Publications

2026

Abdullah M, Kadivella M, Vyas P, C P J, Palanisamy B, Azam S, Faisal SM. A multi-epitope approach for development of a universal vaccine against leptospirosis. Front Immunol. 2026 Mar 20;17:1774717. doi: 10.3389/fimmu.2026.1774717. PMID: 41939898; PMCID: PMC13046716.

2025

Harnvoravongchai P, Mattiello SP, Amabat A, CP J, Faisal SM, Kaushik RS, Scaria J. Gut commensal Bifidobacterium longum confers resistance to Salmonella Typhimurium and Shigella flexneri in a Caenorhabditis elegans model. Microbiology Spectrum. 2025 Dec 5:e01842-25.

Kadivella M, Varma VP, Cp J, Kavela S, Azam S, Faisal SM. Adjuvant activity of a small molecule TLR4 agonist discovered via structure-based virtual screening. Communications Biology. 2025 Sep 29;8(1):1382.

Atre R, Obukhov AG, Sharma R, Siddiqi F, White FA, Faisal SM, Varma VP, Darwhekar GN, Baig MS. Inhibiting TIRAP-mediated inflammatory signaling: A promising therapeutic strategy against sepsis. Biochemical Pharmacology. 2025 Sep 18:117353.

Baig MS, Siddiqi F, Atre R, Parihar SP, Faisal S, Saqib U. Community Series in Targeting Signaling Pathways in Inflammatory Diseases-Volume II. Frontiers in Immunology. 2025 Jun 27;16:1639004.

Abdullah M, Kadivella M, Sharma R, Baig MS, Faisal SM, Azam S. Identification of virulence genes and clade-specific markers through pan-genomic analysis of Leptospira. BMC microbiology. 2025 Apr 26;25(1):248.

Atre R, Obukhov AG, Majmudar CY, Nair K, White FA, Sharma R, Siddiqi F, Faisal SM, Varma VP, Hassan MI, Mohammad T. Dorzolamide intermediates with potential anti-inflammatory activity. European Journal of Pharmacology. 2025 Jan 15;987:177160.

2023

Varma, V. P., Kadivella, M., Kavela, S., & Faisal, S. M. (2023). Leptospira Lipid A Is a Potent Adjuvant That Induces Sterilizing Immunity against Leptospirosis. Vaccines, 11(12), 1824.

Varma VP, Bankala R, Kumar A, Gawai S, Faisal SM. Differential modulation of innate immune response by lipopolysaccharide of Leptospira. Open Biology. 2023 Nov;13(11):230101. doi: 10.1098/rsob.230101. Epub 2023 Nov 8. PMID: 37935355.

Kumar P, Vyas P, Faisal SM, Chang YF, Akif M. Crystal structure of a variable region segment of Leptospira host-interacting outer surface protein, LigA, reveals the orientation of Ig-like domains. International Journal of Biological Macromolecules. 2023 Jun 17;244:125445. doi: 10.1016/j.ijbiomac.2023.125445. Epub ahead of print. PMID: 37336372.

Sajjan Rajpoot, Ashutosh Kumar, Vadim Gaponenko, Teresa LM Thurston, Dolly Mehta, Syed M Faisal, Kam YJ Zhang, Hem C Jha, Gajanan N Darwhekar, and Mirza S Baig.Dorzolamide suppresses PKCδ -TIRAP-p38 MAPK signaling axis to dampen the inflammatory response.Future Medicinal Chemistry 2023 15:6, 533-554

Kavela S, Vyas P, Cp J, Kushwaha SK, Majumdar SS, Faisal SM. Use of an Integrated Multi-Omics Approach To Identify Molecular Mechanisms and Critical Factors Involved in the Pathogenesis of Leptospira. Microbiology Spectrum. 2023 Feb 28;11(2):e0313522. doi: 10.1128/spectrum.03135-22. Epub ahead of print. PMID: 36853003; PMCID: PMC10100824.

