Studies

ExploreASL has been/is used in several clinical studies: including the AMYPAD(1), APGEM(2), BioCog(3), COBRA(4), DDI(5), EDIS(6), EPAD(7), GENFI(8,9), PHOA(10), and NTR(11) consortia:

1. Frisoni GB, Boccardi M, Barkhof F, et al. Strategic roadmap for an early diagnosis of Alzheimer ’ s disease based on biomarkers. Lancet Neurol. 2017;661–676.

2. Kirsebom B-E, Espenes R, Waterloo K, et al. Screening for Alzheimer’s Disease: Cognitive Impairment in Self-Referred and Memory Clinic-Referred Patients. J Alzheimer’s Dis JAD. 2017;60(4):1621–1631http://search.ebscohost.com/login.aspx?direct=true&db=cmedm&AN=28984581&site=ehost-live.

3. Mutsaerts MHJ, Kant I, Petr J, et al. Perfusion changes following elective surgery in the elderly. Eur Soc Magn Reson Med Biol. 2017. p. 3–5.

4. van Zoest RA, Underwood J, De Francesco D, et al. Structural Brain Abnormalities in Successfully Treated HIV Infection: Associations With Disease and Cerebrospinal Fluid Biomarkers. J Infect Dis. 2017;217(1):69–81http://fdslive.oup.com/www.oup.com/pdf/production_in_progress.pdf. Accessed January 8, 2018.

5. Fladby T, Palhaugen L, Selnes P, et al. Detecting at-risk Alzheimer’s disease cases. J Alzheimer’s Dis. 2017;60(1):97–105.

6. Hilal S, Ikram MK, Saini M, et al. Prevalence of cognitive impairment in Chinese: Epidemiology of Dementia in Singapore study. J Neurol Neurosurg Psychiatry. 2013;84(6):686–692.

7. Ritchie CW, Molinuevo JL, Truyen L, Satlin A, Van der Geyten S, Lovestone S. Development of interventions for the secondary prevention of Alzheimer’s dementia: The European Prevention of Alzheimer’s Dementia (EPAD) project. The Lancet Psychiatry. 2016;3(2):179–186.

8. Rohrer JD, Nicholas JM, Cash DM, et al. Presymptomatic cognitive and neuroanatomical changes in genetic frontotemporal dementia in the Genetic Frontotemporal dementia Initiative (GENFI) study: a cross-sectional analysis. Lancet Neurol. p. 253–262.

9. Mutsaerts H, Petr J, Thomas DL, et al. Comparison of arterial spin labeling registration strategies in the multi-center GENetic frontotemporal dementia initiative (GENFI). J Magn Reson Imaging. United States; 2018;47(1):131–140.

10. Blokhuis C, Mutsaerts HJMM, Cohen S, et al. Higher subcortical and white matter cerebral blood flow in perinatally HIV-infected children. Medicine (Baltimore). 2017;96(7):e5891.

11. Willemsen G, Vink JM, Abdellaoui A, et al. The Adult Netherlands Twin Register: Twenty-five years of survey and biological data collection. Twin Res Hum Genet. 2013;16(1):271–281.


Recent review of the CamCan study "As to my experience with xASL, it works really well and all the extra features are worthwhile."