Curriculum

Education

2012 – PhD in Neurobiology, SISSA/ISAS, Trieste, Italy

Thesis title: An electrophysiological analysis of permeation and gating properties of CNGA1 channels,

Thesis director: Prof. Vincent Torre

2008 – MA in Neuroscience, Università degli Studi di Trieste, Italy

2006 – BS in Psichology, Università degli Studi di Trieste, Italy

Professional experience

2017 - 2018 Marie Curie Postdoctoral Fellow, FM4B-Lab @LAI, U1006 and U1067 INSERM (Supervisor, Felix Rico)

2015 - 2016 EMBO Postdoctoral Fellow at U1006 INSERM (Supervisor, Simon Scheuring)

2013 – 2015 Postdoc at Vincent Torre lab, Neurobiology area, SISSA/ISAS, Trieste, Italy

Research – Molecular mechanisms of ion channel and transporters operation

I’m pursuing transmembrane proteins structure-function relationship by means of a multi-pronged approach, combining cutting edge technologies in the field of scanning probe microscopy (namely high-speed single molecule force spectroscopy and high-speed atomic force microscopy imaging) to well established tools like molecular biology and electrohysiology.

Selected publications

(*corresponding author, ^¶equal contribution) Researchgate Proflie

Marchesi A, Gao X, Adaixo R, Rheinberg J, Stahlberg H, Nimigean C & Scheuring S. An iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel. Nat. Commun. 2018; 9:3978

Napolitano LM, Bisha I, De March M, Marchesi A, Arcangeletti M, Demitri N, Mazzolini M, Rodriguez A, Magistrato A, Onesti S, Laio A, Torre V. A structural, functional, and computational analysis suggests pore flexibility as the base for the poor selectivity of CNG channels. Proc Natl Acad Sci U S A. 2015 Jul 7;112(27).

Marchesi A, Arcangeletti M, Mazzolini M, Torre V. Proton transfer unlocks inactivation in cyclic nucleotide-gted A1 channels. J Physiol. 2015 Feb 15;593(4):857-70.

Marchesi A, Mazzolini M, Torre V. Gating of cyclic nucleotide-gated channels is voltage dependent. Nat Commun. 2012 Jul 24;3:973.