2022

Varma VP, Kadivella M, Kumar A, Kavela S, Faisal SM. LigA formulated in AS04 or Montanide ISA720VG induced superior immune response compared to alum, which correlated to protective efficacy in a hamster model of leptospirosis. Fronteirs Immunology. 2022 Oct 10;13:985802. doi: 10.3389/fimmu.2022.985802. PMID: 36300125; PMCID: PMC9590693.

Kumar A, Varma VP, Faisal SM. Screening of Surface-Exposed Lipoproteins of Leptospira Involved in Modulation of Host Innate Immune Response. Fronteirs Microbiology. 2022 Mar 24;13:761670. doi: 10.3389/fmicb.2022.761670. PMID: 35401498; PMCID: PMC8988195.

Rajpoot, S., Solanki, K., Syed M. Faisal. et al. In-Silico Design of a Novel Tridecapeptide Targeting Spike Protein of SARS-CoV-2 Variants of Concern. International Journal of Peptide Research and Therapeutics 28, 28 (2022). https://doi.org/10.1007/s10989-021-10339-0

2021

Kumar A, Varma VP, Sridhar K, Abdullah M, Vyas P, Ashiq Thalappil M, Chang YF, Faisal SM. Deciphering the Role of Leptospira Surface Protein LigA in Modulating the Host Innate Immune Response. Fronteirs Immunology. 2021 Dec 16;12:807775. doi: 10.3389/fimmu.2021.807775. PMID: 34975922; PMCID: PMC8716722.

2020

Baig MS, Anjali Roy, Rajpoot S, Dongfang Liu, Faisal SM et. al,. Tumor-derived exosomes in the regulation of macrophage polarization. Journal of Inflammation Research 2020 (In press)

2018

Mirza S. Baig, Anjali Roy, Kannan Muthu, Syed M. Faisal, Mansi Srivastava, Dongfang Liu. Repurposing Thioridazine (TDZ) as an anti-inflammatory agent Scientific Reports 2018(Aug 20): 8, 12471.

2017

Ramakrishna Bulugonda, Kotha Anil Kumar, Gangappa D, Muralidhara Rao* Syed M. Faisal* Mangiferin from Pueraria tuberosa reduces inflammation via inactivation of NLRP3 inflammasome. Scientific Reports 2017, Feb 20;7: 42683. (*corresponding author).

2016

Syed M. Faisal*, Vivek Verma, Subathra M, Anil K Sunkara, Sarwar Azam, Mohd Akif, Mirza S Baig, Chang YF, (2016). Leptospira surface protein Lsa21 induce proiflammatory cytokines by Toll like receptor 2 and 4 mediated signaling pathways. Scientific Reports 2016, Dec 20;6: 39530. (*corresponding author).

2011

Syed M. Faisal, Chen JW, McDonough SP and Yung-Fu Chang. Immunostimulatory and antigen delivery properties of liposomes made up of total polar lipids from non-pathogenic bacteria leads to efficient induction of both innate and adaptive immune response. Vaccine 2011;(29): 2381-2391.

2009

Syed M. Faisal, WeiWei Yan, Sean P. McDonough, and Yung-Fu Chang. Immune response and prophylactic efficacy of smegmosomes in hamster model of leptospirosis. Vaccine. 2009 Oct 19;27(44):6129-36.

Syed M. Faisal, WeiWei Yan, Sean P. McDonough, and Yung-Fu Chang. Leptosome entrapped protective antigens conferred significantly higher level of protection than those delivered in conventional liposomes against hamster leptospirosis. Vaccine. 2009 Nov 5;27(47):6537-45.

Syed M. Faisal, WeiWei Yan, Sean P. McDonough, and Yung-Fu Chang. Leptospira immunoglobulin-like protein A variable region (LigAvar) incorporated in Liposomes and PLGA-Microspheres produces a robust immune response correlating to protective immunity. Vaccine. 2009, Jan 14;27(3):378-87.

2008

Syed M. Faisal, WeiWei Yan, Chia-Sui Chen, Raghavan UM Palaniappan, Sean P. McDonough, and Yung-Fu Chang. Evaluation of protective immunity of Leptospira immunoglobulin like protein A (LigA) DNA vaccine against challenge in hamsters. Vaccine. 2008 Jan 10;26(2):277-87.

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