Dr. Nicolas Buzhinsky

Current Position:

Research Engineer, FM4B-Lab, INSERM UMRS* 1006

*Unité Mixte de Recherche Scientifique

Education and Professional experience:

2012 – Present Research Engineer, INSERM UMRS 1006

2006 – 2011 Post-Doc, Institut Curie, France

2002 – 2005 PhD program, University of Bordeaux, France

1999 – 2001 Teaching assistant; Biological Faculty of Odessa National University, Ukraine

1999 – MS in Microbiology and Immunology, Odessa National University, Ukraine

Protein molecules, especially those located in biological membranes, carry out a number of functions vital to a living cell including transport, energy transformation, signal reception and transduction, intercellular interaction, etc. Often the proteins work in complex assemblies whose structure is regulated by the cell depending on its conditional requirements. Dysfunction of membrane proteins often provokes development of various pathologies. Therefore, it is important to investigate membrane proteins in both healthy and pathological states in order to elaborate a clear picture of the mechanism of their biological function with the potential to develop more efficient methods of cure and correction of the related pathologies.

Selected publications:

Rico F, Picas L, Colom A, Buzhynskyy N, and Scheuring S. The mechanics of membrane proteins is a signature of biological function. Soft Matter. 2013 9 (32): 7866-73.

Hozic A, Rico F, Colom A, Buzhynskyy N, Scheuring S. Nanomechanical characterization of the stiffness of eye lens cells: a pilot study. Invest Ophthalmol Vis Sci. 2012 Apr 6;53(4): 2151-6.

Buzhynskyy N, Salesse C and Scheuring S. Rhodopsin is spatially heterogeneously distributed in rod outer segment disk membranes. J Mol Recognit. 2011 24(3): 483-9.

Mangenot S#, Buzhynskyy N#, Girmens JF and Scheuring S. Malformation of junctional microdomains in cataract lens membranes from a type II diabetes patient. Eur J Physiol, 2009 457(6):1265-74. # equal author contribution

Buzhynskyy N, Prima V, Sens P, Sturgis JN, and Scheuring S. Rows of ATP synthase dimers in native mitochondrial inner membranes. Biophys J, 2007 93(8): 2870-6.

Buzhynskyy N, Hite RK, Walz T, and Scheuring S. The supramolecular architecture of junctional microdomains in native lens membranes. EMBO R, 2007 8(1): 51-5.