Dr. Nicolas Buzhinsky
Current Position:
Research Engineer, INSERM UMRS* 1067
*Unité Mixte de Recherche Scientifique
Education and Professional experience:
2018 – Present Research Engineer, INSERM UMRS 1067
2012 – 2017 Research Engineer, INSERM UMRS 1006
2006 – 2011 Post-Doc, Institut Curie, France
2002 – 2005 PhD program, University of Bordeaux, France
1999 – 2001 Teaching assistant; Biological Faculty of Odessa National University, Ukraine
1999 – MS in Microbiology and Immunology, Odessa National University, Ukraine
Cells and tissues are the constituents of organs, their biochemical and mechanical properties are essential for normal physiology of organisms. Among the methods of cell study the Atomic Force Microscopy in combination with various methods of Optical Microscopy has evolved into a powerful tool of assessment of cell and tissue mechanics and its correlation with the structural information. My current research is focused on study of mechanical properties of osteoblasts, the cell responsible for formation of bone mineral and organic components. Another projects deals with mechanics of stromal part of tissue and its influence on fate of cancerous stem cells.
Selected publications:
Rico F, Picas L, Colom A, Buzhynskyy N, and Scheuring S. The mechanics of membrane proteins is a signature of biological function. Soft Matter. 2013 9 (32): 7866-73.
Hozic A, Rico F, Colom A, Buzhynskyy N, Scheuring S. Nanomechanical characterization of the stiffness of eye lens cells: a pilot study. Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4): 2151-6.
Buzhynskyy N, Salesse C and Scheuring S. Rhodopsin is spatially heterogeneously distributed in rod outer segment disk membranes. J Mol Recognit. 2011 24(3): 483-9.
Mangenot S#, Buzhynskyy N#, Girmens JF and Scheuring S. Malformation of junctional microdomains in cataract lens membranes from a type II diabetes patient. Eur J Physiol, 2009 457(6):1265-74. # equal author contribution
Buzhynskyy N, Prima V, Sens P, Sturgis JN, and Scheuring S. Rows of ATP synthase dimers in native mitochondrial inner membranes. Biophys J, 2007 93(8): 2870-6.
Buzhynskyy N, Hite RK, Walz T, and Scheuring S. The supramolecular architecture of junctional microdomains in native lens membranes. EMBO R, 2007 8(1): 51-5.