC content in feed. The results of differential scanning calorimetry (DSC) demonstrate that the glass transition temperature of copolymers increases with the increase of MBC content in copolymers. The copolymers of MMD and MBC are amorphous copolymers, as indicated by DSC results, while the homopolymer of MMD is semicrystalline. 0852c4b9a8
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